Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function
Keyword(s):
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is a receptor-type PTP (RPTP), predominantly expressed in vascular endothelial cells. It regulates embryonic and tumor angiogenesis and controls vascular permeability and homeostasis in inflammation. Major substrates are the tyrosine kinase receptor Tie-2 and the adhesion molecule VE-cadherin. This review describes how VE-PTP controls vascular functions by its various substrates and the therapeutic potential of VE-PTP in various pathophysiological settings.
2014 ◽
Vol 289
(10)
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pp. 6451-6461
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Keyword(s):
1993 ◽
Vol 46
(1-2)
◽
pp. 223-224
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Keyword(s):
2000 ◽
Vol 113
(17)
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pp. 3117-3123
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2020 ◽