D1 receptor regulation of preprotachykinin-A gene by extracellular signal-regulated kinase pathway in striatal cultures

Neuroreport ◽  
2008 ◽  
Vol 19 (2) ◽  
pp. 187-191 ◽  
Author(s):  
Mihaela Sin ◽  
Sharon K. Michelhaugh ◽  
Michael J. Bannon
Keyword(s):  
D1 Receptor ◽  
Receptor Regulation ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Kinase Pathway

scholarly journals Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal-Regulated Kinase Pathway

2014 ◽  
Vol 88 (20) ◽  
pp. 12133-12145 ◽  
Author(s):  
C.-H. Hung ◽  
L.-W. Chen ◽  
W.-H. Wang ◽  
P.-J. Chang ◽  
Y.-F. Chiu ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Extracellular Signal Regulated Kinase ◽  
Barr Virus ◽  
Extracellular Signal ◽  
Epstein Barr ◽  
Kinase Pathway

Senkyunolide I Relieves Neuropathic Pain Induced by Chronic Constriction Injury by Inhibiting Activation of Microglia

2021 ◽  
Vol 20 (2) ◽  
pp. 253-258
Author(s):  
Xiaomin Huang ◽  
Miao Huo
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Biological Activities ◽  
Bioactive Components ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Induced Apoptosis ◽  
Kinase Pathway ◽  
Senkyunolide I

As an alternative to the use of narcotics, generally refractory to long-term effectiveness, for the management of neuropathic pain, we have explored the utility of senkyunolide I. Senkyunolide I is one of the bioactive components isolated from Ligusticum chuanxiong Hort known to exhibit multiple biological activities. In this study, we report senkyunolide I inhibition of chronic constriction injury induced neuropathic pain. Mechanistically, senkyunolide I inhibited chronic constriction injury induced apoptosis and the activity of microglia via extracellular signal regulated kinase pathway. We therefore suggest that senkyunolide I could serve as a promising drug for the treatment of neuropathic pain.

scholarly journals Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest

2004 ◽  
Vol 127 (4) ◽  
pp. 1033-1040 ◽  
Author(s):  
Deog-Gon Cho ◽  
Matthew R Mulloy ◽  
Paul A Chang ◽  
Mahlon D Johnson ◽  
Alon S Aharon ◽  
...  
Keyword(s):  
Neuronal Damage ◽  
Circulatory Arrest ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Kinase Pathway
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