scholarly journals Word structure tunes electrophysiological and hemodynamic responses in the frontal cortex

2021 ◽  
Author(s):  
Fei Gao ◽  
Lin Hua ◽  
Yuwen He ◽  
Zhen Yuan
Keyword(s):  
Frontal Cortex ◽  
Priming Effect ◽  
Lexical Processing ◽  
Distinct Pattern ◽  
Structure Effect ◽  
Hemodynamic Responses ◽  
Word Structure ◽  
Morphological Priming ◽  
Structure Modulation ◽  
First Time

As a morphological impoverished language, how does word structure impact Chinese lexical processing in the brain? To address this issue, the current study examined the temporal signatures and localizations in the human brain for morphological priming effect (compound/derivation constitute priming vs. non-morphological priming) and word structure modulation (derivation vs. compound) in light of EEG-fNIRS fusion. Whilst morphological priming effect was manifested in behavioral performance and left prefrontal hemodynamic responses, word structure effect was prominent drawing on behavioral, ERP, and fNIRS data. Chinese derivations elicited greater activation in the frontal cortex and engaged more distributed network than lexicalized compounds. The results were interpreted by the differing connection patterns between constitute morphemes within a given word structure from spreading activation perspective. Together, Chinese word structure effect showed a distinct pattern from the dual-route mechanism in alphabetic languages. Meanwhile, the current study for the first time identified dissociable behavioral and neurophysiological responses of Chinese derivations and coordinate compounds.

scholarly journals Finding a 'flower' in a 'peanut' is as easy as in a 'garden': towards a lemma-based model of bilingual word recognition

2020 ◽  
Author(s):  
Xin Wang ◽  
Marcus Taft
Keyword(s):  
Word Recognition ◽  
Priming Effect ◽  
Lexical Processing ◽  
Semantic Transparency ◽  
Morphological Decomposition ◽  
Strong Trend ◽  
Priming Paradigm ◽  
Morphological Priming ◽  
Language Activation ◽  
Cross Language

The present study investigates how morphological information is processed and represented in the bilingual lexicon. We employed a masked cross-language morphological priming paradigm to examine morphological decomposition and semantic transparency in bilingual lexical processing. A robust and reliable morphological priming effect was observed for both transparent compounds and opaque compounds, though there was a strong trend for more facilitation in the former than the latter. To account for these results, we propose a lemma-based bilingual model specifying the activation/competition between lemmas during cross-language activation at the morphological level. Our novel findings advance the understanding of interplay between morphology and bilingualism.

scholarly journals Paradigmatic enhancement of stem vowels in regular English inflected verb forms

Morphology ◽  
2021 ◽  
Vol 31 (2) ◽  
pp. 171-199
Author(s):  
Fabian Tomaschek ◽  
Benjamin V. Tucker ◽  
Michael Ramscar ◽  
R. Harald Baayen
Keyword(s):  
Cognitive Psychology ◽  
Speech Production ◽  
Lexical Processing ◽  
Mental Lexicon ◽  
Morphological Processing ◽  
Word Structure ◽  
Verb Forms ◽  
Growing Body ◽  
Complex Words ◽  
Phonetic Realization

AbstractMany theories of word structure in linguistics and morphological processing in cognitive psychology are grounded in a compositional perspective on the (mental) lexicon in which complex words are built up during speech production from sublexical elements such as morphemes, stems, and exponents. When combined with the hypothesis that storage in the lexicon is restricted to the irregular, the prediction follows that properties specific to regular inflected words cannot co-determine the phonetic realization of these inflected words. This study shows that the stem vowels of regular English inflected verb forms that are more frequent in their paradigm are produced with more enhanced articulatory gestures in the midsaggital plane, challenging compositional models of lexical processing. The effect of paradigmatic probability dovetails well with the Paradigmatic Enhancement Hypothesis and is consistent with a growing body of research indicating that the whole is more than its parts.

scholarly journals Task-Dependent Modulation of Regions in the Left Inferior Frontal Cortex during Semantic Processing

2001 ◽  
Vol 13 (6) ◽  
pp. 829-843 ◽  
Author(s):  
A. L. Roskies ◽  
J. A. Fiez ◽  
D. A. Balota ◽  
M. E. Raichle ◽  
S. E. Petersen
Keyword(s):  
Frontal Cortex ◽  
Language Processing ◽  
Semantic Processing ◽  
Semantic Analysis ◽  
Lexical Processing ◽  
Temporal Cortex ◽  
Dependent Manner ◽  
Inferior Frontal Cortex ◽  
Semantic Judgment ◽  
The Right

To distinguish areas involved in the processing of word meaning (semantics) from other regions involved in lexical processing more generally, subjects were scanned with positron emission tomography (PET) while performing lexical tasks, three of which required varying degrees of semantic analysis and one that required phonological analysis. Three closely apposed regions in the left inferior frontal cortex and one in the right cerebellum were significantly active above baseline in the semantic tasks, but not in the nonsemantic task. The activity in two of the frontal regions was modulated by the difficulty of the semantic judgment. Other regions, including some in the left temporal cortex and the cerebellum, were active across all four language tasks. Thus, in addition to a number of regions known to be active during language processing, regions in the left inferior frontal cortex were specifically recruited during semantic processing in a task-dependent manner. A region in the right cerebellum may be functionally related to those in the left inferior frontal cortex. Discussion focuses on the implications of these results for current views regarding neural substrates of semantic processing.

