Titanium Three-Dimensional Printed Cranioplasty for Fronto-Nasal Bone Defect

AbstractMethods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded mouse caudal vertebral bone defect model. Using rtFE analysis combined with adaptive mechanical loading, mouse bone healing was significantly improved over non-loaded controls, with no incidence of vertebral fractures. Such rtFE-driven adaptive loading regimes demonstrated here could be relevant to clinical bone defect healing scenarios, where mechanical loading can become patient-specific and more efficacious. This is achieved by accounting for initial bone defect conditions and spatio-temporal healing, both being factors that are always unique to the patient.

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Effects of Velvet Antler Polypeptide-Collagen/Chitosan Materials on Proliferation of Osteoblast

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.380-384.4295 ◽

2013 ◽

Vol 380-384 ◽

pp. 4295-4298

Author(s):

Wen He Zhu ◽

Jun Jie Xu ◽

Wei Zhang ◽

Yan Li ◽

Xiao Jing Lu ◽

...

Keyword(s):

Drug Treatment ◽

Bone Defect ◽

Three Dimensional ◽

Chitosan Scaffold ◽

Release Drug ◽

Dimensional Network ◽

Velvet Antler ◽

Result Show ◽

Long Time ◽

Velvet Antler Polypeptide

A highly osteogenic hybrid bioabsorbable scaffold was developed for bone reconstruction. Though the use of a bioabsorbable collagen and chitosan scaffold for loading velvet antler polypeptide to repair bone defect and drug treatment. Velvet antler polypeptide and collagen were extracted for developing the compounded material. The SEM results show that the collagen and chitosan scaffold maintain the natural three dimensional network structures. The cell proliferation experiment result show that the can promote the osteoblast proliferation for a long time . These results indicated that this compound scaffold can sustainable to release drug and is a good material in bone defect and drug treatment.

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Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment

Bioactive Materials ◽

10.1016/j.bioactmat.2021.03.030 ◽

2021 ◽

Vol 6 (11) ◽

pp. 3659-3670

Author(s):

Teng Zhang ◽

Qingguang Wei ◽

Hua Zhou ◽

Zehao Jing ◽

Xiaoguang Liu ◽

...

Keyword(s):

Bone Defect ◽

Three Dimensional ◽

Large Bone Defect ◽

Bone Interface ◽

Fusion Concept ◽

Bone Defect Treatment ◽

Large Bone

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Computed Tomography evaluation of maxillofacial injuries

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v12i4.16372 ◽

2017 ◽

Vol 12 (4) ◽

pp. 131-136

Author(s):

V Natraj Prasad ◽

Ashish Khanal

Keyword(s):

Computed Tomography ◽

Multidetector Computed Tomography ◽

Three Dimensional ◽

Nasal Bone ◽

Imaging Features ◽

Maxillofacial Injuries ◽

Female Population ◽

Complex Anatomy ◽

Plain Films ◽

Maxillofacial Fractures

Background & Objectives: The maxillofacial region, a complex anatomical structure, can be evaluated by conventional (plain) films, Tomography, Multidetector Computed Tomography, Three-Dimensional Computed Tomography, Orthopantomogram and Magnetic Resonance Imaging. The study was conducted with objective of describing various forms of maxillofacial injuries, imaging features of different types of maxillofacial fractures and the advantage of using Three- Dimensional Computed Tomography reconstructed image. Materials & Methods: A hospital based cross-sectional study was conducted among 50 patients during April 2014 to September 2016 using Toshiba Aquilion Prime 160 slice Multi Detector Computed Tomography scanner.Results: The maxillofacial fractures were significantly higher in male population (88%) than female population (12 %). Road traffic accidents were the most common cause of injury others being physical assault and fall from height. It was most common in 31-40 years (26%) and 21-30 (24%) years age group. Maxillary sinus was the commonest fracture (36%) followed by nasal bone and zygomatic bone (30%), mandible and orbital bones (28%). Soft tissue swelling was the commonest associated finding. Three dimensional images (3 D) compared to the axial scans missed some fractures. However, the extension of the complex fracture lines and degree of displacement were more accurately assessed. Complex fractures found were Le fort (6%) and naso-orbito-ethmoid (4%) fractures.Conclusion: The proper evaluation of complex anatomy of the facial bones requires Multidetector Computed Tomography which offers excellent spatial resolution enabling multiplanar reformations and three dimensional reconstructions for enhanced diagnostic accuracy and surgical planning.

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In Vivo Reconstruction of the Acetabular Bone Defect by the Individualized Three-Dimensional Printed Porous Augment in a Swine Model

BioMed Research International ◽

10.1155/2020/4542302 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Jun Fu ◽

Yi Xiang ◽

Ming Ni ◽

Xiaojuan Qu ◽

Yonggang Zhou ◽

...

