scholarly journals Ocular vestibular evoked myogenic potential (VEMP) reveals subcortical HTLV-1-associated neurological disease

2019 ◽  
Author(s):  
Tatiana Rocha Silva ◽  
Marco Aurélio Rocha Santos ◽  
Luciana Macedo de Resende ◽  
Ludimila Labanca ◽  
Rafael Teixeira Scoralick Dias ◽  
...  
Keyword(s):  
Neurological Disease ◽  
Evoked Potential ◽  
Hearing Level ◽  
Vestibular Evoked Myogenic Potential ◽  
Asymptomatic Group ◽  
Cross Sectional ◽  
Recording Time ◽  
Ocular Vemp ◽  
Human T Cell ◽  
Cervical Vemp

AbstractIntroductionVestibular Myogenic Evoked Potential (VEMP) evaluates vestibulo-ocular and vestibulospinal reflexes associated with posture.PurposeTo compare cervical and ocular VEMP in individuals with HTLV-1 associated myelopathy (HAM) and with HTLV-1-asymptomatic infection.Materials and MethodsThis cross-sectional study included 52 HTLV-1-infected individuals (26 HAM and 26 asymptomatic carriers) and 26 negative controls. The groups were similar regarding age and gender. Participants underwent ocular and cervical VEMP that were performed simultaneously. The stimulus used to generate VEMP was a sound, low-frequency toneburst, intensity of 120 decibels normalized hearing level (dB nHL), bandpass filter from 10 to 1,500 Hz, with 100 stimuli at 500 Hertz (Hz) and 50 milliseconds (ms) recording time. An alteration in the electrophysiological waves P13 and N23 for cervical VEMP and N10 and P15 waves for ocular VEMP was compared between groups.ResultsCervical VEMP was different among the groups for P13 (p=0.001) and N23 (p=0.003). Ocular VEMP was similar for N10 (p=0.375) and different for P15 (p=0.000). In the HTLV-1-asymptomatic group, 1(3.8%) individual presented changes in both ocular and cervical VEMP, while in HAM group, 16(61.5%) presented changes in both tests.ConclusionNeurological impairment in HAM was not restricted to the spinal cord. The mesencephalic and thalamic connections, tested by ocular VEMP, were also altered. Damage of the oculomotor system, responsible for eye stabilization during head and body movements, may explain why dizziness is such a frequent complaint in HAM.Authors’ summaryHuman T-cell lymphotropic virus type 1 (HTLV-1) infection is endemic in Brazil and can cause HTLV-1-associated myelopathy (HAM). This neurological disease progresses slowly and, within ten years after its onset, can confine the patient to a wheelchair. Changes in HAM inflammatory characteristics can subsequently occur in the cortex, subcortical white matter, cerebellum, and brainstem. In the present study, we used the electrophysiological test Vestibular Myogenic Evoked Potential (VEMP) to evaluate the thalamic, brainstem, and spinal neural connections. This test evaluates the peripheral and the central vestibular pathway and has been used to test the postural reflexes involved in the control of one’s balance. The VEMP from the oculomotor muscles demonstrated that a subcortical impairment occurs in HAM and can also occur in the asymptomatic phase of HTLV-1 infection.

Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease

2017 ◽  
Vol 22 (3) ◽  
pp. 190-195 ◽  
Author(s):  
Keishi Fujiwara ◽  
Shinya Morita ◽  
Kimiko Hoshino ◽  
Atsushi Fukuda ◽  
Yuji Nakamaru ◽  
...  
Keyword(s):  
Autoimmune Disorder ◽  
University Hospital ◽  
Caloric Test ◽  
Subjective Symptoms ◽  
Vestibular Evoked Myogenic Potential ◽  
Caloric Testing ◽  
Ocular Vemp ◽  
Cervical Vemp ◽  
Vestibular Symptoms ◽  
Vkh Disease

Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Subjective symptoms such as dizziness or vertigo and the results of various vestibular examinations including nystagmus testing, caloric testing, and vestibular-evoked myogenic potential (VEMP) testing were investigated. Eight of 42 patients (19.0%) complained of subjective vestibular symptoms. On the other hand, 12 of 28 patients (42.9%) showed nystagmus, and 7 of 15 patients (46.7%) showed unilateral or bilateral weakness in the caloric test. VEMP testing was performed for 16 patients. Seven (43.8%) and 8 (50.0%) patients were evaluated as abnormal in cervical VEMP and ocular VEMP testing, respectively. The rate of detection of nystagmus was significantly higher than that of subjective symptoms. As vestibular dysfunction in patients with VKH disease cannot be detected through history taking alone, nystagmus testing, caloric testing, and VEMP testing should be performed to evaluate vestibular functions associated with VKH disease. It is considered that abnormal VEMP findings are associated with otolith organ dysfunction.