scholarly journals Synaptic biomarker reduction and impaired cognition in the sub-chronic PCP mouse model for schizophrenia

2019 ◽  
Vol 34 (1) ◽  
pp. 115-124 ◽  
Author(s):  
John Gigg ◽  
Francesca McEwan ◽  
Rebecca Smausz ◽  
Joanna Neill ◽  
Michael K Harte
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Frontal Cortex ◽  
Ventral Hippocampus ◽  
Acid Decarboxylase ◽  
Object Recognition Memory ◽  
Synaptic Markers ◽  
Inter Trial Interval ◽  
First Time ◽  
Interval Expression

Background: Sub-chronic phencyclidine treatment (scPCP) provides a translational rat model for cognitive impairments associated with schizophrenia (CIAS). CIAS genetic risk factors may be more easily studied in mice; however, CIAS associated biomarker changes are relatively unstudied in the scPCP mouse. Aim: To characterize deficits in object recognition memory and synaptic markers in frontal cortex and hippocampus of the scPCP mouse. Methods: Female c57/bl6 mice received 10 daily injections of PCP (scPCP; 10 mg/kg, s.c.) or vehicle ( n = 8/group). Mice were tested for novel object recognition memory after either remaining in the arena (‘no distraction’) or being removed to a holding cage (‘distraction’) during the inter-trial interval. Expression changes for parvalbumin (PV), glutamic acid decarboxylase (GAD67), synaptosomal-associated protein 25 (SNAP-25) and postsynaptic density 95 (PDS95) were measured in frontal cortex, dorsal and ventral hippocampus. Results: scPCP mice showed object memory deficits when distracted by removal from the arena, where they treated previously experienced objects as novel at test. scPCP significantly reduced PV expression in all regions and lower PSD95 levels in frontal cortex and ventral hippocampus. Levels of GAD67 and SNAP-25 were unchanged. Conclusions: We show for the first time that scPCP mice: (a) can encode and retain object information, but that this memory is susceptible to distraction; (b) display amnesia after distraction; and (c) express reduced PV and PSD95 in frontal cortex and hippocampus. These data further support reductions in PV-dependent synaptic inhibition and NMDAR-dependent glutamatergic plasticity in CIAS and highlight the translational significance of the scPCP mouse.

Psycholinguistic Approaches to Morphology: Theoretical Issues

2017 ◽  
Author(s):  
Christina L. Gagné
Keyword(s):  
Human Mind ◽  
Phonological Representations ◽  
Word Structure ◽  
Theoretical Approaches ◽  
Morphological Priming ◽  
Types Of Information ◽  
Complex Words ◽  
Whole Word ◽  
Theoretical Issues

Psycholinguistics is the study of how language is acquired, represented, and used by the human mind; it draws on knowledge about both language and cognitive processes. A central topic of debate in psycholinguistics concerns the balance between storage and processing. This debate is especially evident in research concerning morphology, which is the study of word structure, and several theoretical issues have arisen concerning the question of how (or whether) morphology is represented and what function morphology serves in the processing of complex words. Five theoretical approaches have emerged that differ substantially in the emphasis placed on the role of morphemic representations during the processing of morphologically complex words. The first approach minimizes processing by positing that all words, even morphologically complex ones, are stored and recognized as whole units, without the use of morphemic representations. The second approach posits that words are represented and processed in terms of morphemic units. The third approach is a mixture of the first two approaches and posits that a whole-access route and decomposition route operate in parallel. A fourth approach posits that both whole word representations and morphemic representations are used, and that these two types of information interact. A fifth approach proposes that morphology is not explicitly represented, but rather, emerges from the co-activation of orthographic/phonological representations and semantic representations. These competing approaches have been evaluated using a wide variety of empirical methods examining, for example, morphological priming, the role of constituent and word frequency, and the role of morphemic position. For the most part, the evidence points to the involvement of morphological representations during the processing of complex words. However, the specific way in which these representations are used is not yet fully known.

scholarly journals Morphological priming of inflectional suffixes

2020 ◽  
Author(s):  
Katarina Marjanovic ◽  
Davide Crepaldi
Keyword(s):  
Priming Effect ◽  
Word Identification ◽  
Masked Priming ◽  
Visual Word ◽  
Priming Paradigm ◽  
Morphological Priming ◽  
Visual Word Identification ◽  
The Rich ◽  
Complex Words

Morphologically complex words are processed through their constituent morphemes during visual word recognition. While this has been primarily established through the stem priming paradigm, the role of shared affixes is more controversial. Also, most evidence on affix priming comes from derivation, while inflectional priming remains largely unaddressed. Here we present two lexical decision, masked priming experiments filling this gap. Taking advantage of the rich inflectional pattern of Slovene, we assessed inflectional suffix priming (mestam–HALJAM), and compared it to the well-established stem priming effect (haljov–HALJAM): while the latter is solid as expected, the former seems to be weak to non–existing. Results further indicate that there is no interaction between sharing a stem and sharing an inflectional suffix—neither stem nor suffix priming is boosted when primes and targets also share the other morpheme. These data indicate an important difference between stems, derivational affixes and inflectional affixes, which we consider in the context of models of visual word identification and information theory.

