scholarly journals An Aging Focused Unobtrusive and Privacy-Preserving Digital Behaviorome

2021 ◽  
Author(s):  
Narayan Schuetz ◽  
Samuel E.J. Knobel ◽  
Angela Amira Botros ◽  
Michael Single ◽  
Bruno Pais ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Remote Monitoring ◽  
Fall Risk ◽  
Wearable Devices ◽  
Privacy Preserving ◽  
Late Life Depression ◽  
Outcome Assessments ◽  
Clinical Outcome Assessments ◽  
Digital Biomarkers

Digital measures are increasingly used as objective health measures in remote-monitoring settings. In addition to their use in purely clinical research, such as in clinical trials, one promising application area for sensor-derived digital measures is in technology-assisted ageing and ageing-related research. In this context, digital measures may be used to measure the risk of certain adverse events such as falls, and also to provide novel research insights into ageing and ageing-related conditions, like cognitive impairment. While major emphasis has been placed on deriving one or more digital measures from wearable devices, a more holistic approach inspired by systems biology that leverages large, non-exhaustive sets of digital measures may prove highly beneficial. Such an approach would be useful if combined with modern big data approaches like machine learning. As such, extensive sets of digital measures, which may be referred to as digital behavioromes, could help characterise new phenotypes in deep phenotyping efforts. These measures could also assist in the discovery of novel digital biomarkers or in the creation of digital clinical outcome assessments. While clinical research into digital measures focuses primarily on measures derived from wearable devices, proven technology used for long-term remote monitoring of older adults is generally contactless, unobtrusive, and privacy-preserving. In this context, we introduce and describe a digital behaviorome: a large, non-exhaustive set of digital measures based entirely on contactless, unobtrusive, and privacy-preserving sensor technologies. We also demonstrate how such a behaviorome can be used to build digital clinical outcome assessments that are relevant to ageing and derived from machine learning. These outcomes included fall risk, frailty, mild cognitive impairment, and late-life depression. With the exception of late-life depression, all digital outcome assessments demonstrated a promising ability (ROC AUC ≥ 0.7) to discriminate between positive and negative health outcomes, often in the range of comparable work with wearable devices. Finally, we highlight the possibility of using these digital behaviorome-based outcome assessments to discover novel potential digital biomarkers for each outcome. Here, we found reasonable contributors but also some potentially interesting new candidates regarding fall risk and mild cognitive impairment.

scholarly journals Detecting Mild Cognitive Impairment via Digital Biomarkers of Cognitive Performance Found in Klondike Solitaire: A Machine-Learning Study

2021 ◽  
pp. 44-52
Author(s):  
Karsten Gielis ◽  
Marie-Elena Vanden Abeele ◽  
Katrien Verbert ◽  
Jos Tournoy ◽  
Maarten De Vos ◽  
...  
Keyword(s):  
Machine Learning ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Performance ◽  
Vector Model ◽  
Gradient Boosting ◽  
Support Vector ◽  
Digital Biomarkers

Background: Mild cognitive impairment (MCI) is a condition that entails a slight yet noticeable decline in cognition that exceeds normal age-related changes. Older adults living with MCI have a higher chance of progressing to dementia, which warrants regular cognitive follow-up at memory clinics. However, due to time and resource constraints, this follow-up is conducted at separate moments in time with large intervals in between. Casual games, embedded into the daily life of older adults, may prove to be a less resource-intensive medium that yields continuous and rich data on a patient’s cognition. Objective: To explore whether digital biomarkers of cognitive performance, found in the casual card game Klondike Solitaire, can be used to train machine-learning models to discern games played by older adults living with MCI from their healthy counterparts. Methods: Digital biomarkers of cognitive performance were captured from 23 healthy older adults and 23 older adults living with MCI, each playing 3 games of Solitaire with 3 different deck shuffles. These 3 deck shuffles were identical for each participant. Using a supervised stratified, 5-fold, cross-validated, machine-learning procedure, 19 different models were trained and optimized for F1 score. Results: The 3 best performing models, an Extra Trees model, a Gradient Boosting model, and a Nu-Support Vector Model, had a cross-validated F1 training score on the validation set of ≥0.792. The F1 score and AUC of the test set were, respectively, >0.811 and >0.877 for each of these models. These results indicate psychometric properties comparative to common cognitive screening tests. Conclusion: The results suggest that commercial card games, not developed to address specific mental processes, may be used for measuring cognition. The digital biomarkers derived from Klondike Solitaire show promise and may prove useful to fill the current blind spot between consultations.

scholarly journals Identifying Fall Risk Predictors by Monitoring Daily Activities at Home Using a Depth Sensor Coupled to Machine Learning Algorithms

