scholarly journals Disability-Adjusted Life-Years (DALYs) for Breast Cancer and Risk Factors in 195 countries: Findings from Global Burden of Disease Study 2017

2020 ◽  
Author(s):  
Jieyu Liu ◽  
Jiaxiang Wang
Keyword(s):  
Breast Cancer ◽  
High Body Mass Index ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Cancer Burden ◽  
Disability Adjusted Life ◽  
Life Years ◽  
The World ◽  
High Fasting Plasma Glucose ◽  
Disease Study

AbstractBackgroundBreast cancer is a leading cancer burden for females. In order to picture the patterns and time trends of the breast cancer burden across different regions, the disability-adjusted life years (DALYs) were used to estimate breast cancer burden in 1990–2017.MethodsData from Global Burden of Disease Study 2017 (GBD 2017) was used to estimate the disability-adjusted life-years (DALYs) for the burden of breast cancer by locations, regions, years (with corresponding 95% uncertainty intervals [UI]). Besides, the associated potentially modifiable risk factors were estimated to provide targeted means for controlling the burden of breast cancer.ResultsAll-age numbers of DALYs reached over 17.42 million years in 2017 globally, despite the decreasing trends in all-age and age-standardized rate. The rates for DALYs was the highest in Western Sub-Saharan Africa [694.23 (534.43 to 906.05)] in 2017. High fasting plasma glucose [1.07 million (0.20 to 2.43) DALYs] and high body-mass index (BMI) [0.81 million (0.27 to 1.53) DALYs] have become great attributors to DALYs of breast cancer in 2017.ConclusionsThe levels and trends in causes of DALYs of breast cancer, generally show similiarities between 2007 and 2017, although differences exist. The differences observed countries can be attributed high fasting plasma glucose and high body-mass index across the world. Concerned efforts at national and regional levels are required to tackle the emerging burden of breast cancer in the world.

scholarly journals Global, Regional, and National Death, and Disability-Adjusted Life-Years (DALYs) for Cardiovascular Disease in 2017 and Trends and Risk Analysis From 1990 to 2017 Using the Global Burden of Disease Study and Implications for Prevention

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhiyong Li ◽  
Longfei Lin ◽  
Hongwei Wu ◽  
Lei Yan ◽  
Huanhuan Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Heart Disease ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
The World ◽  
Disease Study ◽  
Cvd Mortality

Background: Cardiovascular disease is the leading cause of death worldwide and a major barrier to sustainable human development. The objective of this study was to evaluate the global, sex, age, region, and country-related cardiovascular disease (CVD) burden, as well as the trends, risk factors, and implications for the prevention of CVD.Methods: Detailed information from 1990 to 2017, including global, regional, and national rates of CVD, and 11 categories of mortality and disability-adjusted life years (DALYs) were collected from the Global Burden of Disease Study 2017. The time-dependent change in the trends of CVD burdens was evaluated by annual percentage change.Results: More than 17 million people died from CVD in 2017, which was approximately two times as many as cancer, and increased nearly 50% compared with 1990. Ischemic heart disease and stroke accounted for 85% of the total age-standardized death rate (ASDR) of CVD. The ASDR and age-standardized DALYs rate (ASYR) of CVD were 1.5 times greater in men compared with women. People over the age of 50 were especially at risk for developing CVD, with the number of cases and deaths in this age group accounting for more than 90% of all age groups. CVD mortality was related to regional economic development and the social demographic index. In regions with a high economic income or socio-demographic index, there was a greater decline in the ASDR of CVD. The ASDR of CVD in high SDI regions decreased more than 50% from 1990 to 2017. Tobacco use, diets low in whole grains, diets high in sodium, and high systolic blood pressure were the important risk factors related to CVD mortality.Conclusions: CVD remains a major cause of death and chronic disability in all regions of the world. Ischemic heart disease and stroke account for the majority of deaths related to CVD. Although the mortality rate for CVD has declined in recent years from a global perspective, the results of CVD data in 2017 suggest that the mortality and DALYs of CVD varied in different ages, sexes, and countries/regions around the world. Therefore, it is necessary to elucidate the specific characteristics of global CVD burden and establish more effective and targeted prevention strategies.

Examination of incidence, mortality and disability-adjusted life years and risk factors of breast cancer in 49 Asian countries, 1990–2019: estimates from Global Burden of Disease Study 2019

2021 ◽  
Author(s):  
Rajesh Sharma
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Mortality Rate ◽  
Burden Of Disease ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Asian Countries ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Standardized Mortality Rate

