scholarly journals Exploring the potential for collaborative use of an app-based platform for n-of-1 trials among healthcare professionals that treat patients with insomnia

Author(s):  
Jason R. Bobe ◽  
Jessica K. De Freitas ◽  
Benjamin S. Glicksberg

AbstractBackgroundN-of-1 trials are single patient, multiple crossover, comparative effectiveness experiments. Despite their rating as “level 1” evidence, they are not routinely used in clinical medicine to evaluate the effectiveness of treatments.ObjectiveWe explored the potential for implementing a mobile app-based n-of-1 trial platform for collaborative use by clinicians and patients to support data-driven decisions around the treatment of insomnia.MethodsA survey assessing awareness and utilization of n-of-1 trials was administered to healthcare professionals that frequently treat patients with insomnia at the Icahn School of Medicine at Mount Sinai in New York City. 1M electronic health records were analyzed to evaluate evidence for a comorbid relationship between insomnia and dementia or Alzheimer’s disease among a patient population that may benefit from n-of-1 trials for the selection of optimal sleep treatments.ResultsA total of 45 healthcare professionals completed the survey and were included in the analysis. We found that 64% of healthcare professionals surveyed had not heard of n-of-1 trials. After a brief description of these methods, 75% of healthcare professionals reported that they are likely or highly likely to use an app-based n-of-1 trial at least once in the next year if the service were free and easy to offer to their patients.ConclusionsAn app-based n-of-1 trials platform might be a valuable tool for clinicians and patients to identify the best treatments for insomnia. Educational interventions that raise awareness and provide training are also likely necessary. The electronic health record (EHR) may help identify eligible patients.

2020 ◽  
Author(s):  
Sooyoung Yoo ◽  
Kahyun Lim ◽  
Se Young Jung ◽  
Keehyuck Lee ◽  
Donghyun Lee ◽  
...  

BACKGROUND The US Health Information Technology for Economic and Clinical Health Act of 2009, which was intended to stimulate the use of electronic health record (EHR) systems, has been amended to cover the behavioral health sector. Consequently, there is an increased need for research on the adoption of behavioral EHR systems by healthcare professionals. Various quantitative studies based on the unified theory of acceptance and use of technology model and technology acceptance model have been conducted in the general medical sectors, but few studies have been conducted in the behavioral sector and they have all been interview-based qualitative studies. OBJECTIVE To evaluate the adoption and implementation of a behavioral EHR system for behavioral clinical professionals through a modified clinical adoption (CA) research model quantitative study. METHODS We modified the existing CA framework to be suitable for evaluating the adoption of the EHR system by behavioral clinical professionals. The existing CA framework did not present questionnaire items. Accordingly, we designed a questionnaire with items that fit into the dimensions of the CA framework and it was verified through the review of behavioral clinical professionals and a pre-survey. The full-scale survey was administered in 5 US behavioral hospitals. The data were analyzed using a structural equation analysis. Additionally, open-ended question responses were qualitatively analyzed. RESULTS We derived a total of 7 dimensions, excluding dimensions that were evaluated as inappropriate for behavioral clinical professionals to respond. In addition, for 2 dimensions, 2 sub-dimensions were classified. A total of 409 behavioral clinical experts from 5 hospitals were surveyed. The ease of use and organizational support significantly influenced the use of the behavioral EHR system. Although the results were not significant, information quality (path coefficient=1.19, P>.05) and service quality (path coefficient=.085, P>.05) tended to influence the ease of use of the system. And Ease of Use (path coefficient=.253, P<.05) and the Organization (path coefficient=.802, P<.05) influenced the use of the system. The qualitative results indicated that the greatest advantage of the adoption of the behavioral EHR system was the ability to search for information quickly, work efficiently, and access patient information even outside of the hospital through the mobile app, resulting in having more time with patients. Conversely, the greatest disadvantage was an overdependence on the EHR system. Many staff members voiced concerns that their work could be paralyzed when the system was unstable. CONCLUSIONS This study designed a model for evaluating behavioral EHR adoption and conducted a quantitative study to derive the factors associated with the successful introduction of an EHR system in a behavioral environment. CLINICALTRIAL The study was approved by the Institutional Review Board of Seoul National University Bundang Hospital (SNUBH) (IRB No.: B-1904-534-301).


