scholarly journals FOCUSED REVIEW ON NUTRITIONAL STATUS OF PATIENTS WITH IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS

2021 ◽  
Author(s):  
Shana Souza Grigoletti ◽  
Priccila Zuchinali ◽  
Emilie Lemieux-Blanchard ◽  
Stephanie Bechard ◽  
Bernard Lemieux ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Weight Loss ◽  
Nutritional Status ◽  
Light Chain ◽  
Complex Disease ◽  
Negative Impact ◽  
Al Amyloidosis ◽  
Immunoglobulin Light Chain ◽  
Negatively Associated

Background: Immunoglobulin light chain (AL) amyloidosis is a complex disease marked by a poor clinical portrait and prognosis generally leading to organ dysfunction and shortened survival. We aimed to review the available evidence on whether AL amyloidosis can lead to malnutrition, thus having a negative impact on quality of life (QoL) and survival. Materials: We searched Pubmed with no restrictions to the year of publication or language. Retrospective or prospective, observational, and interventional studies that reported data regarding AL amyloidosis and nutritional status were included. Results: From 62 articles retrieved, 23 were included. Malnutrition was prevalent in up to 65% of patients with AL Amyloidosis. Prevalence of weight loss of 10% or more ranged from 6 to 22% of patients, while a body mass index of < 22 kg/m2 was found in 22 to 42%. Weight loss, lower BMI and other indicators of poor nutritional status were negatively associated with quality of life and survival. Only one RCT focused on nutritional counselling was found and reported positive results on patients' QoL and survival. Conclusion Despite inconsistencies across assessment criteria, the available data reveal that weight loss and malnutrition are common features in patients with AL amyloidosis. This review reinforces the premise that an impaired nutritional status can be negatively associated with QoL and survival in patients with AL amyloidosis, and therefore should be further investigated.

Nutritional status independently affects quality of life of patients with systemic immunoglobulin light-chain (AL) amyloidosis

2011 ◽  
Vol 91 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Riccardo Caccialanza ◽  
Giovanni Palladini ◽  
Catherine Klersy ◽  
Emanuele Cereda ◽  
Chiara Bonardi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nutritional Status ◽  
Light Chain ◽  
Al Amyloidosis ◽  
Immunoglobulin Light Chain

Nutritional counseling improves quality of life and preserves body weight in systemic immunoglobulin light-chain (AL) amyloidosis

Nutrition ◽  
2015 ◽  
Vol 31 (10) ◽  
pp. 1228-1234 ◽  
Author(s):  
Riccardo Caccialanza ◽  
Giovanni Palladini ◽  
Emanuele Cereda ◽  
Chiara Bonardi ◽  
Paolo Milani ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Weight ◽  
Light Chain ◽  
Al Amyloidosis ◽  
Immunoglobulin Light Chain ◽  
Nutritional Counseling

Amyloidosis: diagnosis and new therapies for a misunderstood and misdiagnosed disease

2019 ◽  
Vol 9 (6) ◽  
Author(s):  
Victoria E Thomas ◽  
Justin Smith ◽  
Merrill D Benson ◽  
Noel R Dasgupta
Keyword(s):  
Quality Of Life ◽  
Light Chain ◽  
Protein Identification ◽  
Amyloid Fibril ◽  
Immunoglobulin Light Chain ◽  
Transthyretin Amyloidosis ◽  
Identification Methods ◽  
Novel Treatments ◽  
Noninvasive Cardiac Imaging

Amyloidosis is a group of diseases characterized by extracellular deposition of amyloid fibril complexes. Fibril deposition results in organ dysfunction and possible failure. Amyloidosis is regarded as a rare disease, but in general is underdiagnosed. The two main types of systemic amyloidosis are immunoglobulin light chain and transthyretin amyloidosis. The increased availability of noninvasive cardiac imaging, genetic testing and improved laboratory assays and protein identification methods have led to increased diagnosis. However, in many cases, the diagnosis is not made until the patient develops organ impairment. Earlier diagnosis is required to prevent irreversible organ failure. Novel treatments for immunoglobulin light chain and transthyretin amyloidosis that halt disease progression, prolong and increase quality of life have recently become available.