Keyword(s):

Compressive Strength ◽

Elastic Modulus ◽

Bone Defect ◽

Bone Ingrowth ◽

Structural Parameters ◽

Three Dimensional ◽

Acetabular Bone ◽

Acetabular Bone Defect ◽

3D Printed ◽

Matching Degree

Background and Purpose. This study established an animal model of the acetabular bone defect in swine and evaluated the bone ingrowth, biomechanics, and matching degree of the individualized three-dimensional (3D) printed porous augment. Methods. As an acetabular bone defect model created in Bama miniswine, an augment individually fabricated by 3D print technique with Ti6Al4V powders was implanted to repair the defect. Nine swine were divided into three groups, including the immediate biomechanics group, 12-week biomechanics group, and 12-week histological group. The inner structural parameters of the 3D printed porous augment were measured by scanning electron microscopy (SEM), including porosity, pore size, and trabecular diameter. The matching degree between the postoperative augment and the designed augment was assessed by CT scanning and 3D reconstruction. In addition, biomechanical properties, such as stiffness, compressive strength, and the elastic modulus of the 3D printed porous augment, were measured by means of a mechanical testing machine. Moreover, bone ingrowth and implant osseointegration were histomorphometrically assessed. Results. In terms of the inner structural parameters of the 3D printed porous augment, the porosity was 55.48 ± 0.61 % , pore size 319.23 ± 25.05 μ m , and trabecular diameter 240.10 ± 23.50 μ m . Biomechanically, the stiffness was 21464.60 ± 1091.69 N / mm , compressive strength 231.10 ± 11.77 MPa , and elastic modulus 5.35 ± 0.23 GPa , respectively. Furthermore, the matching extent between the postoperative augment and the designed one was up to 91.40 ± 2.83 % . Besides, the maximal shear strength of the 3D printed augment was 929.46 ± 295.99 N immediately after implantation, whereas the strength was 1521.93 ± 98.38 N 12 weeks after surgery ( p = 0.0302 ). The bone mineral apposition rate (μm per day) 12 weeks post operation was 3.77 ± 0.93 μ m / d . The percentage bone volume of new bone was 22.30 ± 4.51 % 12 weeks after surgery. Conclusion. The 3D printed porous Ti6Al4V augment designed in this study was well biocompatible with bone tissue, possessed proper biomechanical features, and was anatomically well matched with the defect bone. Therefore, the 3D printed porous Ti6Al4V augment possesses great potential as an alternative for individualized treatment of severe acetabular bone defects.

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Analysis of the nasal bone and nasal pyramid by three-dimensional computed tomography

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-007-0476-9 ◽

2007 ◽

Vol 265 (4) ◽

pp. 421-424 ◽

Cited By ~ 16

Author(s):

Seung Ho Lee ◽

Tae Yong Yang ◽

Gil Soo Han ◽

Young Hyo Kim ◽

Tae Young Jang

Keyword(s):

Computed Tomography ◽

Three Dimensional ◽

Nasal Bone ◽

Nasal Pyramid

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Three-dimensional printed PLA scaffold and human gingival stem cell-derived extracellular vesicles: a new tool for bone defect repair

Stem Cell Research & Therapy ◽

10.1186/s13287-018-0850-0 ◽

2018 ◽

Vol 9 (1) ◽

Cited By ~ 65

Author(s):

Francesca Diomede ◽

Agnese Gugliandolo ◽

Paolo Cardelli ◽

Ilaria Merciaro ◽

Valeria Ettorre ◽

...

Keyword(s):

Stem Cell ◽

Bone Defect ◽

Extracellular Vesicles ◽

Three Dimensional ◽

Bone Defect Repair ◽

Defect Repair

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Diagnostic tools in maxillofacial fractures: Is there really a need of three-dimensional computed tomography?

Indian Journal of Plastic Surgery ◽

10.4103/0970-0358.191320 ◽

2016 ◽

Vol 49 (02) ◽

pp. 225-233 ◽

Cited By ~ 4

Author(s):

Sheerin Shah ◽

Sanjeev K. Uppal ◽

Rajinder K. Mittal ◽

Ramneesh Garg ◽

Kavita Saggar

Keyword(s):

Computed Tomography ◽

Clinical Examination ◽

Computed Radiography ◽

Three Dimensional ◽

Nasal Bone ◽

Conventional Radiography ◽

Diagnostic Tools ◽

Ct Reconstruction ◽

Management Protocol ◽

Maxillofacial Fractures

ABSTRACTIntroduction: Because of its functional and cosmetic importance, facial injuries, especially bony fractures are clinically very significant. Missed and maltreated fractures might result in malocclusion and disfigurement of the face, thus making accurate diagnosis of the fracture very essential. In earlier times, conventional radiography along with clinical examination played a major role in diagnosis of maxillofacial fractures. However, it was noted that the overlapping nature of bones and the inability to visualise soft tissue swelling and fracture displacement, especially in face, makes radiography less reliable and useful. Computed tomography (CT), also called as X-ray computed radiography, has helped in solving this problem. This clinical study is to compare three-dimensional (3D) CT reconstruction with conventional radiography in evaluating the maxillofacial fractures preoperatively and effecting the surgical management, accordingly. Materials and Methods: Fifty patients, with suspected maxillofacial fractures on clinical examination, were subjected to conventional radiography and CT face with 3D reconstruction. The number and site of fractures in zygoma, maxilla, mandible and nose, detected by both the methods, were enumerated and compared. The final bearing of these additional fractures, on the management protocol, was analysed. Results: CT proved superior to conventional radiography in diagnosing additional number of fractures in zygoma, maxilla, mandible (subcondylar) and nasal bone. Coronal and axial images were found to be significantly more diagnostic in fracture sites such as zygomaticomaxillary complex, orbital floor, arch, lateral maxillary wall and anterior maxillary wall. Conclusion: 3D images gave an inside out picture of the actual sites of fractures. It acted as mind’s eye for pre-operative planning and intra-operative execution of surgery. Better surgical treatment could be given to 33% of the cases because of better diagnostic ability of CT.

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