scholarly journals Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users

2022 ◽  
Author(s):  
Ann-Kathrin Kexel ◽  
Bruno Kluwe-Schiavon ◽  
Markus R. Baumgartner ◽  
Etna J. E. Engeli ◽  
Monika Visentini ◽  
...  
Keyword(s):  
Stress Response ◽  
Psychosocial Stress ◽  
Social Stress ◽  
Acute Stress ◽  
Physiological Stress ◽  
Growth Models ◽  
Stress Test ◽  
Trier Social Stress Test ◽  
Chronic Cocaine ◽  
Cocaine Users

There is evidence that stress and craving contribute to the development, maintenance, and relapse in cocaine use disorder. Previous research has shown altered physiological responses to psychosocial stress as well as increased vegetative responding to substance-related cues in chronic cocaine users (CU). However, how psychosocial stress and cue-induced craving interact in relation to the physiological response of CU is largely unknown. Therefore, we investigated the interaction between acute psychosocial stress and cocaine-cue-related reactivity in 47 CU and 38 controls. Participants were randomly exposed first to a video-based cocaine-cue paradigm and second to the Trier Social Stress Test (TSST) or vice versa in a crossed and balanced design to investigate possible mutually augmenting effects of both stressors on the physiological stress response. Plasma cortisol, ACTH, and noradrenaline as well as subjective stress and craving were assessed repeatedly over the course of the experimental procedure. Growth models and discontinuous growth models were used to estimate the responses during the cocaine-cue paradigm and TSST. Overall, both groups did not differ in their endocrinological responses to the TSST but CU displayed lower ACTH levels at baseline. The TSST did not elevate craving in CU. However, if the cocaine-cue video was shown first, CU displayed an enhanced cortisol response to the subsequent TSST. Cocaine-cues robustly evoked craving in CU but no stress response, while cue-induced craving was intensified after the TSST. Taken together, CU did not show an altered acute stress response during the TSST but stress and craving together seem to have mutually augmenting effects on their stress response.

scholarly journals Does Psychosocial Stress Impact Cognitive Reappraisal? Behavioral and Neural Evidence

2017 ◽  
Vol 29 (11) ◽  
pp. 1803-1816 ◽  
Author(s):  
Maheen Shermohammed ◽  
Pranjal H. Mehta ◽  
Joan Zhang ◽  
Cassandra M. Brandes ◽  
Luke J. Chang ◽  
...  
Keyword(s):  
Heart Rate ◽  
Psychosocial Stress ◽  
Social Stress ◽  
Acute Stress ◽  
Stress Test ◽  
Cognitive Reappraisal ◽  
Self Report ◽  
Trier Social Stress Test ◽  
Control Group ◽  
Stress Group

Cognitive reappraisal (CR) is regarded as an effective emotion regulation strategy. Acute stress, however, is believed to impair the functioning of prefrontal-based neural systems, which could result in lessened effectiveness of CR under stress. This study tested the behavioral and neurobiological impact of acute stress on CR. While undergoing fMRI, adult participants ( n = 54) passively viewed or used CR to regulate their response to negative and neutral pictures and provided ratings of their negative affect in response to each picture. Half of the participants experienced an fMRI-adapted acute psychosocial stress manipulation similar to the Trier Social Stress Test, and a control group received parallel manipulations without the stressful components. Relative to the control group, the stress group exhibited heightened stress as indexed by self-report, heart rate, and salivary cortisol throughout the scan. Contrary to our hypothesis, we found that reappraisal success was equivalent in the control and stress groups, as was electrodermal response to the pictures. Heart rate deceleration, a physiological response typically evoked by aversive pictures, was blunted in response to negative pictures and heightened in response to neutral pictures in the stress group. In the brain, we found weak evidence of stress-induced increases of reappraisal-related activity in parts of the PFC and left amygdala, but these relationships were statistically fragile. Together, these findings suggest that both the self-reported and neural effects of CR may be robust to at least moderate levels of stress, informing theoretical models of stress effects on cognition and emotion.

scholarly journals The impact of maternal care and blood glucose availability on the cortisol stress response in fasted women