scholarly journals The prevalence of depressive and anxiety symptoms and their associations with quality of life among clinically stable older patients with psychiatric disorders during the COVID-19 pandemic

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wen Li ◽  
Na Zhao ◽  
Xiaona Yan ◽  
Siyun Zou ◽  
Huan Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychiatric Disorders ◽  
Older Patients ◽  
Negative Impact ◽  
Anxiety Symptoms ◽  
Poor Adherence ◽  
Adherence To Treatment ◽  
Negatively Associated ◽  
The Impact

AbstractThe impact of the COVID-19 pandemic on clinically stable older patients with psychiatric disorders is unclear. This study examined the prevalence of depressive and anxiety symptoms, and their associations with quality of life (QOL) in clinically stable older patients with psychiatric disorders during the COVID-19 pandemic. This was a multicenter, cross-sectional study. Depressive and anxiety symptoms, insomnia, pain, and QOL were assessed with standardized instruments. A total of 1063 patients were included. The prevalence of depressive and anxiety symptoms, and combined depressive and anxiety symptoms were 62.3% (95%CI = 59.4–65.2%), 52.4% (95%CI = 49.3–55.4%), and 45.9% (95%CI = 42.9–48.9%), respectively. Patients with depressive and anxiety symptoms had significantly lower QOL than those without (P < 0.01). Binary logistic regression analyses revealed that having depressive symptoms was positively associated with more severe insomnia (OR = 1.29, P < 0.01) and pain (OR = 1.14, P < 0.01), and was negatively associated with other psychiatric diagnoses (except for major depressive disorder, schizophrenia, and organic mental disorder; OR = 0.50, P < 0.01), while having anxiety symptoms was positively associated with severe physical diseases (OR = 1.57, P = 0.02), poor adherence to treatment (OR = 1.50, P < 0.01), and more severe insomnia (OR = 1.15, P < 0.01) and pain (OR = 1.11, P < 0.01). Having combined depression and anxiety symptoms was positively associated with poor adherence to treatment (OR = 1.42, P = 0.02) and more severe insomnia (OR = 1.19, P < 0.01) and pain (OR = 1.15, P < 0.01), and was negatively associated with the diagnosis of schizophrenia (OR = 0.50, P = 0.04) and others (OR = 0.53, P < 0.01). Depressive and anxiety symptoms were common in clinically stable older patients with psychiatric disorders during the COVID-19 pandemic. Considering the negative impact of these symptoms on QOL, regular screening and appropriate treatment are recommended for this population.

scholarly journals Nutritional status and life quality in patients undergoing bariatric surgery

2014 ◽  
Vol 27 (suppl 1) ◽  
pp. 35-38 ◽  
Author(s):  
Paulo Roberto Bezerra da SILVA ◽  
Marcela Ramos de SOUZA ◽  
Evane Moises da SILVA ◽  
Silvia Alves da SILVA
Keyword(s):  
Quality Of Life ◽  
Bariatric Surgery ◽  
Weight Loss ◽  
Nutritional Status ◽  
Positive Impact ◽  
Clinical Manifestations ◽  
Life Quality ◽  
Excess Weight ◽  
Global Epidemic

