scholarly journals Constraints on somite formation in developing embryos

2019 ◽  
Vol 16 (158) ◽  
pp. 20190451
Author(s):  
Jonas S. Juul ◽  
Mogens H. Jensen ◽  
Sandeep Krishna

Segment formation in vertebrate embryos is a stunning example of biological self-organization. Here, we present an idealized framework, in which we treat the presomitic mesoderm (PSM) as a one-dimensional line of oscillators. We use the framework to derive constraints that connect the size of somites, and the timing of their formation, to the growth of the PSM and the gradient of the somitogenesis clock period across the PSM. Our analysis recapitulates the observations made recently in ex vivo cultures of mouse PSM cells, and makes predictions for how perturbations, such as increased Wnt levels, would alter somite widths. Finally, our analysis makes testable predictions for the shape of the phase profile and somite widths at different stages of PSM growth. In particular, we show that the phase profile is robustly concave when the PSM length is steady and slightly convex in an important special case when it is decreasing exponentially. In both cases, the phase profile scales with the PSM length; in the latter case, it scales dynamically. This has important consequences for the velocity of the waves that traverse the PSM and trigger somite formation, as well as the effect of errors in phase measurement on somite widths.

2019 ◽  
Author(s):  
Jonas S. Juul ◽  
Mogens H. Jensen ◽  
Sandeep Krishna

Segment formation in vertebrate embryos is a stunning example of biological self-organisation. Here, we present an idealized model of the presomitic mesoderm (PSM) as a one-dimensional line of oscillators. We use the model to derive constraints that connect the size of somites, and the timing of their formation, to the growth of the PSM and the gradient of the somitogenesis clock period across the PSM. Our analysis recapitulates the observations made recently in ex-vivo cultures of mouse PSM cells, and makes predictions for how perturbations, such as increased Wnt levels, would alter somite widths. Finally, our model makes testable predictions for the shape of the phase profile and somite widths at different stages of PSM growth. In particular, we show that the phase profile is robustly concave when the PSM length is steady and slightly convex in an important special case when it is decreasing exponentially. In both cases, the phase profile scales with the PSM length; in the latter case, it scales dynamically. This has important consequences for the velocity of the waves that traverse the PSM and trigger somite formation, as well as the effect of errors in phase measurement on somite widths.


2006 ◽  
Vol 13 (04) ◽  
pp. 455-462 ◽  
Author(s):  
O. Kálmán ◽  
P. Földi ◽  
M. G. Benedict

A one-dimensional mesoscopic ring with one input and two output leads acts as a spintronic beam splitter. The spatial degree of freedom, i.e., the presence of two different possible output channels, gets intertwined with the spin direction as a consequence of quantum interference and spin-orbit interaction. We investigate this kind of spatial-spin correlation, and show that the output density operator contains no quantum entanglement in the important special case when the device polarizes a perfectly random input spin state. However, the correlations are in general not purely classical, we also present specific input states with maximal spatial-spin entanglement after the ring.


Nanophotonics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 443-452
Author(s):  
Tianshu Jiang ◽  
Anan Fang ◽  
Zhao-Qing Zhang ◽  
Che Ting Chan

AbstractIt has been shown recently that the backscattering of wave propagation in one-dimensional disordered media can be entirely suppressed for normal incidence by adding sample-specific gain and loss components to the medium. Here, we study the Anderson localization behaviors of electromagnetic waves in such gain-loss balanced random non-Hermitian systems when the waves are obliquely incident on the random media. We also study the case of normal incidence when the sample-specific gain-loss profile is slightly altered so that the Anderson localization occurs. Our results show that the Anderson localization in the non-Hermitian system behaves differently from random Hermitian systems in which the backscattering is suppressed.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nikolaos Vasios ◽  
Bolei Deng ◽  
Benjamin Gorissen ◽  
Katia Bertoldi

AbstractMulti-welled energy landscapes arising in shells with nonzero Gaussian curvature typically fade away as their thickness becomes larger because of the increased bending energy required for inversion. Motivated by this limitation, we propose a strategy to realize doubly curved shells that are bistable for any thickness. We then study the nonlinear dynamic response of one-dimensional (1D) arrays of our universally bistable shells when coupled by compressible fluid cavities. We find that the system supports the propagation of bidirectional transition waves whose characteristics can be tuned by varying both geometric parameters as well as the amount of energy supplied to initiate the waves. However, since our bistable shells have equal energy minima, the distance traveled by such waves is limited by dissipation. To overcome this limitation, we identify a strategy to realize thick bistable shells with tunable energy landscape and show that their strategic placement within the 1D array can extend the propagation distance of the supported bidirectional transition waves.


