Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish
Keyword(s):
Mycobacterial granuloma formation involves significant stromal remodeling and the growth of leaky, granuloma-associated vasculature. These permeable blood vessels aid mycobacterial growth, as anti-angiogenic or vascular normalizing therapies are beneficial host-directed therapies in pre-clinical models of tuberculosis. Here we demonstrate that vascular normalization through vascular endothelial-protein tyrosine phosphatase inhibition decreases granuloma hypoxia, the opposite effect of hypoxia-inducing anti-angiogenic therapy. Vascular normalization leads to increased T cell and decreased neutrophil recruitment to granulomas, correlates of a protective immune response against mycobacterial infection.
2015 ◽
Vol 35
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pp. 163-174
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1999 ◽
Vol 248
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pp. 329-338
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2008 ◽
Vol 102
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pp. 1182-1191
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2014 ◽
Vol 289
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pp. 5904-5913
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2013 ◽
Vol 105
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pp. 1188-1201
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