2021 ◽  
Author(s):  
Ulrike U. Bentele ◽  
Maria Meier ◽  
Annika B. E. Benz ◽  
Bernadette F. Denk ◽  
Stephanie J. Dimitroff ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Stress Response ◽  
Maternal Care ◽  
Social Stress ◽  
Acute Stress ◽  
Blood Glucose Concentration ◽  
Stress Test ◽  
Trier Social Stress Test ◽  
The Impact ◽  
Glucose Availability

AbstractIndividuals with a history of low maternal care (MC) frequently present a blunted, yet sometimes also show an increased cortisol stress response. Fasted individuals with low blood glucose levels who are exposed to acute stress typically show an attenuated response pattern in this endocrine marker. Despite well-documented metabolic dysregulations after low MC, a possible interaction of both factors has not been investigated yet. Here, we examined the effects of MC and blood glucose concentration on various aspects of the stress response. Fasted women (N = 122, meanage = 22.12, sdage = 2.56) who experienced either very high, high, or low MC (based on the Parental Bonding Instrument) were randomly assigned to consume grape juice (condition sugar), or water (condition water) prior to being exposed to the Trier-Social-Stress-Test for groups. Salivary cortisol and alpha amylase, blood glucose, and mood ratings were assessed repeatedly. Using multilevel mixed models, we replicated the boosting effect of glucose on the cortisol stress response. While we found neither an effect of MC, nor an interaction between MC and blood glucose availability on the cortisol stress response, we observed an effect of MC on the amylase stress response. We discuss the results in the light of links between various stress/energy systems that possibly mediate health-related MC effects.

scholarly journals Evaluating the inoculation effect of music on stress reactivity in healthy young and older adults: the moderating role of music absorption

2021 ◽  
Author(s):  
Katlyn J. Peck
Keyword(s):  
Older Adults ◽  
Stress Response ◽  
White Noise ◽  
Social Stress ◽  
Stress Reactivity ◽  
Acute Stress ◽  
Stress Test ◽  
Self Report ◽  
Trier Social Stress Test ◽  
Music Listening

Chronic exposure to stress at any age is associated with a myriad of negative physiological and psychological consequences, and as such, development of effective low-cost and non-invasive stress reduction interventions are important. Music listening has been shown to promote faster physiological recovery from acute stress. However, there is a paucity of research examining the potential inoculation effect of music on stress reactivity, as well as potential modifier’s that may influence this effect such as music selection and music absorption. Hence, the current study examined the potential inoculation effect of music in response to acute stress, as measured by a comprehensive set of stress indices. It was hypothesized that listening to music prior to acute stress exposure would decrease stress reactivity compared to white noise (WN), and that self-selected music (SSM) would serve as a stronger inoculator than researcher-selected music (RSM). Finally, it was hypothesized that music absorption would moderate the inoculation effect of music, with a greater decrease in stress reactivity observed in high absorbers. Exploratory sub-groups analyses were also performed to examine any potential age differences in the aforementioned associations. Participants were randomly assigned to either RSM (n = 37), SSM (n = 38), or a WN group (n = 33) and listened to either music or white noise prior to undergoing the Trier Social Stress Test (TSST). Outcome indices of stress included skin conductance, heart rate, salivary cortisol and self-report affect. Mixed analyses of covariance showed that music listening did not inoculate the stress response compared with WN and SSM did not serve as a more effective inoculator than RSM. A main effect of music absorption was found, suggesting that high absorbers are more reactive than low absorbers. Although the study hypotheses were not supported, exploratory sub-group analyses in older adults suggest that music listening and absorption may modulate the stress response. This study provides new insight into the effect of music listening on stress reactivity and presents a new line of questions that require further investigation.

scholarly journals Evaluating the inoculation effect of music on stress reactivity in healthy young and older adults: the moderating role of music absorption

2021 ◽  
Author(s):  
Katlyn J. Peck
Keyword(s):  
Older Adults ◽  
Stress Response ◽  
White Noise ◽  
Social Stress ◽  
Stress Reactivity ◽  
Acute Stress ◽  
Stress Test ◽  
Self Report ◽  
Trier Social Stress Test ◽  
Music Listening