Morpho-orthographic segmentation of opaque and transparent derived words: New evidence for Spanish

2020 ◽  
pp. 174702182097703
Author(s):  
Miguel Lázaro ◽  
Lorena García ◽  
Víctor Illera
Keyword(s):  
Lexical Decision ◽  
Priming Effect ◽  
Lexical Processing ◽  
Masked Priming ◽  
Error Rates ◽  
The Other ◽  
Semantic Transparency ◽  
Related Condition ◽  
Priming Paradigm ◽  
New Evidence

Semantic transparency has been extensively analysed in research on visual word recognition. Under the masked priming paradigm, it has consistently been shown that opaque and transparent words are facilitated relative to form-related controls, but differences in priming between one condition and another have not been conclusively proven. Hence, research has been unable to theoretically elucidate the possible value of semantic transparency in the processing of derived words. This study describes two lexical decision experiments in Spanish. Experiment 1 revealed differences between the transparent and orthographic conditions, with no differences between the other conditions in the analyses of the error rates. In the second experiment, the participants visited the laboratory on two occasions, separated by a week. The task was administered twice, with participants responding to one of the experimental lists on each day. The results of this second experiment revealed significant differences in the size of the priming effect of the opaque and transparent conditions compared with the form-related condition, but without differences between these two effects. We discuss these findings from the perspective of current models of visual lexical processing.

Can masked synonym priming replicate masked translation priming?

2019 ◽  
Vol 72 (10) ◽  
pp. 2554-2562 ◽  
Author(s):  
Naoko Witzel
Keyword(s):  
High Frequency ◽  
Priming Effect ◽  
Lexical Processing ◽  
Low Frequency ◽  
Masked Priming ◽  
Semantic Interpretation ◽  
Priming Effects ◽  
Translation Priming ◽  
Masked Translation Priming ◽  
Robust Evidence

This study examines whether synonyms are represented similarly to translation equivalents in the bilingual mind. In particular, this study investigated whether there is masked synonym priming such that it will simulate masked translation priming in the L1-L2 direction. Given that masked translation priming studies consistently show priming in the L1-L2 direction, it was predicted that synonyms should show a masked priming effect if the prime was higher in frequency than the target. Contrary to what Bilingual Interactive Activation models would predict, there was no priming for synonyms in the high-to-low frequency (HF-LF) condition or in the low-to-high frequency (LF-HF) condition in Experiment 1. Experiment 2 only tested the HF-LF condition to ensure that previous exposure to LF words within the experiment did not affect the results. Again, no HF-LF synonym priming was observed. The effect sizes of these synonym priming effects were comparable with that of L2-L1 translation priming, all of which were weak. This is not surprising given that semantic interpretation of a given word usually occurs post-lexically and requires partial awareness. What is surprising is that there is robust evidence showing strong L1-L2 masked translation priming effect, which bilingual lexical processing models should attempt to explain, thereby uncovering the relations between L1 words and their L2 translations.

scholarly journals Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
S. U. Sixt ◽  
R. Alami ◽  
J. Hakenbeck ◽  
M. Adamzik ◽  
A. Kloß ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Healthy Subjects ◽  
Distress Syndrome ◽  
Distinct Pattern ◽  
Alveolar Space ◽  
Chromatographic Purification ◽  
Cell Pellet ◽  
First Time

There is increasing evidence that proteasomes have a biological role in the extracellular alveolar space, but inflammation could change their composition. We tested whether immunoproteasome protein-containing subpopulations are present in the alveolar space of patients with lung inflammation evoking the acute respiratory distress syndrome (ARDS). Bronchoalveolar lavage (BAL) supernatants and cell pellet lysate from ARDS patients (n=28) and healthy subjects (n=10) were analyzed for the presence of immunoproteasome proteins (LMP2 and LMP7) and proteasome subtypes by western blot, chromatographic purification, and 2D-dimensional gelelectrophoresis. In all ARDS patients but not in healthy subjects LMP7 and LMP2 were observed in BAL supernatants. Proteasomes purified from pooled ARDS BAL supernatant showed an altered enzyme activity ratio. Chromatography revealed a distinct pattern with 7 proteasome subtype peaks in BAL supernatant of ARDS patients that differed from healthy subjects. Total proteasome concentration in BAL supernatant was increased in ARDS (971 ng/mL±1116 versus59±25;P<0.001), and all fluorogenic substrates were hydrolyzed, albeit to a lesser extent, with inhibition by epoxomicin (P=0.0001). Thus, we identified for the first time immunoproteasome proteins and a distinct proteasomal subtype pattern in the alveolar space of ARDS patients, presumably in response to inflammation.

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