Human Papillomavirus-specific Genotypes in Cervical Lesions of Women Referred for Smears With Atypical Glandular Cells or Adenocarcinoma In Situ

2009 ◽  
Vol 28 (3) ◽  
pp. 272-278 ◽  
Author(s):  
Silvia Helena Rabelo-Santos ◽  
Sophie Françoise Mauricette Derchain ◽  
Luísa Lina Villa ◽  
Maria Cecília Costa ◽  
Luis Otávio Zanatta Sarian ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Adenocarcinoma In Situ ◽  
Cervical Lesions ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Human papillomavirus DNA detection and histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in their Pap smears

2004 ◽  
Vol 95 (3) ◽  
pp. 618-623 ◽  
Author(s):  
Sophie Françoise Mauricette Derchain ◽  
Silvia Helena Rabelo-Santos ◽  
Luis Otávio Sarian ◽  
Luiz Carlos Zeferino ◽  
Eliane Regina de Oliveira Zambeli ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Dna Detection ◽  
Pap Smears ◽  
Adenocarcinoma In Situ ◽  
Histological Findings ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Papillomavirus Dna

Significance of High-Risk Human Papillomavirus Testing for Atypical Glandular Cells on Cervical Cytology

2018 ◽  
Vol 62 (5-6) ◽  
pp. 405-410 ◽  
Author(s):  
Hiroaki Komatsu ◽  
Tetsuro Oishi ◽  
Daiken Osaku ◽  
Mayumi Sawada ◽  
Akiko Kudoh ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Intraepithelial Neoplasia ◽  
Adenocarcinoma In Situ ◽  
Diagnostic Significance ◽  
Predictive Values ◽  
Squamous Cells ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Objectives: The aim of this study was to evaluate the diagnostic significance of high-risk human papillomavirus (hrHPV) testing for managing women with atypical glandular cells (AGC) and to explore the distribution of hrHPV genotypes. Methods: We analyzed cytologic and histopathologic diagnoses in patients referred to our institution due to AGC or atypical squamous cells of undetermined significance (ASC-US). All patients underwent hrHPV testing and genotyping, and positive (PPV) and negative predictive values (NPV) for cervical intraepithelial neoplasia (CIN) 2 or worse [CIN2+/adenocarcinoma in situ (AIS)+] were calculated. Results: Among 41 cases previously diagnosed with AGC, 22 (53%) were classified as CIN2+ (2 squamous cell carcinomas), whereas only 2 were AIS or adenocarcinoma. Twenty-seven (65.8%) cases in the AGC group were hrHPV positive. The most frequent genotypes in both the ASC-US and AGC groups were HPV16 and HPV52. The PPV of hrHPV testing for CIN2+/AIS+ was significantly higher in the AGC than in the ASC-US group (74.1 vs. 35.0%; p = 0.0005). The NPV for CIN2+/AIS+ was significantly lower in the AGC than in the ASC-US group (74.4 vs. 100%; p = 0.0441). Conclusion: In patients with AGC, both glandular and squamous lesions must be monitored. hrHPV testing is useful for detecting CIN2+/AIS+ in AGC.

Cytological Diagnoses of Adenocarcinoma in situ of the Cervix: Common Misdiagnoses

2015 ◽  
Vol 59 (1) ◽  
pp. 91-96
Author(s):  
Shuxia Li ◽  
Dan Tian ◽  
Ying Li
Keyword(s):  
False Negative ◽  
Adenocarcinoma In Situ ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Squamous Cells ◽  
Not Otherwise Specified ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Intraepithelial Lesion ◽  
Intraepithelial Lesions

Objective: In routine screening, glandular lesions have high false-negative and false-positive rates. Our study sought to improve the cytological diagnoses and differentiation of glandular lesions. Study Design: A total of 24 cytology slides were retrospectively reviewed. Among these slides, 15 were confirmed via histology to have varying amounts of adenocarcinoma in situ (AIS) components. The other 9 cytology slides exhibited AIS mimics that had been originally considered to be AIS or atypical glandular cells (AGCs) and were selected for differentiation from AIS. Results: Overall, 12 of the 15 cytological slides exhibited significant atypical glandular features that met the criteria for AIS. However, the original cytological diagnoses included 2 cases of AIS, 3 AGCs-favor neoplasia (AGC-FN), 2 AGCs, 1 case that was not otherwise specified (AGC-NOS), 1 NILM (negative for intraepithelial lesion and malignancy), 3 HSILs (high-grade squamous intraepithelial lesions), and 2 ASC-Hs (atypical squamous cells, cannot exclude HSIL). The latter 9 cytological slides were subsequently histologically confirmed to be 2 metaplasias, 2 reactive lesions, 1 decidual change, 3 serous adenocarcinomas, and 1 SCNEC (small-cell neuroendocrine carcinoma). Conclusion: Cytological screening will be valuable for identifying glandular lesions as effectively as squamous lesions if the doubly high false rates can be decreased.

