scholarly journals Radiation Exposure Determination in a Secure, Cloud-based Online Environment

2021 ◽  
Author(s):  
Ben C. Shirley ◽  
Eliseos J Mucaki ◽  
Joan H.M. Knoll ◽  
Peter K Rogan
Keyword(s):  
Radiation Dose ◽  
Research Assessment ◽  
Radiation Doses ◽  
Online Environment ◽  
Dose Estimation ◽  
Radiation Accidents ◽  
Time Frames ◽  
And Training ◽  
Radiation Research ◽  
Manual Review

Background: In a major radiation incident, the speed of sample processing and interpretation of estimated exposures will be critical for triaging individuals. The Automated Dicentric Chromosome (DC) Identifier and Dose Estimator System (ADCI) selects and processes images to identify DCs and determines radiation dose without manual review. The goal of this study was to broaden accessibility and speed of this system with data parallelization while protecting data and software integrity. Methods: ADCI_Online is a secure web-streaming platform that can be accessed worldwide from distributed local nodes. Data and software are separated until they are linked for estimation of radiation exposures. Performance is assessed with data from multiple biodosimetry laboratories. Results: Dose estimates from ADCI_Online are identical to ADCI running on dedicated GPU-accelerated hardware. Metaphase image processing, automated image selection, calibration curve generation, and radiation dose estimation of a typical set of samples of unknown exposures were completed in <2 days. Parallelized processing and analyses using cloned software instances on different hardware configurations of samples at the scale of an intermediate-sized radiation accident (54,595 metaphase images) accelerated estimation of radiation doses to within clinically-relevant time frames. Conclusions: The ADCI_Online streaming platform is intended for on-demand, standardized radiation research assessment, biodosimetry proficiency testing, inter-laboratory comparisons, and training. The platform has the capacity to handle analytic bottlenecks in intermediate to large radiation accidents or events.

scholarly journals New approaches to biological dosimetry: development of complex biodosimetric systems (review of foreign literature)

2019 ◽  
pp. 90-96
Author(s):  
N. V. Sotnik ◽  
V. L. Rybkina ◽  
T. V. Azizova
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Biological Markers ◽  
Large Scale ◽  
Accurate Estimate ◽  
Dose Assessment ◽  
Radiation Doses ◽  
Biological Dosimetry ◽  
Radiation Accidents ◽  
Combined Use

Relevance. In case of emergency due to large-scale radiation accidents, biological dosimetry becomes a critical tool for early radiation dose assessment and enables identification of individuals exposed to ionizing radiation and facilitates further medical follow-up decisions.Intention. To assess the feasibility of a number of biological markers for bioindication and biodosimetry purposes based on literature data.Methodology. Literature sources were searched in MEDLINE databases, PubMed, CyberLeninka, elibrary.ru, using the terms: radiation, irradiation, biodosimetry. The review presents the results of studies from full-text sources of literature in English.Results and Discussion. Depending on an accidental exposure scenario, various biodosimetry techniques should be used to assess radiation doses with optimal accuracy and speed. In addition to physical methods and clinical techniques used to assess radiation doses, biological dosimetry defines a level of ionizing radiation exposure for certain individuals and is useful in making decisions about medical treatment strategy. To date, combined use of several biological markers within a biodosimetry system providing reliable radiation dose estimates.Conclusion. Analysis of the data presented in the review showed that combined use of several biological markers and development of a complex biodosimetric system will provide a more accurate estimate of doses, which is especially important in case of radiation accidents and incidents when physical dosimetry data are not available.

The Employment of 197Hg EDTA in Kidney Scanning

1965 ◽  
Vol 05 (01) ◽  
pp. 56-67
Author(s):  
I. Pál ◽  
J. Földes ◽  
I. Krasznai
Keyword(s):  
Radiation Dose ◽  
Renal Cortex ◽  
Radiation Doses ◽  
Intravenous Pyelography ◽  
Edta Complex

SummaryThe authors investigated the use of 197Hg EDTA complex for kidney scanning. They describe the physical, biological and toxicological properties of the compound; its distribution within the organism, its excretion with urine and faeces and its uptake by the kidneys. The authors have established that the renal cortex selectively secretes the material which makes it suitable for kidney scanning. Some scintigrams of both normal and pathologic kidneys are presented.Finally a detailed discussion of the dosimetry is included. The radiation doses due to 197Hg EDTA are compared with those due to 203Hg-neohydrin and to intravenous pyelography. This comparison shows clearly that the use of 197Hg EDTA considerably decreases the radiation dose to the patient.

