Salicylic Acid Attenuates Gentamicin-Induced Nephrotoxicity in Rats

Gentamicin (GM) is a widely used antibiotic against serious and life-threatening infections, but its usefulness is limited by the development of nephrotoxicity. The present study was designed to determine the protective effect of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rats. Quantitative evaluation of gentamicin-induced structural alterations and degree of functional alterations in the kidneys were performed by histopathological and biochemical analyses in order to determine potential beneficial effects of SA coadministration with gentamicin. Gentamicin was observed to cause a severe nephrotoxicity which was evidenced by an elevation of serum urea and creatinine levels. The significant increases in malondialdehyde (MDA) levels and protein carbonyl groups indicated that GM-induced tissue injury was mediated through oxidative reactions. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. Exposure to GM caused necrosis of tubular epithelial cells. Necrosis of tubules was found to be prevented by SA pretreatment. The results from our study indicate that SA supplement attenuates oxidative-stress associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats.

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Protein carbonyl group content in patients affected by familiar chronic nail candidiasis

Mediators of Inflammation ◽

10.1080/09629350310001599693 ◽

2003 ◽

Vol 12 (4) ◽

pp. 247-249 ◽

Cited By ~ 2

Author(s):

S. Gangemi ◽

A. Saija ◽

A. Tomaino ◽

F. Cimino ◽

R. A. Merendino ◽

...

Keyword(s):

Oxidative Stress ◽

Defense Mechanisms ◽

Protein Carbonyl ◽

Intercellular Adhesion Molecule ◽

Carbonyl Groups ◽

Intercellular Adhesion Molecule 1 ◽

Protein Carbonyl Groups ◽

Halide System ◽

Reactive Nitrogen Intermediates ◽

Hands And Feet

Familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular adhesion molecule 1. Host defense mechanisms against candidiasis require the cooperation of many immune cells through several candidacidal mechanisms, including oxygen-dependent killing mechanisms, mediated by a superoxide anion radical myeloperoxidase-H2O2-halide system, and reactive nitrogen intermediates. We analyzed protein carbonyl groups (considered a useful marker of oxidative stress) in the serum of patients belonging to a five-generation Italian family with an isolated form of FCNC.Serum protein carbonyl groups in FCNC patients were significantly lower than those measured in healthy donors.Also, if this hypothesis is merely speculative, we could suggest that the decreased circulating level of protein carbonyl groups in these patients is not a marker of a lower oxidative stress condition, but might be linked to a lower protease activity.

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Behaviour of protein carbonyl groups in juvenile myocardial infarction

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-2012-1551 ◽

2013 ◽

Vol 53 (4) ◽

pp. 297-302 ◽

Cited By ~ 4

Author(s):

Gregorio Caimi ◽

Baldassare Canino ◽

Egle Incalcaterra ◽

Eleonora Ferrera ◽

Maria Montana ◽

...

Keyword(s):

Myocardial Infarction ◽

Protein Carbonyl ◽

Carbonyl Groups ◽

Protein Carbonyl Groups

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Protein carbonyl groups’ content as a useful clinical marker of antioxidant barrier impairment in plasma of children with juvenile chronic arthritis

Free Radical Biology and Medicine ◽

10.1016/s0891-5849(00)00288-4 ◽

2000 ◽

Vol 29 (2) ◽

pp. 101-104 ◽

Cited By ~ 38

Author(s):

Joanna Renke ◽

Stefan Popadiuk ◽

Maria Korzon ◽

Bożena Bugajczyk ◽

Michał Woźniak

Keyword(s):

Juvenile Chronic Arthritis ◽

Protein Carbonyl ◽

Chronic Arthritis ◽

Carbonyl Groups ◽

Clinical Marker ◽

Protein Carbonyl Groups

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Analysis of Association between Intake of Red Wine Polyphenols and Oxidative Stress Parameters in the Liver of Growing Male Rats

Applied Sciences ◽

10.3390/app10186389 ◽

2020 ◽

Vol 10 (18) ◽

pp. 6389

Author(s):

Aleksandra Kołota ◽

Dominika Głąbska ◽

Michał Oczkowski ◽

Joanna Gromadzka-Ostrowska

Keyword(s):

Red Wine ◽

Sinapic Acid ◽

Protein Carbonyl ◽

Male Rats ◽

Carbonyl Groups ◽

Coumaric Acid ◽

Oxidative Stress Parameters ◽

Protein Carbonyl Groups ◽

Stress Parameters ◽

Oxidative Effect

Red wine is a complex alcoholic beverage containing various substances, including those of a potential health-promoting properties, such as polyphenols, responsible for the sensory features of wine. Their potential positive influence is associated with possibility of antioxidative, anti-inflammatory, anticancer, immunomodulating, and antiallergenic effects, but at the same time, there is a possibility of their pro-oxidative effect. In spite of the fact that in adolescence alcohol may be highly damaging, as it may disturb the development, it is abused frequently. The aim of the study was to verify the association between red wine consumption as well as dietary polyphenol intake with wine and the oxidative stress parameters in the liver of growing male rats. The growing male Wistar rats were studied, while divided into three groups of six animals, receiving red wine in a solution characterized by 10% of ethanol content since 30th day of life, for two, four, and six weeks. The alcohol intake was controlled and the content of total phenolic compounds, selected phenolic acids (hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, and sinapic acid), total anthocyanidins and selected anthocyanins (cyanidin, cyanidin 3-glucoside, cyanidin 3-rutinoside, delphinidin, and pelargonidin) were assessed. At the same time, for the liver homogenates, the levels of Thiobarbituric Acid Reactive Substances (TBARS) and protein carbonyl groups were verified. The analysis revealed statistically significant influence of red wine intake, as well as of supply of phenolic acids (hydroxybenzoic acid, caffeic acid, p-coumaric acid, ferulic acid, and sinapic acid), and anthocyanins (cyanidin, cyanidin 3-glucoside, cyanidin 3-rutinoside, delphinidin, and pelargonidin) on TBARS and protein carbonyl groups level (R > 0.80; p < 0.05), but the influence was stated only for the period of two weeks. The obtained results may suggest pro-oxidative effect of both ethanol and polyphenols for the liver of the growing male rats. At the same time, for the periods of four and six weeks, no influence on TBARS and protein carbonyl groups level was observed (p > 0.05), which may allow to suppose an adaptive mechanism of the growing organism while the ethanol and polyphenols exposition is prolonged. Further studies are required to confirm the mechanism of the pro-oxidative effect of polyphenols contained in red wine for the liver of growing organism.