Prediction of high-grade cervical disease with human papillomavirus detection in women with glandular and squamous cytologic abnormalities

2006 ◽  
Vol 16 (3) ◽  
pp. 1055-1062 ◽  
Author(s):  
E. R.Z.M. De Oliveira ◽  
S. F.M. Derchain ◽  
L. O.Z. Sarian ◽  
S. H. Rabelo-Santos ◽  
R. C. Gontijo ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Pap Smears ◽  
High Grade ◽  
Strongly Correlated ◽  
Cervical Lesions ◽  
Cervical Disease ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
High Risk Hpv

The objective of this study was to assess whether human papillomavirus (HPV) detection with hybrid capture II (HC II) can help predict the presence and the nature, glandular or squamous, of histologic cervical lesions in women referred due to atypical glandular cells (AGC) or high-grade squamous intraepithelial lesion (HSIL). A total of 247 women were included. Referral Pap smears comprised AGC (51 cases), AGC plus HSIL (28 cases), adenocarcinoma in situ (10 cases), and HSIL (158 cases). All patients were tested for high-risk HPV with HC II and had a histologic assessment of their cervix. Histologic analysis showed 38 women with (15.3%) cervicitis, 194 with (75.5%) squamous lesions, and 15 with (9.2%) glandular neoplasia. The overall rate of high-risk HPV detection was 77%. Almost 70% of AGC-HPV–negative patients did not have a pathologically proven cervical neoplasia, whereas 76% of women with AGC-HPV–positive result were diagnosed with a squamous or glandular neoplasia. Most (95%) of the lesions in patients with AGC-HSIL were of squamous nature, and HPV detection did not contribute to their differentiation from glandular lesions. We conclude that in women with AGC, HPV positivity strongly correlated with the presence of glandular or squamous cervical lesion but did not help distinguishing women with squamous from those with glandular neoplasia.

Geolocation of uterine cervical neoplasms (UCN) in the context of a prevention program in Tucumán, Argentina.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e13535-e13535
Author(s):  
Silvia Victoria Holgado ◽  
Ana Vinuales ◽  
Daniel Gustavo Goroso ◽  
William Tsutomu Watanabe ◽  
Juan Jose Zarba ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Cross Sectional Study ◽  
Adenocarcinoma In Situ ◽  
Online Information ◽  
Cervical Lesions ◽  
Invasive Adenocarcinoma ◽  
Cross Sectional ◽  
Screening Population ◽  
Short Time

e13535 Background: : UCN is one of the major public health problems in Tucumán, that must be related to the type of population to which it belongs (Rural or Urban). Geolocation allows the processing and analysis of geographic information whose results support decision-making in solving complex planning and management problems on the territory. The objective of this study is to carry out management quality controls of the PPCCUT (Programa de Prevención de Cáncer Cervical Uterino-Tucumán) to achieve adequate prevention and detection of uterine cervical lesions in the province. Methods: An observational cross-sectional study of 1343 women, (16-90 years), with a biopsy diagnosis UCN, under PPCCUT (years 2013-2020). Preanalytical work: allowed the review quality the registries and the diagnoses follow-up. Data recollection from SITAM (Online Information System for Screening), population registry database. Variables: Address: registered in SITAM, joined by information from the provincial female electoral roll 2019. Histological Diagnosis: High grade squamous intraepithelial lesion (HSIL), Invasive Squamous Carcinoma (ISC), Adenocarcinoma In situ (AIS), Invasive Adenocarcinoma (IDA). Analytical work: The conversion from address to latitude and longitude was performed by programming Google Sheet. This data was segmented by hospital center and opened in layers inside QGIS, as well as the map of Argentina. Results: Preanalytical. Register showed from 1343 patients received 1748 biopsies, were excluded 160 without address (incomplete data loading by the effectors). Lack of coordination in diagnosis area: 33 patients received first “in situ diagnosis” and in a short time later were consider “invasive lesions”. Some Patients had 2 bis 6 biopsies with same diagnosis. Analytical (geolocation): showed the influence of PPCCUT outside the province, including living abroad. It was found correlation between patients’ distribution with the population density. Conclusions: The importance of the work lays in the lack of antecedents in the application of the geolocation tool in programs of UCN in Tucumán and in other regions of Argentina. This allowed monitoring in different aspects of the programmatic management.

Sign in / Sign up

Export Citation Format

Share Document