Comparative Incidence and Outcomes of COVID-19 in Kidney or Kidney-Pancreas Transplant Recipients Versus Kidney or Kidney-Pancreas Waitlisted Patients: A Pilot Study

Comparative COVID-19 epidemiologic studies between immunosuppressed and immunocompetent patients may provide insight into the impact of immunosuppressive medications on clinical outcomes. In this retrospective cohort pilot study, we determined the incidence and outcomes of COVID-19 in kidney or kidney-pancreas transplant recipients and kidney or kidney-pancreas waitlisted patients in our center. COVID-19 testing was performed in 63 of 537 kidney or kidney-pancreas transplanted patients, versus 43 of 383 kidney or kidney-pancreas waitlisted patients as of June 4, 2020 (12% versus 11%, p=0.81). COVID-19 was identified in 14 of 537 kidney or kidney-pancreas transplanted patients, versus 9 of 383 kidney or kidney-pancreas waitlisted patients (2.6% versus 2.3%, p=0.81). Hospitalization occurred in 11 of 14 transplanted patients, and 4 of 9 waitlisted patients with COVID-19 (79% versus 44%, p=0.18). Intensive care unit admission occurred in 5 of 14 transplanted patients, and 1 of 9 waitlisted patients with COVID-19 (36% versus 11%, p=0.34). Two transplanted patients with COVID-19 were mechanically ventilated and died, whereas no waitlisted patients with COVID-19 died or were mechanically ventilated. Our study provides preliminary data that can be used for power calculations to inform multicenter studies designed to validate these findings.

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Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts

Blood ◽

10.1182/blood-2010-08-300491 ◽

2011 ◽

Vol 117 (12) ◽

pp. 3277-3285 ◽

Cited By ~ 91

Author(s):

Sharon Avery ◽

Weiji Shi ◽

Marissa Lubin ◽

Anne Marie Gonzales ◽

Glenn Heller ◽

...

Keyword(s):

High Resolution ◽

Cord Blood ◽

Human Leukocyte ◽

Transplant Recipients ◽

Myeloablative Conditioning ◽

Leukocyte Antigen ◽

Cell Dose ◽

Unit Unit ◽

The Impact ◽

Insight Into

Abstract The influence of cell dose and human leukocyte antigen (HLA) match on double-unit cord blood (CB) engraftment is not established. Therefore, we analyzed the impact of cell dose and high-resolution HLA match on neutrophil engraftment in 84 double-unit CB transplant recipients. The 94% sustained engraftment rate was accounted for by 1 unit in nearly all patients. Higher CD3+ cell doses (P = .04) and percentage of CD34+ cell viability (P = .008) were associated with unit dominance. After myeloablative conditioning, higher dominant unit total nucleated cell (TNC), CD34+ cell, and colony-forming unit doses were associated with higher sustained engraftment and faster neutrophil recovery (P = .07, P = .0008, and P < .0001, respectively). Total infused TNC (P = .0007) and CD3+ cell doses (P = .001) also significantly influenced engraftment. At high-resolution extensive donor-recipient HLA disparity was frequent, but had no influence on engraftment (P = .66), or unit dominance (P = .13). Although the unit-unit HLA match also did not affect sustained engraftment (P = 1.0), recipients of units closely (7-10 to 10-10) HLA-matched to each other were more likely to demonstrate initial engraftment of both units (P < .0001). Our findings have important implications for unit selection and provide further insight into double-unit biology.

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Water Resources Management

Governometrics and Technological Innovation for Public Policy Design and Precision ◽

10.4018/978-1-4666-5146-3.ch008 ◽

2014 ◽

pp. 180-200 ◽

Cited By ~ 1

Author(s):

Sabyasachi Nayak

Keyword(s):

Water Management ◽

Pilot Study ◽

Water Resources ◽

Water Resources Management ◽

Social Economic ◽

The State ◽

Resources Management ◽

Partnership Approach ◽

The Impact ◽

Insight Into

This chapter explores grassroots interventions by forging partnerships with stakeholders in improving the management of water resources at the community level. In order to gain insight into the nuances of managing water resources in partnership, a pilot study was instituted in the State of Rajasthan, India. The efficacy of the partnership approach in ensuring equitable water management is demonstrated. The analysis is supported by data collected through the administration of a questionnaire for five different stakeholders. The impact of the intervention reiterates the positive social, economic, and environmental outcomes in a more sustainable manner.

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A Pilot Study to Evaluate the Impact of Nebivolol Versus Metoprolol On Quality of Life Measures in Stable Renal Transplant Recipients.

Transplantation Journal ◽

10.1097/00007890-201407151-02883 ◽

2014 ◽

Vol 98 ◽

pp. 844

Author(s):

S. Gabardi ◽

M. Grafals ◽

S. Conte ◽

H. Gilligan ◽

M. Simpsom ◽

...

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Renal Transplant ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Quality Of Life Measures ◽

The Impact

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THE IMPACT OF HYPOALBUMINEMIA IN SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANT RECIPIENTS

Transplantation Journal ◽

10.1097/00007890-199805131-00362 ◽

1998 ◽

Vol 65 (Supplement) ◽

pp. 169

Author(s):

B N Becker ◽

Y T Becker ◽

J S Odorico ◽

A M D'Alessandro ◽

S J Knechtle ◽

...

Keyword(s):

Pancreas Transplant ◽

Transplant Recipients ◽

The Impact

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Water Resources Management

Agri-Food Supply Chain Management ◽

10.4018/978-1-5225-1629-3.ch002 ◽

2016 ◽

pp. 15-31

Author(s):

Sabyasachi Nayak

Keyword(s):

Water Management ◽

Pilot Study ◽

Water Resources ◽

Water Resources Management ◽

Social Economic ◽

The State ◽

Resources Management ◽

Partnership Approach ◽

The Impact ◽

Insight Into

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THE IMPACT OF HYPOALBUMINEMIA IN SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANT RECIPIENTS

Transplantation Journal ◽

10.1097/00007890-199806270-00383 ◽

1998 ◽

Vol 65 (12) ◽

pp. S93

Author(s):

B N Becker ◽

Y T Becker ◽

J S Odorico ◽

A M D'Alessandro ◽

S J Knechtle ◽

...

Keyword(s):

Pancreas Transplant ◽

Transplant Recipients ◽

The Impact

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Progressive multifocal leukoencephalopathy: new concepts

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130154 ◽

2013 ◽

Vol 71 (9B) ◽

pp. 699-702 ◽

Cited By ~ 13

Author(s):

Marco A. Lima

Keyword(s):

Progressive Multifocal Leukoencephalopathy ◽

Demyelinating Disease ◽

Jc Virus ◽

Treatment Strategies ◽

Antiretroviral Drugs ◽

Transplant Recipients ◽

New Concepts ◽

Immunosuppressive Medications ◽

New Treatment ◽

The Impact

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression. Originally, PML was observed in patients with advanced HIV infection, lymphoproliferative disorders and transplant recipients. However, the widespread use of HIV antiretroviral drugs and the new selective immunomodulatory and immunosuppressive medications, such as Rituximab and Natalizumab, has recently modified the epidemiology, clinical presentation and prognosis of PML. Herein, we discuss the new concepts on PML, emphasizing the recent modification in the epidemiology; the impact of new immunomodulatory treatments in the disease, PML-IRIS (Immune reconstitution inflammatory síndrome), new treatment strategies and other JCV related CNS diseases.

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