Diagnostic Accuracies of Glycated Hemoglobin, Fructosamine, and Homeostasis Model Assessment of Insulin Resistance in Predicting Impaired Fasting Glucose, Impaired Glucose Tolerance, or New Onset Diabetes After Transplantation

2016 ◽  
Vol 100 (7) ◽  
pp. 1571-1579 ◽  
Author(s):  
Kerri Rosettenstein ◽  
Andrea Viecelli ◽  
Kenneth Yong ◽  
Hung Do Nguyen ◽  
Aron Chakera ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Glycated Hemoglobin ◽  
Fasting Glucose ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Onset Diabetes ◽  
New Onset

scholarly journals Study of New onset Diabetes Mellitus in Acute Coronary Syndrome Patients

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Clinical Status ◽  
Limited Information ◽  
Coronary Syndrome ◽  
Onset Diabetes ◽  
New Onset

Introduction: There is limited information on the incidence of diabetes despite INDIA being the Global capital for Diabetes. Though much of data is available in patients already diagnosed with diabetes but data regarding the new onset diabetes in the subset of Acute coronary syndrome (ACS) is very limited. Materials and methods: This was a Cohort study in which 200 consecutive ACS patients were included. Lab data about their FBS; PPBS; Lipid profile & Hba1c, BMI, BP and their clinical status was collected at the time of admission, after discharge at 2 weeks, 6 weeks & 3,6 & 12 months post ACS. Results: In study 85% were males. Mean age was 56 years. Prevalence of various atherosclerotic risk factors in study population matched the regional prevalence of them. 20% (n=40) developed New onset diabetes (NOD), 2.5% (n=5) developed Impaired fasting Glucose, 6% (n=12) developed Impaired glucose tolerance in and 1.5% (n=3) developed both Impaired fasting glucose and Impaired Glucose tolerance over a follow up period of 1 year. MACE rates & Revascularisation rates were significantly higher in NOD population. NOD patients had significantly higher BMI, waist circumference, BP, TG, LDL and Low HDL. NOD patients were on Higher dosage of statins, diuretics and Beta blockers. Conclusion: The study highlights two important things, first incidence of new onset diabetes in acute coronary syndrome patients is High, second new onset diabetes has a significant impact on the clinical outcome of ACS patients

scholarly journals Adipose Triglyceride Lipase Single Nucleotide Polymorphism is Associated with Heart Failure Development after Acute Myocardial Infarction in Patients with Dyslipidemia

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Clinical Status ◽  
Limited Information ◽  
Coronary Syndrome ◽  
Onset Diabetes ◽  
New Onset

Introduction: There is limited information on the incidence of diabetes despite INDIA being the Global capital for Diabetes. Though much of data is available in patients already diagnosed with diabetes but data regarding the new onset diabetes in the subset of Acute coronary syndrome (ACS) is very limited. Materials and methods: This was a Cohort study in which 200 consecutive ACS patients were included. Lab data about their FBS; PPBS; Lipid profile & Hba1c, BMI , BP and their clinical status was collected at the time of admission, after discharge at 2 weeks, 6 weeks & 3,6 & 12 months post ACS. Results: In study 85% were males. Mean age was 56 years. Prevalence of various atherosclerotic risk factors in study population matched the regional prevalence of them. 20% (n=40) developed New onset diabetes (NOD), 2.5% (n=5) developed Impaired fasting Glucose, 6% (n=12) developed Impaired glucose tolerance in and 1.5% (n=3) developed both Impaired fasting glucose and Impaired Glucose tolerance over a follow up period of 1 year. MACE rates & Revascularisation rates were significantly higher in NOD population. NOD patients had significantly higher BMI, waist circumference, BP, TG, LDL and Low HDL. NOD patients were on Higher dosage of statins, diuretics and Beta blockers. Conclusion: The study highlights two important things, first incidence of new onset diabetes in acute coronary syndrome patients is High, Second new onset diabetes has a significant impact on the clinical outcome of ACS patients

scholarly journals Adipose Triglyceride Lipase Single Nucleotide Polymorphism is Associated with Heart Failure Development after Acute Myocardial Infarction in Patients with Dyslipidemia

