scholarly journals Quantitative T1-relaxation corrected metabolite mapping of 12 metabolites in the human brain at 9.4 T

2021 ◽  
Author(s):  
Andrew Martin Wright ◽  
Saipavitra Murali-Manohar ◽  
Anke Henning
Keyword(s):  
Magnetic Resonance ◽  
Imaging Modality ◽  
Relaxation Times ◽  
Magnetic Resonance Spectroscopic Imaging ◽  
Non Invasive ◽  
T1 Relaxation ◽  
Single Slice ◽  
Single Voxel ◽  
Quantitative Results ◽  
Correction Step

Magnetic resonance spectroscopic imaging (MRSI) is a non-invasive imaging modality that enables observation of metabolites. Applications of MRSI for neuroimaging applications has shown promise for monitoring and detecting various diseases. This study builds off previously developed techniques of short TR, 1H FID MRSI by correcting for T1-weighting of the metabolites and utilizing an internal water reference to produce quantitative (mmol kg-1) metabolite maps. This work reports and shows quantitative metabolite maps for 12 metabolites for a single slice. Voxel-specific T1-corrections for water are common in MRSI studies; however, most studies use either averaged T1-relaxation times to correct for T1-weighting of metabolites or omit this correction step entirely. This work employs the use of voxel-specific T1-corrections for metabolites in addition to water. Utilizing averaged T1-relaxation times for metabolites can bias metabolite maps for metabolites that have strong differences between T1-relaxation for GM and WM (i.e. Glu). This work systematically compares quantitative metabolite maps to single voxel quantitative results and qualitatively compares metabolite maps to previous works.

Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia

2005 ◽  
Vol 20 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Filip Spaniel ◽  
Vit Herynek ◽  
Tomas Hajek ◽  
Monika Dezortova ◽  
Jiri Horacek ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Globus Pallidus ◽  
Relaxation Times ◽  
Monozygotic Twins ◽  
T2 Relaxation ◽  
T1 Relaxation ◽  
Significant Prolongation ◽  
Healthy Control ◽  
Genetic Loading ◽  
Mz Twins

AbstractT1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins.

Magnetic resonance imaging T1 relaxation times for the liver, pancreas and spleen in healthy children at 1.5 and 3 tesla

2019 ◽  
Vol 49 (8) ◽  
pp. 1018-1024 ◽  
Author(s):  
Leah A. Gilligan ◽  
Jonathan R. Dillman ◽  
Jean A. Tkach ◽  
Stavra A. Xanthakos ◽  
Jacqueline K. Gill ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
3 Tesla ◽  
Healthy Children ◽  
Resonance Imaging ◽  
T1 Relaxation

Gadolinium-DTPA Enhancement of Experimental Soft Tissue Carcinoma and Hemorrhage in Magnetic Resonance Imaging

1987 ◽  
Vol 28 (1) ◽  
pp. 75-78 ◽  
Author(s):  
H. Pettersson ◽  
N. Ackerman ◽  
J. Kaude ◽  
R. E. Googe ◽  
A. A. Mancuso ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Body Weight ◽  
Magnetic Resonance ◽  
Tumor Tissue ◽  
Soft Tissues ◽  
Relaxation Times ◽  
Resonance Imaging ◽  
Benign Lesions ◽  
Gadolinium Dtpa ◽  
T1 Relaxation

An experimental series in the rabbit was performed to test gadolinium-DTPA (Gd-DTPA) enhancement of VX-2 carcinoma and hemorrhages induced in the soft tissues. The recognition of both malignant and benign lesions was greatly facilitated on T1 weighted images after intravenous administration of 0.3 mmol Gd-DTPA/kg body weight because of reduced T1 relaxation times. Gd-DTPA enhancement reached its maximum after 10–15 minutes and was most apparent in tumor tissue, connective tissue surrounding the tumor and in the area of fresh hemorrhage.

Non Invasive Quantification of Manganese Deposits in the Rat Brain by Local Measurement of NMR Proton T1 Relaxation Times

2001 ◽  
Vol 22 (3) ◽  
pp. 387-392 ◽  
Author(s):  
Bernard Gallez ◽  
Roger Demeure ◽  
Christine Baudelet ◽  
Nadia Abdelouahab ◽  
Nelson Beghein ◽  
...  
Keyword(s):  
Rat Brain ◽  
Relaxation Times ◽  
Local Measurement ◽  
Non Invasive ◽  
T1 Relaxation ◽  
Manganese Deposits

scholarly journals Recent advances in cardiac magnetic resonance

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2253 ◽  
Author(s):  
Simon Greulich ◽  
Andrew E. Arai ◽  
Udo Sechtem ◽  
Heiko Mahrholdt
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Tissue Characterization ◽  
Imaging Modality ◽  
T2 Mapping ◽  
Diffuse Fibrosis ◽  
Myocardial Tissue ◽  
Clinical Tool ◽  
Clinical Routine ◽  
Non Invasive

Cardiac magnetic resonance (CMR) is a non-invasive imaging modality that has rapidly emerged during the last few years and has become a valuable, well-established clinical tool. Beside the evaluation of anatomy and function, CMR has its strengths in providing detailed non-invasive myocardial tissue characterization, for which it is considered the current diagnostic gold standard. Late gadolinium enhancement (LGE), with its capability to detect necrosis and to separate ischemic from non-ischemic cardiomyopathies by distinct LGE patterns, offers unique clinical possibilities. The presence of LGE has also proven to be a good predictor of an adverse outcome in various studies. T2-weighted (T2w) images, which are supposed to identify areas of edema and inflammation, are another CMR approach to tissue characterization. However, T2w images have not held their promise owing to several technical limitations and potential physiological concerns. Newer mapping techniques may overcome some of these limitations: they assess quantitatively myocardial tissue properties in absolute terms and show promising results in studies for characterization of diffuse fibrosis (T1 mapping) and/or inflammatory processes (T2 mapping). However, these techniques are still research tools and are not part of the clinical routine yet. T2* CMR has had significant impact in the management of thalassemia because it is possible to image the amount of iron in the heart and the liver, improving both diagnostic imaging and the management of patients with thalassemia. CMR findings frequently have clinical impact on further patient management, and CMR seems to be cost effective in the clinical routine.

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