scholarly journals Disgust: the disease-avoidance emotion and its dysfunctions

2011 ◽  
Vol 366 (1583) ◽  
pp. 3453-3465 ◽  
Author(s):  
Graham C. L. Davey
Keyword(s):  
Separation Anxiety ◽  
Small Animal ◽  
Current Evidence ◽  
Disease Avoidance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Injection Injury ◽  
Interpretation Biases ◽  
Animal Phobias ◽  
Shame And Guilt

This review analyses the accumulating evidence from psychological, psychophysiological, neurobiological and cognitive studies suggesting that the disease-avoidance emotion of disgust is a predominant emotion experienced in a number of psychopathologies. Current evidence suggests that disgust is significantly related to small animal phobias (particularly spider phobia), blood–injection–injury phobia and obsessive–compulsive disorder contamination fears, and these are all disorders that have primary disgust elicitors as a significant component of their psychopathology. Disgust propensity and sensitivity are also significantly associated with measures of a number of other psychopathologies, including eating disorders, sexual dysfunctions, hypochondriasis, height phobia, claustrophobia, separation anxiety, agoraphobia and symptoms of schizophrenia—even though many of these psychopathologies do not share the disease-avoidance functionality that characterizes disgust. There is accumulating evidence that disgust does represent an important vulnerability factor for many of these psychopathologies, but when disgust-relevant psychopathologies do meet the criteria required for clinical diagnosis, they are characterized by significant levels of both disgust and fear/anxiety. Finally, it has been argued that disgust may also facilitate anxiety and distress across a broad range of psychopathologies through its involvement in more complex human emotions such as shame and guilt, and through its effect as a negative affect emotion generating threat-interpretation biases.

Neurobiology and Treatment of OCD

2013 ◽  
pp. 646-661
Author(s):  
Susanne E. Ahmari ◽  
H. Blair Simpson
Keyword(s):  
Environmental Factors ◽  
Behavioral Therapy ◽  
Treatment Strategies ◽  
Current Evidence ◽  
Evidence Based ◽  
Preclinical Studies ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Evidence Based Treatments ◽  
Genetic And Environmental Factors

Obsessive Compulsive Disorder (OCD) is a chronic, disabling disorder with a lifetime prevalence of up to 2-3%, and is a leading cause of illness-related disability. OCD is characterized by recurrent intrusive thoughts, images, or impulses (obsessions) that cause anxiety or distress, and repetitive mental or behavioral acts (compulsions). Though the etiology of OCD is unclear, current evidence implicates both genetic and environmental factors in its development. Our understanding of the neurobiology underlying OCD is still evolving, with convergent evidence from clinical and preclinical studies highlighting the importance of abnormalities in cortico-striatal-thalamo-cortical (CSTC) circuits. Evidence-based treatments for OCD include both pharmacotherapy and cognitive-behavioral therapy. This chapter will review the etiology and neurobiology of OCD, and will provide an overview of treatment strategies.

scholarly journals Why disgust matters

2011 ◽  
Vol 366 (1583) ◽  
pp. 3478-3490 ◽  
Author(s):  
Valerie Curtis
Keyword(s):  
Diarrhoeal Disease ◽  
Post Traumatic Stress ◽  
Human Flourishing ◽  
Disease Avoidance ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
New Synthesis ◽  
Hidden Cost ◽  
Post Traumatic ◽  
Pandemic Flu

The new synthesis about disgust is that it is a system that evolved to motivate infectious disease avoidance. There are vital practical and intellectual reasons why we need to understand disgust better. Practically, disgust can be harnessed to combat the behavioural causes of infectious and chronic disease such as diarrhoeal disease, pandemic flu and smoking. Disgust is also a source of much human suffering; it plays an underappreciated role in anxieties and phobias such as obsessive compulsive disorder, social phobia and post-traumatic stress syndromes; it is a hidden cost of many occupations such as caring for the sick and dealing with wastes, and self-directed disgust afflicts the lives of many, such as the obese and fistula patients. Disgust is used and abused in society, being both a force for social cohesion and a cause of prejudice and stigmatization of out-groups. This paper argues that a better understanding of disgust, using the new synthesis, offers practical lessons that can enhance human flourishing. Disgust also provides a model system for the study of emotion, one of the most important issues facing the brain and behavioural sciences today.

Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies

2017 ◽  
Vol 46 ◽  
pp. 25-32 ◽  
Author(s):  
A. Rasgon ◽  
W.H. Lee ◽  
E. Leibu ◽  
A. Laird ◽  
D. Glahn ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Anterior Cingulate ◽  
Primary Data ◽  
Current Evidence ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Referential Processing ◽  
Habitual Responding

AbstractObsessive compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive ritualistic behaviors and has been associated with diverse functional brain abnormalities. We sought to synthesize current evidence from functional magnetic resonance imaging (fMRI) studies and examine their alignment to pathogenetic models of OCD. Following systematic review, we identified 54 task-fMRI studies published in the last decade comparing adults with OCD (n = 1186) to healthy adults (n = 1159) using tasks of affective and non-affective cognition. We used voxel-based quantitative meta-analytic methods to combine primary data on anatomical coordinates of case-control differences, separately for affective and non-affective tasks. We found that functional abnormalities in OCD cluster within cortico-striatal thalamic circuits. Within these circuits, the abnormalities identified showed significant dependence on the affective or non-affective nature of the tasks employed as circuit probes. In studies using affective tasks, patients overactivated regions involved in salience, arousal and habitual responding (anterior cingulate cortex, insula, caudate head and putamen) and underactivated regions implicated in cognitive and behavioral control (medial prefrontal cortex, posterior caudate). In studies using non-affective cognitive tasks, patients overactivated regions involved in self-referential processing (precuneus, posterior cingulate cortex) and underactivated subcortical regions that support goal-directed cognition and motor control (pallidum, ventral anterior thalamus, posterior caudate). The overall pattern suggests that OCD-related brain dysfunction involves increased affective and self-referential processing, enhanced habitual responding and blunted cognitive control.

The relationship between obsessive–compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study

2001 ◽  
Vol 31 (3) ◽  
pp. 481-487 ◽  
Author(s):  
G. NESTADT ◽  
J. SAMUELS ◽  
M. A. RIDDLE ◽  
K.-Y. LIANG ◽  
O. J. BIENVENU ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Obsessive Compulsive Disorder ◽  
Affective Disorders ◽  
Substance Dependence ◽  
Separation Anxiety ◽  
Family Study ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Relationship

Objective. This study investigates the relationship of specific anxiety and affective disorders to obsessive–compulsive disorder (OCD) in a blind, controlled family study.Method. Eighty case and 73 control probands, as well as 343 case and 300 control first-degree relatives of these probands, participated in the study. Subjects were examined by psychologists or psychiatrists using the Schedule for Affective Disorder and Schizophrenia-Lifetime Anxiety version (SADS-LA). Two experienced psychiatrists independently reviewed all clinical materials, and final diagnoses were made according to DSM-IV criteria, by consensus procedure.Results. Except for bipolar disorder, all anxiety and affective disorders investigated were more frequent in case than control probands. Substance dependence disorders were not more frequent. Generalized anxiety disorder (GAD), panic disorder, agoraphobia, separation anxiety disorder (SAD) and recurrent major depression were more common in case than control relatives. These disorders occurred more frequently if the relative was diagnosed with OCD. Only GAD and agoraphobia were more frequent in case relatives independent of OCD.Conclusion. GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome.

scholarly journals A Brazilian version of the "Children's Interview for Psychiatric Syndromes" (ChIPS)

2009 ◽  
Vol 58 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Isabella G. S. de Souza ◽  
Maria Antonia Serra-Pinheiro ◽  
Renata Mousinho ◽  
Paulo Mattos
Keyword(s):  
Anxiety Disorder ◽  
Psychotic Disorders ◽  
Separation Anxiety ◽  
Child And Adolescent Psychiatry ◽  
Brazilian Portuguese ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Children And Adolescent ◽  
Compulsive Disorder ◽  
Oppositional Defiant

