scholarly journals Portable smartphone-integrated paper sensors for fluorescence detection of As(III) in groundwater

2020 ◽  
Vol 7 (12) ◽  
pp. 201500
Author(s):  
Sha Liu ◽  
Yong Li ◽  
Chao Yang ◽  
Liqiang Lu ◽  
Yulun Nie ◽  
...  
Keyword(s):  
Environmental Problem ◽  
Visual Detection ◽  
High Sensitivity ◽  
Integration System ◽  
Detection Range ◽  
Sensitivity And Selectivity ◽  
Toxic Metalloid ◽  
Interfering Ions ◽  
Cu Nanoclusters

Arsenic contamination in groundwater is a supreme environmental problem, and levels of this toxic metalloid must be strictly monitored by a portable, sensitive and selective analytical device. Herein, a new system of smartphone-integrated paper sensors with Cu nanoclusters was established for the effective detection of As(III) in groundwater. For the integration system, the fluorescence emissive peak of Cu nanoclusters at 600 nm decreased gradually with increasing As(III) addition. Meanwhile, the fluorescence colour also changed from orange to colourless, and the detection limit was determined as 2.93 nM (0.22 ppb) in a wide detection range. The interfering ions also cannot influence the detection selectivity of As(III). Furthermore, the portable paper sensors based on Cu nanoclusters were fabricated for visual detection of As(III) in groundwater. The quantitative determination of As(III) in natural groundwater has also been accomplished with the aid of a common smartphone. Our work has provided a portable and on-site detection technique toward As(III) in groundwater with high sensitivity and selectivity.

Photometric Analysis Reagents of Rare Earths and their Application in Metallurgical Analysis

2011 ◽  
Vol 233-235 ◽  
pp. 311-316
Author(s):  
Song Tao Tian ◽  
Xiu Lan Yu ◽  
Li Qing Zhang
Keyword(s):  
Rare Earths ◽  
High Sensitivity ◽  
Molar Absorptivity ◽  
Photometric Analysis ◽  
Metallurgical Analysis ◽  
Sensitivity And Selectivity ◽  
Molar Absorptivity Coefficient ◽  
Interfering Ions ◽  
Maximum Absorption Wavelength

In this paper, photometric analysis reagents of rare earths and their application in metallurgical analysis at home and abroad in the past 10 years was reviewed, pertaining especially to various coloring reagents of rare earths and its conditions of coloring reaction, the maximum absorption wavelength, molar absorptivity coefficient, limit of detaction, as well as interference and application of corresponding methods. The key application in the determination of actual samples was summarized for it is very important to eliminate the effect of interfering ions. The purpose is to provide help to establish new analysis methods of high sensitivity and selectivity in the future. 52 references are cited.

Determination of butyltin and phenyltin analogues in sea products by Grignard derivatization and gas chromatography-triple quadrupole tandem mass spectrometry

2014 ◽  
Vol 6 (23) ◽  
pp. 9333-9339 ◽  
Author(s):  
Zongyan Cui ◽  
Yunkai Qian ◽  
Na Ge ◽  
Jinjie Zhang ◽  
Yongming Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Tandem Mass Spectrometry ◽  
High Sensitivity ◽  
Tandem Mass ◽  
Triple Quadrupole ◽  
Sensitivity And Selectivity

A GC MS/MS method was development with high sensitivity and selectivity for organotin speciation in sea products.

scholarly journals Exploring peptide capture by anti-protein antibodies for LC-MS-based biomarker determination

2018 ◽  
Author(s):  
Maren Levernæs ◽  
Bassem Farhat ◽  
Inger Oulie ◽  
Sazan S. Abdullah ◽  
Elisabeth Paus ◽  
...  
Keyword(s):  
Protein Extraction ◽  
High Sensitivity ◽  
Intact Protein ◽  
Protein Biomarkers ◽  
Promising Technique ◽  
Intact Proteins ◽  
Protein Levels ◽  
Endogenous Protein ◽  
Sensitivity And Selectivity

