A successful approach for angiosarcoma of the scalp using helical tomotherapy and customized surface mold brachytherapy

Purpose: To evaluate the usefulness of helical tomotherapy (HT) in the treatment of advanced esophageal cancer (EC) and compare target homogeneity, conformity and normal tissue doses between HT and fixed-field intensity-modulated radiotherapy (ff-IMRT).Methods: In all, 23 patients with cT3-4N0-1M0-1a thoracic EC (upper esophagus, 9 patients; middle esophagus, 6; distal esophagus, 6 and esophagogastric junction, 2) who were treated with ff-IMRT (60 Gy in 30 fractions) were re-planned for HT and ff-IMRT with the same clinical requireÂments. Comparisons were performed using the Wilcoxon matched-pair signed-rank test.Results: Compared with ff-IMRT, HT significantly reduced the homogeneity index for thoracic, upper, middle and distal ECs by 38%, 31%, 36% and 33%, respectively (P < 0.05). The conformity index was increased by HT for thoracic, upper and middle ECs by 9%, 9% and 18%, respectively (P < 0.05). Target coverage was improved by 1% with HT (P < 0.05). The mean lung dose was significantly reduced by HT for thoracic and upper ECs (P < 0.05). The V20 (volume receiving at least 20 Gy) and higher dose volumes of the lungs were decreased by HT in all cases, but the differences were significant for thoracic, upper and distal ECs (P < 0.05), with reductions of 2.1%, 3.1% and 2.2%, respectively. HT resulted in a larger lung V5 for thoracic, upper, middle and distal ECs, with increases of 3.5%, 1.5%, 7.2% and 3.2%, respectively. Heart sparing was significantly better with HT than with ff-IMRT in terms of the V30 and V40 for thoracic, upper, middle and distal ECs (P < 0.05).Conclusions: Compared to ff-IMRT, HT provides superior target coverage, conformity and homogeneity, with reduced the volume of high doses to the lungs and heart for advanced EC. HT may be a treatment option for advanced EC, especially upper EC.

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Combine Micro-Probing and OBIRCH to Catch Non-Recognizable Fault in RF and Mixed-Mode Integrated Circuits

ISTFA 2007: Conference Proceedings from the 33rd International Symposium for Testing and Failure Analysis ◽

10.31399/asm.cp.istfa2007p0327 ◽

2007 ◽

Author(s):

Cha-Ming Shen ◽

Yen-Long Chang ◽

Lian-Fon Wen ◽

Tan-Chen Chuang ◽

Shi-Chen Lin ◽

...

Keyword(s):

Integrated Circuits ◽

Radio Frequency ◽

Failure Analysis ◽

Case Studies ◽

Mixed Mode ◽

Failure Mechanisms ◽

Deep Submicron ◽

Digital Logic ◽

Successful Approach ◽

Cmos Processes

Abstract Highly-integrated radio frequency and mixed-mode devices that are manufactured in deep-submicron or more advanced CMOS processes are becoming more complex to analyze. The increased complexity presents us with many eccentric failure mechanisms that are uniquely different from traditional failure mechanisms found during failure analysis on digital logic applications. This paper presents a novel methodology to overcome the difficulties and discusses two case studies which demonstrate the application of the methodology. Through the case studies, the methodology was proven to be a successful approach. It is also proved how this methodology would work for such non-recognizable failures.

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Catching an Atom Spy: MI5 and the Investigation of Klaus Fuchs

The Oxford Handbook of National Security Intelligence ◽

10.1093/oxfordhb/9780195375886.003.0034 ◽

2010 ◽

pp. 554-567

Author(s):

Timothy Gibbs

Keyword(s):

Cold War ◽

High Risk ◽

Klaus Fuchs ◽

Key Issues ◽

Successful Approach ◽

Anglo American ◽

Atomic Espionage ◽

Signals Intelligence

This article focuses on M15 organization and Klaus Fuchs, a German-born physicist and Soviet “Atom Spy” who was arrested in 1950 and served fourteen years for offences related to atomic espionage. It examines how Fuchs was identified as an “Atom Spy” in 1949 and describes the MI5's investigation, which ended in the early 1950 with the successful arrest, prosecution, and imprisonment of this highly significant Cold War figure. Key issues discussed in this article include the difficulties encountered by MI5 and the budding British atomic program in the sphere of security. It also discusses the role of Signals intelligence (SIGINT) in the investigation of Fuchs, and the high-risk but ultimately successful approach taken by MI5's key interrogator, William Skardon. This case study highlights both the unparalleled level of international intelligence cooperation between the British agencies and their American counterparts, which made the resolution of this case possible, and some of the frailties in the Anglo-American alliance that were brought to the fore by the exposure of Fuchs as an Atom Spy.

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Dosimetric Influences and Reproducibility of Flexed Neck and Extended Neck Set-up Positions in Helical Tomotherapy of Nasopharyngeal Carcinoma.

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2018.07.1000 ◽

2018 ◽

Vol 102 (3) ◽

pp. e323

Author(s):

J.C.P. LAM ◽

V. Wu ◽

G. Chiu ◽

Y.P. Ng ◽

P.S.W. Kong

Keyword(s):

Nasopharyngeal Carcinoma ◽

Helical Tomotherapy ◽

Set Up

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Staged reconstruction of unilateral neglected hip dislocation through total hip arthroplasty and subsequent intramedullary femoral lengthening

International Orthopaedics ◽

10.1007/s00264-021-05099-x ◽

2021 ◽

Author(s):

Bjoern Vogt ◽

Christoph Theil ◽

Georg Gosheger ◽

Adrien Frommer ◽

Burkhard Moellenbeck ◽

...

Keyword(s):

Total Hip Arthroplasty ◽

Hip Arthroplasty ◽

Plate Fixation ◽

Hip Dislocation ◽

Leg Length ◽

Total Hip ◽

Femoral Lengthening ◽

Shortening Osteotomy ◽

Successful Approach ◽

Staged Reconstruction

Abstract Background and purpose Total hip arthroplasty (THA) is a successful approach to treat unilateral symptomatic neglected hip dislocation (NHD). However, the extensive leg length discrepancy (LLD) can hereby only be partially corrected. In case of residual LLD of more than 2 cm, subsequent femoral lengthening can be considered. Patients/material/methods Retrospective analysis of clinical data and radiographs of five patients (age 38.1 (28–51) years) with unilateral NHD who underwent THA with (n = 3) or without (n = 2) subtrochanteric shortening osteotomy (SSO) and secondary intramedullary femoral lengthening through a retrograde magnetically-driven lengthening nail (follow-up 18.4 (15–27) months). Results LLD was 51.0 (45–60) mm before and 37.0 (30–45) mm after THA. Delayed bone union at one SSO site healed after revision with autologous bone grafting and plate fixation. Subsequent lengthening led to leg length equalisation in all patients. Complete consolidation was documented in all lengthened segments. Conclusion Staged reconstruction via THA and secondary femoral lengthening can successfully be used to reconstruct the hip joint and equalise LLD. The specific anatomical conditions have to be taken into consideration when planning treatment, and patients ought to be closely monitored.

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