Chronic exposure to stress at any age is associated with a myriad of negative physiological and psychological consequences, and as such, development of effective low-cost and non-invasive stress reduction interventions are important. Music listening has been shown to promote faster physiological recovery from acute stress. However, there is a paucity of research examining the potential inoculation effect of music on stress reactivity, as well as potential modifier’s that may influence this effect such as music selection and music absorption. Hence, the current study examined the potential inoculation effect of music in response to acute stress, as measured by a comprehensive set of stress indices. It was hypothesized that listening to music prior to acute stress exposure would decrease stress reactivity compared to white noise (WN), and that self-selected music (SSM) would serve as a stronger inoculator than researcher-selected music (RSM). Finally, it was hypothesized that music absorption would moderate the inoculation effect of music, with a greater decrease in stress reactivity observed in high absorbers. Exploratory sub-groups analyses were also performed to examine any potential age differences in the aforementioned associations. Participants were randomly assigned to either RSM (n = 37), SSM (n = 38), or a WN group (n = 33) and listened to either music or white noise prior to undergoing the Trier Social Stress Test (TSST). Outcome indices of stress included skin conductance, heart rate, salivary cortisol and self-report affect. Mixed analyses of covariance showed that music listening did not inoculate the stress response compared with WN and SSM did not serve as a more effective inoculator than RSM. A main effect of music absorption was found, suggesting that high absorbers are more reactive than low absorbers. Although the study hypotheses were not supported, exploratory sub-group analyses in older adults suggest that music listening and absorption may modulate the stress response. This study provides new insight into the effect of music listening on stress reactivity and presents a new line of questions that require further investigation.

An intervention study on the effectiveness of an anti-stress-app on psychophysiological acute and chronic stress (Preprint)

2018 ◽  
Author(s):  
Franziska Lautenbach
Keyword(s):  
Chronic Stress ◽  
Acute Stress ◽  
Physiological Stress ◽  
Stress Test ◽  
Experimental Studies ◽  
Trier Social Stress Test ◽  
Control Group ◽  
Subjective Perception ◽  
Face To Face ◽  
Acute And Chronic Stress

BACKGROUND Dealing with stress is of central importance. Lately, smartphone applications (apps) are deployed in stress interventions as they offer maximal flexibility for users. First results of experimental studies show that anti-stress apps effect subjective perception of stress positively (Ly et al., 2014). However, current literature lacks studies on physiological stress reactions (e.g., cortisol), although they are of special interest to health issues. OBJECTIVE Therefore, the aim of this study was to investigate the effectiveness of an anti-stress app in chronic and acute stress reduction on a physiological (cortisol) and psychological level (subjective perception of stress) in comparison to a face-to-face and a control group in a pre-post design, for the first time. METHODS Sixty-two participants took part in the pretesting procedure (drop-out of 53 %). Based on age, gender, physical activity and subjectively perceived acute stress due to the Trier Social Stress Test for groups (TSST-G; von Dawans et al., 2011) as well as based on subjectively chronic stress assessed during the pretest, participants were parallelized in three groups (anti-stress-app: n = 10, face-to-face: n = 11, control group: n = 9). RESULTS After six weeks of the cognitive-based resource-oriented intervention, participants were exposed to the TSST-G for post testing. Results did not show a change of cortisol secretion or cognitive appraisal of the acute stressor. Further, no changes were detected in the chronic physiological stress reaction. CONCLUSIONS Possible causes are discussed extensively. CLINICALTRIAL no

A Virtual Reality Version of the Trier Social Stress Test: A Pilot Study

2011 ◽  
Vol 20 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Mattias Wallergård ◽  
Peter Jönsson ◽  
Gerd Johansson ◽  
Björn Karlson
Keyword(s):  
Virtual Reality ◽  
Stress Response ◽  
Pilot Study ◽  
Social Stress ◽  
Stress Test ◽  
Structured Interview ◽  
Trier Social Stress Test ◽  
Physiological Data ◽  
Virtual Humans ◽  
Arithmetic Task