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Acute Coronary Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Clinical Status ◽  
Limited Information ◽  
Coronary Syndrome ◽  
Onset Diabetes ◽  
New Onset

Introduction: There is limited information on the incidence of diabetes despite INDIA being the Global capital for Diabetes. Though much of data is available in patients already diagnosed with diabetes but data regarding the new onset diabetes in the subset of Acute coronary syndrome (ACS) is very limited. Materials and Methods: This was a Cohort study in which 200 consecutive ACS patients were included. Lab data about their FBS; PPBS; Lipid profile & Hba1c, BMI , BP and their clinical status was collected at the time of admission, after discharge at 2 weeks, 6 weeks & 3,6 & 12 months post ACS. Results: In study 85% were males. Mean age was 56 years. Prevalence of various atherosclerotic risk factors in study population matched the regional prevalence of them. 20% (n=40) developed New onset diabetes (NOD), 2.5% (n=5) developed Impaired fasting Glucose, 6% (n=12) developed Impaired glucose tolerance in and 1.5% (n=3) developed both Impaired fasting glucose and Impaired Glucose tolerance over a follow up period of 1 year. MACE rates & Revascularisation rates were significantly higher in NOD population. NOD patients had significantly higher BMI, waist circumference, BP, TG, LDL and Low HDL. NOD patients were on Higher dosage of statins, diuretics and Beta blockers. Conclusion: The study highlights two important things, first incidence of new onset diabetes in acute coronary syndrome patients is High, Second new onset diabetes has a significant impact on the clinical outcome of ACS patients.

scholarly journals Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum

2015 ◽  
Vol 6 ◽  
pp. JCM.S32743 ◽  
Author(s):  
Hiroko Katayama ◽  
Daisuke Tachibana ◽  
Akihiro Hamuro ◽  
Takuya Misugi ◽  
Koka Motoyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Plasma Glucose Level ◽  
Fasting Glucose ◽  
Japanese Women ◽  
Insulinogenic Index ◽  
Model Assessment ◽  
Homeostasis Model Assessment

Objective The aim of this study was to compare glucose intolerance in the antenatal and the postpartum periods using a 75-g oral glucose tolerance test (OGTT) in the Japanese women with gestational diabetes mellitus (GDM) using a retrospective design. Patients and Methods Data were obtained from 85 Japanese women with GDM who delivered from April 2011 through April 2015 and who underwent an OGTT 6–14 weeks postpartum. The women were divided into two groups based on the results of the postpartum OGTT: one group with normal glucose tolerance (NGT) and the other with impaired glucose tolerance (IGT) as well as impaired fasting glucose (IFG). We analyzed the associations between postpartum IGT–IFG and various factors. Results Antenatally, a significant difference was observed between the groups only in the 1-hour plasma glucose level of the 75-g OGTT. Postpartum results of plasma glucose level were significantly higher at 0.5, 1, and 2 hours in the IGT–IFG group than those in the NGT group. Moreover, a significant decrease in the levels of 0.5-hour immunoreactive insulin and insulinogenic index was observed in the IGT–IFG group compared to those in the NGT group. Homeostasis model assessment-insulin resistance and homeostasis model assessment β-cell function of both groups were found to significantly decrease in the postpartum period; however, there was no significant change in the insulinogenic index of either group. Conclusions Our study clearly showed that the postpartum IGT and IFG levels of Japanese women with GDM are affected by impaired early-phase insulin secretion; however, insulin resistance promptly improves.

scholarly journals Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups

2004 ◽  
pp. 199-206 ◽  
Author(s):  
S Wiegand ◽  
U Maikowski ◽  
O Blankenstein ◽  
H Biebermann ◽  
P Tarnow ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Children And Adolescents ◽  
Fasting Glucose ◽  
Sensitivity Index ◽  
Model Assessment ◽  
Abnormal Glucose Tolerance

