scholarly journals A comparison between the neural correlates of laser and electric pain stimulation and their modulation by expectation

2017 ◽  
Author(s):  
EJ. Hird ◽  
D. Talmi ◽  
AKP. Jones ◽  
W. El-Deredy
Keyword(s):  
Evoked Potentials ◽  
Pain Intensity ◽  
Electric Stimulation ◽  
Pain Perception ◽  
Neural Correlates ◽  
Event Related Potential ◽  
Subjective Ratings ◽  
Laser Evoked Potentials ◽  
Specific Stimulus ◽  
Pain Ratings

AbstractBackgroundPain is modulated by expectation. Event-related potential (ERP) studies of the influence of expectation on pain typically utilise laser heat stimulation to provide a controllable nociceptive-specific stimulus. Short painful electric stimulation has a number of practical advantages, but is less nociceptive-specific. We compared the modulation of electric versus laser-evoked pain by expectation, and their corresponding pain-evoked and anticipatory ERPs.New MethodWe developed understanding of recognised methods of laser and electric stimulation. We tested whether pain perception and neural activity induced by electric stimulation was modulated by expectation, whether this expectation elicited anticipatory neural correlates, and how these measures compared to those associated with laser stimulation. We elicited cue-evoked expectations of high and low pain and compared subjective ratings and corresponding ERPs in response to the delivery of laser and electric stimulation in a within-participant design.ResultsDespite sensory and affective differences between laser and electric pain, intensity ratings and pain-evoked potentials were modulated equivalently by expectation, though ERPs only correlated with pain ratings in the laser pain condition. Anticipatory correlates significantly differentiated pain intensity expectation to laser but not electric pain.Comparison with Existing MethodPrevious studies have consistently shown that laser-evoked potentials are modulated by expectation. We extend this by showing electric pain-evoked potentials are equally modulated by expectation, within the same participants. We also show a difference between the pain types in anticipation.ConclusionsThough laser-evoked potentials express a stronger relationship with pain perception, both laser and electric stimulation may be used to study the modulation of pain-evoked potentials by expectation. Anticipatory-evoked potentials are elicited by both pain types, but they may reflect different processes and did not correlate with pain perception.

Focal Mechanical Vibration Does not Change Laser-Pain Perception and Laser-Evoked Potentials: A Pilot Study

Pain Practice ◽  
2016 ◽  
Vol 17 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Costanza Pazzaglia ◽  
Filippo Camerota ◽  
Claudia Celletti ◽  
Ileana Minciotti ◽  
Elisa Testani ◽  
...  
Keyword(s):  
Pilot Study ◽  
Evoked Potentials ◽  
Pain Perception ◽  
Mechanical Vibration ◽  
Laser Evoked Potentials

Association and dissociation between laser-evoked potentials and pain perception

Neuroreport ◽  
1997 ◽  
Vol 8 (17) ◽  
pp. 3785-3789 ◽  
Author(s):  
Luis Garcí-Larrea ◽  
Roland Peyron ◽  
Bernard Laurent ◽  
François Mauguière
Keyword(s):  
Evoked Potentials ◽  
Pain Perception ◽  
Laser Evoked Potentials

Aerobic Exercise Reduces Pressure More Than Heat Pain Sensitivity in Healthy Adults

Pain Medicine ◽  
2019 ◽  
Vol 20 (8) ◽  
pp. 1534-1546 ◽  
Author(s):  
Matthew D Jones ◽  
James L Nuzzo ◽  
Janet L Taylor ◽  
Benjamin K Barry
Keyword(s):  
Evoked Potentials ◽  
Aerobic Exercise ◽  
Tibialis Anterior ◽  
Pain Sensitivity ◽  
Healthy Adults ◽  
Heat Pain ◽  
Laser Evoked Potentials ◽  
Pain Thresholds ◽  
Pain Ratings ◽  
Exercise Induced

