Association Between Genetic Polymorphisms of MIR3142HG and the Risk of Steroid-induced Osteonecrosis of the Femoral Head in the Population of Northern China

Abstract Background: Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis of the femoral head caused by glucocorticoid use. Once necrotic femoral head necrosis occurs, it irreversibly affects the quality of life seriously. Studies have shown that the susceptibility to steroid-induced ONFH is likely to be related to the variation of miRNA coding genes. Therefore, this study aimed was to investigate the effect of MIR3142HG on steroid-induced ONFH.Methods: Agena MassARRAY was used to genotype MIR3142HG gene rs1582417, rs2431689, rs7727155 and rs17057846 in 199 patients and 506 healthy people. A genetic model and haplotype analysis were used to evaluate the relationship between the MIR3142HG polymorphism and the risk of steroid-induced ONFH. The odds ratio (OR) and 95% confidence intervals (CIs) were obtained through logistic regression to assess the influence of gene polymorphisms on the occurrence of steroid-induced ONFH.Results: The consequences show that rs7727115(OR=0.76,p=0.036) is a protective factor, it could reduce the risk of steroid-induced ONFH, rs1582417(OR=1.28, p=0.041) could increase the risk of steroid-induced ONFH. Stratified analysis , according to each clinical index shows that MIR3142HG TC-CC genotype facilitated the risk of steroid-induced ONFH in male ( p<0.05). In addition, rs2431689 is related to HDL-C(p=0.012) and ApoA1 (p=0.010) levels, and rs17057846 (p=0.024) is related to ApoB levels.The linkage analysis indicated that three SNPs (rs2431689, rs7727115 and rs17057846) in MIR3142HG with significant chain imbalance. In addition, haplotype “GGG” of MIR3142HG was found out is harmful for steroid-induced ONFH.Conclusion: Our results firstly confirm that the genetic polymorphism of MIR3142HG is associated with steroid-induced ONFH susceptibility in Chinese Han population.

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Association between Genetic Polymorphisms of MIR3142HG and the Risk of Steroid-Induced Osteonecrosis of the Femoral Head in the Population of Northern China

Public Health Genomics ◽

10.1159/000519577 ◽

2021 ◽

pp. 1-9

Author(s):

Tiantian Wang ◽

Huiqiang Wu ◽

Menghu Sun ◽

Tingting Liu ◽

Feimeng An ◽

...

Keyword(s):

Femoral Head ◽

Protective Factor ◽

Genetic Model ◽

Additive Model ◽

Northern China ◽

Dominant Model ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Aseptic Necrosis ◽

Increased Risk

Background: Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis of the femoral head caused by glucocorticoid use. Once necrotic femoral head necrosis occurs, it irreversibly affects the quality of life seriously. Studies have shown that the susceptibility to steroid-induced ONFH is likely to be related to the variation of miRNA-coding genes. Therefore, this study aimed was to investigate the effect of MIR3142HG on steroid-induced ONFH. Methods: Agena MassARRAY was used to genotype MIR3142HG gene rs1582417, rs2431689, rs7727155, and rs17057846 in 199 patients and 725 healthy people. A genetic model and haplotype analysis were used to evaluate the relationship between the MIR3142HG polymorphism and the risk of steroid-induced ONFH. The odds ratio and 95% confidence intervals were obtained through logistic regression to assess the influence of gene polymorphisms on the occurrence of steroid-induced ONFH. Results: The consequences show that rs7727115 is a protective factor, it could reduce the risk of steroid-induced ONFH, and rs1582417 could increase the risk of steroid-induced ONFH. In the genetic model, rs1582417 was associated with increased risk of alcohol-induced ONFH in dominant model and log-additive model. rs7727115 showed a decreased risk in codominant model, dominant model, and log-additive model. In addition, rs2431689 is related to HDL-C (p = 0.012) and ApoA1 (p = 0.010) levels, and rs17057846 (p = 0.024) is related to ApoB levels. Thelinkage analysis indicated 3 single-nucleotide polymorphisms (rs2431689, rs7727115, and rs17057846) in MIR3142HG with significant chain imbalance. In addition, haplotype “GGG” of MIR3142HG was found out and is harmful for steroid-induced ONFH. Conclusion: Our results first confirm that the genetic polymorphism of MIR3142HG is associated with steroid-induced ONFH susceptibility in Chinese Han population.

