Evidence of a subcommissural organ involvement in the brain response to lead exposure and a modulatory potential of curcumin

Neuroreport ◽  
2016 ◽  
Vol 27 (4) ◽  
pp. 264-271 ◽  
Author(s):  
Hind Benammi ◽  
Omar El Hiba ◽  
Halima Gamrani
Entropy ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 286
Author(s):  
Soheil Keshmiri

Recent decades have witnessed a substantial progress in the utilization of brain activity for the identification of stress digital markers. In particular, the success of entropic measures for this purpose is very appealing, considering (1) their suitability for capturing both linear and non-linear characteristics of brain activity recordings and (2) their direct association with the brain signal variability. These findings rely on external stimuli to induce the brain stress response. On the other hand, research suggests that the use of different types of experimentally induced psychological and physical stressors could potentially yield differential impacts on the brain response to stress and therefore should be dissociated from more general patterns. The present study takes a step toward addressing this issue by introducing conditional entropy (CE) as a potential electroencephalography (EEG)-based resting-state digital marker of stress. For this purpose, we use the resting-state multi-channel EEG recordings of 20 individuals whose responses to stress-related questionnaires show significantly higher and lower level of stress. Through the application of representational similarity analysis (RSA) and K-nearest-neighbor (KNN) classification, we verify the potential that the use of CE can offer to the solution concept of finding an effective digital marker for stress.


1967 ◽  
Vol 45 (1) ◽  
pp. 117-126 ◽  
Author(s):  
M. A. Hafeez ◽  
P. Ford

The morphohistology and some histochemical aspects of the pineal organ in the sockeye salmon were studied. The distal part of the organ lies in a pineal fossa in the cranial roof. Photosensory cells and two kinds of ependymal supporting cells are present throughout its epithelium, which is entirely devoid of either melanin or lipofuchsin. Besides sensory nerve fibers, efferent end-loops are present on the photosensory as well as the supporting cells. The dorsal pineal nerve tract probably contains both sensory and efferent fibers. The apocrine secretion of sensory as well as some supporting cells is probably associated with either the maintenance of a constant chemical composition of the cerebrospinal fluid or with supply of certain chemical substances to the brain tissue. The secretion in the pineal and the subcommissural organ consists of glycogen, mucopolysaccharides, mucoproteins, and aldehyde fuchsin positive granules.It is proposed that the pineal organ is photosensory as well as secretory and that its photosensitivity might be of some significance in the light-dependent behavior of this species in terms of intensity detection.


2012 ◽  
Vol 63 (4) ◽  
pp. 411-425 ◽  
Author(s):  
A. Rahman ◽  
K. Khan ◽  
G. Al-Khaledi ◽  
I. Khan ◽  
Sreeja Attur

Author(s):  
M. S. Chafi ◽  
V. Dirisala ◽  
G. Karami ◽  
M. Ziejewski

In the central nervous system, the subarachnoid space is the interval between the arachnoid membrane and the pia mater. It is filled with a clear, watery liquid called cerebrospinal fluid (CSF). The CSF buffers the brain against mechanical shocks and creates buoyancy to protect it from the forces of gravity. The relative motion of the brain due to a simultaneous loading is caused because the skull and brain have different densities and the CSF surrounds the brain. The impact experiments are usually carried out on cadavers with no CSF included because of the autolysis. Even in the cadaveric head impact experiments by Hardy et al. [1], where the specimens are repressurized using artificial CSF, this is not known how far this can replicate the real functionality of CSF. With such motivation, a special interest lies on how to model this feature in a finite element (FE) modeling of the human head because it is questionable if one uses in vivo CSF properties (i.e. bulk modulus of 2.19 GPa) to validate a FE human head against cadaveric experimental data.


2020 ◽  
Author(s):  
Katja Junttila ◽  
Anna-Riikka Smolander ◽  
Reima Karhila ◽  
Anastasia Giannakopoulou ◽  
Maria Uther ◽  
...  

