Safety of the BNT162b2 mRNA COVID-19 vaccine in oncologic patients undergoing numerous cancer treatment options

Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, which create a great amount of data related to the unique molecular signatures of each tumor subtype, have emerged as an important tool for detailed profiling of tumors. They provide an opportunity to develop targeting agents for early detection and diagnosis, and to select the most effective combinatorial treatment options. Alongside, the design of the nanoscale carriers needs to cope with novel trends of molecular screening. Also, multiple targeting ligands needed for robust and specific interactions with the targeted cell populations have to be introduced, which should result in substantial improvements in safety and efficacy of the cancer treatment. This article will focus on novel design strategies for nanoscale drug delivery systems, based on the unique molecular signatures of myeloid leukemia and EGFR/CD44-positive solid tumors, and the impact of novel discoveries in molecular tumor profiles on future chemotherapeutic protocols.

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Thyroid Cancer Treatment Choice: A Pilot Study of a Tool to Facilitate Conversations with Patients with Papillary Microcarcinomas Considering Treatment Options

Thyroid ◽

10.1089/thy.2018.0105 ◽

2018 ◽

Vol 28 (10) ◽

pp. 1325-1331 ◽

Cited By ~ 15

Author(s):

Juan P. Brito ◽

Jae Hoon Moon ◽

Rebecca Zeuren ◽

Sung Hye Kong ◽

Yeo Goon Kim ◽

...

Keyword(s):

Thyroid Cancer ◽

Pilot Study ◽

Cancer Treatment ◽

Treatment Options ◽

Treatment Choice ◽

Papillary Microcarcinomas

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Knowledge of Low-risk Prostate Cancer Treatment Options Survey

PsycTESTS Dataset ◽

10.1037/t69907-000 ◽

2018 ◽

Author(s):

Richard M. Hoffman ◽

Stephen K. Van Den Eeden ◽

Kimberly M. Davis ◽

Tania Lobo ◽

George Luta ◽

...

Keyword(s):

Prostate Cancer ◽

Cancer Treatment ◽

Treatment Options ◽

Low Risk ◽

Prostate Cancer Treatment ◽

Risk Prostate Cancer ◽

Low Risk Prostate Cancer

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Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

International Journal of Molecular Sciences ◽

10.3390/ijms21207575 ◽

2020 ◽

Vol 21 (20) ◽

pp. 7575 ◽

Cited By ~ 1

Author(s):

Shruti S. Sawant ◽

Suyash M. Patil ◽

Vivek Gupta ◽

Nitesh K. Kunda

Keyword(s):

Cancer Therapy ◽

Cancer Treatment ◽

Treatment Options ◽

Current Treatment ◽

Genetically Engineered ◽

Cancer Therapies ◽

Anti Cancer ◽

Tumor Environment ◽

Systemic Side Effects ◽

Hypoxic Tumor

Conventional anti-cancer therapy involves the use of chemical chemotherapeutics and radiation and are often non-specific in action. The development of drug resistance and the inability of the drug to penetrate the tumor cells has been a major pitfall in current treatment. This has led to the investigation of alternative anti-tumor therapeutics possessing greater specificity and efficacy. There is a significant interest in exploring the use of microbes as potential anti-cancer medicines. The inherent tropism of the bacteria for hypoxic tumor environment and its ability to be genetically engineered as a vector for gene and drug therapy has led to the development of bacteria as a potential weapon against cancer. In this review, we will introduce bacterial anti-cancer therapy with an emphasis on the various mechanisms involved in tumor targeting and tumor suppression. The bacteriotherapy approaches in conjunction with the conventional cancer therapy can be effective in designing novel cancer therapies. We focus on the current progress achieved in bacterial cancer therapies that show potential in advancing existing cancer treatment options and help attain positive clinical outcomes with minimal systemic side-effects.

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Understanding and Managing Erectile Dysfunction in Patients Treated for Cancer

Journal of Oncology Practice ◽

10.1200/jop.2016.010678 ◽

2016 ◽

Vol 12 (4) ◽

pp. 297-304 ◽

Cited By ~ 13

Author(s):

Maria Voznesensky ◽

Kiran Annam ◽

Karl J. Kreder

Keyword(s):

Body Image ◽

Erectile Dysfunction ◽

Adverse Effects ◽

Cancer Treatment ◽

Hormone Therapy ◽

Sexual Intercourse ◽

Erectile Function ◽

Treatment Options ◽

Signs And Symptoms ◽

Patient Age

Cancer can cause sexual adverse effects by direct and indirect pathways. It can involve sexual organs, indirectly affect body image, or cause fatigue or depression with subsequent effects on libido. Erectile dysfunction (ED), the inability to obtain or maintain an erection firm enough for sexual intercourse, can also result from adverse effects of cancer treatment, such as fatigue, pain, or anxiety about therapy. In addition, depressed feelings about having cancer can affect sexuality, causing a range of signs and symptoms that can lead to ED. Chemotherapy, hormone therapy, surgery, and radiation can all cause sexual adverse effects. Additional factors that play a role include patient age and degree of ED before starting cancer treatment. In this article, we discuss how chemotherapy, hormone therapy, surgery, and radiation affect erectile function as well as possible treatment options for ED.

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