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MMP2andMMP10Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population

BioMed Research International ◽

10.1155/2019/8298193 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Ye Tian ◽

Feimeng An ◽

Jiaqi Wang ◽

Chang Liu ◽

Huiqiang Wu ◽

...

Keyword(s):

Femoral Head ◽

Genetic Model ◽

Model Analysis ◽

Chinese Han Population ◽

Chinese Han ◽

Han Population ◽

Susceptibility Factors ◽

Increased Risk ◽

Chi Squared

Background. Steroid-induced osteonecrosis of the femoral head is a relatively serious condition which seriously reduces patient quality of life. However, the pathogenesis of steroid-induced ONFH is still unclear. In recent years, more scholars have found that the pathogenesis of steroid-induced ONFH is related to susceptibility factors such asMMPs/TIMPssystem. The main purpose of this study is to investigate the correlation betweenMMP2andMMP10gene polymorphisms and steroid-induced ONFH in Chinese Han population.Methods. Six SNPs inMMP2and two SNPs inMMP10were genotyped using Agena MassARRAY RS1000 system from 286 patients of steroid-induced ONFH and in 309 healthy controls. The association betweenMMP2andMMP10polymorphisms and steroid-induced ONFH risk were estimated by the Chi-squared test, genetic model analysis, haplotype analysis, and stratification analysis. The relative risk was estimated by odd ratios (ORs) and 95% confidence intervals (CIs).Result. We found that the minor TG allele of rs470154 inMMP10was associated with an increased risk of steroid-induced ONFH (OR = 1.45, 95% CI, 1.03 – 2.05,p= 0.032). In the genetic model analysis, we found that rs2241146 inMMP2gene and rs470154 inMMP10gene showed a statistically significant association with increased risk of steroid-induced ONFH. The six SNPs (rs470154, rs243866, rs243864, rs865094, rs11646643, and rs2241146) showed a statistically significant association with different clinical phenotypes.Conclusion. Our results verify that genetic polymorphisms ofMMP2andMMP10contribute to steroid-induced ONFH susceptibility in the population of Chinese Han population, and our study provides new insights into the role thatMMP2andMMP10plays in the mechanism of ONFH.

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DPP4 rs16822665 and rs2268694 had Protective Effect on Osteonecrosis of the Femoral Head

10.21203/rs.3.rs-1069362/v1 ◽

2021 ◽

Author(s):

Chang Liu ◽

Xuan Liu ◽

Xiaolin Li

Keyword(s):

Femoral Head ◽

Additive Models ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Single Nucleotide ◽

Gender Stratification ◽

Risk Of Disease ◽

Orthopedic Diseases ◽

Stratified Analysis ◽

The Relationship

Abstract Background: It is reported that DPP4 is associated with bone metabolism, osteoporosis and other orthopedic diseases, but the correlation between DPP4 and osteonecrosis of the femoral head (ONFH) is not clear. It was the purpose of this study that was to explore the relationship between DPP4 gene and ONFH.Methods: We genotyped four single nucleotide polymorphisms (SNPs) from DPP4 gene using the Agena MassARRAY platform. The association between DPP4 variants and ONFH susceptibility was assessed using odds ratio (OR) and 95% confidence intervals (CIs) via logistic regression. Results: The results showed that the allele C of rs16822665 was related to a lower risk of ONFH (OR = 0.76, 95%CI = 0.63-0.92, p = 0.006). In the case of stratified analysis, we found that rs16822665 could reduce the incidence of ONFH risk in four genetic models (dominant, codominant, log-additive, and recessive models) in drinkers and people age ≤51 years (p < 0.05). In gender stratification analysis, both rs2268694 and rs16822665 were contributed to bring down the risk of disease, which were mainly reflected in the codominant, dominant and log-additive models in female (p < 0.05). The subgroup analysis was conducted based on smokers revealing that rs2268894 was vitally correlated with a decreased risk of ONFH in the codominant (C vs. T: OR = 0.51, 95% CI: 0.34-0.76, p = 0.001), dominant (TC-CC vs. TT: OR = 0.53, 95% CI: 0.36-0.77, p = 0.001), and log-additive (OR = 0.65, 95% CI: 0.48-0.88, p = 0.006) models, while it was not found in the non-smokers.Conclusions: This finding provide evidence that DPP4 variants play a key role in the occurrence of ONFH among the Chinese Han population.

