Prognostic value of 18F-fluorodeoxyglucose PET/computed tomography metabolic parameters measured in the primary tumor and suspicious lymph nodes before neoadjuvant therapy in patients with esophageal carcinoma

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Francisco Tustumi ◽  
Paulo Schiavom Duarte ◽  
David Gutiérrez Albenda ◽  
Flávio Roberto Takeda ◽  
Rubens Antonio Aissar Sallum ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lymph Nodes ◽  
Esophageal Carcinoma ◽  
Neoadjuvant Therapy ◽  
Primary Tumor ◽  
Prognostic Value ◽  
Metabolic Parameters ◽  
18F Fluorodeoxyglucose ◽  
Fluorodeoxyglucose Pet

scholarly journals Prognostic Value of Quantitative 18F-FDG PET/CT Parameters Measured in Primary Tumors and Suspicious Lymph Nodes in Patients With Esophageal Carcinoma

2020 ◽  
Author(s):  
Francisco Tustumi ◽  
Flávio Roberto Takeda ◽  
Paulo Schiavom Duarte ◽  
David Gutiérrez Albenda ◽  
Rubens Antonio Aissar Sallum ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Nodes ◽  
Neoadjuvant Therapy ◽  
Burden Of Disease ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Primary Tumors ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Objective:Quantitative 18F-FDG PET/CT parameters have been described as prognostic indicators in esophageal cancer. The objective of this study isto evaluate the prognostic value of the maximum standardized uptake value (SUVmax), metabolic tumor value (MTV) and total lesion glycolysis (TLG) measured in the primary tumor and suspicious lymph nodes.Methods: A cohort study was performed to assess the association of SUVmax, MTV and TLG measured prior to and post neoadjuvant therapywithoverall survival (OS) of patients with esophageal cancer who received trimodal therapy. The quantitative techniques were applied in the primary tumor and suspicious lymph nodes. The OS rates were analyzed. Results: Before neoadjuvant therapy, 106 patients underwent PET/CT, and 39 patients underwent post-neoadjuvant therapy PET/CT exams. Before neoadjuvanttherapy, PET/CT showed that all the variables of the evaluated lymph nodes were statistically significant in predicting OS. Postneoadjuvanttherapy, none of the PET/CT variables of lymph nodes were related to prognosis. On the other hand, all primary tumor volumetric variables were related to overall survival. The MTV (HR: 4.66; 95% CI: 1.54-14.08) and TLG (HR: 4.86; 95% CI: 1.66-14.26) of the primary tumor post neoadjuvanttherapy and the variations in MTV (HR: 2.95; 95% CI: 1.01-3.52) and TLG (HR: 3.49; 95% CI: 1.01-3.52) of the primary tumor pre-to-post-neoadjuvanttherapy were prognostic variables. Conclusion: In patients with esophageal cancer, the burden of disease in suspicious lymph nodes and the primary tumor prior to therapy and the residual burden of disease in the primary tumor post therapy assessed by PET/CT were associated with prognosis.

scholarly journals Prognostic Value of Quantitative 18F-FDG PET/CT Parameters Measured in Primary Tumors and Suspicious Lymph Nodes in Patients with Esophageal Carcinoma.

2020 ◽  
Author(s):  
Francisco Tustumi ◽  
Flávio Roberto Takeda ◽  
Paulo Schiavom Duarte ◽  
David Gutiérrez Albenda ◽  
Rubens Antonio Aissar Sallum ◽  
...  
Keyword(s):  
Overall Survival ◽  
Esophageal Cancer ◽  
Lymph Nodes ◽  
Neoadjuvant Therapy ◽  
Burden Of Disease ◽  
Primary Tumor ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Background: Quantitative 18F-FDG PET/CT parameters have been described as prognostic indicators in esophageal cancer. The aim of this study was to evaluate the prognostic value of the maximum standardized uptake value (SUVmax), metabolic tumor value (MTV) and total lesion glycolysis (TLG) measured in the primary tumor and suspicious lymph nodes. A cohort study was performed to assess the association of SUVmax, MTV and TLG measured prior to and post neoadjuvant therapy with overall survival (OS) of patients with esophageal cancer who received trimodal therapy. The quantitative techniques were applied in the primary tumor and suspicious lymph nodes. The OS rates were analyzed. Results: Before neoadjuvant therapy, 106 patients underwent PET/CT, and 39 patients underwent post-neoadjuvant therapy PET/CT exams. Before neoadjuvant therapy, PET/CT showed that all the variables of the evaluated lymph nodes were statistically significant in predicting OS. Post neoadjuvant therapy, none of the PET/CT variables of lymph nodes were related to prognosis. On the other hand, all primary tumor volumetric variables were related to overall survival. The MTV (HR: 4.66; 95% CI: 1.54-14.08) and TLG (HR: 4.86; 95% CI: 1.66-14.26) of the primary tumor post neoadjuvant therapy and the variations in MTV (HR: 2.95; 95% CI: 1.01-3.52) and TLG (HR: 3.49; 95% CI: 1.01-3.52) of the primary tumor pre-to-post-neoadjuvant therapy were prognostic variables. Conclusion: In patients with esophageal cancer, the burden of disease in suspicious lymph nodes and the primary tumor prior to therapy and the residual burden of disease in the primary tumor post therapy assessed by PET/CT were associated with prognosis.

