Granulomatosis With Polyangiitis (Wegener Granulomatosis) as a Differential Diagnosis of Sternal Osteomyelitis

2013 ◽  
Vol 19 (8) ◽  
pp. 446-448 ◽  
Author(s):  
Sang-Dong Kim ◽  
Gun-Woo Kim ◽  
Tae-Eun Kim ◽  
Eun-Jung Nam ◽  
Seung-Woo Han
Keyword(s):  
Differential Diagnosis ◽  
Granulomatosis With Polyangiitis ◽  
Wegener Granulomatosis ◽  
Sternal Osteomyelitis

scholarly journals IgG4-associated disease in differential diagnosis of inflammatory orbitopathy

2019 ◽  
Vol 65 (5) ◽  
pp. 367-372
Author(s):  
Yaroslav O. Grusha ◽  
Dilyara S. Ismailova ◽  
Natalya Yu. Sviridenko ◽  
Pavel I. Novikov ◽  
Alla M. Kovrigina
Keyword(s):  
Differential Diagnosis ◽  
Gold Standard ◽  
Granulomatosis With Polyangiitis ◽  
Plasma Cells ◽  
Eye Disease ◽  
Systemic Diseases ◽  
Long Period ◽  
Inappropriate Treatment ◽  
Systemic Inflammatory Disease ◽  
Systemic Process

IgG4-associated disease (IgG4-RD) is a systemic inflammatory disease characterized by tumorlike sclerosing masses in different organs. Differential diagnosis in orbital IgG4-RD includes majority of conditions, such as thyroid eye disease (TED), sarcoidosis, granulomatosis with polyangiitis, idiopatic orbital inflammation, limphoproliferative diseases and others. A case of IgG4-RD with different organs involvement and complicated differential diagnosis is presented. This case demonstrates very uncommon manifestation of IgG4-RD, when orbital involvement was very similar with TED. Systemic process was not recognized during a long period of time and diagnosis of IgG4-RD was established only after biopsy of abnormally increased lacrimal gland. Differential diagnosis included other systemic diseases, first of all sarcoidosis, GPA, and lymphoma. Biopsy results were consistent with the gold standard of diagnosis, e. g. more than 40% of plasma cells were IgG4 positive. This case demonstrates the necessity of orbital biopsy before starting immunosuppression to avoid inappropriate treatment strategy.

scholarly journals Rheumatoid Arthritis and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis): A Rare Association

2020 ◽  
Vol 31 (2) ◽  
pp. 114-119
Author(s):  
Wafia Najifa ◽  
Mohiuddin Sharif ◽  
Rajib Roy ◽  
Mahfuzul Haque ◽  
Md Robed Amin
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Wegener's Granulomatosis ◽  
Overlap Syndrome ◽  
Wegener Granulomatosis ◽  
Overlap Syndromes ◽  
Rare Association

The presentation of Rheumatoid arthritis (RA) combined with a second rheumatological disorder thatis, different RA overlap syndromes are frequently encountered in clinical practice. But RA-vasculitisoverlaps are relatively rare. This paper presents a case of Rheumatoid arthritis and Granulomatosiswith polyangiitis (Wegener granulomatosis) overlap syndrome which is first of its kind reported from Bangladesh. Bangladesh J Medicine July 2020; 31(2) : 114-119

scholarly journals Primary Sternal Tuberculosis Osteomyelitis: A Case Report and Discussion

2009 ◽  
Vol 20 (4) ◽  
pp. e181-e184 ◽  
Author(s):  
Miten Vasa ◽  
Christine Ohikhuare ◽  
Leslea Brickner
Keyword(s):  
United States ◽  
Differential Diagnosis ◽  
Case Report ◽  
Surgical Intervention ◽  
Clinical Manifestations ◽  
The United States ◽  
Typical Case ◽  
Antituberculous Therapy ◽  
Sternal Osteomyelitis ◽  
The World

As immigration to the United States from countries endemic for tuberculosis (TB) increases, the incidence of pulmonary and extrapulmonary TB disease may increase. Primary tuberculous sternal osteomyelitis is one form of extrapulmonary TB that is exceedingly rare throughout the world, and falls under the differential diagnosis for chest wall masses. Management involves standard antituberculous therapy with antibiotics similar to treating other forms of extrapulmonary TB, as well as consideration of surgical intervention depending on the extent of osteomyelitis. A typical case of primary sternal TB osteomyelitis is reported, and the epidemiology, differential diagnosis, clinical manifestations and management are reviewed.