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The Association between Hope and Quality of Life among Adolescents with Chronic Diseases: A Systematic Review

Child Health Nursing Research ◽

10.4094/chnr.2020.26.3.323 ◽

2020 ◽

Vol 26 (3) ◽

pp. 323-328

Author(s):

Ai Mardhiyah ◽

Koshy Philip ◽

Henny Suzana Mediani ◽

Iyus Yosep

Keyword(s):

Quality Of Life ◽

Chronic Diseases ◽

English Language ◽

Protective Factor ◽

Current Knowledge ◽

Future Studies ◽

Long Term Impact ◽

The Relationship

Purpose: Hope has been identified as a protective factor that contributes to achieving a better quality to life, especially in patients with chronic disease. The purpose of this review was to synthesize current knowledge about the relationship between hope and quality of life among adolescents living with chronic illnesses.Methods: We searched major English-language databases (PsycINFO, PubMed, and CINAHL) for studies from January 1, 2002 to July 12, 2019. Studies were included if they provided data on hope and its relationship with quality of life among adolescents with chronic diseases.Results: In total, five articles were selected from the 336 studies that were retrieved. All five studies reported a positive correlation between hope and quality of life, such that people with a higher level of hope had a better quality of life. Hope was found to have direct and indirect effects on quality of life in adolescents with chronic diseases.Conclusion: Healthcare professionals should make more efforts to enhance hope in adolescents with chronic diseases in order to improve their quality of life. Future studies exploring how hope develops in adolescents with chronic diseases and the long-term impact of hope on quality of life are necessary.

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Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

10.21203/rs.3.rs-374738/v1 ◽

2021 ◽

Author(s):

Tingting Liu ◽

Yuju Cao ◽

Changxu Han ◽

Feimeng An ◽

Tiantian Wang ◽

...

Keyword(s):

Femoral Head ◽

Gene Mutations ◽

Density Lipoprotein ◽

Northern China ◽

Recessive Model ◽

Control Group ◽

Nucleotide Polymorphisms ◽

Clinical Indicators ◽

Increased Risk ◽

The Relationship

Abstract IntroductionSteroid-induced osteonecrosis of the femoral head (ONFH ) is a disease of bone metabolism, and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in MIR17HG and MIR155HG and the risk of steroid-induced ONFH in the population of northern China.MethodsA total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of MIR17HG and seven SNPs of MIR155HG were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH.ResultsIn the codominant model, patients with the MIR17HG SNPs(rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79, p = 0.039), in the recessive model, patients with the MIR17HG SNP(rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78, p = 0.032). Stratified analysis showed that a MIR17HG SNP (rs7318578) and MIR155HG SNPs(rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein (HDL-C) levels between the ONFH group and the control group (p = 0.005). MIR17HG SNP(rs75267932) and MIR155HG SNPs(rs77699734, rs1893650 and rs34904192) were correlated with different lipid indexes.ConclusionOur results confirm that MIR17HG and MIR155HG gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.

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Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese

BioMed Research International ◽

10.1155/2021/9920631 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Yu Liu ◽

Xin Li ◽

Yan-Ping Huang ◽

Zi-Yu Cui ◽

Jia Bao ◽

...