Radiation Minimisation and Outcome Maximisation in Cardiac Computed Tomograpy

2010 ◽  
Vol 6 (1) ◽  
pp. 15
Author(s):  
James P Earls ◽  
Jonathon A Leipsic ◽  
◽  
Keyword(s):  
Radiation Dose ◽  
Dose Reduction ◽  
New Technologies ◽  
Cardiac Computed Tomography ◽  
Substantial Reduction ◽  
Radiation Doses ◽  
Tube Current ◽  
Prospective Triggering ◽  
Effective Radiation ◽  
Selection Of

Recent reports have raised general awareness that cardiac computed tomography (CT) has the potential for relatively high effective radiation doses. While the actual amount of risk this poses to the patient is controversial, the increasing concern has led to a great deal of research on new CT techniques capable of imaging the heart at substantially lower radiation doses than was available only a few years ago. Methods of dose reduction include optimised selection of user-defined parameters, such as tube current and voltage, as well as use of new technologies, such as prospective triggering and iterative reconstruction. These techniques have each been shown to lead to substantial reduction in radiation dose without loss of diagnostic accuracy. This article will review the most frequently used and widely available methods for radiation dose reduction in cardiac CT and give practical advice on their use and limitations.

Threshold square model of the dependence of radiation effects on radiation dose

2020 ◽  
Vol 89 ◽  
pp. 65-74
Author(s):  
A. G. Zavorotnyy ◽  
Keyword(s):  
Radiation Dose ◽  
Emergency Services ◽  
Least Squares Method ◽  
Threshold Model ◽  
Operating Conditions ◽  
Quadratic Model ◽  
Modern World ◽  
Stochastic Effects ◽  
Radiation Accidents ◽  
Increased Risk

Introduction. Operation of radiation hazardous facilities is a reality of the modern world, and the future of the world economy is impossible without the development of nuclear and radiation technologies. At the same time, the widespread use of atomic energy puts forward an important and responsible task of ensuring the safety of the population and the environment in conditions of an increased risk of exposure to ionizing radiation and radioactive substances. In accordance with clause 3.2.1 of the "Radiation Safety Standards NRB-99/2009", the planned increased exposure of persons involved in emergency rescue operations related to the elimination of the consequences of radiation accidents is allowed for men, as a rule, over 30 years old only with their voluntary written consent, after informing about possible radiation doses and health risks. Increased exposure refers to exposure in excess of the basic dose limits under controlled (normal) operating conditions of radiation sources. Goals and objectives. The aim of the study is to increase the functionality of emergency services and fire and rescue subdivisions to perform tasks as intended in the elimination of radiation accidents. The tasks include the construction and substantiation of a model that allows converting the risks of deterministic effects into stochastic effects risks. Methods. When calculating the probability of output of stochastic and deterministic effects depending on the radiation dose and developing a threshold quadratic model, the least squares method and the probabilistic-statistical method were used. Results and discussion. The article shows that a linear non-threshold model of the interaction of radiation with matter greatly overestimates the risk of a stochastic effect emerging at doses of radiation. For example, this overestimation is 8,13 at a dose of D = 0,2 Sv/year. In this regard, a threshold quadratic model has been developed and proposed to be replaced by a threshold quadratic model, which makes it possible to increase the planned irradiation of personnel of emergency services and fire and rescue units during the elimination of radiation accidents in an effective dose from 0,2 Sv to 0,57 Sv, moreover, the probability of emergence of stochastic effects P2 = 0,0084 remains the same for both models. Conclusions. An increase in the maximum permissible dose of radiation for personnel of emergency services and fire and rescue units from 0,2 Sv/year to 0,5 Sv/year will make it possible to increase the functionality of the emergency services and fire and rescue units to perform tasks as intended by 2,5 times when elimination of radiation accidents. For example, the scope of rescue operations may be increased from 100 %, performed at a dose of D = 0,2 Sv/year, to 250 %, performed at a dose of D = 0,5 Sv/year. Key words: emergency services, fire and rescue units, radiation accidents, irradiation, linear no-threshold model, threshold quadratic model.

scholarly journals Optimal Radiation Dose For Stage III Lung Cancer – Should “Definitive” Radiation Doses Be Used in the Pre-Operative Setting?

