scholarly journals Investigating the first wave of the COVID-19 pandemic in Ukraine using epidemiological and genomic sequencing data

Author(s):  
Yuriy Gankin ◽  
Vladimir Koniukhovskii ◽  
Alina Nemira ◽  
Gerardo Chowell ◽  
Thomas A. Weppelmann ◽  
...  

AbstractThe novel coronavirus SARS-CoV-2 emerged in China in December 2019 and has rapidly spread around the globe. The World Health Organization declared COVID-19 a pandemic in March 2020 just three months after the introduction of the virus. Individual nations have implemented and enforced with varying degrees of success a variety of social distancing interventions to slow the virus spread. Investigating the role of non-pharmaceutical interventions on COVID-19 transmission in different settings is an important research. While most transmission modeling studies have focused on the dynamics in China, neighboring Asian counties, Western Europe, and North America, there is a scarcity of studies for Eastern Europe. This study starts to fill this gap by analyzing the characteristics of the first epidemic wave in Ukraine using mathematical and statistical models together with epidemiological and genomic sequencing data. Using an agent-based model, the trajectory of the first wave in terms of cases and deaths and explore the impact of quarantine strategies via simulation studies have been characterized. The implemented stochastic model for epidemic counts suggests, that even a small delay of weeks could have increased the number of cases by up to 50%, with the potential to overwhelm hospital systems. The genomic data analysis suggests that there have been multiple introductions of SARS-CoV-2 into Ukraine during the early stages of the epidemic with eight distinct transmission clusters identified. The basic reproduction number for the epidemic has been estimated independently both from case counts data and from genomic data. The findings support the hypothesis that, the public health measures did not have a decreasing effect on the existing viral population number at the time of implementation, since strains were detected after the quarantine date. However, the public health measures did help to prevent the appearance of new (and potentially more virulent) SARS-CoV-2 variants in Ukraine.

Author(s):  
Chris Bullen ◽  
Jessica McCormack ◽  
Amanda Calder ◽  
Varsha Parag ◽  
Kannan Subramaniam ◽  
...  

Abstract Background: The global COVID-19 pandemic has disrupted healthcare worldwide. In low- and middle-income countries (LMICs), where people may have limited access to affordable quality care, the COVID-19 pandemic has the potential to have a particularly adverse impact on the health and healthcare of individuals with noncommunicable diseases (NCDs). A World Health Organization survey found that disruption of delivery of healthcare for NCDs was more significant in LMICs than in high-income countries. However, the study did not elicit insights into the day-to-day impacts of COVID-19 on healthcare by front-line healthcare workers (FLHCWs). Aim: To gain insights directly from FLHCWs working in countries with a high NCD burden, and thereby identify opportunities to improve the provision of healthcare during the current pandemic and in future healthcare emergencies. Methods: We recruited selected frontline healthcare workers (general practitioners, pharmacists, and other medical specialists) from nine countries to complete an online survey (n = 1347). Survey questions focused on the impact of COVID-19 pandemic on clinical practice and NCDs; barriers to clinical care during the pandemic; and innovative responses to the many challenges presented by the pandemic. Findings: The majority of FLHCWs responding to our survey reported that their care of patients had been impacted both adversely and positively by the public health measures imposed. Most FLHCs (95%) reported a deterioration in the mental health of their patients. Conclusions: Continuity of care for NCDs as part of pandemic preparedness is needed so that chronic conditions are not exacerbated by public health measures and the direct impacts of the pandemic.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
R Singh ◽  
K Sharma

Abstract Background World Health Organization (WHO) declared that the outbreak of novel coronavirus (2019-nCoV) constituted a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 and characterized the novel coronavirus disease (COVID-19) as a pandemic on 11 March 2020. India enacted such measures early on for effective mitigation and suppression to reduce community transmission, including an onerous national lockdown. The impact of the health system governance is quite apparent among all stakeholders including the public in such emergency contexts. Methods We compiled the daily data on the number of COVID-19 cases, recoveries and deaths from January 30th until June 16th, 2020. Different stages were categorized from post PHEIC declaration (pre-lockdown) phase to lockdown phases and unlocking phase as implemented. The several measures adopted by the national government were structured in four broad categories as Governance and socioeconomic, travel restrictions, lockdown and public health measures. These measures were compared during each phase. Results It was revealed that while the cases are rising the phased restrictions has helped in delaying the peak and remarkably interrupted the rate of transmission. The national average doubling rate was 3 days at the beginning which improved to 22 days. The basic reproduction number remained close to 1 during the last week of lockdown. However, the initial interruption of needed aid and technical support had negative social and economic impacts on the affected population. Conclusions As the situation abates following the measures adopted by the government, an articulate strategy of unlocking through increased testing and prompt isolation needs to be developed for more effective reduction and protecting the livelihoods allowing to further relax the lockdown measures. Key messages There is need for the local government to consider a strategic easing of the lockdown for protecting the rights of the most affected population. As the transmission rates are low, the easing of lockdown can be benefited from improved testing and prompt isolation.


Author(s):  
Amy C Sherman ◽  
Ahmed Babiker ◽  
Andrew J Sieben ◽  
Alexander Pyden ◽  
James Steinberg ◽  
...  

