Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors

Background: Soft tissue tumors constitute a large and heterogenous group of neoplasms. Benign tumors out number their malignant counterparts by a ratio of about 100:1 in hospital population. FNAC has emerged as a major outpatient procedure for the diagnosis of soft tissue tumors due to low cost of the procedure, less complications, feasibility, quick results and high therapeutic efficiency with specificity and sensitivity of approximately 95%. The diagnostic accuracy of FNAC of soft tissue tumors in distinguishing benign and malignant lesion is also very high. The objectives of this study were to study the role of FNAC in the diagnosis of soft tissue tumors and its correlation with histopathology. Also, this study aimed at studying various cytomorphological patterns of soft tissue tumors and correlating cytological grading with histopathological grading.Methods: It was a hospital based study of 5 years which included 479 patients of all age groups, clinically presenting with soft tissue swellings. FNAC was performed. Smears were stained with Papanicolaou (PAP)/May Grunwald Geimsa (MGG). The cytological details of soft tissue tumors were studied and broadly classified into benign, malignant and indeterminate and suspicious. Cytomorphological subtyping and grading of tumors on FNAC was done. The cytological findings were correlated with the histopathological results, wherever available.Results: Benign tumors comprised of 423 cases (88.3%) and malignant tumors comprised 56 cases (11.69%)only. Maximum number of cases were seen in well differentiated/lipomatous group (339 cases) followed by spindle cell category (88 cases). Histopathological correlation carried out in 136 out of 479 cases (benign:111 and malignant :25) revealed that out of 111 cases diagnosed as benign by cytology, one case was malignant (liposarcoma) and among 25 malignant cases diagnosed by cytology one case was benign (myofibroblastoma). Overall sensitivity and specificity of FNAC was 96% and 99% respectively. Comparison of cytological and histopathological grading of 24 sarcomas showed overall concordance of 75%.Conclusions: FNAC is an excellent diagnostic modality in early diagnosis of soft tissue tumors. FNAC is highly reliable and obviates surgical procedures especially in high risk patients thus facilitating initiation of appropriate therapy and saving time and manpower. It is also highly sensitive in detecting benign soft tissue tumors and highly specific for malignant soft issue tumors.

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Clinical significance of thallium-201 scintigraphy in bone and soft tissue tumors

Journal of Orthopaedic Science ◽

10.1007/s007760200052 ◽

2002 ◽

Vol 7 (3) ◽

pp. 304-312 ◽

Cited By ~ 20

Author(s):

Yoshinari Goto ◽

Koichiro Ihara ◽

Shigeto Kawauchi ◽

Ritsuko Ohi ◽

Kohsuke Sasaki ◽

...

Keyword(s):

Soft Tissue ◽

Clinical Significance ◽

Soft Tissue Tumors ◽

Thallium 201 ◽

Thallium 201 Scintigraphy

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Imaging of soft tissue tumors

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405616666200713183400 ◽

2020 ◽

Vol 16 ◽

Author(s):

Shinji Tsukamoto ◽

Andreas F. Mavrogenis ◽

Yasuhito Tanaka ◽

Costantino Errani

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Soft Tissue ◽

Tumor Size ◽

Critical Role ◽

Evaluation Criteria ◽

Soft Tissue Tumors ◽

Resonance Imaging ◽

Benign Soft Tissue Tumors ◽

Response To Chemotherapy

: Differentiation of malignant from benign soft tissue tumors is challenging with imaging alone, including that by magnetic resonance imaging and computed tomography. However, the accuracy of this differentiation has increased owing to the development of novel imaging technology. Detailed patient history and physical examination remain essential for differentiation between benign and malignant soft tissue tumors. Moreover, measurement only of tumor size based on Response Evaluation Criteria In Solid Tumors criteria is insufficient for the evaluation of response to chemotherapy or radiotherapy. Change in metabolic activity measured by 18F-fluorodeoxyglucose positron emission tomography or dynamic contrast enhanced-derived quantitative endpoints can more accurately evaluate treatment response compared to change in tumor size. Magnetic resonance imaging can accurately evaluate essential factors in surgical planning such as vascular or bone invasion and “tail sign”. Thus, imaging plays a critical role in the diagnosis and treatment of soft tissue tumors.

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Hand tumors: A review of 186 patients at a single institute

Journal of Orthopaedic Surgery ◽

10.1177/2309499021993994 ◽

2021 ◽

Vol 29 (1) ◽

pp. 230949902199399

Author(s):

Taketsugu Fujibuchi ◽

Hiroshi Imai ◽

Joji Miyawaki ◽

Teruki Kidani ◽

Hiroshi Kiyomatsu ◽

...

Keyword(s):