Learning is increasingly assisted by technology. Digital games may be useful for learning, especially in children. However, more research is needed to understand the factors that induce gaming benefits to cognition. In this study, we investigated the effectiveness of digital game-based learning approach in children by comparing the learning of foreign speech sounds and words in a digital game or a non-game digital application with equal amount of exposure and practice. To evaluate gaming-induced plastic changes in the brain function, we used the mismatch negativity (MMN) brain response that reflects the activation of long-term memory representations for speech sounds and words. We recorded auditory event-related potentials (ERPs) from 37 school-aged Finnish-speaking children before and after playing the “Say it again, kid!” (SIAK) language-learning game where they explored game boards, produced English words aloud, and got stars as feedback from an automatic speech recognizer to proceed in the game. The learning of foreign speech sounds and words was compared in two conditions embedded in the game: a game condition and a non-game condition with the same speech production task but lacking visual game elements and feedback. The MMN amplitude increased between the pre-measurement and the post-measurement for the word trained with the game but not for the word trained with the non-game condition, suggesting that the gaming intervention enhanced learning more than the non-game intervention. The results indicate that digital game-based learning can be beneficial for children’s language learning and that gaming elements per se, not just practise time, support learning.


2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Chuanfu Li ◽  
Jun Yang ◽  
Jinbo Sun ◽  
Chunsheng Xu ◽  
Yuanqiang Zhu ◽  
...  

In recent years, neuroimaging studies of acupuncture have explored extensive aspects of brain responses to acupuncture in finding its underlying mechanisms. Most of these studies have been performed on healthy adults. Only a few studies have been performed on patients with diseases. Brain responses to acupuncture in patients with the same disease at different pathological stages have not been explored, although it may be more important and helpful in uncovering its underlying mechanisms. In the present study, we used fMRI to compare brain responses to acupuncture in patients with Bell’s palsy at different pathological stages with normal controls and found that the brain response to acupuncture varied at different pathological stages of Bell’s palsy. The brain response to acupuncture decreased in the early stages, increased in the later stages, and nearly returned to normal in the recovered group. All of the changes in the brain response to acupuncture could be explained as resulting from the changes in the brain functional status. Therefore, we proposed that the brain response to acupuncture is dependent on the brain functional status, while further investigation is needed to provide more evidence in support of this proposition.


Author(s):  
Naveen Kumar Bhardwaj ◽  
Vykuntaraju K. Gowda ◽  
Ashwin Vivek Sardesai

AbstractAlternating hemiplegia of childhood (AHC) is a rare autosomal dominant neurodevelopmental disorder with mutation on ATP1A3 gene. Delay in diagnosis and inappropriate diagnosis are common. We describe four genetically confirmed AHC patients to provide an improved understanding of the disorder. First symptom in two patients was seizures and in other two patients was abnormal eye deviation. All had onset of plegic attacks within the first 18 months of their life. Tone abnormalities and movement disorders were present in all patients. Electroencephalogram was abnormal in two patients and all had normal magnetic resonance imaging of the brain. Response to treatment of plegic attacks was poor and also epilepsy was drug resistant. All cases had significant development delay and disability as of last follow-up. Although there is no effective treatment so far, early diagnosis is required to avoid unnecessary treatment.


2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Shi Qiu ◽  
Junjun Li ◽  
Mengdi Cong ◽  
Chun Wu ◽  
Yan Qin ◽  
...  

Solitary pulmonary nodules are the main manifestation of pulmonary lesions. Doctors often make diagnosis by observing the lung CT images. In order to further study the brain response structure and construct a brain-computer interface, we propose an isolated pulmonary nodule detection model based on a brain-computer interface. First, a single channel time-frequency feature extraction model is constructed based on the analysis of EEG data. Second, a multilayer fusion model is proposed to establish the brain-computer interface by connecting the brain electrical signal with a computer. Finally, according to image presentation, a three-frame image presentation method with different window widths and window positions is proposed to effectively detect the solitary pulmonary nodules.


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