The relationship among GNB3 rs5443, PNPLA3 rs738409, GCKR rs780094 gene polymorphisms, type of maternal gestational weight gain and neonatal outcomes (STROBE-compliant article)

Objective The study aimed to evaluate perinatal outcomes associated with introduction of and adherence to early diabetes screening guidelines. Study Design Retrospective cohort study of all women who received prenatal care at a single, high-volume tertiary care center before (“preguidelines”) and after (“postguidelines”) American College of Obstetrics and Gynecology guidelines for early pregnancy diabetes screening for women at high risk for diabetes. Women with known pregestational diabetes, late entry to prenatal care, a fetus with a known anomaly, or multiple gestation were excluded. Multivariable linear and logistic regression models were constructed to compare maternal and neonatal outcomes between women in the preguidelines cohort to those in the postguidelines cohort. Similarly, adherence to screening guidelines was assessed, and among all women who were eligible for early diabetes screening, multivariable linear, and logistic models were created to compare outcomes between those women who were screened early to those who were not. Results Of the 2,069 women eligible for analysis, 64.6% (n = 1,337) were in the postguideline cohort. Women in the postguideline cohort were older, less likely to have a history of smoking, and more likely to be non-Hispanic white. On multivariable analysis, women in the postguideline cohort had significantly less gestational weight gain (aβ = −2.3; 95% confidence interval [CI]: −3.4 to −1.1), but a higher odds of 5-minute Apgar's score of <7 (adjusted odds ratio: 2.51; 95% CI: 1.11–5.66). Of 461 women who met ACOG early diabetes screening criteria, 58.7% (n = 270) were screened appropriately. Adherence to screening was associated with parity, race, insurance, and BMI. On multivariable analysis, there were no significant differences in neonatal outcomes between women meeting early screening criteria who were screened early and those who were not. Conclusion Introduction of early diabetes screening guidelines was associated with a significant decrease in gestational weight gain, but did not improve neonatal outcomes. Key Points

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Gestational weight gain adequacy for favourable obstetric and neonatal outcomes: a nationwide hospital-based cohort Gestational weight gain for favourable obstetric and neonatal outcomes

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2021.02.024 ◽

2021 ◽

Author(s):

Thelma Brandão ◽

Patricia de Carvalho Padilha ◽

Denise Cavalcante de Barros ◽

Karina dos Santos ◽

Silvana Granado Nogueira da Gama ◽

...

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Neonatal Outcomes ◽

Gestational Weight

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The Relationship Between Pre-Pregnancy Attempts to Lose Weight and Gestational Weight Gain: An Exploratory Primary Care Prospective Cohort Study

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/j.jogc.2020.09.023 ◽

2020 ◽

Author(s):

Helena Piccinini-Vallis ◽

Christy Woolcott ◽

Laura Miller ◽

Erna Snelgrove-Clarke ◽

Susan Cahill

Keyword(s):

Primary Care ◽

Cohort Study ◽

Weight Gain ◽

Gestational Weight Gain ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Gestational Weight ◽

The Relationship

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445: The relationship between gestational weight gain and gestational diabetes mellitus

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2014.10.491 ◽

2015 ◽

Vol 212 (1) ◽

pp. S229

Author(s):

Amy O'Higgins ◽

Lisa O'Higgins ◽

Anne Fennessy ◽

Thomas McCartan ◽

Laura Mullaney ◽

...

Keyword(s):

Diabetes Mellitus ◽

Weight Gain ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Gestational Weight Gain ◽

Gestational Weight ◽

The Relationship

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Higher gestational weight gain and lower serum estradiol levels on the day of human chorionic gonadotropin administration are associated with increased risk of preeclampsia after in vitro fertilization

10.21203/rs.2.21456/v1 ◽

2020 ◽

Author(s):

Yu-Chen Chen ◽

Yun-Ju Lai ◽

Yu-Ting Su ◽

Ni-Chin Tsai ◽

Kuo-Chung Lan

Keyword(s):