Abstract To assess the impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on seasonal respiratory viruses, absolute case counts and viral reproductive rates from 2019–2020 were compared against previous seasons. Our findings suggest that the public health measures implemented to reduce SARS-CoV-2 transmission significantly reduced the transmission of other respiratory viruses.


2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Veronica Pereda-Loth ◽  
Aldair Martínez Pineda ◽  
Lenka Tisseyre ◽  
Monique Courtade-Saidi ◽  
Christophe Bousquet ◽  
...  

Abstract Background In response to the SARS-CoV-2 pandemic, governments have taken drastically restrictive public health measures with significant collateral effects. It is important to understand the impact of these measures on SARS-CoV-2 circulation. However, pandemic indicators lag behind the actual level of viral circulation and these delays are an obstacle to assessing the effectiveness of policy decisions. Here, we propose one way to solve this problem by synchronizing the indicators with viral circulation in a country (France) based on a landmark event. Methods Based on a first lockdown, we measured the time lag between the peak of governmental and non-governmental surveillance indicators and the highest level of virus circulation. This allowed alignment of all surveillance indicators with viral circulation during the second period of the epidemic, overlaid with the type of public health measures implemented. Results We show that the second peak in viral circulation in France happened ~21 October 2020, during the public health state of emergency but before the lockdown (31 October). Indicators also suggest that viral circulation decreased earlier in locations where curfews were implemented. Indicators did, however, begin to rise once the autumnal lockdown was lifted and the state of emergency resumed. Conclusions Overall, these results suggest that in France, the 2020 autumnal lockdown was not the main initiator of the decrease in SARS-CoV-2 circulation and curfews were important in achieving control of the transmission. Less-restrictive measures may need to be balanced with more-stringent measures to achieve desirable public health outcomes over time.


Parasitology ◽  
2000 ◽  
Vol 121 (S1) ◽  
pp. S39-S50 ◽  
Author(s):  
D.W.T. CROMPTON

The public health significance of hookworm disease is briefly reviewed. The latest evidence confirms that blood loss caused by the worms' feeding activity in the gut is a contributing factor in the development of poor iron status leading to iron-deficiency anaemia. The World Health Organization has identified adolescent girls and women of child-bearing age as high-risk groups regarding the impact of hookworm disease. The merits of treating pregnant women with anthelminthic drugs after the first trimester are discussed.


2020 ◽  
Author(s):  
Haitham Bashier ◽  
Aamer Ikram ◽  
Mumtaz Ali Khan ◽  
Mirza Baig ◽  
Magid Al Gunaid ◽  
...  

UNSTRUCTURED In March 2020, the World Health Organization declared COVID-19 as a global pandemic. The COVID-19 pandemic has affected various public health functions and essential services in different ways and magnitudes. Although all countries have witnessed the effect of COVID-19, the impact differed based on many factors including the integrity and resiliency of the countries’ health systems. This paper presents opinions and expectations of the authors about the anticipated changes in the future of public health at the global, regional, and national levels. The viewpoint is based on the current efforts and challenges that various stakeholders have carried out to control COVID-19 and the contribution from the literature on the future of public health. Numerous agencies and actors are involved in the fight against COVID-19 with variations in their effectiveness. The public health services showed weaknesses in most of the countries, in addition to the lack of adequate curative medicine settings. The pandemic highlighted the need for better governance and stronger and more resilient health systems and capacities. The COVID-19 experience has also emphasized the importance of coordination and collaboration among the countries and stakeholders. The COVID-19 pandemic might lead to a wide discussion to improve international and national approaches to prepare for and respond to similar events in terms of preparedness and response mechanisms and tools. Public health will not be the same as before COVID-19. New health priorities, approaches, and new agendas will be on the table of the global platforms and initiatives. More investment in research and technology to meet the demand for new vaccines and medicines, innovative methods like distance learning and working, more respect and remuneration to health professionals, and normalization of the public health and social measures that were induced during the COVID-19 pandemic are expected to be seen in future.


2020 ◽  
Vol 3 (1) ◽  
pp. 121
Author(s):  
Souad Guessar

In March 2020, the World Health Organization announced that the new Corona virus is a global pandemic. The World Health Organization and the public health authority of various countries are working to contain the spread of the virus through quarantine. But these crises raise the level of stress and psychological tension on individuals and society. As well as Algeria is not an exception and this research will be on the extent of the impact of the pandemic on the conduct of lessons at the universities level in Algeria, which were not equipped for such situations during the outbreak of the emerging corona virus, and try to analyze the situation and then proposing some solutions that can work if it hurts humanity and the Algerians, especially an epidemic like the Corona virus pandemic (COVID-19).


2020 ◽  
Author(s):  
Amy C. Sherman ◽  
Ahmed Babiker ◽  
Andrew J. Sieben ◽  
Alexander Pyden ◽  
James Steinberg ◽  
...  

AbstractTo assess the impact of the SARS-CoV-2 pandemic on seasonal respiratory viruses, absolute case counts and viral reproductive rates from 2019-2020 were compared against previous seasons. Our findings suggest that the public health measures implemented to reduce SARS-CoV-2 transmission significantly reduced the transmission of other respiratory viruses.