Soft Tissue ◽

Clinical Features ◽

Malignant Tumors ◽

Proximal Phalanx ◽

Delayed Diagnosis ◽

Ring Finger ◽

Soft Tissue Tumors ◽

Body Parts ◽

Maximal Diameter ◽

Benign Soft Tissue Tumors

Purpose: The spectrum of diagnoses and clinical features of hand tumors differ from those of tumors in other body parts. However, only a few reports have comprehensively referenced the diagnosis and clinical features of hand tumors. This study aimed to elucidate the diagnostic distribution and the clinical features of hand tumors undergone surgery in our institute. Patients and methods: A total of 235 lesions in 186 patients diagnosed with hand tumors between 1978 and 2020 were reviewed. Age at surgery, gender, chief complaint, tumor location, and pathological diagnosis were analyzed. Results: There were 121 benign bone tumors, 98 benign soft tissue tumors, and 16 malignant tumors. Chondroma and tenosynovial giant cell tumor were common benign bone and soft tissue tumors at the proximal phalanx of the ring finger and the palm, respectively. Meanwhile, chondrosarcoma and synovial sarcoma were common malignant tumors at the dorsal part of the hand. Local pain and painless mass were the chief complaints in patients with benign bone and soft tissue tumors, respectively. Most patients with malignant tumors were referred after unplanned resection. When patients were classified into two categories by tumor size according to maximal diameter, tumors larger than 19 mm had a significantly higher risk of malignant ( p = 0.031) despite being smaller than other tumors in different body parts. Conclusion: When a tumor malignancy is suspected, the patient should be referred to a specialist to avoid unplanned resection or delayed diagnosis due to misdiagnosis. Knowing the distribution and clinical features should help in diagnosing hand tumors.

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Lipoleiomyoma: An incidental finding in a case of uterine serous adenocarcinoma

Case Reports in Clinical Pathology ◽

10.5430/crcp.v7n1p15 ◽

2020 ◽

Vol 7 (1) ◽

pp. 15

Author(s):

John G Weichsler ◽

Shane Starr

Keyword(s):

Soft Tissue ◽

Postmenopausal Women ◽

Female Patient ◽

Rare Case ◽

Incidental Finding ◽

Soft Tissue Tumors ◽

Gynecologic Malignancies ◽

Serous Adenocarcinoma ◽

Benign Soft Tissue Tumors ◽

The Relationship

We present a rare case of a lipoleiomyoma which was discovered incidentally in a hysterectomy specimen of a 74-year old female patient who underwent surgery for a biopsy proven serous adenocarcinoma of the uterus. Lipoleiomyomas represent uncommon, usually benign soft-tissue tumors, generally found in obese menopausal as well as postmenopausal women aged 50 to 70 years. The reported incidence varies from 0.03\% to 0.2\%. The relationship between lipoleiomyomas and gynecologic malignancies has only been reported in a few cases. We report this case of lipoleiomyoma due to its rarity and its association with a serous adenocarcinoma in our patient.

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Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Evaluation, Diagnosis, and Classification of Benign Soft-Tissue Tumors*†

The Journal of Bone and Joint Surgery (American) ◽

10.2106/00004623-199601000-00018 ◽

1996 ◽

Vol 78 (1) ◽

pp. 126-40 ◽

Cited By ~ 17

Author(s):

FRANK J. FRASSICA ◽

ROBY C. THOMPSON

Keyword(s):

Soft Tissue ◽

American Academy ◽

Soft Tissue Tumors ◽

Orthopaedic Surgeons ◽

Benign Soft Tissue Tumors ◽

Diagnosis And Classification

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Benign Soft Tissue Tumors and Tumor-Like Lesions of Prostate

Surgical Pathology of Prostate and Seminal Vesicles ◽

10.1201/9781003210375-17 ◽

2021 ◽

pp. 243-247

Author(s):

Joseph Kovi

Keyword(s):

Soft Tissue ◽

Soft Tissue Tumors ◽

Benign Soft Tissue Tumors ◽

Tumor Like Lesions

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Efficacy of fine needle aspiration cytology in diagnosing soft tissue tumors

Journal of Pathology of Nepal ◽

10.3126/jpn.v2i4.6884 ◽

2012 ◽

Vol 2 (4) ◽

pp. 305-308 ◽

Cited By ~ 2

Author(s):

S Parajuli ◽

M Lakhey

Keyword(s):

Soft Tissue ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Soft Tissue Tumors ◽

Aspiration Cytology ◽

Fine Needle ◽

Benign Soft Tissue Tumors ◽

Needle Aspiration Cytology ◽

Malignant Soft Tissue

Background: Fine needle aspiration cytology has an established role in the diagnosis of various neoplastic and non-neoplastic lesions. Its accuracy when applied by experienced and well trained practitioners matches that of histopathology in providing an equivocal diagnosis; so it can also be used as a very useful alternative to excision biopsy in the diagnostic workup of soft tissue tumors.Materials and Methods: This retrospective study was done in the Department of Pathology, Kathmandu Medical College for a period of one year from January 2006 to December 2006. A total of 60 cases presented with soft tissue tumors, of which only 50 were biopsied and the correlation done. A detailed history, clinical findings, routine relevant laboratory investigations and radiological findings were carried.Results: Fine needle aspiration cytology revealed diagnostic materials in 47 cases and 3 cases were inconclusive for a definite diagnosis. 40 cases were diagnosed as benign lesions and 7 cases as malignant lesions. Out of the benign cases, the most common were lipomas which accounted for 52.5% of cases followed by benign mesenchymal tumor- 17.5%. Out of the malignant cases 71.42% were diagnosed as malignant mesenchymal tumor and 28.57% as malignant nerve sheath tumor. The overall diagnostic accuracy of fine needle aspiration cytology in soft tissue tumors in the present study was 86%. The sensitivity and specificity of diagnosing benign soft tissue tumors was 97.36% and 66.67% respectively and for malignant soft tissue tumors 66.67% and 97.36% respectively.Conclusion: Fine needle aspiration cytology can be effective and reliable diagnostic tool in the evaluation of soft tissue tumors. It is highly sensitive to detect benign soft tissue tumors and highly specific for malignant soft tissue tumors.Journal of Pathology of Nepal (2012) Vol. 2, 305-308DOI: http://dx.doi.org/10.3126/jpn.v2i4.6884

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