Immediate splenectomy down-regulates the MAPK–NF-κB signaling pathway in rat brain after severe traumatic brain injury

2013 ◽  
Vol 74 (6) ◽  
pp. 1446-1453 ◽  
Author(s):  
Weihua Chu ◽  
Mei Li ◽  
Fei Li ◽  
Rong Hu ◽  
Zhi Chen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Signaling Pathway ◽  
Severe Traumatic Brain Injury

scholarly journals Aquaporin 9 in rat brain after severe traumatic brain injury

2012 ◽  
Vol 70 (3) ◽  
pp. 214-220 ◽  
Author(s):  
Hui Liu ◽  
Mei Yang ◽  
Guo-ping Qiu ◽  
Fei Zhuo ◽  
Wei-hua Yu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Severe Traumatic Brain Injury ◽  
Early Stage ◽  
Blue Staining ◽  
Tetrazolium Chloride ◽  
Aquaporin 9 ◽  
Polymerase Chain ◽  
Two Peaks

OBJECTIVE: To reveal the expression and possible roles of aquaporin 9 (AQP9) in rat brain, after severe traumatic brain injury (TBI). METHODS: Brain water content (BWC), tetrazolium chloride staining, Evans blue staining, immunohistochemistry (IHC), immunofluorescence (IF), western blot, and real-time polymerase chain reaction were used. RESULTS: The BWC reached the first and second (highest) peaks at 6 and 72 hours, and the blood brain barrier (BBB) was severely destroyed at six hours after the TBI. The worst brain ischemia occurred at 72 hours after TBI. Widespread AQP9-positive astrocytes and neurons in the hypothalamus were detected by means of IHC and IF after TBI. The abundance of AQP9 and its mRNA increased after TBI and reached two peaks at 6 and 72 hours, respectively, after TBI. CONCLUSIONS: Increased AQP9 might contribute to clearance of excess water and lactate in the early stage of TBI. Widespread AQP9-positive astrocytes might help lactate move into neurons and result in cellular brain edema in the later stage of TBI. AQP9-positive neurons suggest that AQP9 plays a role in energy balance after TBI.

Neurocognitive status and return to work after moderate to severe traumatic brain injury.

2019 ◽  
Vol 64 (4) ◽  
pp. 435-444
Author(s):  
Tessa Hart ◽  
Jessica M. Ketchum ◽  
Therese M. O'Neil-Pirozzi ◽  
Thomas A. Novack ◽  
Doug Johnson-Greene ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Return To Work ◽  
Severe Traumatic Brain Injury

Problem-solving therapy for suicide prevention in veterans with moderate-to-severe traumatic brain injury.

2017 ◽  
Vol 62 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Sean M. Barnes ◽  
Lindsey L. Monteith ◽  
Georgia R. Gerard ◽  
Adam S. Hoffberg ◽  
Beeta Y. Homaifar ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Problem Solving ◽  
Suicide Prevention ◽  
Severe Traumatic Brain Injury ◽  
Problem Solving Therapy
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