scholarly journals Predicting Morphological Disparities in Sea Urchin Skeleton Growth and Form

2017 ◽  
Author(s):  
Maria Abou Chakra ◽  
Miroslav Lovric ◽  
Jonathon Stone
Keyword(s):  
Sea Urchins ◽  
Skeletal Growth ◽  
Polar Regions ◽  
Evolutionary Time ◽  
Plate Number ◽  
Theoretical Morphology ◽  
Apical System ◽  
Individual Effects ◽  
Genetic Level ◽  
The Individual

AbstractSea urchins exhibit among their many species remarkable diversity in skeleton form (e.g., from spheroid to discoid shapes). However, we still do not understand how some related species show distinct morphologies despite inherent similarities at the genetic level. For this, we use theoretical morphology to disentangle the ontogenic processes that play a role in skeletal growth and form. We developed a model that simulates these processes involved and predicted trajectory obtaining 94% and 77% accuracies. We then use the model to understand how morphologies evolved by exploring the individual effects of three structures (ambulacral column, plate number, and polar regions). These structures have changed over evolutionary time and trends indicate they may influence skeleton shape, specifically height–to-diameter ratio, h:d. Our simulations confirm the trend observed but also show how changes in the attributes affect shape; we show that widening the ambulacral column or increasing plate number in columns produces a decrease in h:d (flattening); whereas increasing apical system radius to column length ratio produces an increase in h:d (gloublar shape). Computer simulated h:d matched h:d measured from real specimens. Our findings provide the first explanation of how small changes in these structures can create the diversity in skeletal morphologies.

ALTERNATIVE ROUTES TO INNOVATION — THE EFFECTS OF CULTURAL AND STRUCTURAL FIT

2019 ◽  
Vol 24 (01) ◽  
pp. 2050006
Author(s):  
DAG INGVAR JACOBSEN ◽  
TORE HILLESTAD ◽  
BIRGITTE YTTRI ◽  
JARLE HILDRUM
Keyword(s):  
Response Rate ◽  
Organic Structure ◽  
Configurational Approach ◽  
Culture Strength ◽  
Individual Effects ◽  
Collective Phenomenon ◽  
The Individual ◽  
Alternative Routes ◽  
Innovative Culture ◽  
The Empirical Analysis

A configurational approach to organizations assumes that structural and cultural characteristics must be in “fit” to produce the wanted outcome. With a focus on innovation, this study examines empirically to what extent innovative activities with a large, global telecom company are produced by an innovative culture, an innovative structure, as well as the fit between the two. Based on an extensive survey (N = 21064, response rate = 65) of employees in seven countries in Europe and Asia, data was aggregated to unit level as culture by nature is a collective phenomenon. The empirical analysis detected both the individual effects of culture strength and homogeneity, structure, as well as the fit between the two. The results indicate that an innovative culture and an organic structure indeed fosters innovation, but that, somewhat surprisingly, there are not effects of the fit between the two. Both practical and theoretical implications are discussed.

Factors influencing the individual effects of blood transfusions on oxygen delivery and oxygen consumption*

2001 ◽  
Vol 29 (Supplement) ◽  
pp. S173-S179 ◽  
Author(s):  
Mattias Casutt ◽  
Burkhardt Seifert ◽  
Thomas Pasch ◽  
Edith R. Schmid ◽  
Marko I. Turina ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Oxygen Delivery ◽  
Blood Transfusions ◽  
Factors Influencing ◽  
Individual Effects ◽  
The Individual

scholarly journals Influence of process variables on release properties of paracetamol tablets

2007 ◽  
Vol 57 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Gbenga Alebiowu ◽  
Oludele Itiola
Keyword(s):  
Interaction Effects ◽  
Process Variables ◽  
Factorial Experimental Design ◽  
Disintegration Time ◽  
Individual Effects ◽  
Pregelatinized Starch ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
The Individual ◽  
Paracetamol Tablet

Influence of process variables on release properties of paracetamol tablets A 23 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e., N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N-c > c-d > N-d for all formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.

scholarly journals The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells

Blood ◽  
2011 ◽  
Vol 118 (25) ◽  
pp. 6499-6505 ◽  
Author(s):  
Edgardo D. Carosella ◽  
Silvia Gregori ◽  
Joel LeMaoult
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Immune Responses ◽  
Recent Work ◽  
Large Body ◽  
Regulatory Cells ◽  
Individual Effects ◽  
The Individual ◽  
Key Aspects ◽  
Antigen Presenting

Abstract Myeloid antigen-presenting cells (APCs), regulatory cells, and the HLA-G molecule are involved in modulating immune responses and promoting tolerance. APCs are known to induce regulatory cells and to express HLA-G as well as 2 of its receptors; regulatory T cells can express and act through HLA-G; and HLA-G has been directly involved in the generation of regulatory cells. Thus, interplay(s) among HLA-G, APCs, and regulatory cells can be easily envisaged. However, despite a large body of evidence on the tolerogenic properties of HLA-G, APCs, and regulatory cells, little is known on how these tolerogenic players cooperate. In this review, we first focus on key aspects of the individual relationships between HLA-G, myeloid APCs, and regulatory cells. In its second part, we highlight recent work that gathers individual effects and demonstrates how intertwined the HLA-G/myeloid APCs/regulatory cell relationship is.

Is natural openness or trade policy good for the environment?

