Testicular tumors: discriminative value of conventional MRI and diffusion weighted imaging

Objectives: The present study aimed to study whether combined inflow-based vascular-space-occupancy (iVASO) MR imaging (MRI) and diffusion-weighted imaging (DWI) improve the diagnostic accuracy in the preoperative grading of gliomas. Methods: Fifty-one patients with histopathologically confirmed diffuse gliomas underwent preoperative structural MRI, iVASO, and DWI. We performed 2 qualitative consensus reviews: (1) structural MR images alone and (2) structural MR images with iVASO and DWI. Relative arteriolar cerebral blood volume (rCBVa) and minimum apparent diffusion coefficient (mADC) were compared between low-grade and high-grade gliomas. Receiver operating characteristic (ROC) curve analysis was performed to compare the tumor grading efficiency of rCBVa, mADC, and the combination of the two parameters. Results: Two observers diagnosed accurate tumor grade in 40 of 51 (78.4%) patients in the first review and in 46 of 51 (90.2%) in the second review. Both rCBVa and mADC showed significant differences between low-grade and high-grade gliomas. ROC analysis gave a threshold value of 1.52 for rCBVa and 0.85 × 10−3 mm2/s for mADC to provide a sensitivity and specificity of 88.0 and 81.2% and 100.0 and 68.7%, respectively. The area under the ROC curve (AUC) was 0.87 and 0.85 for rCBVa and mADC, respectively. The combination of rCBVa and mADC values increased the AUC to 0.92. Conclusion: The combined application of iVASO and DWI may improve the diagnostic accuracy of glioma grading.

Download Full-text

Magnetic resonance, magnetisation transfer, and diffusion weighted imaging correlates of optic nerve, brain, and cervical cord damage in Leber's hereditary optic neuropathy

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.70.4.431 ◽

2001 ◽

Vol 70 (4) ◽

pp. 431-431

Author(s):

C LIU

Keyword(s):

Optic Nerve ◽

Magnetic Resonance ◽

Optic Neuropathy ◽

Diffusion Weighted Imaging ◽

Cervical Cord ◽

Magnetisation Transfer ◽

Leber's Hereditary Optic Neuropathy ◽

Diffusion Weighted ◽

And Diffusion ◽

Hereditary Optic Neuropathy

Download Full-text

The role of magnetic resonance cholangiopancreatography and diffusion-weighted imaging for the differential diagnosis of obstructive biliary disorders

South African Journal of Radiology ◽

10.4102/sajr.v21i1.1193 ◽

2017 ◽

Vol 21 (1) ◽

Author(s):

Zeynep Cetiner-Alpay ◽

Fatma Kulali ◽

Aslihan Semiz-Oysu ◽

Yasar Bukte ◽

Kamil Ozdil

Keyword(s):

Magnetic Resonance ◽

Sensitivity And Specificity ◽

Gold Standard ◽

Diffusion Weighted Imaging ◽

Magnetic Resonance Cholangiopancreatography ◽

Malignant Tumours ◽

Diagnostic Efficacy ◽

Diffusion Weighted ◽

Sensitivity Specificity ◽

And Diffusion

Background: Although endoscopic retrograde cholangiopancreatography (ERCP) is accepted as the gold standard, there is a place for magnetic resonance cholangiopancreatography (MRCP) and diffusion-weighted imaging (DWI) in the diagnosis of obstructive biliary disorders.Aim: To compare the findings of MRCP with ERCP in patients with obstructive biliary disorders and to investigate the diagnostic efficacy of MRCP combined with DWI.Study design: Retrospective, analytic, cross-sectional study.Methods: The MRCP images of 126 patients who underwent both MRCP and ERCP owing to biliary obstruction were reviewed. Nine patients were excluded because of incomplete diagnostic workup or a long period (>3 months) between MRCP and ERCP. Ninety-two patients underwent DWI, which was also evaluated. The sensitivity, specificity and accuracy of MRCP and DWI were analysed.Results: The sensitivity, specificity and accuracy of MRCP according to ERCP results as the gold standard was 97%, 71% and 93% for assessment of biliary dilatation; 100%, 94.7% and 97.5% for the diagnosis of choledocholithiasis; 93.7%, 100% and 99% for the identification of benign strictures; 100%, 100% and 100% for the diagnosis of malignant tumours; and 100%, 100% and 100% for the detection of complicated hydatid cysts; respectively. The sensitivity and specificity of DWI for the diagnosis of malignant tumour was 100%. In the detection of choledocholithiasis, the sensitivity and specificity of DWI was 70.8% and 100%.Conclusions: MRCP is an alternative, non-invasive, diagnostic modality, comparable with ERCP for the evaluation of pancreaticobiliary diseases. DWI can be helpful for diagnosis of choledocholithiasis and tumours.

Download Full-text

Evaluation parameters between intra-voxel incoherent motion and diffusion-weighted imaging in grading and differentiating histological subtypes of meningioma: A prospective pilot study

Journal of the Neurological Sciences ◽

10.1016/j.jns.2016.11.037 ◽

2017 ◽

Vol 372 ◽

pp. 60-69 ◽

Cited By ~ 13

Author(s):

Lu Yiping ◽

Shek Kawai ◽

Wen Jianbo ◽

Liu Li ◽

Geng Daoying ◽

...

Keyword(s):

Pilot Study ◽

Diffusion Weighted Imaging ◽

Histological Subtypes ◽

Prospective Pilot Study ◽

Diffusion Weighted ◽

And Diffusion ◽

Evaluation Parameters

Download Full-text

Role of Diffusion Weighted Imaging in Differentiating Benign from Pathological Vertebral Compression

QJM ◽

10.1093/qjmed/hcab106.010 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Faten Mohammed Mahmoud Kamel ◽

Hazem Ibrahim Abdel Rahman ◽

Amany Sayed Khaleel Ahmed Elkhayat

Keyword(s):

Vertebral Fractures ◽

Diffusion Weighted Imaging ◽

Laboratory Evaluation ◽

Vertebral Collapse ◽

Adc Value ◽

Conventional Mri ◽

Diffusion Weighted ◽

Significant Difference

Abstract Background Vertebral collapse is a common problem due to benign conditions (trauma, infection, osteoporosis) or malignant process. And although the spine is the most common site of bone metastases (39% of bony metastases in patients with primary neoplasms) benign vertebral fractures due to osteopenia occur in one third of cancer patients, making it essential to determine whether the cause of vertebral collapse is benign or malignant. Aim of the Work To establish the role of DWI in differentiating benign from pathologic vertebral fractures using ADC values in comparison with histopathology report /laboratory evaluation and clinical follow-up. Patients and Methods A cross sectional study is approved by the ethics review board of Ain Shams University Hospital (Al Demerdash). All patients provided informed consent for the MR imaging examinations and for inclusion of their data in this analysis. From April 2020 to october 2020, 25 cases with previous imaging with vertebral compression underwent conventional MRI study on the affected region. Diffusion weighted imaging and ADC was added. Results We performed DWI using maximum b-values 600, and quantitative analysis, named apparent diffusion coefficient (ADC). We correlated the ADC number to histopathology, laboratory finding and clinical follow up. In our study there was significant difference (p < 0.04) between DWI of the benign and malignant groups. Also the ADC value showed significant difference <0.001. The mean ADCs of benign VCFs were higher significantly than those of pathological fractures. Conclusion DWI with ADC value was helpful when added to conventional MRI to differentiate benign from pathological (malignant) vertebral compression. It should be a routine sequence in patients with vertebral compression fractures for accurate diagnosis and successful management also can decrease no of biopsies.

Download Full-text