scholarly journals Diagnostic capabilities of the vestibular evoked myogenic potential test in children with vestibular dysfunction

2020 ◽  
Vol 6 (4) ◽  
pp. 606 ◽  
Author(s):  
Kalina I. Madzharova ◽  
Ana P. Beshkova
Keyword(s):  
Vestibular Dysfunction ◽  
Otolith Organs ◽  
Vestibular Evoked Myogenic Potential ◽  
Additional Method ◽  
Analysis And Evaluation ◽  
Myogenic Potential ◽  
Ocular Vemp ◽  
Cervical Vemp ◽  
Diagnostic Capabilities

<p class="abstract"><strong>Background:</strong> Vestibular evoked myogenic potential (VEMP) testing is used in the diagnosis of vestibular disorders. It is an objective method for testing the the otolith organs of the vestibular system. VEMP test is an additional method for diagnosing vestibular neuritis (VN). The combination of cervical VEMP (cVEMP) and ocular VEMP (oVEMP) testing has an advantage in long-term monitoring of patients with VN. The VEMP test is well-studied for adults but studies involving children are insufficient. The aim of this study was to analysis and evaluation of the results from VEMP testing of children diagnosed with vestibular dysfunction. Analysis and evaluation of the results from VEMP testing of children diagnosed with vestibular dysfunction.</p><p class="abstract"><strong>Methods:</strong> History, examination of ENT organs, tone threshold audiometry, tympanometry, otoneurological examination, VEMP test.  </p><p class="abstract"><strong>Results:</strong> Children with vestibular dysfunction who were examined showed changes predominantly in the oVEMP test. The upper branch of the vestibular nerve is affected.   </p><p class="abstract"><strong>Conclusions:</strong> The VEMP test is an additional method for diagnosing patients with vestibular dysfunction. It is safe when used for children.</p>

scholarly journals The Aging Slow Wave: A Shifting Amalgam of Distinct Slow Wave and Spindle Coupling Subtypes Define Slow Wave Sleep Across the Human Lifespan

SLEEP ◽  
2021 ◽  
Author(s):  
Brice V McConnell ◽  
Eugene Kronberg ◽  
Peter D Teale ◽  
Stefan H Sillau ◽  
Grace M Fishback ◽  
...  
Keyword(s):  
Slow Wave ◽  
Neurological Disease ◽  
Mixed Model ◽  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Slow Waves ◽  
Cross Sectional ◽  
Relative Contribution ◽  
Human Lifespan ◽  
Development And Aging

Abstract Study Objectives Slow wave and spindle coupling supports memory consolidation, and loss of coupling is linked with cognitive decline and neurodegeneration. Coupling is proposed to be a possible biomarker of neurological disease, yet little is known about the different subtypes of coupling that normally occur throughout human development and aging. Here we identify distinct subtypes of spindles within slow wave upstates and describe their relationships with sleep stage across the human lifespan. Methods Coupling within a cross-sectional cohort of 582 subjects was quantified from stages N2 and N3 sleep across ages 6-88 years old. Results were analyzed across the study population via mixed model regression. Within a subset of subjects, we further utilized coupling to identify discrete subtypes of slow waves by their coupled spindles. Results Two different subtypes of spindles were identified during the upstates of (distinct) slow waves: an “early-fast” spindle, more common in stage N2 sleep, and a “late-fast” spindle, more common in stage N3. We further found stages N2 and N3 sleep contain a mixture of discrete subtypes of slow waves, each identified by their unique coupled-spindle timing and frequency. The relative contribution of coupling subtypes shifts across the human lifespan, and a deeper sleep phenotype prevails with increasing age. Conclusions Distinct subtypes of slow waves and coupled spindles form the composite of slow wave sleep. Our findings support a model of sleep-dependent synaptic regulation via discrete slow wave/spindle coupling subtypes and advance a conceptual framework for the development of coupling-based biomarkers in age-associated neurological disease.