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Increase in serum protein carbonyl groups is associated with more advanced stage of disease in multiple myeloma patients

Biomarkers ◽

10.3109/1354750x.2011.629059 ◽

2011 ◽

Vol 16 (8) ◽

pp. 718-719 ◽

Cited By ~ 5

Author(s):

Caterina Musolino ◽

Andrea Alonci ◽

Alessandro Allegra ◽

Antonella Saija ◽

Giuseppa Penna ◽

...

Keyword(s):

Multiple Myeloma ◽

Serum Protein ◽

Protein Carbonyl ◽

Advanced Stage ◽

Carbonyl Groups ◽

Stage Of Disease ◽

Protein Carbonyl Groups

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Activities of brain antioxidant enzymes, lipid and protein peroxidation

Open Medicine ◽

10.2478/s11536-011-0065-6 ◽

2011 ◽

Vol 6 (5) ◽

pp. 588-594 ◽

Cited By ~ 3

Author(s):

Anna Łukaszewicz-Hussain

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Antioxidant Enzymes ◽

Protein Carbonyl ◽

Organophosphate Pesticides ◽

Carbonyl Groups ◽

Chronic Intoxication ◽

Protein Carbonyl Groups ◽

Protein Peroxidation ◽

Antioxidant Enzymes Activities

AbstractOrganophosphate pesticides are known to induce oxidative stress and cause oxidative tissue damage, as has been reported in studies concerning acute and chronic intoxication with these compounds.Our objective was to investigate the activities of brain antioxidant enzymes and malonyldialdehyde, as well as the level of carbonyl groups, in rats sub-chronically intoxicated with chlorpyrifos at doses of 0.2, 2 and 5 mg per kg of body weight per day. It was found that chlorpyrifos induces change in brain antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidise, but to a different degree in comparison to proper control values; however, the elevated antioxidant enzymes activities failed to check lipid and protein peroxidation in the brains of rats. Thus, in sub-chronic intoxication with chlorpyrifos, as evidenced by increased level of malonyldialdehyde and carbonyl groups, oxidative stress is induced.Measurements of protein carbonyl groups appeared to give more consistent responses in the rats’ brains when compared to the malonyldialdehyde level after sub-chronic chlorpyrifos treatment.

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Decrease in Serum Protein Carbonyl Groups Concentration and Maintained Hyperhomocysteinemia in Patients Undergoing Bariatric Surgery

Obesity Surgery ◽

10.1007/s11695-008-9691-8 ◽

2008 ◽

Vol 19 (3) ◽

pp. 321-326 ◽

Cited By ~ 24

Author(s):

T. Sledzinski ◽

E. Goyke ◽

R. T. Smolenski ◽

Z. Sledzinski ◽

J. Swierczynski

Keyword(s):

Bariatric Surgery ◽

Serum Protein ◽

Protein Carbonyl ◽

Carbonyl Groups ◽

Protein Carbonyl Groups

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Oxidative stress in the testis of hyperglycemic rabbits treated with repaglinide

Open Life Sciences ◽

10.2478/s11535-007-0034-x ◽

2007 ◽

Vol 2 (4) ◽

pp. 538-546

Author(s):

Anna Gumieniczek ◽

Hanna Hopkała ◽

Marcin Pruchniak

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Ascorbic Acid ◽

Superoxide Dismutase ◽

Glutathione Peroxidase ◽

Protective Effect ◽

Protein Carbonyl ◽

Carbonyl Groups ◽

Protein Carbonyl Groups ◽

Diabetic Rabbits

AbstractIn the present study, the induction of oxidative stress was examined in the testis of alloxan-induced diabetic rabbits. In addition, the protective effect of repaglinide, an oral anti-diabetic, at a dose of 1 mg daily was studied after four and eight weeks of the treatment. For these purposes, the levels of superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), glutathione (GSH), ascorbic acid (AA), lipid peroxidation products (LPO) and protein carbonyl groups (PCG) were quantified. Hyperglycemia resulted in significant increases in the antioxidative enzymes, Cu, Zn-SOD, CAT, GSH-Px, and GSSG-R after four and eight weeks, respectively. There was also an increase in GSH level, and a decrease in the level of AA. These effects were accompanied by an elevation in testicular LPO levels and PCG levels. Repaglinide was found to normalize the activity of GSSG-R and levels of GSH and AA, and blunted the increased lipid peroxidation, however no decrease in PCG levels were observed. In conclusion, some oxidative changes provoked in the testis of rabbits by hyperglycemia, were found to be reduced with repaglinide treatment at therapeutic dose.

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