BACKGROUND: The obesity has achieved an alarming increase in recent years, which led this disease to global epidemic condition. AIM: To evaluate the nutritional status as well as the quality of life of obese patients undergoing bariatric surgery. METHODS: A transversal study was conducted with obese adults of both genders who underwent bariatric surgery by Fobi-Capella technique for at least 30 days. It was evaluated: age, gender, marital status, occupation, weight before surgery, current weight, height, preoperative and current BMI, weight loss and loss of excess weight percentages, presence of clinical manifestations and food intolerances. RESULTS: The sample consisted of 70 patients, being 81.4% female, 37.1% aged 30 to 39 years, 58.6% were married, 41.4% have undergone the bariatric surgery in the last 12 months. It was observed a reduction in BMI from 37.2 kg/m2 (one to three months) to 28.9 kg/m2 (>12 months) and consequent increase in weight loss and loss of excess weight percentages. The most frequent clinical manifestation was alopecia (62.9%). The most reported food intolerance was on the red meat (24%). According to the Baros questionnaire, 50% of patients were classified as having good quality of life. CONCLUSION: The operation of Fobi-Capella proved to be effective in promoting gradual and lasting weight loss. Quality of life was considered good in most patients, indicating that the operation had a positive impact on their lives.

Response of factor X deficiency to darutumumab in the treatment of AL amyloidosis: a novel finding

2021 ◽  
Vol 14 (4) ◽  
pp. e240631
Author(s):  
Ethan Mar ◽  
Kerry Taylor ◽  
Peter Mollee
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Light Chain ◽  
Al Amyloidosis ◽  
Factor X ◽  
Haematological Response ◽  
Factor X Deficiency ◽  
First Case ◽  
Complete Haematological Response

We report a case of progressive light-chain amyloidosis (otherwise known as AL amyloidosis) with acquired factor X (aFX) deficiency with a complete haematological response and rapid normalisation of FX levels following daratumumab monotherapy. To our knowledge, this is the first case report documenting successful treatment with daratumumab of aFX deficiency secondary to AL amyloidosis. The patient responded well to this therapy, with excellent symptomatic and quality of life improvements as well as a reduction in bleeding manifestations. This case highlights the value in considering daratumumab treatment when AL amyloidosis is complicated by FX deficiency.

scholarly journals Time-Limited Eating and Continuous Glucose Monitoring in Adolescents with Obesity: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3697
Author(s):  
Alaina P. Vidmar ◽  
Monica Naguib ◽  
Jennifer K. Raymond ◽  
Sarah Jeanne Salvy ◽  
Elizabeth Hegedus ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Weight Loss ◽  
Pilot Study ◽  
Continuous Glucose Monitoring ◽  
Eating Behaviors ◽  
Negative Impact ◽  
Glucose Monitoring

Due to its simplicity, time-limited eating (TLE) may represent a more feasible approach for treating adolescents with obesity compared to other caloric restriction regimens. This pilot study examines the feasibility and safety of TLE combined with continuous glucose monitoring (CGM) in adolescents. Fifty adolescents with BMI ≥95th percentile were recruited to complete a 12-week study. All received standard nutritional counseling, wore a CGM daily, and were randomized to: (1) Prolonged eating window: 12 h eating/12 h fasting + blinded CGM; (2) TLE (8 h eating/16 h fasting, 5 days per week) + blinded CGM; (3) TLE + real-time CGM feedback. Recruitment, retention, and adherence were recorded as indicators of feasibility. Weight loss, dietary intake, physical activity, eating behaviors, and quality of life over the course of the intervention were explored as secondary outcomes. Forty-five participants completed the study (16.4 ± 1.3 years, 64% female, 49% Hispanic, 75% public insurance). There was high adherence to prescribed eating windows (TLE 5.2 d/wk [SD 1.1]; control 6.1 d/wk [SD 1.4]) and daily CGM wear (5.85 d/wk [SD 4.8]). Most of the adolescents (90%) assigned to TLE reported that limiting their eating window and wearing a CGM was feasible without negative impact on daily functioning or adverse events. There were no between-group difference in terms of weight loss, energy intake, quality of life, physical activity, or eating behaviors. TLE combined with CGM appears feasible and safe among adolescents with obesity. Further investigation in larger samples, with a longer intervention duration and follow-up assessments are needed.

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