Pain, psychoaffective symptoms, and quality of life in human T cell lymphotropic virus type 1 (HTLV-1): a cross-sectional study

2021 ◽  
Author(s):  
Dislene Nascimento dos Santos ◽  
Katia Nunes Sá ◽  
Fernanda C. Queirós ◽  
Alaí Barbosa Paixão ◽  
Kionna Oliveira Bernardes Santos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
T Cell ◽  
Virus Type ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Human T Cell

scholarly journals The importance of central auditory evaluation in Friedreich's ataxia

2018 ◽  
Vol 76 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Bianca Simone Zeigelboim ◽  
Hélio A. G. Teive ◽  
Michèlli Rodrigues da Rosa ◽  
Jéssica Spricigo Malisky ◽  
Vinicius Ribas Fonseca ◽  
...  
Keyword(s):  
Pure Tone ◽  
Evoked Potential ◽  
Pure Tone Audiometry ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Auditory Evoked Potential ◽  
Acoustic Reflex ◽  
Cross Sectional ◽  
Significant Difference ◽  
Central Auditory Function

ABSTRACT Objective To assess central auditory function in Friedreich's ataxia. Methods A cross-sectional, retrospective study was carried out. Thirty patients underwent the anamnesis, otorhinolaryngology examination, pure tone audiometry, acoustic immittance measures and brainstem auditory evoked potential (BAEP) assessments. Results The observed alterations were: 43.3% in the pure tone audiometry, bilateral in 36.7%; 56.6% in the BAEP test, bilateral in 50%; and 46.6% in the acoustic immittance test. There was a significant difference (p < 0.05) in the comparison between the tests performed. Conclusion In the audiological screening, there was a prevalence of the descending audiometric configuration at the frequency of 4kHz, and absence of the acoustic reflex at the same frequency. In the BAEP test, there was a prevalence of an increase of the latencies in waves I, III and V, and in the intervals of interpeaks I-III, I-V and III-V. In 13.3% of the patients, wave V was absent, and all waves were absent in 3.3% of patients.

Vestibular-Evoked Myogenic Potential (VEMP) to Evaluate Cervical Myelopathy in Human T-Cell Lymphotropic Virus Type I Infection

Spine ◽  
2008 ◽  
Vol 33 (11) ◽  
pp. 1180-1184 ◽  
Author(s):  
Lilian Felipe ◽  
Denise Utsch Gonçalves ◽  
Marco Aurélio Rocha Santos ◽  
Fernando Augusto Proietti ◽  
João Gabriel Ramos Ribas ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Cervical Myelopathy ◽  
Type I ◽  
Vestibular Evoked Myogenic Potential ◽  
Myogenic Potential ◽  
Human T Cell

scholarly journals NO EVIDENCE OF OSTEOPOROSIS IN YOUNG HTLV-1-INFECTED CARRIERS

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Antonio Carlos Silva Santos ◽  
Ney Boa Sorte ◽  
Carolina Carneiro de Campos ◽  
Sandra Rocha Gadelha ◽  
Maria Fernanda Rios Grassi ◽  
...  
Keyword(s):  
Spastic Paraparesis ◽  
Cross Sectional Study ◽  
Z Score ◽  
Mineral Density ◽  
Aged Patients ◽  
Cross Sectional ◽  
Human T Cell ◽  
Asymptomatic Individuals ◽  
The Relationship

Osteoporosis has been reported among Human T-cell Lymphotropic Virus type 1 (HTLV-1) infected aged patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) diagnosis. However, the association between osteoporosis and HTLV-1 infection remains unclear. This study aimed to evaluate the presence of bone disorders in young HTLV-1 asymptomatic individuals. A cross sectional study was carried out at the HTLV Reference Center in Salvador, Brazil. Forty-seven HTLV-1 infected asymptomatic and 108 healthy subjects aged between 20 to 45 years were included. Biochemical markers of bone metabolism were measured and bone mineral density (BMD) was determined at the femoral neck and at the lumbar spine (L1 -L4). Significant low BMD (Z-score <-1 ) was found in HTLV-1 infected individuals (1.177 ± 0.103) compared to control subjects (1.225 ± 0.146). In logistics regression analysis HTLV-1 infected subjects were more likely to have low BMD (OR = 3.48; 95%CI 1.29- 9.43) adjusted for low education and body mass index (BMI). Osteoporosis (Z-score <-2) was not found among HTLV-1-infected group. In conclusion, our results found a low BMD in patients infected with HTLV-1 compared to uninfected controls. However, osteoporosis was not observed. Further studies should be conducted to evaluate the relationship between HTLV-1-infection and low BMD.