Weight Gain ◽

In Vitro Fertilization ◽

Gestational Weight Gain ◽

Chorionic Gonadotropin ◽

Serum Estradiol ◽

Vitro Fertilization ◽

Gestational Weight ◽

Relationship Of ◽

The Relationship

Abstract Background Very few previous studies have examined the effect of endocrine parameters during ART on preeclampsia. Moreover, there is little known about the relationship of steroid hormone levels on development of the placenta. The purpose of this study is to assess the association of preeclampsia with serum estradiol (E2) and progesterone (P4) levels on the day of human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods This was a hospital-based cohort study using clinical data from the Kaohsiung Chang Gung Memorial Hospital Obstetric and Neonatal Database (KCGMHOND) from Jan 1, 2001 to December 1, 2018. Eligible women underwent at least one autologous IVF/ICSI cycle and had a live-born infant with a gestational age (GA) of more than 20 weeks. Results A total of 622 women who had live births after fresh IVF/ICSI-ET during the study period met our inclusion criteria. Twenty-eight women (4.5%) met the diagnostic criteria for preeclampsia. However, women in the preeclampsia group had a significantly higher body mass index (22 vs. 24, p =0.05), body weight at delivery (70.0 vs. 80.5 kg, p <0.001) and gestational weight gain (13.0 vs. 19.6 kg, p =0.002) and had lower use of ICSI (29.9% vs. 10.7%, p =0.021). Logistic regression analysis of the relationship of patient and treatment characteristics with preeclampsia. The crude ORs indicated that young female age >34, not using ICSI, E2 peak <1200 pg/mL and gestational weight gain >20 kg were associated with preeclampsia. After adjustment for confounding, the only factors that remained significant were E2 peak <1200 pg/mL (aOR = 4.634, 95% CI = 1.061 to 20.222), and gestational weight gain >20 kg (aOR: 13.601, 95% CI: 3.784, 48.880). Conclusions For women receiving IVF/ICSI, lower estradiol hormone levels on the day of hCG administration and higher pregnancy weight gain are related with subsequent preeclampsia.

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The Relationship Between Continued Smoking During Pregnancy and Gestational Weight Gain in a Culturally Diverse Population

Journal of the American Dietetic Association ◽

10.1016/s0002-8223(97)00639-1 ◽

1997 ◽

Vol 97 (9) ◽

pp. A90

Author(s):

E. Metallinos-Katsaras ◽

C. Taft Bayerl ◽

C. Jones ◽

A. Pearson

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Culturally Diverse ◽

Diverse Population ◽

Smoking During Pregnancy ◽

Gestational Weight ◽

The Relationship

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Pre-Pregnancy Obesity, Excessive Gestational Weight Gain, and the Risk of Pregnancy-Induced Hypertension and Gestational Diabetes Mellitus

Journal of Clinical Medicine ◽

10.3390/jcm9061980 ◽

2020 ◽

Vol 9 (6) ◽

pp. 1980 ◽

Cited By ~ 4

Author(s):

Małgorzata Lewandowska ◽

Barbara Więckowska ◽

Stefan Sajdak

Keyword(s):

