scholarly journals Genomic human immunodeficiency virus type 1 RNA variation in mother and child following intra-uterine virus transmission

1993 ◽  
Vol 74 (9) ◽  
pp. 1747-1756 ◽  
Author(s):  
G. A. Mulder-Kampinga ◽  
C. Kuiken ◽  
J. Dekker ◽  
H. J. Scherpbier ◽  
K. Boer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Virus Transmission ◽  
Immunodeficiency Virus ◽  
Mother And Child

scholarly journals Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells

2002 ◽  
Vol 76 (15) ◽  
pp. 7812-7821 ◽  
Author(s):  
Rogier W. Sanders ◽  
Esther C. de Jong ◽  
Christopher E. Baldwin ◽  
Joost H. N. Schuitemaker ◽  
Martien L. Kapsenberg ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Dendritic Cells ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Virus Transmission ◽  
Viral Envelope ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Dendritic cells (DC) support human immunodeficiency virus type 1 (HIV-1) transmission by capture of the virus particle in the mucosa and subsequent transport to the draining lymph node, where HIV-1 is presented to CD4+ Th cells. Virus transmission involves a high-affinity interaction between the DC-specific surface molecule DC-SIGN and the viral envelope glycoprotein gp120 and subsequent internalization of the virus, which remains infectious. The mechanism of viral transmission from DC to T cells is currently unknown. Sentinel immature DC (iDC) develop into Th1-promoting effector DC1 or Th2-promoting DC2, depending on the activation signals. We studied the ability of these effector DC subsets to support HIV-1 transmission in vitro. Compared with iDC, virus transmission is greatly upregulated for the DC1 subset, whereas DC2 cells are inactive. Increased transmission by DC1 correlates with increased expression of ICAM-1, and blocking studies confirm that ICAM-1 expression on DC is important for HIV transmission. The ICAM-1-LFA-1 interaction is known to be important for immunological cross talk between DC and T cells, and our results indicate that this cell-cell contact is exploited by HIV-1 for efficient transmission.

scholarly journals Persistent Infection with Primate Foamy Virus Type 1 Increases Human Immunodeficiency Virus Type 1 Cell Binding via a Bet-Independent Mechanism

2004 ◽  
Vol 78 (20) ◽  
pp. 11405-11410 ◽  
Author(s):  
Cecile Schiffer ◽  
Charles-Henri Lecellier ◽  
Abdelkrim Mannioui ◽  
Nathalie Felix ◽  
Elisabeth Nelson ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Foamy Virus ◽  
Virus Transmission ◽  
Target Cells ◽  
Virus Attachment ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT We report that human T cells persistently infected with primate foamy virus type 1 (PFV-1) display an increased capacity to bind human immunodeficiency virus type 1 (HIV-1), resulting in increased cell permissiveness to HIV-1 infection and enhanced cell-to-cell virus transmission. This phenomenon is independent of HIV-1 receptor, CD4, and it is not related to PFV-1 Bet protein expression. Increased virus attachment is specifically inhibited by heparin, indicating that it should be mediated by interactions with heparan sulfate glycosaminoglycans expressed on the target cells. Given that both viruses infect similar animal species, the issue of whether coinfection with primate foamy viruses interferes with the natural course of lentivirus infections in nonhuman primates should be considered.

scholarly journals Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection

2015 ◽  
Vol 89 (15) ◽  
pp. 8101-8101
Author(s):  
Christina F. Thobakgale ◽  
Andrew Prendergast ◽  
Hayley Crawford ◽  
Nompumelelo Mkhwanazi ◽  
Danni Ramduth ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Disease Progression ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
Mother And Child

scholarly journals Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances trans infection of CD4+ T lymphocytes

2007 ◽  
Vol 88 (9) ◽  
pp. 2568-2573 ◽  
Author(s):  
Sandra Thibault ◽  
Mélanie R. Tardif ◽  
Caroline Gilbert ◽  
Michel J. Tremblay
Keyword(s):  
Human Immunodeficiency Virus ◽  
Endothelial Cells ◽  
T Lymphocytes ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Virus Transmission ◽  
Surface Proteins ◽  
Immunodeficiency Virus ◽  
Hiv 1

Previous studies have identified several host-derived cell-surface proteins incorporated within emerging human immunodeficiency virus type 1 (HIV-1) particles. Some of these molecules play a role in different steps of the virus life cycle and are often advantageous for the virus. We report here that the leukocyte L-selectin (also called CD62L) remains functional when inserted within the envelope of HIV-1. Indeed, we demonstrate that adsorption of virions to endothelial cells is enhanced upon acquisition of host-derived CD62L. The more important binding of CD62L-bearing HIV-1 particles resulted in a more efficient virus transmission to CD4+ T lymphocytes. Capture and eventual transfer of such CD62L-bearing virions by the endothelium could play a role in the pathogenesis of HIV-1 infection.

scholarly journals Short Communication: Phylodynamics Analysis of the Human Immunodeficiency Virus Type 1 Envelope Gene in Mother and Child Pairs

2015 ◽  
Vol 31 (9) ◽  
pp. 913-920 ◽  
Author(s):  
Luciane Amorim Santos ◽  
Rebecca R. Gray ◽  
Joana Paixão Monteiro-Cunha ◽  
Evandra Strazza ◽  
Simone Kashima ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Short Communication ◽  
Envelope Gene ◽  
Immunodeficiency Virus ◽  
Mother And Child
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