2007 ◽  
Vol 6 (1) ◽  
pp. 39-44
Author(s):  
Harrison W. Farber ◽  
Mark Gladwin ◽  
Evelyn M. Horn ◽  
Myung H. Park

This discussion was moderated by Evelyn M. Horn, MD, Associate Professor of Clinical Medicine and Director, Pulmonary Vascular Disease, Center for Advanced Cardiac Care, Columbia University Medical Center, New York, New York. Panel members included Harrison W. Farber, MD, Director, Pulmonary Hypertension Center, Boston Medical Center, Boston University School of Medicine; Mark Gladwin, MD, Chief, Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD; Myung H. Park, MD, Director, Pulmonary Vascular Disease Program, University of Maryland School of Medicine.


Biology Open ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. bio057182

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Samanta Sarti is first author on ‘Inducible modulation of miR-204 levels in a zebrafish melanoma model’, published in BiO. Samanta conducted the research described in this article while a PhD student in Laura Poliseno's lab at the Oncogenomics Unit Core Research Laboratory (CRL), ISPRO/Institute of Clinical Physiology (IFC), CNR, in Pisa, Italy. She is now a Postdoctoral researcher in the lab of Samuel Sidi in the Department of Medicine, Division of Hematology and Medical Oncology and Department of Cell, Developmental and Regenerative Biology, at the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai in New York, investigating the role of miR-204 in melanoma development by its inducible modulation in a zebrafish melanoma model.


2021 ◽  
Vol 14 (4) ◽  

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Marte Molenaars and Bauke Schomakers are co-first authors on ‘Metabolomics and lipidomics in Caenorhabditis elegans using a single-sample preparation’, published in DMM. Marte conducted the research described in the article while a PhD student in the lab of Riekelt Houtkooper at Amsterdam UMC, Amsterdam, The Netherlands, and is now a postdoc in the lab of Richard Possemato at New York University School of Medicine, New York, NY, USA. During her PhD, she was investigating cellular metabolic pathways and how to use them to target ageing and age-related diseases, and currently she focuses on metabolic pathways in cancer cells as a postdoc. Bauke is a Research Analyst in the lab of Riekelt Houtkooper at Amsterdam UMC, Amsterdam, The Netherlands, investigating liquid chromatography–mass spectrometry-based omics methods for the comprehensive analysis of biological samples.


1978 ◽  
Vol 17 (3) ◽  
pp. 382-383
Author(s):  
Javed Iqbal

This book is essentially a selection of the articles written by Arther T. Mosher during his long career as a rural development expert. Also appended at the end is a complete list of writings by him. The Agricultural Development Council has chosen to publish this book to honour the author, who was its President during 1967-1973, The publication of this book is welcome in the context of the recent rediscovery of rural development as a principal plank of need-oriented develop¬ment strategies. A basic defect of writing on rural development has been excessive resort to stereotype rehtoric, over-enthusiasm and a certain pedanticism. Fortunately, Mosher's orientation is practical, not doctrinaire. Although the book is titled "Thinking About Rural Development", the author keeps on bring¬ing together the thinking and practice into their validly interactive perspectives. Not surprisingly so, for the author has himself worked in the field as a rural development practitioner for a considerable length of time.


2019 ◽  
Vol 24 (6) ◽  
pp. 689-696 ◽  
Author(s):  
LaVerne W. Thompson ◽  
Kathryn D. Bass ◽  
Justice O. Agyei ◽  
Hibbut-Ur-Rauf Naseem ◽  
Elizabeth Borngraber ◽  
...  

