scholarly journals Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 180 ◽  
Author(s):  
Rodolfo Mauceri ◽  
Denise Murgia ◽  
Orazio Cicero ◽  
Luigi Paternò ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Healing ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Critical Size ◽  
Large Bone ◽  
Alveolar Bone Defect ◽  
Positive Results ◽  
Autologous Platelet

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

scholarly journals Metformin-Incorporated Gelatin/Nano-Hydroxyapatite Scaffolds Promotes Bone Regeneration in Critical Size Rat Alveolar Bone Defect Model

2022 ◽  
Vol 23 (1) ◽  
pp. 558
Author(s):  
Chih-Hsiang Fang ◽  
Chung-Kai Sun ◽  
Yi-Wen Lin ◽  
Min-Chih Hung ◽  
Hung-Ying Lin ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Critical Size ◽  
Lower Percentage ◽  
Type I ◽  
Defect Model ◽  
Good Biocompatibility ◽  
Alveolar Bone Defect

In this study, we fabricated gelatin/nano-hydroxyapatite/metformin scaffold (GHMS) and compared its effectiveness in bone regeneration with extraction-only, Sinbone, and Bio-Oss Collagen® groups in a critical size rat alveolar bone defect model. GHMS was synthesized by co-precipitating calcium hydroxide and orthophosphoric acid within gelatin solution, incorporating metformin, and cross-linked by microbial transglutaminase. The morphology, characterization, and biocompatibility of scaffold were examined. The in vitro effects of GHMS on osteogenic gene and protein expressions were evaluated. In vivo bone formation was assessed in a critical size rat alveolar bone defect model with micro-computed tomography and histological examination by comparing GHMS with extraction-only, Sinbone, and Bio-Oss Collagen®. The synthesized GHMS had a highly interconnected porous structure with a mean pore size of 81.85 ± 13.8 µm. GHMS exhibited good biocompatibility; promoted ALPL, RUNX2, SP7, BGLAP, SPARC and Col1a1 gene expressions; and upregulated the synthesis of osteogenic proteins, including osteonectin, osteocalcin, and collagen type I. In critical size rat alveolar bone defects, GHMS showed superior bone regeneration compared to extraction-only, Sinbone, and Bio-Oss Collagen® groups as manifested by greater alveolar ridge preservation, while more bone formation with a lower percentage of connective tissue and residual scaffold at the defect sites grafted with GHMS in histological staining. The GHMS presented in this study may be used as a potential bone substitute to regenerate alveolar bone. The good biocompatibility, relatively fast degradation, interconnected pores allowing vascularization, and higher bioactivity properties of the components of the GHMS (gelatin, nHA, and metformin) may contribute to direct osteogenesis.

Wharton's Jelly for Augmented Cleft Palate Repair in a Rat Critical-Size Alveolar Bone Defect Model

2020 ◽  
Vol 26 (11-12) ◽  
pp. 591-601 ◽  
Author(s):  
Suchit Sahai ◽  
Marysuna Wilkerson ◽  
Hasen Xue ◽  
Nicolas Moreno ◽  
Louis Carrillo ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Critical Size ◽  
Wharton’S Jelly ◽  
Defect Model ◽  
Wharton's Jelly ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Alveolar Bone Defect

scholarly journals Predifferentiated Gingival Stem Cell-Induced Bone Regeneration in Rat Alveolar Bone Defect Model

2020 ◽  
Author(s):  
Umadevi Kandalam ◽  
Toshihisa Kawai ◽  
Geeta Ravindran ◽  
Ross Brockman ◽  
Jorge Romero ◽  
...  
Keyword(s):  
Stem Cell ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Defect Model ◽  
Alveolar Bone Defect

Guided bone regeneration to repair an alveolar bone defect in a girl whose cleft lip and palate had been repaired

2005 ◽  
Vol 43 (5) ◽  
pp. 420-422 ◽  
Author(s):  
Toshitsugu Kawata ◽  
Miho Yuki ◽  
Yoshihiro Miyamoto ◽  
Tadashi Fujita ◽  
Masato Kaku ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Alveolar Bone Defect

A Synthetic Biodegradable Polymer Membrane for Guided Bone Regeneration in Bone Defect

2021 ◽  
Vol 17 (3) ◽  
pp. 456-465
Author(s):  
Kangjie Ma ◽  
Dongmei Mei ◽  
Xiaodong Lin ◽  
Li Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Bone Regeneration ◽  
Polylactic Acid ◽  
Bone Defect ◽  
Biodegradable Polymer ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Collagen Membrane ◽  
Gbr Membrane ◽  
Alveolar Bone Defect

Guided bone regeneration (GBR) technique is most commonly used to treat alveolar bone defect. Polylactic acid (PLA) attracts much attention to utilize as a GBR membrane because it has relatively high mechanical strength and biodegradability. However, randomized controlled trials of PLA as a GBR membrane in animals were rare. The aim of this work is to observe the efficacy of polylactic acid membrane in guiding bone regeneration in Beagle canine alveolar bone defect restoration and to compare efficacy with the collagen membrane, providing an experimental basis for further clinical use of the polylactic acid membrane. The tests of physical and chemical properties showed that the PLA membrane has well mechanical strength to maintenance the space for the new bone, and has proper aperture for the attachment of osteoblasts. Through X-ray and histopathological examination of the different time points, the bone grafting material covered with PLA membrane can form similar mature bone compared to collagen membrane ones. Meanwhile, biodegradable speed of the PLA membrane was slower. Thus, this study showed that polylactic acid membrane as synthetic biodegradable polymer was reliably effective in guiding bone regeneration of alveolar bone defects, showed the favorable osteogenic capability and forecasts well applications in bone augmentation.

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