Abstract Objectives The hypoalgesic effects of exercise are well described, but there are conflicting findings for different modalities of pain; in particular for mechanical vs thermal noxious stimuli, which are the most commonly used in studies of exercise-induced hypoalgesia. The aims of this study were 1) to investigate the effect of aerobic exercise on pressure and heat pain thresholds that were well equated with regard to their temporal and spatial profile and 2) to identify whether changes in the excitability of nociceptive pathways—measured using laser-evoked potentials—accompany exercise-induced hypoalgesia. Subjects Sixteen healthy adults recruited from the University of New South Wales. Methods Pressure and heat pain thresholds and pain ratings to laser stimulation and laser-evoked potentials were measured before and after aerobic cycling exercise and an equivalent period of light activity. Results Pressure pain thresholds increased substantially after exercise (rectus femoris: 29.6%, d = 0.82, P < 0.001; tibialis anterior: 26.9%, d = 0.61, P < 0.001), whereas heat pain thresholds did not (tibialis anterior: 4.2%, d = 0.30, P = 0.27; foot: 0.44%, d = 0.02, P = 1). Laser-evoked potentials and laser heat pain ratings also changed minimally after exercise (d = −0.59 to 0.3, P > 0.06). Conclusions This is the first investigation to compare the effects of exercise on pressure and heat pain using the same stimulation site and pattern. The results show that aerobic exercise reduces mechanical pain sensitivity more than thermal pain sensitivity.

scholarly journals Dissociation Between Individual Differences in Self-Reported Pain Intensity and Underlying Brain Activation

2020 ◽  
Author(s):  
M.E. Hoeppli ◽  
H. Nahman-Averbuch ◽  
W.A. Hinkle ◽  
E. Leon ◽  
J. Peugh ◽  
...  
Keyword(s):  
Individual Differences ◽  
Pain Intensity ◽  
Pain Sensitivity ◽  
Pain Perception ◽  
Objective Measure ◽  
Brain Activation ◽  
Individual Experience ◽  
Bold Signal ◽  
Pain Ratings ◽  
Healthy Participants

AbstractPain is a uniquely individual experience. Previous studies have highlighted changes in brain activation and morphology associated with inter- and intra-individual pain perception. In this study we sought to characterize brain mechanisms associated with individual differences in pain in a large sample of healthy participants (N = 101). Pain ratings varied widely across individuals. Moreover, individuals reported changes in pain evoked by small differences in stimulus intensity in a manner congruent with their pain sensitivity, further supporting the utility of subjective reporting as a measure of the true individual experience. However, brain activation related to inter-individual differences in pain was not detected, despite clear sensitivity of the BOLD signal to small differences in noxious stimulus intensities within individuals. These findings raise questions about the utility of fMRI as an objective measure to infer reported pain intensity.

Dissociating the neural mechanisms of pain consistency and pain intensity in the trigemino-nociceptive system

Cephalalgia ◽  
2015 ◽  
Vol 36 (8) ◽  
pp. 790-799 ◽  
Author(s):  
Inga L Kröger ◽  
Mareike M Menz ◽  
Arne May
Keyword(s):  
Pain Intensity ◽  
Pain Perception ◽  
Vascular System ◽  
Brain Structures ◽  
Anterior Cingulate ◽  
Nociceptive System ◽  
Antinociceptive System ◽  
Pain Ratings ◽  
The Stability ◽  
High Level

Background Individual differences in pain perception to a standardized nociceptive input are a well-known phenomenon within pain research. Brain structures known to play a crucial role in pain modulatory processes are the rostral/subgenual anterior cingulate cortex (sACC) as well as the periaqueductal gray (PAG), which belong to the endogenous antinociceptive system. However, the exact mechanisms possibly leading to this high level of variance in pain perception are still a matter of debate. Methods Pain perception within the trigemino-vascular system was investigated in 37 healthy volunteers using functional magnetic resonance imaging. Results Behavioral results show high levels of variance being inversely correlated to mean pain ratings as well as to an increase in BOLD signal intensity within the sACC. In addition, higher sACC activation was coupled with activation in the PAG the lower the level of intra-individual variance. Conclusion This study gives first indications that coupled BOLD response within brain structures of the antinociceptive system seems to rather not code pain intensity within the trigemino-nociceptive system but the stability of volunteers’ pain ratings. Intrinsic mechanisms may modulate the pain perception in the trigemino-vascular system, which is highly involved in headache disorders.

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