On the relation between the anterior pituitary body and the gonads.- Part II. The induction of ovulation in the anæstrous ferret
The factors responsible for the alternation of reproductive activity and anæstrous quiesecence are imperfectly known, but in view of much recent work on the regulation of the ovary (Smith and Engle, 1927, Zondek and aschheim, 1927), it is necessary to suppose that the anterior pituitary body is involved. On such a view anæstrus might be caused by inability of the ovary to respond to stimulation from the hypophysis, but it is more reasonable to suppose that the onset of the breeding season is due to increased activity of the anterior pituiary body, and that anæstrus results from decreased activity. In the circumstances it seemed that results of interest might be obtained by the administration of preparations containing the gonad-stimulating principles of the anterior pituitary body to animals during anæstrus. Most of the common labortory animals have no definite anæstrus, and the choice of an animal for work on anæstrus is almost limited to the ferret ot the dog. Of these, the former is obviously more suitable, especially as a considerable amount id now known about its reproductive processes. The work of Marshall (1904), Robinson (1918) and Marshall and Hammond (1930) has made it possible to make the following statements regarding the œstrous cycle in the ferret:- ( a ) The breeding season in restricted and lasts only from April to August. During the remainder of the are the reproductive organs are in a state of quiescent anæstrus.