2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Vishal Diwan ◽  
Ponnaiah Manickam ◽  
Viduthalai Virumbi Balagurusamy ◽  
Priyank Soni ◽  
Ashish Pathak ◽  
...  

ObjectiveTo study operation feasibility and prepadness of a a tablet-based participatory syndromic surveillance among pilgrims during annual ritual circumbulation (Panchkroshi Yatra) coveirng 15 miles daily in Ujjain, Madhya Pradesh IndiaIntroductionPanchkroshi yatra is an annual ritual of circumambulation (yatra) of temples (Mahadevs) and 100,000 devotees walk for around 15 miles per day for six days and cover a total of 73 miles to worship important Mahadevs. The festival is held every year at the city of Ujjain, Madhya Pradesh, Central India. The yatra attracts large number of pilgrims especially from rural areas and usually women outnumber men. During the yatra, the pilgrims halt at several places and prepare their food in outdoors. We described the public health preparedness, implemented a tablet-based participatory syndromic surveillance among pilgrims of the yatra and reviewed satisfaction of the pilgrims regarding implementation of public health measures, Ujjain during 21-26, April, 2017.MethodsWe described preparedness and arrangements done for the Yatra. We designed tablet-based android to collect information from pilgrims on socio-demographic-economic details, location and self-reported health problems (syndromes). Trained investigators collected data from consenting pilgrims at strategically located halting places. We interviewed a convenient sample of consenting participants to assess satisfaction regarding the public health measures such as sanitation, water, safety, food and cleanliness.ResultsThe district team organized round-the-clock medical camps in strategic locations (mainly at temple or halting place) of the route of the Yatra with few camps having admission facility for emergency conditions. There were no mobile medical units. Ambulance services were on standby at all medical camps. Our satisfactory survey of 360 participants indicated that 79% were satisfied with these medical facilities (79%). District administration alongwith local village administration (panchayat) had set up outlets selling provisions necessary meeting cooking needs. Eighty percent pilgrims were satisfied with food and refreshment arrangements. Permanent and temporary toilets were set-up at the halt-locations but not on the route. Snitation measures such as chlorination and solid waste management were in place. Pilgrims’ satisfaction for urinals (53%) and toilets (60%) was less as compared to cleanliness (74%). Electrical supply and lighting were arranged properly. Volunteers were available to provide assistance to pilgrims. Provision of safe drinking water and potable water were arranged by the authorities and the village-residents made water available through well, pots etc. The survey suggested that only 5% of them were not satisfied with water related arrangements. Security arrangements such as deployment of police, crowd management, and traffic control and fire safety were well-arranged by the authorities and majority of the respondents expressed satisfaction on these arrangements (79-84%).We interviewed 6435 pilgrims for any self-reported symptoms. More than half (56%) of the responders were female and majority (64%) aged 15- 59 years. Around 44% were from Ujjain district. Every second person (around 47%) reported illness with one or other symptoms. Most of them complained of injury with blister (11%). Other common complaints include stomach ache (8%), redness in eyes (7%), fever (7%), cough (6%), vomiting (4%), diarrhea (4%) and throat pain (3%) (Figure)ConclusionsThe participants’ response indicates that all the public health and safety measures were satisfactory except the need for setting up urinals along the fixed route of circumambulation. Table-based surveillance during the yatra indicated that injury was the most commonly self-reported health problem. Implementation of such surveillance helps in tracking health events and therefore, may facilitate preparedness and response. We recommend implementation of such tablet-based surveillance during such mass gathering events.References1. Qanta A Ahmed, Yaseen M Arabi, Ziad A Memish, Health risks at the Hajj, Lancet 2006; 367: 1008–15 2. Tam JS, Barbeschi M, Shapovalova N, Briand S, Memish ZA & Kieny MP. Research agenda for mass gatherings: a call to action. The Lancet infectious diseases, 2012;12,3, 231-239 3. Henning KJ, Overview of syndromic surveillance. What is syndromic surveillance? MMWR Morb Mortal Wkly Rep 53 (Suppl): 5-11 (2004). 4. Chandrasekhar, CP, Ghosh J Information and communication technologies and health in low income countries: the potential and the constraints. Bulletin of the World Health Organization, 2001, 79: 850–855 


2020 ◽  
Vol 1 (2) ◽  
pp. 59-86
Author(s):  
Tatjana Josipović

In this text, the author analyses the intervention measures within the realm of private law relations that were aimed at alleviating or possibly also eliminating the consequences of the serious epidemic.  The author presents and analyses the measures introduced in Croatian law to protect private law entities in their private law relations affected by the consequences of the pandemic and the public health measures. The author’s focus is on the impact of these measures on the protection and restriction of fundamental rights in private law relations to establish whether they met all the necessary requirements when allowing for such restrictions of fundamental rights in private law relations. The aim of this paper is to consider the criteria for the assessment and proportionality of these measures which in private law relations restrict people’s fundamental rights while being imposed to protect people’s health in a serious epidemic.


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