OBJETIVE: The advance of research in child and adolescent psychiatry in Brazil heavily depends on the existence of instruments for the investigation of psychiatric syndromes adapted to Brazilian Portuguese. METHODS: This article describes a careful process of translation of the Children's Interview for Psychiatric Syndromes for the purpose of use in research in Brazil. The Children's Interview for Psychiatric Syndromes has a version for parents (P-ChIPs) and a version for children (ChIPS). In this article, the sections of P-ChIPS referring to attention-deficit hyperactivity disorder, oppositional-defiant disorder, conduct disorder, mania/hypomania, anorexia nervosa, bulimia nervosa and psychotic disorders were translated to Brazilian Portuguese. The sections of the ChIPS referring to substance use disorders, social anxiety disorder, specific phobias, obsessive-compulsive disorder, generalized anxiety disoder, separation anxiety disorder, post-traumatic disorders and depression/dysthimia were also adapted. Each section was translated by two independent translators and later discussed in a committee composed of experts in the field of Psychiatry and a professional of the field of linguistics. RESULT: A final version containing an interview for the main psychiatric syndromes was defined. CONCLUSION: The translated P-ChIPS is a helpful instrument in children and adolescent clinical evaluation.

scholarly journals Translation and Adaptation of the Spence Children’s Anxiety Scale (SCAS)-Parent Version at a Tertiary Level Hospital

2018 ◽  
Vol 7 (1) ◽  
pp. 40-45
Author(s):  
B.S. Gurung ◽  
M. Rana ◽  
S. Shakya
Keyword(s):  
Anxiety Disorder ◽  
Internal Consistency ◽  
Separation Anxiety ◽  
Separation Anxiety Disorder ◽  
Clinical Samples ◽  
Clinical Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Metric Properties ◽  
Specificity And Sensitivity

Introduction: The study has examined the psycho-metric properties of the Nepali translation of SCAS-PV in terms of internal consistency and criterion validity Material and Method: Non probability sampling method was used. Participants were selected purposively under two groups of samples called clinical group and non clinical group. Study population of the study was the patient visiting outdoor and inpatient services of Department of Psychiatry and Mental Health, TUTH. Results: Among 200 (clinical= 98 and a non-clinical=102) sample of Nepalese children and adolescents. The specificity and sensitivity of the tool was assessed. Cronbach Alpha for the total scale (α =0.89), panic disorder (α =0.78), physical injury fear (α =0.72) and separation anxiety disorder (α =0.76) were of acceptable to good range. However, internal consistency of generalized anxiety disorder (α =0.67), obsessive compulsive disorder (α =0.59) and social anxiety disorder (α =0.68) were in questionable range. AUC statistic for total scale was in fair range, with optimum cut off score of 19.5 for the total scale with sensitivity of 65.3% and specificity of 64.7%. Conclusion: The study supports the utility of the SCAS-PV as a measure of anxiety symptoms in children. It can be used to directly compare symptom reporting across children in clinical. Because of the psychometric properties of the SCAS-PV that have been demonstrated in community and clinical samples, it is recommended that the SCAS-PV can be used in clinical and research contexts.

Obsessive-compulsive disorder – A question of conscience? An fMRI study of behavioural and neurofunctional correlates of shame and guilt

2015 ◽  
Vol 68 ◽  
pp. 354-362 ◽  
Author(s):  
Kristina Hennig-Fast ◽  
Petra Michl ◽  
Johann Müller ◽  
Nico Niedermeier ◽  
Ute Coates ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Fmri Study ◽  
Shame And Guilt

Preliminary evidence of biased attentional mechanisms and reward processing in adults with obsessive-compulsive disorder

2019 ◽  
Vol 83 (2) ◽  
pp. 128-151 ◽  
Author(s):  
Jennifer L. O'Brien ◽  
Marni L. Jacob ◽  
Morgan King
Keyword(s):  
Obsessive Compulsive Disorder ◽  
High Probability ◽  
Preliminary Evidence ◽  
Reward Processing ◽  
Current Evidence ◽  
Limited Attention ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Stimulus Response ◽  
Low Probability

Individuals with obsessive-compulsive-disorder (OCD) may have difficulties in using feedback from rewarding and punishing experiences to optimally guide future decisions. The current aim was to examine how adults with OCD use associative learning feedback to direct attention toward learned stimuli when the action-outcome contingency for those stimuli has changed. Participants first learned to select high-probability (over low-probability) rewarding stimuli and low-probability (over high-probability) loss stimuli. Participants then saw these stimuli as the second of two targets in a task where available attentional resources were limited. Recognition of learned stimuli during limited attention was driven by previously learned stimulus-response associations instead of an attentional benefit toward the most favorable action-outcome associations (reward-associated stimuli), as demonstrated in prior research with non-OCD adults. The current evidence supports the hypothesis that individuals with OCD have difficulties shifting from learned stimulus-response associations when the response-outcome contingencies change.

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