Clinical Features and Outcomes of 37 Argentinean Patients With Severe Granulomatosis With Polyangiitis (Wegener Granulomatosis)

2013 ◽  
Vol 19 (2) ◽  
pp. 62-66 ◽  
Author(s):  
Alberto Omar Orden ◽  
Sebastián Andrés Muñoz ◽  
María Cristina Basta ◽  
Alberto Allievi
Keyword(s):  
Clinical Features ◽  
Granulomatosis With Polyangiitis ◽  
Wegener Granulomatosis

scholarly journals Differential diagnosis of granulomatous lung disease: clues and pitfalls

2017 ◽  
Vol 26 (145) ◽  
pp. 170012 ◽  
Author(s):  
Shinichiro Ohshimo ◽  
Josune Guzman ◽  
Ulrich Costabel ◽  
Francesco Bonella
Keyword(s):  
Differential Diagnosis ◽  
Lung Diseases ◽  
Granulomatosis With Polyangiitis ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Needle Aspiration ◽  
Endobronchial Ultrasound ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
High Resolution Computed Tomography ◽  
Transbronchial Needle Aspiration

Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis). Bronchoalveolar lavage, endobronchial ultrasound-guided transbronchial needle aspiration, transbronchial cryobiopsy, positron emission tomography and genetic evaluation are potential candidates to improve the diagnostic accuracy for granulomatous lung diseases. As granuloma alone is a nonspecific histopathological finding, the multidisciplinary approach is important for a confident diagnosis.

scholarly journals Difficulties in the differential diagnosis of granulomatosis with polyangiitis and scarring pemphigoid

2020 ◽  
Vol 10 (5) ◽  
pp. 398-402
Author(s):  
N. A. Magdeeva ◽  
A. A. Kobriseva ◽  
M. A. Reznikova ◽  
I. F. Melehina
Keyword(s):  
Differential Diagnosis ◽  
Renal Damage ◽  
Clinical Case ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Vasculitis ◽  
Organ Damage ◽  
Pathological Process ◽  
Poor Knowledge ◽  
Eye Damage ◽  
Positive Results

The article presents a clinical case of a rare pathology. The patient for several years visited various specialists. In connection with a similar clinical picture, multi-organ damage, differential diagnosis was performed between systemic vasculitis (granulomatosis with polyangiitis) and scarring pemphigoid.The mucous membrane of the mouth and nose is involved in the pathological process with granulomatosis with polyangiitis in the form of ulcerative defects, which subsequently lead to deformation of the nose. The danger with this systemic vasculitis is renal damage with the development of nephritis, renal failure. With scarring pemphigoid, eye damage is typical. In granulomatosis with polyangiitis, damage to the organ of vision is also sometimes possible, but mainly in the form of an orbit pseudotumor. Despite the fact that treatment for both forms of pathology involves the use of glucocorticoids and cytostatics, with a scarring pemphigoid, the main care is provided by dermatologists and ophthalmologists, while the diagnosis and treatment of systemic vasculitis is the task of rheumatologists. One of the criteria for a scarring pemphigoid is loss of vision. However, in this case, it was possible to establish a diagnosis, obtain the first positive results of therapy before the patient shows signs of disability. So, there is a hope for the possibility of preserving vision and a favorable outcome. The rarity of the disease and its poor knowledge, difficulties in diagnosis and the absence of certain standards of therapy, this diagnosis requires more attention from the specialists.

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