Diuretic 18F-Fluorodeoxyglucose PET/Computed Tomography in Evaluation of Genitourinary Malignancies

PET Clinics ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Krishan Kant Agarwal ◽  
Shambo Guha Roy ◽  
Rakesh Kumar
Keyword(s):  
Computed Tomography ◽  
18F Fluorodeoxyglucose ◽  
Fluorodeoxyglucose Pet

scholarly journals Clinical Utility of Functional Imaging with 18F-FDOPA in Von Hippel-Lindau Syndrome

2012 ◽  
Vol 97 (4) ◽  
pp. E613-E617 ◽  
Author(s):  
Allison B. Weisbrod ◽  
Mio Kitano ◽  
Krisana Gesuwan ◽  
Corina Millo ◽  
Peter Herscovitch ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Neuroendocrine Tumors ◽  
Clinical Utility ◽  
Laboratory Data ◽  
Imaging Modalities ◽  
Metabolic Imaging ◽  
High Risk Population ◽  
Von Hippel Lindau ◽  
18F Fluorodeoxyglucose ◽  
Fluorodeoxyglucose Pet

Context: Von Hippel-Lindau (VHL) syndrome is an inherited cancer syndrome in which patients are at risk of developing multiple tumors in different organs. 6-L-18F-fluorodihydroxyphenylalanine (18F-FDOPA) positron emission tomography (PET) is a relatively new metabolic imaging tracer proposed for the use of localizing sites of neuroendocrine tumors. There are limited data on the clinical utility of using 18F-FDOPA PET for identifying neuroendocrine tumors in a high-risk population such as VHL. Objective: The aim of this prospective study was to evaluate the clinical utility of 18F-FDOPA PET in patients with VHL-related tumors. Design: Radiological findings were prospectively collected from four imaging modalities: computed tomography, magnetic resonance imaging (MRI), 18F-fluorodeoxyglucose PET, and 18F-FDOPA PET. 18F-FDOPA PET findings were compared with those from other imaging modalities, as well as with clinical and laboratory data, and pathology findings if patients underwent an operation. Results: In 52 patients with VHL, 390 lesions were identified by computed tomography (n = 139), MRI (n = 117), 18F-fluorodeoxyglucose PET (n = 94), and 18F-FDOPA PET (n = 40). 18F-FDOPA PET identified 20 pancreatic and 20 extrapancreatic tumors, including lesions in the adrenal gland (n = 11), kidney (n = 3), liver (n = 4), lung (n = 1), and cervical paraganglioma (n = 1). These tumor sites were not seen by conventional imaging studies in 9.6% of patients and 4.4% of lesions. Seven of eight patients who had an 18F-FDOPA PET-positive lesion underwent resection, and pathology showed a neuroendocrine tumor. Four of 10 patients with positive adrenal uptake had elevated catecholamine levels, and six of 10 patients had a discrete mass on axial imaging. Conclusions: 18F-FDOPA PET is a useful complementary imaging study to detect neuroendocrine tumors in patients with VHL undergoing surveillance, especially in those suspected to have adrenal pheochromocytoma or unusual ectopic locations.

scholarly journals Prognostic value of metabolic parameters on 18F-fluorodeoxyglucose positron tomography/computed tomography in classical rectal adenocarcinoma

2021 ◽  
Author(s):  
Byung Wook Choi ◽  
Sungmin Kang ◽  
Sung Uk Bae ◽  
Woon Kyung Jeong ◽  
Seong Kyu Baek ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Prognostic Factors ◽  
Fdg Pet ◽  
Prognostic Value ◽  
Univariate Analysis ◽  
Rectal Adenocarcinoma ◽  
Metabolic Parameters ◽  
Factors Affecting ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract We aimed to investigate the prognostic value of the metabolic parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in classical rectal adenocarcinoma (CRAC). We retrospectively reviewed 149 patients with CRAC who underwent preoperative 18F-FDG PET/CT at initial diagnosis followed by curative surgical resection. 18F-FDG PET/CT metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) for disease-free survival (DFS) and overall survival (OS) were evaluated for prognostic significance by univariate and multivariate analyses, along with conventional risk factors including pathologic T (pT) stage, lymph node (LN) metastasis, lymphovascular invasion (LVI), perineural invasion (PNI), and preoperative carcinoembryonic antigen (CEA) level. On univariate analysis, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG were significant prognostic factors affecting DFS (all P < 0.05), while CEA level, high pT stage, positive LN metastasis, LVI, PNI, MTV, and TLG affected OS (all P < 0.05). On multivariate analysis, positive LN metastasis, LVI, MTV, and TLG were independent prognostic factors affecting DFS (all P < 0.05), while CEA level, positive LN metastasis, and MTV affected OS (all P < 0.05). Thus, MTV and TLG are independent prognostic factors for DFS and OS in CRAC patients.

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