Keyword(s):

Metabolic Syndrome ◽

Psoriasis Vulgaris ◽

Chronic Inflammatory Disease ◽

Chinese Han Population ◽

Nucleotide Polymorphisms ◽

Chinese Han ◽

Single Nucleotide ◽

Han Population ◽

Stratified Analysis ◽

The Relationship

Aim. Psoriasis is a chronic inflammatory disease with a complex etiology, and psoriasis vulgaris (PsV) is the most common type of psoriasis. Recent studies suggest the relationship between psoriasis and metabolic syndrome in different ethnicities. This study is aimed at evaluating the association of metabolism-related gene variants with the risk of PsV in Chinese Han population. Material and Methods. PsV patients (1030) and healthy controls (965) were enrolled in this study. Eighteen single-nucleotide polymorphisms (SNPs) previously reported to be significantly associated with metabolic syndrome were selected. SNPs were detected by next-generation sequencing. Results. Seven SNPs were significantly associated with PsV: rs805303 ( P = 0.012 , OR = 0.85 ), rs3177928 ( P = 1.37 × 10 − 15 , OR = 2.51 ), and rs2247056 ( P = 3.73 × 10 − 4 , OR = 0.67 ) located in the HLA gene region; rs1047781 ( P = 0.012 , OR = 1.18 ), rs281379 ( P = 0.014 , OR = 1.71 ), and rs492602 ( P = 0.005 , OR = 1.86 ) located in the FUT2 region; and rs2303138 ( P = 0.014 , OR = 1.18 ) located in the LNPEP region. After stratified analysis, rs805303 ( P = 0.017 , OR = 0.74 ) and rs2303138 ( P = 0.041 , OR = 1.30 ) were associated with PsVs when HLA-C ∗ 06 : 02 was positive, and rs805303 ( P = 5.62 × 10 − 5 , OR = 0.68 ), rs3177928 ( P = 0.003 , OR = 1.75 ), rs281379 ( P = 0.034 , OR = 1.96 ), and rs492602 ( P = 0.025 , OR = 2.04 ) were associated with PsVs when HLA-C ∗ 06 : 02 was negative. Conclusion. PsV and metabolic syndrome may have overlapped susceptible genes in Chinese Han population.

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QUALITY OF FAMILY INTERACTIONS AND ADOLES- CENTS' PERSONALITY TRAITS

Journal Human Research in Rehabilitation ◽

10.21554/hrr.021305 ◽

2013 ◽

Vol 3 (1) ◽

pp. 6-12

Author(s):

Tamara Efendić-Spahić ◽

Keyword(s):

Protective Factor ◽

Important Predictor ◽

Family Interactions ◽

Social Unit ◽

Human Needs ◽

Equal Importance ◽

Family Setting ◽

The Relationship ◽

Negative Relationships

Family as the basic social unit is the primary environment of the development of an individual. In the family setting an individual satisfies (or should satisfy) the basic human needs such as the need for safety and love. In the studies of patterns of unadapted behavior of children and adolescents, temperament is most often stated as the key human characteristic feature that is the most important predictor in the development of unadapted and antisocial forms of behavior. The survey of dispositional empirically identified and inheritance-determined characteristics has been described in detail by Eysenck’s dimensional model of personality through mutually orthogonal and bipolar characteristics: Neuroticism, Extraversion and Psychoticism. The formation of these dispositional characteristics is closely related to parents’ sensitivity to child’s needs and the level of parents’ engagement in their parental role. Therefore, the aim of this research was to examine to what extent the assessment of the quality of the relationship with parents is an important predictor for explaining the basic dimensions of adolescents’ personalities. The research was conducted on an appropriate sample of 135 adolescents, students of the Faculty of Philosophy in Tuzla. The results confirm that the aspects of negative relationships with mother and father are important predictors for explaining dimensions of Neuroticism and Psychoticism, which are very significant correlations of unadapted and antisocial behavior. Also, the results indicate less significant importance of positive relations with mother and father for explaining dependent research variables since it is presumed that positive relations act more as a protective factor whereas the assessment of negative relationships with parents is certainly more important, especially for the dimensions related to bad adaptation of adolescents. The results also indicate equal importance of mother and father in the upbringing process for explaining the basic personality dimensions of adolescents since negative relationships with both mother and father appear as equally important predictors for explaining the dimensions of Neuroticism and Psychoticism in adolescents.