Association between vestibular dysfunction and findings of horizontal head-shaking and vibration-induced nystagmus

2020 ◽  
Vol 30 (5) ◽  
pp. 319-327
Author(s):  
Chisato Fujimoto ◽  
Takuya Kawahara ◽  
Masato Yagi ◽  
Toshihisa Murofushi
Keyword(s):  
Medical Records ◽  
Vestibular Function ◽  
Mixed Effects ◽  
Vestibular Dysfunction ◽  
Regression Analyses ◽  
Lateral Semicircular Canal ◽  
Vestibular Evoked Myogenic Potential ◽  
Vestibular Diseases ◽  
Ocular Vemp ◽  
Horizontal Head

BACKGROUND: The association between vestibular function and findings of horizontal head-shaking nystagmus (HHSN) and vibration-induced nystagmus (VIN) tests is not well understood. OBJECTIVE: To investigate the association between function in the five distinct vestibular end organs and findings of these nystagmus tests. METHODS: We retrospectively reviewed the medical records of 50 patients with vestibular diseases who underwent HHSN testing, VIN testing, video head impulse testing (vHIT), cervical vestibular evoked myogenic potential testing to air-conducted sound (ACS cVEMP) and ocular VEMP testing to ACS (ACS oVEMP). We performed mixed-effects logistic regression analyses to see whether age, sex or the presence of nystagmus in HHSN or VIN have an association with the presence of peripheral vestibular dysfunction on the opposite side to the direction of nystagmus. RESULTS: The presence of HHSN had a significant association with abnormal vHIT in the lateral semicircular canal (LSCC) on the opposite side to the direction of nystagmus. The presence of VIN had a significant association with abnormal vHIT in all the SCCs and abnormal ACS oVEMP on the opposite side to the direction of nystagmus. CONCLUSIONS: HHSN had an association with LSCC dysfunction alone. VIN had an association with dysfunction in all the SCCs and the utricle.

scholarly journals Vestibular Function in Psoriasis Patients

2020 ◽  
pp. 014556132097068
Author(s):  
Abdullah Kınar ◽  
Abdulkadir Bucak ◽  
Şahin Ulu ◽  
Nilay Duman ◽  
Nur Betül Baştuğ
Keyword(s):  
Vestibular System ◽  
Inflammatory Disease ◽  
Vestibular Function ◽  
Control Group ◽  
Distortion Product Otoacoustic Emission ◽  
Duration Of Treatment ◽  
Vestibular Evoked Myogenic Potential ◽  
Cross Sectional ◽  
Distortion Product ◽  
Immune Mediated

Introduction: Psoriasis is an inflammatory skin disease that is characterized by T-cell-mediated hyperproliferation of the keratinocytes. It develops through immune-mediated mechanisms and is defined as an immune-mediated inflammatory disease. The inner ear is susceptible to inflammatory attacks, and vertigo and dizziness can occur as a complication. There is little information about psoriasis and the vestibular system. Objective: This study aimed to investigate the cervical vestibular-evoked myogenic potential (cVEMP) results of psoriasis patients and the effect of psoriasis on the vestibular system. Materials and Methods: Randomly selected and included in the study were patients who had been admitted to the Dermatology Outpatient Clinic of the Afyon Kocatepe University Medical Faculty, between November 15, 2017, and March 15, 2018, with the diagnosis of psoriasis, in addition to a healthy control group. This research was designed as cross-sectional study. Ethics committee permission was received. Both cVEMP and distortion product otoacoustic emission (DPOAE) tests were administered to all of the participants. Values were compared between the control group and psoriasis patients. Results: The study included 43 psoriasis patients and 40 controls. The duration of treatment of the patients and the drugs that they were using were noted. The psoriasis patients had lower p13–n23 amplitude differences in their cVEMP tests ( P < .05). These patients also had lower signal to noise ratio values, at 4 and 6 kHz, on their DPOAE tests ( P < .05). Conclusion: Psoriasis is an immune-mediated inflammatory disease that can be associated with vestibulocochlear dysfunction.

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