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 1957
Author(s):  
Amandine Dubois ◽  
Titus Bihl ◽  
Jean-Pierre Bresciani
Keyword(s):  
Machine Learning ◽  
Fall Prevention ◽  
Fall Risk ◽  
Learning Algorithms ◽  
Step Length ◽  
Machine Learning Algorithms ◽  
Daily Activities ◽  
Sitting Time ◽  
Behavioral Parameters ◽  
At Home

Because of population ageing, fall prevention represents a human, economic, and social issue. Currently, fall-risk is assessed infrequently, and usually only after the first fall occurrence. Home monitoring could improve fall prevention. Our aim was to monitor daily activities at home in order to identify the behavioral parameters that best discriminate high fall risk from low fall risk individuals. Microsoft Kinect sensors were placed in the room of 30 patients temporarily residing in a rehabilitation center. The sensors captured the patients’ movements while they were going about their daily activities. Different behavioral parameters, such as speed to sit down, gait speed or total sitting time were extracted and analyzed combining statistical and machine learning algorithms. Our algorithms classified the patients according to their estimated fall risk. The automatic fall risk assessment performed by the algorithms was then benchmarked against fall risk assessments performed by clinicians using the Tinetti test and the Timed Up and Go test. Step length, sit-stand transition and total sitting time were the most discriminant parameters to classify patients according to their fall risk. Coupling step length to the speed required to stand up or the total sitting time gave rise to an error-less classification of the patients, i.e., to the same classification as that of the clinicians. A monitoring system extracting step length and sit-stand transitions at home could complement the clinicians’ assessment toolkit and improve fall prevention.

scholarly journals Privacy Preserving Machine Learning with Homomorphic Encryption and Federated Learning

2021 ◽  
Vol 13 (4) ◽  
pp. 94
Author(s):  
Haokun Fang ◽  
Quan Qian
Keyword(s):  
Machine Learning ◽  
Homomorphic Encryption ◽  
Privacy Preserving ◽  
Great Success ◽  
Learning Framework ◽  
Computational Overhead ◽  
Important Concern ◽  
Speed Up ◽  
Key Length ◽  
Core Idea

Privacy protection has been an important concern with the great success of machine learning. In this paper, it proposes a multi-party privacy preserving machine learning framework, named PFMLP, based on partially homomorphic encryption and federated learning. The core idea is all learning parties just transmitting the encrypted gradients by homomorphic encryption. From experiments, the model trained by PFMLP has almost the same accuracy, and the deviation is less than 1%. Considering the computational overhead of homomorphic encryption, we use an improved Paillier algorithm which can speed up the training by 25–28%. Moreover, comparisons on encryption key length, the learning network structure, number of learning clients, etc. are also discussed in detail in the paper.

Machine Learning for the Prediction of Amyloid Positivity in Amnestic Mild Cognitive Impairment

2021 ◽  
pp. 1-15
Author(s):  
Sung Hoon Kang ◽  
Bo Kyoung Cheon ◽  
Ji-Sun Kim ◽  
Hyemin Jang ◽  
Hee Jin Kim ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Cross Validation ◽  
Good Accuracy ◽  
External Validation ◽  
Amnestic Mild Cognitive Impairment ◽  
Temporal Region ◽  
Apolipoprotein E Genotype

Background: Amyloid (Aβ) evaluation in amnestic mild cognitive impairment (aMCI) patients is important for predicting conversion to Alzheimer’s disease. However, Aβ evaluation through amyloid positron emission tomography (PET) is limited due to high cost and safety issues. Objective: We therefore aimed to develop and validate prediction models of Aβ positivity for aMCI using optimal interpretable machine learning (ML) approaches utilizing multimodal markers. Methods: We recruited 529 aMCI patients from multiple centers who underwent Aβ PET. We trained ML algorithms using a training cohort (324 aMCI from Samsung medical center) with two-phase modelling: model 1 included age, gender, education, diabetes, hypertension, apolipoprotein E genotype, and neuropsychological test scores; model 2 included the same variables as model 1 with additional MRI features. We used four-fold cross-validation during the modelling and evaluated the models on an external validation cohort (187 aMCI from the other centers). Results: Model 1 showed good accuracy (area under the receiver operating characteristic curve [AUROC] 0.837) in cross-validation, and fair accuracy (AUROC 0.765) in external validation. Model 2 led to improvement in the prediction performance with good accuracy (AUROC 0.892) in cross validation compared to model 1. Apolipoprotein E genotype, delayed recall task scores, and interaction between cortical thickness in the temporal region and hippocampal volume were the most important predictors of Aβ positivity. Conclusion: Our results suggest that ML models are effective in predicting Aβ positivity at the individual level and could help the biomarker-guided diagnosis of prodromal AD.

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