Effect of Autologous Platelet-Rich Plasma in Combination With a Biphasic Synthetic Graft Material on Bone Healing in Critical-Size Cranial Defects

2012 ◽  
Vol 23 (5) ◽  
pp. 1318-1323 ◽  
Author(s):  
Gregory Faratzis ◽  
Minas Leventis ◽  
Evanthia Chrysomali ◽  
Lubna Khaldi ◽  
Areti Eleftheriadis ◽  
...  
Keyword(s):  
Bone Healing ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Graft Material ◽  
Synthetic Graft ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Efficacy of autologous platelet-rich plasma on graft uptake in myringoplasty: a single-blinded randomized control trial

2022 ◽  
Vol 38 (1) ◽  
Author(s):  
R. Vignesh ◽  
V. Nirmal Coumare ◽  
S. Gopalakrishnan ◽  
P. Karthikeyan
Keyword(s):  
Otitis Media ◽  
Platelet Rich Plasma ◽  
Successful Outcome ◽  
Control Group ◽  
List Type ◽  
Graft Material ◽  
Group I ◽  
Autologous Platelet Rich Plasma ◽  
Conventional Myringoplasty ◽  
Autologous Platelet

Abstract Background and aim Chronic otitis media is defined as a chronic inflammation of the middle ear cleft producing irreversible pathological changes. The myringoplasty aims at the reconstruction of the tympanic membrane using a graft material. Autologous platelet-rich plasma can be used along with the graft to have a successful outcome. The aim of the study was to assess the efficacy of autologous platelet-rich plasma on graft uptake in myringoplasty. Methods This was a randomized controlled trial with a sample size of 76 patients. All patients were above 18 and below 55 years of age diagnosed with chronic suppurative otitis media and were planned for myringoplasty. The participants were randomly allotted to two groups by block randomization (block of 4). Intra-operatively, group I (n=38) received platelet-rich plasma–soaked gel foam and group II (n=38) was taken as the control group who received saline-soaked gel foam and examined by a blinded examiner at the end of 1st and 3rd months. Results The mean air-bone gap reduction post-operatively in the platelet-rich plasma group was 8.68 ± 4.8 (P value 0.034) and 6.05 ± 4.05 in the control group. The improvement in pure-tone average in the platelet-rich plasma group (P = 0.009) is more than that in the control group. The graft uptake was higher among the platelet-rich plasma group than the control group both at 1st and 3rd months (P value 0.049) which were statistically significant. Conclusion The present study concludes that the usage of platelet-rich plasma in the conventional myringoplasty technique has improved the success rate of graft uptake and reduced the graft migration. Trial registration Clinical Trials Registry-India (ICMR-NIMS) CTRI/2020/04/024416. Date of registration: 01/04/2020. Date of enrolment of the first participant to the trial: 06/04/2020. URL of the trial registry: http://www.ctri.nic.in. Highlights Usage of autologous platelet-rich plasma (PRP) in conventional myringoplasty in underlay technique. Assessment of graft uptake, percentage of perforation closure, and the audiological outcome. Significant mean reduction of ABG in the PRP group. Significant improvement in PTA average in the PRP group. Graft uptake and percentage of perforation closure were higher in the PRP group and the control group. PRP is also beneficial in revision cases.

scholarly journals Autologous Adipose-Derived Stem Cells, Platelet-Rich Plasma, and Fibrin Enhance Healing of Mandibular Bone Defects in Swine

2020 ◽  
pp. 1-9
Author(s):  
Matthew B. Wheeler ◽  
Aaron J. Maki ◽  
Anna C. Ercolin ◽  
Jamey J. Cooper ◽  
Kelly S. Roballo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Volume Fraction ◽  
Critical Size ◽  
Platelet Rich Plasma ◽  
Therapeutic Effects ◽  
Mineral Density ◽  
Bone Volume Fraction ◽  
Critical Size Defects ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

The primary aim of this study was to assess the therapeutic effects of autologous platelet-rich plasma and fibrin scaffolds combined with autologous adipose stem cells (ASCs) for critical-size defects in the pig mandible. Fibrin scaffolds supplemented with calcium hydrogen phosphate and platelet-derived growth factors were hypothesized to accelerate healing in porcine mandible bone compared to ASC-only injections and untreated controls. Three treatments included the use of autologous ASCs from liposuction with the addition of platelet-rich plasma, fibrin scaffolds, or as cell-only controls. All three treatments using ASCs were determined to increase bone mineral density and bone volume fraction compared to untreated controls. In general, the addition of both platelet-rich plasma and fibrin scaffolds to autologous ASCs from liposuction improved bone healing of critical-size defects.

Autologous platelet-rich plasma for assisted reproduction

2021 ◽  
Author(s):  
Dennis Vaidakis ◽  
Eleni Sertedaki ◽  
Vasilios Karageorgiou ◽  
Charalampos S Siristatidis
Keyword(s):  
Assisted Reproduction ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 180 ◽  
Author(s):  
Rodolfo Mauceri ◽  
Denise Murgia ◽  
Orazio Cicero ◽  
Luigi Paternò ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Healing ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Critical Size ◽  
Large Bone ◽  
Alveolar Bone Defect ◽  
Positive Results ◽  
Autologous Platelet

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

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