scholarly journals Temporal and Spatial Changes in the Pattern of Iba1 and CD68 Staining in the Rat Brain Following Severe Traumatic Brain Injury

2015 ◽  
Vol 04 (02) ◽  
pp. 9-23 ◽  
Author(s):  
Debbie Smith ◽  
Diane Brooks ◽  
Eric Wohlgehagen ◽  
Thomas Rau ◽  
David Poulsen
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Severe Traumatic Brain Injury ◽  
Spatial Changes ◽  
Temporal And Spatial

scholarly journals Aquaporin 9 in rat brain after severe traumatic brain injury

2012 ◽  
Vol 70 (3) ◽  
pp. 214-220 ◽  
Author(s):  
Hui Liu ◽  
Mei Yang ◽  
Guo-ping Qiu ◽  
Fei Zhuo ◽  
Wei-hua Yu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Severe Traumatic Brain Injury ◽  
Early Stage ◽  
Blue Staining ◽  
Tetrazolium Chloride ◽  
Aquaporin 9 ◽  
Polymerase Chain ◽  
Two Peaks

OBJECTIVE: To reveal the expression and possible roles of aquaporin 9 (AQP9) in rat brain, after severe traumatic brain injury (TBI). METHODS: Brain water content (BWC), tetrazolium chloride staining, Evans blue staining, immunohistochemistry (IHC), immunofluorescence (IF), western blot, and real-time polymerase chain reaction were used. RESULTS: The BWC reached the first and second (highest) peaks at 6 and 72 hours, and the blood brain barrier (BBB) was severely destroyed at six hours after the TBI. The worst brain ischemia occurred at 72 hours after TBI. Widespread AQP9-positive astrocytes and neurons in the hypothalamus were detected by means of IHC and IF after TBI. The abundance of AQP9 and its mRNA increased after TBI and reached two peaks at 6 and 72 hours, respectively, after TBI. CONCLUSIONS: Increased AQP9 might contribute to clearance of excess water and lactate in the early stage of TBI. Widespread AQP9-positive astrocytes might help lactate move into neurons and result in cellular brain edema in the later stage of TBI. AQP9-positive neurons suggest that AQP9 plays a role in energy balance after TBI.

Immediate splenectomy down-regulates the MAPK–NF-κB signaling pathway in rat brain after severe traumatic brain injury

2013 ◽  
Vol 74 (6) ◽  
pp. 1446-1453 ◽  
Author(s):  
Weihua Chu ◽  
Mei Li ◽  
Fei Li ◽  
Rong Hu ◽  
Zhi Chen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rat Brain ◽  
Signaling Pathway ◽  
Severe Traumatic Brain Injury

scholarly journals Temporal and spatial changes in reactive astrogliosis examined by 18F-THK5351 positron emission tomography in a patient with severe traumatic brain injury

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Tetsuhiro Hatakeyama ◽  
Kenya Kawakita ◽  
Nobuyuki Kawai ◽  
Hajime Shishido ◽  
Yuka Yamamoto ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Positron Emission Tomography ◽  
Brain Injury ◽  
Emission Tomography ◽  
Reactive Astrogliosis ◽  
Positron Emission ◽  
Spatial Changes ◽  
Severe Tbi ◽  
Temporal And Spatial ◽  
The Brain

Abstract Background The positron emission tomography (PET) radioligand 18F-THK5351 is now used to evaluate monoamine oxidase B expression in the reactive astrogliosis seen in various central nervous diseases. Traumatic brain injury (TBI) is known to induce reactive astrogliosis in the lesion site. This is a first report to examine the spatial and temporal changes in reactive astrogliosis as evaluated by 18F-THK5351 after a severe TBI. Case presentation A 27-year-old man suffering from a severe TBI with multiple brain contusions was examined using 18F-THK5351 PET/CT in the subacute and chronic phases after the injury. The first PET scan, performed 46 days after the TBI, showed intense uptake of 18F-THK5351 in and around the brain contusions. The second PET scan, performed 271 days after the TBI, showed reduced uptake of 18F-THK5351 at the original sites of the brain contusions and increased uptakes in the white matter surrounding the contusions and the corpus callosum. The patient exhibited sustained improvement of neuropsychological impairment between the two PET examinations and remarkable recovery from the severe TBI. Conclusions There were evident temporal and spatial changes in 18F-THK5351 uptake in the traumatized brain between the two PET examinations. These changes may have been related to the remarkable neurological recovery in this patient. The degree and distribution of reactive astrogliosis detected by 18F-THK5351 PET may be useful in assessing pathophysiology and predicting prognosis in TBI patients.

Neurocognitive status and return to work after moderate to severe traumatic brain injury.

2019 ◽  
Vol 64 (4) ◽  
pp. 435-444
Author(s):  
Tessa Hart ◽  
Jessica M. Ketchum ◽  
Therese M. O'Neil-Pirozzi ◽  
Thomas A. Novack ◽  
Doug Johnson-Greene ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Return To Work ◽  
Severe Traumatic Brain Injury

Problem-solving therapy for suicide prevention in veterans with moderate-to-severe traumatic brain injury.

2017 ◽  
Vol 62 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Sean M. Barnes ◽  
Lindsey L. Monteith ◽  
Georgia R. Gerard ◽  
Adam S. Hoffberg ◽  
Beeta Y. Homaifar ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Problem Solving ◽  
Suicide Prevention ◽  
Severe Traumatic Brain Injury ◽  
Problem Solving Therapy

Lipofundin®-Induced Intracranial Pressure Rise after Severe Traumatic Brain Injury - A Case Report

2004 ◽  
Vol 65 (02) ◽  
pp. 81-83 ◽  
Author(s):  
S Wolf ◽  
M Krammer ◽  
H Trost ◽  
C Lumenta
Keyword(s):  
Traumatic Brain Injury ◽  
Case Report ◽  
Brain Injury ◽  
Intracranial Pressure ◽  
Severe Traumatic Brain Injury ◽  
Pressure Rise
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