Weight Gain ◽

Pregnant Women ◽

Gestational Weight Gain ◽

Pregnancy Complications ◽

Gestational Hypertension ◽

Institute Of Medicine ◽

Maternal Weight ◽

Odds Ratios ◽

Gestational Weight ◽

The Relationship

Excessive pre-pregnancy weight is a known risk factor of pregnancy complications. The purpose of this analysis was to assess the relationship between several categories of maternal weight and the risk of developing hypertension and diabetes in pregnancy, and the relationship of these complications with the results of the newborn. It was carried out in a common cohort of pregnant women and taking into account the influence of disturbing factors. Our analysis was conducted in a prospective cohort of 912 Polish pregnant women, recruited during 2015–2016. We evaluated the women who subsequently developed diabetes with dietary modification (GDM-1) (n = 125) and with insulin therapy (GDM-2) (n = 21), as well as the women who developed gestational hypertension (GH) (n = 113) and preeclampsia (PE) (n = 24), compared to the healthy controls. Odds ratios of the complications (and confidence intervals (95%)) were calculated in the multivariate logistic regression. In the cohort, 10.8% of the women had pre-pregnancy obesity (body mass index (BMI) ≥ 30 kg/m2), and 36.8% had gestational weight gain (GWG) above the range of the Institute of Medicine recommendation. After correction for excessive GWG and other confounders, pre-pregnancy obesity (vs. normal BMI) was associated with a higher odds ratio of GH (AOR = 4.94; p < 0.001), PE (AOR = 8.61; p < 0.001), GDM-1 (AOR = 2.99; p < 0.001), and GDM-2 (AOR = 11.88; p <0.001). The threshold risk of development of GDM-2 occurred at lower BMI values (26.9 kg/m2), compared to GDM-1 (29.1 kg/m2). The threshold point for GH was 24.3 kg/m2, and for PE 23.1 kg/m2. For GWG above the range (vs. GWG in the range), the adjusted odds ratios of GH, PE, GDM-1, and GDM-2 were AOR = 1.71 (p = 0.045), AOR = 1.14 (p = 0.803), AOR = 0.74 (p = 0.245), and AOR = 0.76 (p = 0.672), respectively. The effect of maternal edema on all the results was negligible. In our cohort, hypertension and diabetes were associated with incorrect birth weight and gestational age at delivery. Conclusions: This study highlights the importance and influence of excessive pre-pregnancy maternal weight on the risk of pregnancy complications such as diabetes and hypertension which can impact fetal outcomes.

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Maternal and neonatal outcomes according to gestational weight gain in twin pregnancies: Are the American IOM guidelines associated with better issues in Europe?

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2018.08.256 ◽

2019 ◽

Vol 234 ◽

pp. e46-e47

Author(s):

Océane Pécheux ◽

Charles Garabedian ◽

Elodie Drumez ◽

Sarah Mizrahi ◽

Sophie Cordiez ◽

...

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Neonatal Outcomes ◽

Gestational Weight ◽

Maternal And Neonatal Outcomes ◽

Twin Pregnancies

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Characteristics of the Family Support Network of Pregnant Adolescents and Its Association with Gestational Weight Gain and Birth Weight of Newborns

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16071222 ◽

2019 ◽

Vol 16 (7) ◽

pp. 1222

Author(s):

Reyna Sámano ◽

Hugo Martínez-Rojano ◽

Gabriela Chico-Barba ◽

Bernarda Sánchez-Jiménez ◽

Daniel Illescas-Zarate ◽

...

Keyword(s):

Weight Gain ◽

Family Support ◽

Gestational Weight Gain ◽

Neonatal Outcomes ◽

Support Network ◽

Pregnant Adolescents ◽

Gestational Weight ◽

The Family ◽

Maternal And Neonatal Outcomes ◽

Primary Support

It has been proposed that, in the Mexican culture, family support can be a factor that contributes to protect the maternal and child health of pregnant adolescents. There may be complex associations between family support and the circumstances of a pregnancy during adolescence. The aim of the study was to analyze the association between the family support network (FSN) characteristic and the maternal and neonatal outcomes in Mexican adolescents. A cross-sectional study was conducted, and 352 pregnant adolescents participated; their FSN during pregnancy was assessed. The gestational weight gain and birth weight/length of newborns were registered. The size of the FSN was described and divided into quartiles; the main members for each quartile were identified. Then, sociodemographic and clinical variables were compared by FSN quartiles. Logistic regression models were performed to assess the association of FSN size and pregnancy and neonatal outcomes. Our results indicate that the mean age was 15 ± 1 year old. The primary support member in the FSN was the mother of the adolescent in each quartile, except for quartile 3, where the primary support was the mother-in-law. In quartile 3 there was a significantly lower gestational weight gain compared to quartile 4 (11.8 ± 5 vs. 13 ± 5 kg, p = 0.054). According to the regression model, a higher risk of small for gestational age (OR 2.99, CI 95% 1.25–7.15) newborns was found in quartile 3. We conclude that the maternal and neonatal outcomes did not differ between quartiles of FSN size, except for quartile 3. Small for gestational age newborns were observed when a non-blood relative was present in the FSN. The quality rather than the network size might be more important for improving pregnancy outcomes.

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