2011 ◽  
Vol 16 (6) ◽  
pp. 657-684 ◽  
Author(s):  
Steven Yamarik ◽  
Sucharita Ghosh
Keyword(s):  
Air Pollution ◽  
Trade Policy ◽  
Factor Endowment ◽  
Trade And Environment ◽  
Population Geography ◽  
Limited Impact ◽  
Individual Effects ◽  
Good For ◽  
The Individual ◽  
Trade Share

AbstractIn this paper, we estimate the individual effects of natural openness and trade policy on air pollution. Natural openness is the component of the trade share (imports and exports as a percentage of GDP) attributable to population, geography and factor endowment differences. We find that natural openness reduces air pollution, while trade policy has a limited impact. The implication is that ‘natural’ geographic and endowment differences play a more important role than deliberate trade policy decisions in explaining the trade and environment link.

Lack of interaction of hyperpnoea with methacholine and histamine in asthma

1998 ◽  
Vol 95 (5) ◽  
pp. 611-619 ◽  
Author(s):  
Suree SOMPRADEEKUL ◽  
Rana HEJAL ◽  
Melissa McLANE ◽  
K. A. LENNER ◽  
J. A. NELSON ◽  
...  
Keyword(s):  
Blood Flow ◽  
Forced Expiratory Volume ◽  
Additive Effects ◽  
Positive Interaction ◽  
Bronchial Responsiveness ◽  
Individual Effects ◽  
The Individual ◽  
Airway Calibre ◽  
Effector Mechanisms

1.The thermal precipitants of asthma (exercise and hyperventilation) appear to have a unique pathogenesis that does not alter bronchial responsiveness. In the present work, we tested whether hyperpnoea interacts with other constrictor stimuli. 2.To provide data on this issue, we exposed 17 subjects with asthma to isocapnic hyperventilation of frigid air (HV), methacholine (METH) and histamine (HIS) alone and in combination. 3.With HV (mean ventilation = 55.6±7.7 litres/min), METH (2.20±0.7 ;mmol/l) and HIS (10.35±5.04 ;mmol/l) alone, the decrements in forced expiratory volume in 1 ;s (FEV1) from baseline were 27.4±3.4, 27.4±3.8 and 32.4±3% respectively (n = 9). Giving the agonists simultaneously did not produce additive effects (ΔFEV1 HV+METH = 32.8±3.6%; HV+HIS = 28.7±5.1%). None of the individual or combined responses was significantly different from each other. Changing the sequence of the experiments and giving METH at the height of the HV-induced bronchial narrowing, instead of during hyperpnoea, did not alter the findings (n = 8). The maximum fall in FEV1 after both bronchoconstrictors in this experiment (ΔFEV1 = 32.3±4.3%) was not significantly different from either alone (HV = 22.8±1.0%; METH = 27.3±1.9%). When METH and HIS were administered together, however (n = 5), a positive interaction ensued (METH = 1.53±0.56 ;mmol/l, ΔFEV1 = 15.6±4.6%; HIS = 4.77±2.07 ;mmol/l, ΔFEV1 = 18.8±3.1%; METH+HIS ΔFEV1 = 33.4±5.2%; P< 0.001 compared with the individual effects). 4.These results indicate that HV does not interact with stimuli that directly or indirectly modulate airway calibre. It is unclear if this effect represents protection conferred from increased bronchial blood flow or derives from differences in effector mechanisms between the thermal and pharmacological agonists.

scholarly journals Comets (Existing Populations)

1994 ◽  
Vol 160 ◽  
pp. 77-94
Author(s):  
Ľ. Kresák
Keyword(s):  
Kuiper Belt ◽  
Dynamical Evolution ◽  
Oort Cloud ◽  
Survival Times ◽  
Evolutionary Time ◽  
Origin And Evolution ◽  
History Of ◽  
The Individual ◽  
Evolutionary Paths

The definition, population, extent, origin and evolution of the individual subsystems of comets and transitions between them are discussed, together with presentation of the relevant statistical data and their changes with time. The largest outer subsystems are unobservable, but their existence is documented by the necessity of progressive replenishment of the observable populations, with limited survival times. There is persuasive evidence for two different evolutionary paths, one from the Oort cloud and another from the Kuiper belt. While the extent and accuracy of the data available is increasing rapidly, the Jupiter family of comets is the only one for which the evolutionary time scales do not exceed by many orders of magnitude the history of astronomical observations. The individual comet populations differ from one another not only by the distribution of orbits, but also by the size distribution and aging rate of their members. Their dynamical evolution is coupled with disintegration processes, which make it questionable whether the present state can be interpreted as a long-term average.

Interazione: modificazione dell’associazione tra esposizione ed esito al variare di un terzo fattore

2019 ◽  
Vol 31 (1) ◽  
pp. 40-42
Author(s):  
Francesco Franco ◽  
Anteo Di Napoli
Keyword(s):  
Interaction Effect ◽  
Additive Model ◽  
Joint Effect ◽  
Effect Modification ◽  
Multiplicative Model ◽  
Total Effect ◽  
Expected Effect ◽  
Individual Effects ◽  
Independent Effects ◽  
The Individual

From a statistical perspective, interaction (effect modification) occurs when the effect of an exposure on an outcome depends on the level of another factor. In epidemiology, effect modification (interaction) occurs if the joint effect of two (or more) factors is different from the expected effect if considering only their independent effects. In an additive model, the effect of one exposure is added to effect of another exposure, and there is interaction if the joint effect of the two exposures together is greater than the sum of their individual effects. In a multiplicative model, the effect of the second exposure multiplies the effect of the first exposure, and there is interaction if the joint effect of the two exposures together is greater than the product of their individual effects. Interaction of two (or more) factors is synergic or antagonistic if the total effect is, respectively, greater or smaller than the sum of the individual effects of each factor. (Epidemiology_statistics)

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