2004 ◽  
Vol 04 (01) ◽  
pp. 63-76 ◽  
Author(s):  
OLIVER JENKINSON

Given a non-empty finite subset A of the natural numbers, let EA denote the set of irrationals x∈[0,1] whose continued fraction digits lie in A. In general, EA is a Cantor set whose Hausdorff dimension dim (EA) is between 0 and 1. It is shown that the set [Formula: see text] intersects [0,1/2] densely. We then describe a method for accurately computing dimensions dim (EA), and employ it to investigate numerically the way in which [Formula: see text] intersects [1/2,1]. These computations tend to support the conjecture, first formulated independently by Hensley, and by Mauldin & Urbański, that [Formula: see text] is dense in [0,1]. In the important special case A={1,2}, we use our computational method to give an accurate approximation of dim (E{1,2}), improving on the one given in [18].


2005 ◽  
Vol 48 (2) ◽  
pp. 221-236 ◽  
Author(s):  
Matt Kerr

AbstractWe state and prove an important special case of Suslin reciprocity that has found significant use in the study of algebraic cycles. An introductory account is provided of the regulator and norm maps on Milnor K2-groups (for function fields) employed in the proof.


1966 ◽  
Vol 21 (7) ◽  
pp. 1098-1106 ◽  
Author(s):  
R. Lust ◽  
M. Scholer

The propagation of waves in the solar atmosphere is investigated with respect to the problem of the chromospheric spiculae and of the heating of the solar chromosphere and corona. In particular the influence of external magnetic fields is considered. Waves of finite amplitudes are numerically calculated by solving the time-dependent magnetohydrodynamic equation for two spatial dimensions by assuming axial symmetry. For the case without a magnetic field the comparison between one dimensional and two dimensional treatment shows the strong influence of the radial propagation on the steepening of waves in the vertical direction. In the presence of a magnetic field it is shown that the propagation is strongly guided along the lines of force. The steepening of the waves along the field is much larger as compared to the case where no field is present.


1972 ◽  
Vol 94 (2) ◽  
pp. 467-472 ◽  
Author(s):  
D. A. P. Jayasinghe ◽  
H. J. Leutheusser

This paper deals with elastic waves which may be generated in a fluid by the sudden movement of a flow boundary. In particular, an analysis of the classical piston, or signalling problem is presented for the special case of arbitrary velocity input into a stationary fluid contained in a circular, semi-infinite waveguide. The decay of the pulse, as well as the resulting flow development in the inlet region of the pipe are analyzed by means of an asymptotic expansion of the suitably nondimensionalized Navier-Stokes equations for a compressible, nonheat-conducting Newtonian fluid. The results differ significantly from those of the more conventional one-dimensional approach based on the so-called telegrapher’s equation of mathematical physics. The present theory realistically predicts the growth of a boundary layer both in time and position and, hence, it appears to represent the transient fluid motion in a manner which is physically more appealing.


Author(s):  
Peter Scholze ◽  
Jared Weinstein

This introductory chapter provides an overview of Drinfeld's work on the global Langlands correspondence over function fields. Whereas the global Langlands correspondence is largely open in the case of number fields K, it is a theorem for function fields, due to Drinfeld and L. Lafforgue. The key innovation in this case is Drinfeld's notion of an X-shtuka (or simply shtuka). The Langlands correspondence for X is obtained by studying moduli spaces of shtukas. A large part of this course is about the definition of perfectoid spaces and diamonds. There is an important special case where the moduli spaces of shtukas are classical rigid-analytic spaces. This is the case of local Shimura varieties. Some examples of these are the Rapoport-Zink spaces.


1970 ◽  
Vol 22 (1) ◽  
pp. 128-133 ◽  
Author(s):  
Wei-Eihn Kuan

1. Let k be an infinite field and let V/k be an irreducible variety of dimension ≧ 2 in a projective n-space Pn over k. Let P and Q be two k-rational points on V In this paper, we describe ideal-theoretically the generic hyperplane section of V through P and Q (Theorem 1) and prove that the section is almost always an absolutely irreducible variety over k1/pe if V/k is absolutely irreducible (Theorem 3). As an application (Theorem 4), we give a new simple proof of an important special case of the existence of a curve connecting two rational points of an absolutely irreducible variety [4], namely any two k-rational points on V/k can be connected by an irreducible curve.I wish to thank Professor A. Seidenberg for his continued advice and encouragement on my thesis research.


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