OBJECTIVETraumatic brain injury is a major sequela of nonaccidental trauma (NAT) that disproportionately affects young children and can have lasting sequelae. Considering the potentially devastating effects, many hospitals develop parent education programs to prevent NAT. Despite these efforts, NAT is still common in Western New York. The authors studied the incidence of NAT following the implementation of the Western New York Shaken Baby Syndrome Education Program in 1998.METHODSThe authors performed a retrospective chart review of children admitted to our pediatric hospital between 1999 and 2016 with ICD-9-CM and ICD-10-CM codes for types of child abuse and intracranial hemorrhage. Data were also provided by the Safe Babies New York program, which tracks NAT in Western New York. Children with a diagnosis of abuse at 0–24 months old were included in the study. Children who suffered a genuine accidental trauma or those with insufficient corroborating evidence to support the NAT diagnosis were excluded.RESULTSA total of 107 children were included in the study. There was a statistically significant rise in both the incidence of NAT (p = 0.0086) and the incidence rate of NAT (p = 0.0235) during the study period. There was no significant difference in trendlines for annual NAT incidence between sexes (y-intercept p = 0.5270, slope p = 0.5263). When stratified by age and sex, each age group had a distinct and statistically significant incidence of NAT (y-intercept p = 0.0069, slope p = 0.0374).CONCLUSIONSDespite educational interventions targeted at preventing NAT, there is a significant rise in the trend of newly reported cases of NAT, indicating a great need for better injury prevention programming.


2009 ◽  
Vol 8 (2) ◽  
pp. 89-94
Author(s):  
Robyn J. Barst ◽  
Marc Humbert ◽  
Ivan M. Robbins ◽  
Lewis J. Rubin ◽  
Robyn J. Park

A discussion among attendees of the 4th World Symposium on Pulmonary Hypertension took place to share “an insider's look” into the current and future research and treatment implications in pulmonary hypertension. Myung H. Park, MD, guest editor of this issue of Advances in Pulmonary Hypertension, Assistant Professor of Medicine and Director, Pulmonary Vascular Diseases Program, Division of Cardiology, University of Maryland School of Medicine, Baltimore, moderated the discussion. Participants included Robyn Barst, MD, Professor Emerita, Columbia University, New York; Marc Humbert, MD, PhD, Universite Paris-Sud, French Referal Center for Pulmonary Hypertension, Hopital Antoine-Beclere, Assistance Publique Hopitaux de Paris, Clamart, France; Ivan Robbins, MD, Associate Professor of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; and Lewis J. Rubin, MD, Clinical Professor, Department of Medicine, University of California, San Diego.


2019 ◽  
Author(s):  
Andrew Mwila

BACKGROUND The Copperbelt University is the second public University in Zambia. The School of Medicine has four major programs namely; Bachelor of Medicine and Surgery, Bachelor of Dental Surgery, Bachelor of Clinical Medicine and Bachelor of Biomedical sciences. The Copperbelt University School of Medicine runs a five-year training program for both the BDS and the MBCHB programs. Students are admitted into the Medical school after successfully completing their first year at the Main campus in the School of Natural Sciences with an average of 4 B grades or higher (B grade is a mark of 65 to 74%). OBJECTIVE The study was done to determine the association between admission criteria and academic performance among preclinical students. Hence, the study compares the academic performance among preclinical students admitted into the Bachelor of Dental Surgery and Bachelor of Medicine and Surgery at the Copperbelt University School of Medicine. METHODS This is a retrospective cohort study conducted at Michael Chilufya Sata School of medicine Campus. A pilot study was conducted with 30 BDS and 30 MBCHB students and the obtained information helped determine the sample size. SPSS was used to analyze the data. The study period lasted approximately 7 weeks at a cost of K1621. RESULTS In 2014, there was an improvement in average performance between 2nd and 3rd year for each program. An average score of 15.4 (SD 4.2) was obtained in 3rd year compared to 12.8 (SD 4.9) in 2nd year (p<0.001). Meanwhile, 3rd MB ChB mean score was 12.6 (SD 3.7) compared to 10.7 (SD 3.6) in 2nd years (p<0.05). However, in 2016, both programs, 3rd year mean scores were lower than 2nd year (MB ChB 2nd year mean score was 12.0 (SD 4.3) compared to 3rd year with a mean score of 9.5 (SD 4.5), p<0.001; BDS 2nd year mean score was 10.6 (SD 4.0) compared to 3rd year mean score of 8.2 (SD 3.4), p<0.01. On average MB ChB students performed better than BDS students in all the years (p<0.05), except in 2016 when the results were comparable. CONCLUSIONS Results from the study shows that entry criteria has a correlation to academic performance as students admitted with higher grades perform much better than those with lower grades.


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