BACKGROUND: The incidence of childhood obesity and type 2 diabetes is an increasing problem in Europe. We determined the prevalence of impaired glucose regulation in a predominantly Caucasian cohort of 491 children and adolescents with obesity. METHODS: Fasting glucose and insulin levels were determined in all 491 subjects. Patients with an abnormal fasting glucose or with additional risk factors (positive family history of type 2 diabetes, acanthosis nigricans, hyperlipidemia; n=102) underwent an oral glucose tolerance test (OGTT; 1.75 g glucose/kg body weight). Homeostasis model assessment was used to estimate insulin resistance in all subjects. The insulin sensitivity index was determined in those subjects who underwent an OGTT. Screening for mutations in the melanocortin 4 receptor (MC4R) gene and the coding region of the brain-derived neutrophic factor (BDNF) in 37 patients with an impaired glucose tolerance was performed by WAVE analysis. RESULTS: Out of the total of 491 patients, 12 had an abnormal fasting glucose level. Of the 102 patients who underwent an OGTT, 37 had impaired glucose tolerance; 6 out of the 102 patients were diagnosed with type 2 diabetes. Eighty-eight per cent of patients with abnormal glucose tolerance and 66% of patients with type 2 diabetes were Caucasian. Insulin resistance indices correlated well with the degree of abnormal glucose tolerance. Using the screening algorithm for type 2 diabetes as advocated by the American Diabetes Association, 68% of patients with impaired glucose tolerance and 66% of patients with type 2 diabetes would have been missed. No abnormalities in the MC4R and BDNF genes were detected. CONCLUSIONS: Impaired glucose tolerance and type 2 diabetes are far more common in obese European children of Caucasian origin than previously thought. Using fasting glucose levels as the main screening tool appears to be insufficient in detecting these children.

scholarly journals The positive association between serum uric acid, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus in the ELSA-Brasil study

2021 ◽  
Vol 37 (9) ◽  
Author(s):  
Aline Isabel Rodrigues Galvão ◽  
Alline Maria R. Beleigoli ◽  
Pedro Guatimosim Vidigal ◽  
Bruce Bartholow Duncan ◽  
Maria Inês Schmidt ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Uric Acid ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Serum Uric Acid ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Newly Diagnosed ◽  
Glycemic Status

Abstract: There is a conflict in the literature regarding the association between serum uric acid (SUA) levels and glycemic status. Therefore, we evaluated the association between SUA level and glycemic status - impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus - and insulin resistance, in a large Brazilian study. This is a cross-sectional, observational study with 13,207 participants aged 35-74 years, at baseline (2008-2010) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). A multinomial regression analysis was performed to test the association between SUA and glycemic status (IFG, IGT, and newly diagnosed type 2 diabetes at the cohort baseline) after adjustments by age, sex, skin color, body mass index, physical activity, smoking, alcohol consumption, comorbidities, and medicines use. Logistic regression model was used to evaluate the association between SUA and insulin resistance by HOMA-IR. Stratified analyses by sex were performed. The mean age (standard deviation) was 51.4 (8.9) years, 55.2% of participants were women. There were 1,439 newly diagnosed diabetes. After all adjustments, higher SUA was associated with IFG, IGT, and diabetes, with odds ratio (OR) = 1.15 (95%CI: 1.06; 1.25), 1.23 (95%CI: 1.14; 1.33), and 1.37 (95%CI: 1.24; 1.51), respectively. There was association between SUA levels and insulin resistance with OR = 1.24 (95%CI: 1.13; 1.36). In analysis stratified by sex, higher SUA persisted independently associated with impaired glycemic status. Our results suggest that a higher SUA levels were significantly associated with glycemic status in a large Latin American population, mainly among women.

scholarly journals Differences in Insulin Resistance in Nondiabetic Subjects With Isolated Impaired Glucose Tolerance or Isolated Impaired Fasting Glucose

Diabetes ◽  
2004 ◽  
Vol 53 (6) ◽  
pp. 1549-1555 ◽  
Author(s):  
A. Festa ◽  
R. D'Agostino ◽  
A. J.G. Hanley ◽  
A. J. Karter ◽  
M. F. Saad ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose
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