One of the most common methods of inducing stress in the laboratory in order to examine the stress response in healthy and clinical populations is the Trier Social Stress Test (TSST). Briefly, the participant is asked to deliver a speech and to perform an arithmetic task in front of an evaluating committee. The committee, consisting of three trained actors, does not respond emotionally during the test, which makes the situation very stressful for the participant. One disadvantage of the TSST is that it can be difficult to hold the experimental conditions constant. In particular, it may be difficult for actors to hold their acting constant across all sessions. Furthermore, there are several practical problems and costs associated with hiring professional actors. A computerized version of the TSST using virtual humans could be a way to avoid these problems provided that it is able to induce a stress response similar to the one of the original TSST. The purpose of the present pilot study was therefore to investigate the stress response to a virtual reality (VR) version of the TSST visualized using an immersive VR system (VR-TSST). Seven healthy males with an average age of 24 years (range: 23–26 years) performed the VR-TSST. This included delivering a speech and performing an arithmetic task in front of an evaluating committee consisting of three virtual humans. The VR equipment was a CAVE equipped with stereoscopy and head tracking. ECG and respiration were recorded as well as the participant's behavior and comments. Afterward, a semi-structured interview was carried out. In general, the subjective and physiological data from the experiment indicated that the VR version of the TSST induced a stress response in the seven participants. In particular, the peak increase in heart rate was close to rates observed in studies using the traditional TSST with real actors. These results suggest that virtual humans visualized with an immersive VR system can be used to induce stress under laboratory conditions.

scholarly journals The brain’s hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers

2018 ◽  
Vol 115 (43) ◽  
pp. E10206-E10215 ◽  
Author(s):  
Immanuel G. Elbau ◽  
Benedikt Brücklmeier ◽  
Manfred Uhr ◽  
Janine Arloth ◽  
Darina Czamara ◽  
...  
Keyword(s):  
Stress Response ◽  
Response Function ◽  
Genetic Variants ◽  
Psychosocial Stress ◽  
Acute Stress ◽  
Physiological Stress ◽  
Hemodynamic Response ◽  
Hemodynamic Response Function ◽  
Ample Evidence ◽  
Acute Psychosocial Stress

Ample evidence links dysregulation of the stress response to the risk for psychiatric disorders. However, we lack an integrated understanding of mechanisms that are adaptive during the acute stress response but potentially pathogenic when dysregulated. One mechanistic link emerging from rodent studies is the interaction between stress effectors and neurovascular coupling, a process that adjusts cerebral blood flow according to local metabolic demands. Here, using task-related fMRI, we show that acute psychosocial stress rapidly impacts the peak latency of the hemodynamic response function (HRF-PL) in temporal, insular, and prefrontal regions in two independent cohorts of healthy humans. These latency effects occurred in the absence of amplitude effects and were moderated by regulatory genetic variants of KCNJ2, a known mediator of the effect of stress on vascular responsivity. Further, hippocampal HRF-PL correlated with both cortisol response and genetic variants that influence the transcriptional response to stress hormones and are associated with risk for major depression. We conclude that acute stress modulates hemodynamic response properties as part of the physiological stress response and suggest that HRF indices could serve as endophenotype of stress-related disorders.

scholarly journals The impact of chronic stress and eating types on active ghrelin levels in response to acute stress

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Christine Fahrngruber ◽  
Kalina Duszka ◽  
Jürgen König
Keyword(s):  
Chronic Stress ◽  
Eating Behavior ◽  
Social Stress ◽  
Acute Stress ◽  
Stress Test ◽  
Primary Objective ◽  
Trier Social Stress Test ◽  
Relaxation Techniques ◽  
Stress Exposure ◽  
The Impact

