scholarly journals Genetic diversity of Streptococcus agalactiae strains and density of vaginal carriage

2009 ◽  
Vol 58 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Nathalie van der Mee-Marquet ◽  
Cindy Jouannet ◽  
Anne-Sophie Domelier ◽  
Laurence Arnault ◽  
Marie-Frédérique Lartigue ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genetic Diversity ◽  
Central Nervous System ◽  
Nervous System ◽  
Genetic Markers ◽  
Streptococcus Agalactiae ◽  
Genetic Characteristics ◽  
Genetic Features ◽  
The Central Nervous System ◽  
Pfge Profiles

We screened 500 pregnant women who had no risk factors for Streptococcus agalactiae vaginal carriage, and isolated 39 S. agalactiae strains (8 %). The density of carriage was low in 16 cases (41 %), intermediate in 16 cases (41 %) and heavy in seven cases (18 %). Strains were mostly of serotype III (41 %), Ia (26 %) and V (18 %). Thirty-five strains had at least one of five genetic markers that have been associated with virulent phylogenetic subgroups of strains. Using PCR, nine strains (23 %) were identified as belonging to CC17. The 39 vaginal strains that were studied exhibited a substantial genetic diversity; there were 39 PFGE profiles and 13 variants defined on the basis of the five genetic markers studied. The prevalence of the studied genetic characteristics was similar for strains associated with all three classes of density of carriage. These data suggest that genetic features that are markers of S. agalactiae strains able to invade the central nervous system of neonates are not determinants for vaginal adaptation.

scholarly journals Inherited cavernous malformations of the central nervous system: clinical and genetic features in 19 Swiss families

2009 ◽  
Vol 33 (1) ◽  
pp. 47-51 ◽  
Author(s):  
C. Graeni ◽  
F. Stepper ◽  
M. Sturzenegger ◽  
A. Merlo ◽  
D. J. Verlaan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cavernous Malformations ◽  
Genetic Features ◽  
The Central Nervous System

scholarly journals Clinicopathologic and Genetic Features of Primary T-cell Lymphomas of the Central Nervous System

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jeemin Yim ◽  
Jiwon Koh ◽  
Sehui Kim ◽  
Seung Geun Song ◽  
Jeong Mo Bae ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
T Cell ◽  
T Cell Lymphomas ◽  
Genetic Features ◽  
The Central Nervous System

scholarly journals Varicella Zoster Virus Encephalitis

2019 ◽  
Vol 3 (4) ◽  
pp. 380-382
Author(s):  
Jared Lizzi ◽  
Tyler Hill ◽  
Julian Jakubowski
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Varicella Zoster Virus ◽  
Immunocompromised Patient ◽  
Clinical Suspicion ◽  
The Body ◽  
Varicella Zoster ◽  
Increased Risk ◽  
The Central Nervous System

Varicella zoster virus in the adult patient most commonly presents as shingles. Shingles is a painful vesicular eruption localized to a specific dermatome of the body. One of the potential complications of this infection is involvement of the central nervous system causing encephalitis. An increased risk of this complication is associated with the immunocompromised patient. In this case report, we review the history and physical exam findings that should raise clinical suspicion for varicella zoster encephalitis, as well as the epidemiology, risk factors, treatment, and prognosis of this type of infection.

scholarly journals CLINICAL-GENETIC FEATURES OF THE KNOBLOCH SYNDROME IN THE RUSSIAN FAMILY

2018 ◽  
Vol 13 (2) ◽  
pp. 109-112
Author(s):  
Olga V. Khlebnikova ◽  
E. L Dadali ◽  
L. A Bessonova ◽  
F. A Konovalov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Compound Heterozygous ◽  
Heterozygous State ◽  
Clinical Genetic ◽  
Central Nervous System Damage ◽  
Genetic Characteristics ◽  
Knobloch Syndrome ◽  
Genetic Features ◽  
Compound Heterozygous State

The article presents the clinical and genetic characteristics of a patient with Knobloch syndrome caused by the previously indescried combination of mutations in the compound heterozygous state c.4054_4055delCT / c.1469-2A>G in the gene COL18A1. The peculiarity of the presented case is the absence of symptoms of central nervous system damage, found in most patients with this syndrome.

scholarly journals Molecular genetics of familial tumour syndromes of the central nervous system

2015 ◽  
Vol 156 (5) ◽  
pp. 171-177 ◽  
Author(s):  
Balázs Murnyák ◽  
Rita Szepesi ◽  
Tibor Hortobágyi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Autosomal Dominant ◽  
Molecular Genetic ◽  
Genetic Characteristics ◽  
Central Nervous System Tumours ◽  
Younger Age ◽  
The Central Nervous System ◽  
Sporadic Cases ◽  
Cycle Regulation

Although most of the central nervous system tumours are sporadic, rarely they are associated with familial tumour syndromes. These disorders usually present with an autosomal dominant inheritance and neoplasia develops at younger age than in sporadic cases. Most of these tumours are bilateral, multiplex or multifocal. The causative mutations occur in genes involved in cell cycle regulation, cell growth, differentiation and DNA repair. Studying these hereditary cancer predisposition syndromes associated with nervous system tumours can facilitate the deeper understating of the molecular background of sporadic tumours and the development of novel therapeutic agents. This review is an update on hereditary tumour syndromes with nervous system involvement with emphasis on molecular genetic characteristics and their clinical implications. Orv. Hetil., 2015, 156(5), 171–177.

ORGANIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM IN PREMATURE NEWBORNS: HOW TO IDENTIFY A PATIENT AT RISK

2021 ◽  
Vol 100 (1) ◽  
pp. 107-112
Author(s):  
E.B. Pavlinova ◽  
◽  
A.A. Gubich ◽  
N.Yu. Vlasenko ◽  
A.G. Mingairova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Central Nervous System ◽  
Nervous System ◽  
Neonatal Period ◽  
Clinical Laboratory ◽  
Periventricular Leukomalacia ◽  
Instrumental Data ◽  
Premature Newborns ◽  
The Central Nervous System ◽  
Patient At Risk

Based on the data available today, it is impossible to accurately predict the occurrence of severe organic disorders of the central nervous system (CNS) in the neonatal period – intraventricular hemorrhages (IVH) of varying severity, periventricular leukomalacia (PVL). Objective of the review: to study the significance of anamnestic, clinical, laboratory and instrumental data, pathogenetic markers as predictors of IVH and PVL in the neonatal period. Identification of the leading risk factors can help doctors provide the earliest and most targeted care for newborns, prevent the development of catastrophic consequences from the CNS in the future.

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