<p>Immunocapture LC-MS/MS is a promising technique to ensure high sensitivity and selectivity of low-abundant protein biomarkers. For this purpose, the use of monoclonal antibodies (mAb) is especially attractive as they are renewable reagents that can be standardized. In this article we investigated the possibility of using mAbs developed against intact proteins (anti-protein antibodies) to capture proteotypic epitope peptides. Three mAbs were tested, and all selectively extracted proteotypic epitope peptides from a complex sample. Compared to intact protein extraction, this concept which we call peptide capture by anti-protein antibodies provided cleaner extracts, which further improved the sensitivity. Analysis of three patient samples demonstrated that p can be used for the determination of different endogenous protein levels. </p><p></p>

scholarly journals Development of the High Sensitivity and Selectivity Method for the Determination of Histamine in Fish and Fish Sauce from Vietnam by UPLC-MS/MS

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Quang Hieu Tran ◽  
Thanh Tan Nguyen ◽  
Kim Phuong Pham
Keyword(s):  
Limit Of Detection ◽  
High Sensitivity ◽  
Fish Sauce ◽  
Limit Of Quantification ◽  
Fish Samples ◽  
The Matrix ◽  
Liquid Chromatography Tandem Mass ◽  
Sensitivity And Selectivity ◽  
Liquid Chromatographic

A selective, sensitive, and rapid method by using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the determination of histamine in fish and fish sauce was developed. The optimal conditions of liquid chromatographic separation and mass spectroscopy of histamine have also been investigated. The linear ranges of the method were 20.0 ÷ 1000 ng/mL, and the corresponding correlation coefficient was 0.9993. Mean recoveries of the analyte at three spike levels (low, medium, and high) were within the range of 98.5% ÷ 102.5% (n = 7). The limit of detection (LOD) and limit of quantification (LOQ) values were 3.83 and 11.50 ng/mL for the fish sauce sample and 4.71 and 14.12 ng/mL for the fish sample, respectively. The influence of the matrix effect on the accuracy, repeatability, and recovery of the method was negligible. The recommended method was applied to determine the content of this substance in 21 fish sauce samples and 4 kinds of fish samples, which were collected from Ho Chi Minh City, Vietnam, in 2019.

scholarly journals Chromatographic Methods for the Determination of Aminexil, Pyridoxine, and Niacinamide in a Novel Cosmetic Hair Preparation

2020 ◽  
Vol 103 (4) ◽  
pp. 1167-1172
Author(s):  
Mamdouh R Rezk ◽  
Hebatallah M Essam ◽  
Enas A Amer ◽  
Dina M S Youssif
Keyword(s):  
High Performance ◽  
High Sensitivity ◽  
Ammonia Solution ◽  
Hplc Method ◽  
The Novel ◽  
Chromatographic Methods ◽  
Ich Guidelines ◽  
Sensitivity And Selectivity ◽  
Keratin Fibers

Abstract Background Aminexil, a new compound patented by L’Oreal, has a stimulating effect on human keratin fibers. Pyridoxine HCl and niacinamide are added to boost the hair tonic effect of aminexil. Objective Two novel chromatographic methods were developed for the determination of aminexil (AX), niacinamide (NA) and pyridoxine HCl (PD) in the novel hair tonic preparation. Methods The developed methods were high-performance liquid chromatography (HPLC) and thin layer chromatography (TLC) with densitometric determination. Different experimental parameters were investigated and optimized to achieve complete baseline separation and well resolved peaks. The RP-HPLC separation was achieved using a Thermoscientific BDS hypersil C18 (250 × 4.6 mm, 5 µm) column using 0.005 M hexane sulfonic acid: methanol (80: 20, v/v) as a mobile phase. For the TLC method, the three analytes were partitioned between propanol: toluene: ammonia solution (40:60:2, v/v/v) and fluorescent silica plates. The two methods were validated in compliance with International Conference on Harmonization (ICH) guidelines. The obtained data were statistically analyzed to confirm the existing results. The developed methods were successfully applied for determination of the studied drugs in pure forms and in the cosmetic preparation. Results For the HPLC method, the RSDs of AX, NA and PD were 0.70, 0.88 and 1.17 respectively. For the TLC method, the RSDs of AX, NA and PD were 1.06, 1.37 and 0.73 respectively. Conclusions The proposed chromatographic methods showed high sensitivity and selectivity for the three compounds under analysis in the laboratory prepared mixture and in the hair tonic preparation. Highlights Aminexil, Pyridoxine, Niacinamide, HPLC. The present work offers two reproducible, accurate, validated, time and cost saving alternatives for the quantitative and qualitative determination of medicated hair preparation.

