Correction: CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications

ObjectiveTo evaluate cerebrospinal fluid (CSF) cytokine profiles in myelin oligodendrocyte glycoprotein IgG-positive (MOG-IgG+) disease in adult and paediatric patients.MethodsIn this cross-sectional study, we measured 27 cytokines in the CSF of MOG-IgG+ disease in acute phase before treatment (n=29). The data were directly compared with those in aquaporin-4 antibody-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) (n=20), multiple sclerosis (MS) (n=20) and non-inflammatory controls (n=14).ResultsIn MOG-IgG+ disease, there was no female preponderance and the ages were younger (mean 18 years, range 3–68; 15 were below 18 years) relative to AQP4-IgG+ NMOSD (41, 15–77) and MS (34, 17–48). CSF cell counts were higher and oligoclonal IgG bands were mostly negative in MOG-IgG+ disease and AQP4-IgG+ NMOSD compared with MS. MOG-IgG+ disease had significantly elevated levels of interleukin (IL)-6, IL-8, granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor, interferon-γ, IL-10, IL-1 receptor antagonist, monocyte chemotactic protein-1 and macrophage inflammatory protein-1α as compared with MS. No cytokine in MOG-IgG+ disease was significantly different from AQP4-IgG+ NMOSD. Moreover many elevated cytokines were correlated with each other in MOG-IgG+ disease and AQP4-IgG+ NMOSD but not in MS. No difference in the data was seen between adult and paediatric MOG-IgG+ cases.ConclusionsThe CSF cytokine profile in the acute phase of MOG-IgG+ disease is characterised by coordinated upregulation of T helper 17 (Th17) and other cytokines including some Th1-related and regulatory T cells-related ones in adults and children, which is similar to AQP4-IgG+ NMOSD but clearly different from MS. The results suggest that as with AQP4-IgG+ NMOSD, some disease-modifying drugs for MS may be ineffective in MOG-IgG+ disease while they may provide potential therapeutic targets.

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Intra‐individual cytokine profile in peri‐implantitis and periodontitis: a cross‐sectional study

Clinical Oral Implants Research ◽

10.1111/clr.13725 ◽

2021 ◽

Author(s):

Leif Jansson ◽

Anna Lundmark ◽

Carolina Modin ◽

Denise Abadji ◽

Tülay Yucel‐Lindberg

Keyword(s):

Cross Sectional Study ◽

Cytokine Profile ◽

Sectional Study ◽

Cross Sectional

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Association of depressive symptoms with allodynia in patients with migraine: A cross-sectional study

Cephalalgia ◽

10.1177/0333102415620285 ◽

2016 ◽

Vol 36 (11) ◽

pp. 1077-1081 ◽

Cited By ~ 5

Author(s):

Marcelo D Mendonça ◽

André Caetano ◽

Miguel Viana-Baptista ◽

Keyword(s):

Depressive Symptoms ◽

Strong Association ◽

Depression Scale ◽

Episodic Migraine ◽

Cross Sectional Study ◽

Multiple Regression Model ◽

Sectional Study ◽

Cross Sectional ◽

Therapeutic Implications ◽

Demographic Questionnaire

Aims Migraine and depression have a strong association. We aimed to determine whether this relationship was particularly evident in migraineurs with allodynia. Methods A cross-sectional study was carried out of 98 consecutive patients with episodic migraine presenting for their first evaluation in an outpatient clinic. The participants completed a demographic questionnaire, the Allodynia Symptom Checklist and the Hospital Anxiety and Depression Scale (HADS). Results Among the migraineurs, 75 (77%) reported allodynia. Allodynia was associated with higher median HADS-Anxiety (9 vs. 6, p = 0.038) and HADS-Depression (6 vs. 4, p = 0.014) scores. In a multiple regression model, the HADS-Depression scores were independently associated with allodynia (odds ratio 1.236, 95% confidence interval 1.046–1.461). An increased severity of allodynia correlated with higher depression scores ( r = 0.224; p = 0.027). Conclusion Anxious and depressive symptoms are more common in migraineurs with allodynia than in those without allodynia. Further studies are necessary to clarify the relationship between depressive symptoms and allodynia, as well as its therapeutic implications in migraine.