2021 ◽  
pp. 100201
Author(s):  
Areo G. Saffarzadeh ◽  
Maureen Canavan ◽  
Benjamin J. Resio ◽  
Samantha L. Walters ◽  
Kaitlin M. Flores ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Dose ◽  
Stage Iii ◽  
Radiation Doses

Diagnostic Reference Levels for Common Orthopedic Hand and Wrist Procedures Using Intraoperative mini C-arm Fluoroscopy

Hand ◽  
2021 ◽  
pp. 155894472199425
Author(s):  
Kiran R. Madhvani ◽  
Matthew J. R. Clark ◽  
Alex A. J. Kocheta
Keyword(s):  
Radiation Dose ◽  
Fracture Fixation ◽  
Wrist Fracture ◽  
Radiation Doses ◽  
Diagnostic Reference Levels ◽  
Reference Levels ◽  
Audit Data ◽  
Small Joint ◽  
Open Fixation ◽  
Phalangeal Fracture

Background: Diagnostic reference levels are radiation dose levels in medical radiodiagnostic practices for typical examinations for groups of standard-sized individuals for broadly defined types of equipment. This study aimed to contribute to national diagnostic reference levels for common hand and wrist procedures using mini C-arm fluoroscopy. Small joint and digital fracture procedure diagnostic reference levels have not been reported in significant numbers previously with procedure-level stratification. Methods: Data were collected from fluoroscopy logbooks and were cross-referenced against the audit log kept on fluoroscopy machines. A total of 603 procedures were included. Results: The median radiation dose for wrist fracture open fixation was 2.73 cGycm2, Kirschner wiring (K-wiring) procedures was 2.36 cGycm2, small joint arthrodesis was 1.20 cGycm2, small joint injections was 0.58 cGycm2, and phalangeal fracture fixation was 1.05 cGycm2. Conclusions: Wrist fracture fixation used higher radiation doses than phalangeal fracture fixation, arthrodeses, and injections. Injections used significantly less radiation than the other procedures. There are significant differences in total radiation doses when comparing these procedures in hand and wrist surgery. National and international recommendations are that institutional audit data should be collected regularly and should be stratified by procedure type. This study helps to define standards for this activity by adding to the data available for wrist fracture diagnostic reference levels and defining standards for digital and injection procedures.

Estimation of Radiation Doses in X-Ray Visualization of Biological Objects

2014 ◽  
Vol 880 ◽  
pp. 53-56 ◽  
Author(s):  
Sergei Stuchebrov ◽  
Andrey Batranin ◽  
Dan Verigin ◽  
Yelena Lukyanenko ◽  
Maria Siniagina ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Biological Object ◽  
Gas Discharge ◽  
Radiation Doses ◽  
Semiconductor Detectors ◽  
Interior Structure ◽  
Dose Calculations ◽  
Object Control ◽  
X Ray ◽  
Biological Objects

Two setups for X-ray visualization of objects interior structure were designed and assembled in TPU. These radiographic systems are based on linear gas-discharge and GaAs semiconductor detectors. During investigation of biological object control of radiation doses has a high priority. In this report radiation dose calculations in X-ray visualization are presented. These calculation also includes dose calculations of sinograms which are used for reconstruction of tomography slices.

scholarly journals Low-Dose Computed Tomography for the Optimization of Radiation Dose Exposure in Patients with Crohn’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Richard G. Kavanagh ◽  
John O’Grady ◽  
Brian W. Carey ◽  
Patrick D. McLaughlin ◽  
Siobhan B. O’Neill ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Crohn’S Disease ◽  
Image Quality ◽  
Crohn's Disease ◽  
Radiation Dose ◽  
Ionizing Radiation ◽  
Low Dose ◽  
Radiation Doses ◽  
Radiation Dose Exposure ◽  
Ct Technology