Abstract Background This study presents an up-to-date, comprehensive and comparative examination of breast cancer’s temporal patterns in females in Asia in last three decades. Methods The estimates of incidence, mortality, disability-adjusted-life-years and risk factors of breast cancer in females in 49 Asian countries were retrieved from Global Burden of Disease 2019 study. Results In Asia, female breast cancer incidence grew from 245 045[226 259–265 260] in 1990 to 914 878[815 789–1025 502] in 2019 with age-standardized incidence rate rising from 21.2/100 000[19.6–22.9] to 35.9/100 000[32.0–40.2] between 1990 and 2019. The death counts more than doubled from 136 665[126 094–148 380] to 337 822[301 454–375 251]. The age-standardized mortality rate rose marginally between 1990 and 2019 (1990: 12.1[11.0–13.1]; 2019: 13.4[12.0–14.9]). In 2019, age-standardized incidence rate varied from 17.2/100 000[13.95–21.4] in Mongolia to 122.5[92.1–160.7] in Lebanon and the age-standardized mortality rate varied 4-fold from 8.0/100 000 [7.2–8.8] in South Korea to 51.9[39.0–69.8] in Pakistan. High body mass index (5.6%), high fasting plasma glucose (5.6%) and secondhand smoke (3.5%) were the main contributory risk factors to all-age disability-adjusted-life-years due to breast cancer in Asia. Conclusion With growing incidence, escalating dietary and behavioural risk factors and lower survival rates due to late-disease presentation in low- and medium-income countries of Asia, breast cancer has become a significant public health threat. Its rising burden calls for increasing breast cancer awareness, preventive measures, early-stage detection and cost-effective therapeutics in Asia.

The global unmet need of congenital cardiac care: a quantitative analysis of the global burden of disease

2020 ◽  
Vol 30 (11) ◽  
pp. 1688-1693 ◽  
Author(s):  
Dominique Vervoort ◽  
Marcelo Cardarelli
Keyword(s):  
Burden Of Disease ◽  
Unmet Need ◽  
Morbidity And Mortality ◽  
Global Burden Of Disease ◽  
Cardiac Care ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Disability Adjusted Life ◽  
Life Years ◽  
The World

AbstractBackground:CHDs are one of the most frequent congenital malformations, affecting one in hundred live births. In total, 70% will require treatment in the first year of life, but over 90% of cases in low- and middle-income countries receive no treatment or suboptimal treatment. As a result, CHDs are responsible for 66% of preventable deaths due to congenital malformations in low- and middle-income countries. This study examines the unmet need of congenital cardiac care around the world based on the global burden of disease.Materials and methods:CHD morbidity and mortality data for 2006, 2011, and 2016 were collected from the Institute for Health Metrics and Evaluation Global Burden of Disease Results Tool and analysed longitudinally to assess trends in excess morbidity and mortality.Results:Between 2006 and 2016, a 20.7% reduction in excess disability-adjusted life years and 20.6% reduction in excess deaths due to CHDs were observed for children under 15. In 2016, excess global morbidity and mortality due to CHDs remained high with 14,788,418.7 disability-adjusted life years and 171,761.8 paediatric deaths, respectively. In total, 90.2% of disability-adjusted life years and 91.2% of deaths were considered excess.Conclusion:This study illustrates the unmet need of congenital cardiac care around the world. Progress has been made to reduce morbidity and mortality due to CHDs but remains high and largely treatable around the world. Limited academic attention for global paediatric cardiac care magnifies the lack of progress in this area.

scholarly journals Mapping the Trends in Esophageal Cancer Disease Burden in the United States: Results from the Global Burden of Disease Study 2017

2021 ◽  
Author(s):  
Di Lu ◽  
jianxue Zhai ◽  
Jintao Zhan ◽  
Xiguang Liu ◽  
Xiaoying Dong ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Burden Of Disease ◽  
Disease Burden ◽  
Global Burden ◽  
Disability Adjusted Life Years ◽  
Cancer Disease ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study ◽  
High Bmi

Abstract Background: Esophageal cancer is the 10th leading cancer in US but given limited research attention. This study aimed to investigate the esophageal cancer disease burden more comprehensively in US. Methods: Having retrieved states-categorized data on esophageal cancer incidence, mortality and disability-adjusted life years from the Global Burden of Disease study online resource, the current trends on esophageal cancer disease burden attributed to different risk factors and their relationship with economic status were analyzed using age-standardized rate and the estimated annual percentage change.Results: In US, the esophageal cancer age-standardized rate of incidence has been stable but age-standardized rates of mortality and disability-adjusted life years trended to decreased with estimated annual percentage changes of -0.237% and -0.471% from 1990 to 2017. Age-standardized rate of incidence was higher in males than in females, but both didn’t increase, so as age-standardized rates of mortality and disability-adjusted life years. The largest increase in age-standardized rates of incidence, mortality and disability-adjusted life years was observed in Oklahoma, whereas the largest decrease was seen in the District of Columbia. Age-standardized rates of mortality and disability-adjusted life years contributed to high BMI or diet low in fruits were growing. per capita disposable personal income trended to negatively correlated with estimated annual percentage changes of incidence, mortality and disability-adjusted life years.Conclusions: The esophageal cancer disease burden in US decreased from 1990 to 2017 but was heavier in males than in females, and increased in economically weaker states and populations with high BMI and low-fruit diet.

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