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The Impact of CYP24A1 Polymorphisms on Hypertension Susceptibility

Kidney & Blood Pressure Research ◽

10.1159/000503925 ◽

2020 ◽

Vol 45 (1) ◽

pp. 28-37

Author(s):

Qiuhong Bao ◽

Dan Wang ◽

Yong Zhang ◽

Lili Bao ◽

Haiyu Jia

Keyword(s):

Protective Factor ◽

Case Control Study ◽

Genetic Variations ◽

Chinese Han ◽

Hypertension Risk ◽

Older Subjects ◽

The Impact ◽

The Relationship ◽

Control Study ◽

Human Death

Background: Hypertension is one of the leading causes of human death and disability. CYP24A1 regulates vitamin D activity and is closely linked to hypertension. However, the relationship between CYP24A1polymorphisms and hypertension risk remains unclear. Methods: This case-control study included 503 hypertensive patients and 498 healthy controls from the Chinese Han population. The genotypes of CYP24A1polymorphisms were detected using the Agena MassARRAY method. The association between genetic variations of CYP24A1and hypertension risk was evaluated with odds ratios (OR) and 95% confidence intervals (CI) in genetic models. Results: We found that rs56229249 of CYP24A1significantlydecreased the hypertension risk in homozygote (OR 0.51, 95% CI 0.29–0.91, p = 0.022) and recessive models (OR 0.51, 95% CI 0.29–0.91, p = 0.023). Further stratification analyses indicated that hypertension risk is related to age and sex, rs2762934 polymorphism increases hypertension risk among younger subjects (<61 years), and rs1977297 influences the risk of hypertension among older subjects (≥61 years). In addition, rs2762940 is related to hypertension risk in men, and rs56229249 is a protective factor against hypertension in women. Conclusions: Our study suggests that genetic variations of the CYP24A1gene were significantly associated with susceptibility to hypertension in the Chinese population.

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Evaluation of Association of LOC105371267 Polymorphisms and Breast Cancer Susceptibility

10.21203/rs.3.rs-39815/v1 ◽

2020 ◽

Author(s):

Xiaoli Liu ◽

Dandan Li ◽

Chunjuan He ◽

Linna Peng ◽

Shishi Xing ◽

...

Keyword(s):

Breast Cancer ◽

Haplotype Analysis ◽

Genetic Model ◽

Cancer Susceptibility ◽

Breast Cancer Susceptibility ◽

Candidate Snps ◽

Healthy Individuals ◽

Stratified Analysis ◽

Relationship Of ◽

The Relationship

Abstract Background: LOC105371267 (also known as PR-lncRNA1) was reported to be a p53-regulated lncRNA, which played essential roles in the pathogenesis of breast cancer (BC). We aimed to investigate the potential associations between LOC105371267 polymorphisms and BC risk. Method: Totally, 555 healthy individuals and 561 BC patients were recruited. Five candidate SNPs of LOC105371267 were genotyped with Agena MassARRAY system. Odds ratio (OR) and 95% confidence intervals (CIs) were applied to evaluate the relationship of LOC105371267 with BC susceptibility. Additionally, stratification analyses based on clinical features and haplotype analysis were also conducted. Results: A decreased BC risk was observed rs3931698 GG genotype (OR = 0.30, P = 0.018) and recessive genetic model (OR = 0.30, P = 0.021). Stratified analysis with age also revealed that this SNP was associated with a lower risk at age < 52 years. Meanwhile, multiple clinical characteristics, including ER and PR status and stage were all correlated with SNPs rs6499221, rs3931698, rs3852740 and rs8044565.Conclusion: Four LOC105371267 SNPs (rs6499221, rs3931698, rs8044565 and rs3852740) were found to be correlated with development of BC. Additionally, ER, PR, and stage were also linked to LOC105371267 polymorphisms, providing novel diagnostic and therapeutic targets for of BC management.

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