Magnetic resonance imaging (MRI) is the mainstay method for the radiological imaging of the small bowel in patients with inflammatory bowel disease without the use of ionizing radiation. There are circumstances where imaging using ionizing radiation is required, particularly in the acute setting. This usually takes the form of computed tomography (CT). There has been a significant increase in the utilization of computed tomography (CT) for patients with Crohn’s disease as patients are frequently diagnosed at a relatively young age and require repeated imaging. Between seven and eleven percent of patients with IBD are exposed to high cumulative effective radiation doses (CEDs) (>35–75 mSv), mostly patients with Crohn’s disease (Newnham E 2007, Levi Z 2009, Hou JK 2014, Estay C 2015). This is primarily due to the more widespread and repeated use of CT, which accounts for 77% of radiation dose exposure amongst patients with Crohn’s disease (Desmond et al., 2008). Reports of the projected cancer risks from the increasing CT use (Berrington et al., 2007) have led to increased patient awareness regarding the potential health risks from ionizing radiation (Coakley et al., 2011). Our responsibilities as physicians caring for these patients include education regarding radiation risk and, when an investigation that utilizes ionizing radiation is required, to keep radiation doses as low as reasonably achievable: the “ALARA” principle. Recent advances in CT technology have facilitated substantial radiation dose reductions in many clinical settings, and several studies have demonstrated significantly decreased radiation doses in Crohn’s disease patients while maintaining diagnostic image quality. However, there is a balance to be struck between reducing radiation exposure and maintaining satisfactory image quality; if radiation dose is reduced excessively, the resulting CT images can be of poor quality and may be nondiagnostic. In this paper, we summarize the available evidence related to imaging of Crohn’s disease, radiation exposure, and risk, and we report recent advances in low-dose CT technology that have particular relevance.

scholarly journals SOME ISSUES OF LIFE ACTIVITIES OF POPULATION IN THE CHORNOBYL EXCLUSION ZONE IN UKRAINE

2021 ◽  
Vol 26 ◽  
pp. 141-161
Author(s):  
N. Gunko ◽  
◽  
O. Ivanova ◽  
K. Loganovsky ◽  
N. Korotkova ◽  
...  
Keyword(s):  
Power Plant ◽  
Nuclear Power Plant ◽  
Radiation Dose ◽  
Nuclear Power ◽  
Radiation Doses ◽  
Total Radiation ◽  
Exclusion Zone ◽  
Permanent Residence ◽  
Total Radiation Dose ◽  
Effective Radiation

Background. Radiation accidents at the Chornobyl Nuclear Power Plant (USSR, 1986) and Fukushima-1 (Japan, 2011) have shown that global environmental contamination is an intervention in normal human life making negative effect on population health. These accidents highlighted a number of statutory and regulatory both with medical and social problems for individuals, who returned voluntarily for permanent residence in the Chornobyl Exclusion Zone i.e. a radiation-hazardous area (they are named the «self-settlers»). Objective: generalization of experience in the settlement of normative-legal, ecological-dosimetric and medicosocial life issues of population living in the Chornobyl NPP (ChNPP) Exclusion Zone («self-settlers»). Object and methods. The chosen problem is complex, necessitating the generalization of radiation-hygienic, medical-biological, socio-economic, demographic and sociological research results obtained by the national and foreign authors. A set of theoretical research and analysis of empirical data methods on the principles of interdisciplinary interaction was used; the systematic, legal, economic, medical-biological, demographic and retrospective-dosimetric approaches of research were applied. Results. It was shown that a part of population refused to evacuate or had returned for permanent residence to the radiation-hazardous lands after the ChNPP accident. In 1986–2009 the number of «self-settlers» ranged from 150 to 2,000 in different years. In 2021 – the 101 people. Those were mainly people of working age, mostly females, single people or widows/widowers. Рrevious medical and dosimetric studies have shown that long-term residence in the Exclusion Zone affects physical and mental health of «self-settlers» and causes atypical aging, including involvement of the central nervous system. According to calculations, the average effective total radiation dose accumulated by «self-settlers» for the first 3 years was 30 % of dose for the entire post-accident period, and the dose accumulated over 20 years was 54 % of the dose accumulated over 35 years. But the effective radiation doses accumulated in different periods after the accident differ significantly in residents of different Exclusion Zone settlements. This information needs further study in terms of the «radiation dose - health status» dependence. Conclusions. The effective radiation doses accumulated in different periods after the accident differ significantly in the residents of different Exclusion Zone settlements. Тhe average effective total radiation dose accumulated by «self-settlers» for the first 3 years was 30 % of the dose for the entire post-accident period, and the dose accumulated over 20 years was 54 % of the dose accumulated over 35 years. The Scientific Council meeting of NAMS approved the NRCRM Annual Report. Key words: Chornobyl Nuclear Power Plant, Exclusion Zone, «self-settlers», radiation doses, health.

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