Spectrophotometric Method for the Assay of Chlorhexiidine Acetate

2014 ◽  
Vol 912-914 ◽  
pp. 321-324
Author(s):  
Yan Hong Lei
Keyword(s):  
Spectrophotometric Method ◽  
High Sensitivity ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Addition Method ◽  
Ultraviolet Spectrophotometry ◽  
Good Linear ◽  
Sensitivity And Selectivity

To establish the determination of the content of chlorhexiidine acetate by ultraviolet spectrophotometry .The spectra (range: λ=200~320 nm) were processed. The linear ranges of chlorhexidine acetate was at 2~ 20 μg mL-1 .the chlorhexiidine acetate showed good linear correlation.The ultraviolet spectrophotometry data of the samples were also used to evaluate the samples quantitative composition.It was shown that recovery of the method by standard addition method was respectively valued 99.55% for chlorhexiidine acetate .The method was simple,reliable,accurate,reproducible with high sensitivity and selectivity.

A highly sensitive and selective “turn-on” fluorescent probe for detection of fleroxacin in human serum and urine based on a lanthanide functionalized metal–organic framework

2019 ◽  
Vol 48 (48) ◽  
pp. 17945-17952 ◽  
Author(s):  
Tian-Yu Liu ◽  
Xiang-Long Qu ◽  
Bing Yan
Keyword(s):  
Human Serum ◽  
Metal Organic Framework ◽  
High Sensitivity ◽  
Luminescent Probe ◽  
Turn On ◽  
Highly Sensitive ◽  
Sensitivity And Selectivity ◽  
Metal Organic ◽  
Serum And Urine

A novel luminescent probe based on a Eu3+ functionalized MOF hybrid (Eu3+@1) with high sensitivity and selectivity has been proved to possess enormous potential for the determination of fleroxacin in human serum and urine.

scholarly journals Exploring peptide capture by anti-protein antibodies for LC-MS-based biomarker determination

2018 ◽  
Author(s):  
Maren Levernæs ◽  
Bassem Farhat ◽  
Inger Oulie ◽  
Sazan S. Abdullah ◽  
Elisabeth Paus ◽  
...  
Keyword(s):  
Protein Extraction ◽  
High Sensitivity ◽  
Intact Protein ◽  
Protein Biomarkers ◽  
Promising Technique ◽  
Intact Proteins ◽  
Protein Levels ◽  
Endogenous Protein ◽  
Sensitivity And Selectivity

<p>Immunocapture LC-MS/MS is a promising technique to ensure high sensitivity and selectivity of low-abundant protein biomarkers. For this purpose, the use of monoclonal antibodies (mAb) is especially attractive as they are renewable reagents that can be standardized. In this article we investigated the possibility of using mAbs developed against intact proteins (anti-protein antibodies) to capture proteotypic epitope peptides. Three mAbs were tested, and all selectively extracted proteotypic epitope peptides from a complex sample. Compared to intact protein extraction, this concept which we call peptide capture by anti-protein antibodies provided cleaner extracts, which further improved the sensitivity. Analysis of three patient samples demonstrated that p can be used for the determination of different endogenous protein levels. </p><p></p>

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