AbstractChronic stress is associated with impacting eating behavior, namely food choice and energy intake, with a shift towards more palatable and energy dense foods. Additionally, eating behavior is influenced by other psychological factors like mood and emotions. The categorization of people into eating types such as restrained, emotional, and external eaters has gained attraction. Reported changes in eating behavior due to psychological stress are only occasionally accompanied by measures of physiological hunger through ghrelin. The primary objective of this study was to investigate how chronic stress and acute cortisol reactivity affect active ghrelin secretion and how these outcomes account for different eating types. 16 healthy, young males (age: 23 ± 3 years, BMI: 22.5 ± 1.3kg/m2) with low (n = 8) and average-to-high (n = 8) chronic stress level were subjected to the Trier Social Stress Test (TSST) and a control version on two separate days. Active ghrelin, cortisol, glucose, and heart rate were measured throughout the test. Subjects rated their hunger by means of visual analog scale and current mood was assessed with the Positive and Negative Affect Scale (PANAS). In addition, participants filled out the Dutch Eating Behavior Questionnaire (DEBQ) to account for their subjective eating behavior. Overall ghrelin values where higher on the test day compared to the control day. Ghrelin values were also higher during the time leading up to the stress or control test (TSST) than during the conclusion of said tests. On both days, mean values for active ghrelin where higher in individuals with low chronic stress exposure compare to those with average-to-high chronic stress exposure. While values from test to control day decreased for lower stressed participants, they slightly increased for higher stressed participants. Cortisol responders displayed higher ghrelin values on test day than cortisol non-responders, but this association inverted for the control day. Results indicate that chronic stress influences acute stress response and further alters active ghrelin production, which in turn can influence eating behavior. Replication in a greater group of participants of differing weight and sex could yield a greater understanding of stress induced eating. Factors such as relaxation techniques and coping mechanisms could further improve our knowledge and evaluate treatment possibilities.

Meta-analysis of the effectiveness of the Trier Social Stress Test in eliciting physiological stress responses in children and adolescents

2020 ◽  
Vol 116 ◽  
pp. 104582 ◽  
Author(s):  
Jessica A. Seddon ◽  
Violeta J. Rodriguez ◽  
Yannick Provencher ◽  
Jacquelyn Raftery-Helmer ◽  
Jacqueline Hersh ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Stress Responses ◽  
Social Stress ◽  
Physiological Stress ◽  
Meta Analysis ◽  
Stress Test ◽  
Trier Social Stress Test

scholarly journals Kinetics and Interrelations of the Renin Aldosterone Response to Acute Psychosocial Stress: A Neglected Stress System

2019 ◽  
Vol 105 (3) ◽  
pp. e762-e773 ◽  
Author(s):  
Angelina Gideon ◽  
Christine Sauter ◽  
Judy Fieres ◽  
Thilo Berger ◽  
Britta Renner ◽  
...  
Keyword(s):  
Psychosocial Stress ◽  
Social Stress ◽  
Stress Test ◽  
Plasma Aldosterone ◽  
Trier Social Stress Test ◽  
Control Group ◽  
Placebo Control ◽  
Stress System ◽  
Stress Induction ◽  
Acute Psychosocial Stress

Abstract Context The renin-angiotensin-aldosterone system (RAAS) plays an important role in cardiovascular homeostasis and its dysfunction relates to negative health consequences. Acute psychosocial stress seems to activate the RAAS in humans, but stress kinetics and interrelations of RAAS parameters compared with a nonstress control group remain inconclusive. Objective We systematically investigated in a randomized placebo-controlled design stress kinetics and interrelations of the reactivity of RAAS parameters measured in plasma and saliva to standardized acute psychosocial stress induction. Methods 58 healthy young men were assigned to either a stress or a placebo control group. The stress group underwent the Trier Social Stress Test (TSST), while the control group underwent the placebo TSST. We repeatedly assessed plasma renin, and plasma and salivary aldosterone before and up to 3 hours after stress/placebo. We simultaneously assessed salivary cortisol to validate successful stress induction and to test for interrelations. Results Acute psychosocial stress induced significant increases in all endocrine measures compared with placebo-stress (all P ≤ .041). Highest renin levels were observed 1 minute after stress, and highest aldosterone and cortisol levels 10 and 20 minutes after stress, with salivary aldosterone starting earlier at 1 minute after stress. Renin completed recovery at 10 minutes, cortisol at 60 minutes, salivary aldosterone at 90 minutes, and plasma aldosterone at 180 minutes after stress. Stress increase scores of all endocrine measures related to each other, as did renin and cortisol areas under the curve with respect to increase (AUCi) and salivary and plasma aldosterone AUCi (all P ≤ .047). Conclusions Our findings suggest that in humans acute psychosocial stress induces a differential and interrelated RAAS parameter activation pattern. Potential implications for stress-related cardiovascular risk remain to be elucidated.

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