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Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

10.20944/preprints202108.0162.v1 ◽

2021 ◽

Author(s):

Maria del Carmen Moleon ◽

Estrella Martinez-Gomez ◽

Marisa Flook ◽

Andreina Peralta-Leal ◽

Juan Antonio Gallego ◽

...

Keyword(s):

Autoimmune Diseases ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Cross Sectional Study ◽

Cytokine Profile ◽

Sectional Study ◽

Meniere Disease ◽

Cross Sectional ◽

Menière Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profile in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early onset MD (EOMD, <35 years old), and 39 with late onset MD (LOMD, > 50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p=0.004) and a higher prevalence of migraine than LOMD (p=0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3 and CXCL4 were different between patients with MD or migraine and controls.

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The Attitudes of Progressive Neurological Disease Patients and Their Family Members to End of Life Care: A Cross-Sectional Study

OMEGA - Journal of Death and Dying ◽

10.1177/0030222820936922 ◽

2020 ◽

pp. 003022282093692

Author(s):

Radka Bužgová ◽

Radka Kozáková ◽

Michal Bar ◽

Monika Škutová ◽

Pavel Ressner ◽

...

Keyword(s):

End Of Life ◽

End Of Life Care ◽

Neurological Disease ◽

Family Members ◽

Cross Sectional Study ◽

Life Care ◽

Sectional Study ◽

Cross Sectional ◽

Care Plans ◽

Individual Care

The objective was to identify the attitudes of progressive neurological disease (PND) patients and their family members regarding end-of-life care, and their worries about dying. The sample included 327 participants. The Attitudes of Patients with PND to End-of-Life Care questionnaire was used to collect the data. Statistically significant differences in the assessment of attitudes towards end-of-life care between patients and family members were identified (p < 0.001). Family members more frequently favored patients being kept alive at any cost; patients more commonly wished to have their end of life under control. Respondents most frequently deferred to doctors when it came to decisions on treatment to keep patients alive. However, both patients and family members wanted patients to be able to decide on their treatment by leaving a written record of their previously stated wishes. The demands of patients and their families regarding end-of-life care should be documented in individual care plans.

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Therapeutic implications of prevalence and predictor risk factors for burn out syndrome in Egyptian dermatologists: A cross sectional study

Dermatologic Therapy ◽

10.1111/dth.14327 ◽

2020 ◽

Vol 33 (6) ◽

Author(s):

Mohamed L. Elsaie ◽

Sherief M. Hussein ◽

Mohamed S. Zaky ◽

Noha S. Hanafy ◽

Mohammad Jafferany

Keyword(s):

Risk Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Therapeutic Implications ◽

Burn Out

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Can serum cytokine profile discriminate irritant-induced and allergen-induced symptoms? A cross-sectional study in workers mostly exposed to laboratory animals

Occupational and Environmental Medicine ◽

10.1136/oemed-2016-104137 ◽

2017 ◽

Vol 74 (8) ◽

pp. 592-600

Author(s):

Muriel Lemaire ◽

Anne Oppliger ◽

Philipp Hotz ◽

Jean-Christophe Renauld ◽

Julia Braun ◽

...

Keyword(s):

Cross Sectional Study ◽

Cytokine Profile ◽

Laboratory Animals ◽

Sectional Study ◽

Serum Cytokine ◽

Cross Sectional

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Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional Study

International Scholarly Research Notices ◽

10.1155/2017/6053267 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Sheida Khosravani ◽

Farhad Handjani ◽

Reyhaneh Alimohammadi ◽

Nasrin Saki

Keyword(s):

Bullous Pemphigoid ◽

Neurological Disorders ◽

Neurological Disease ◽

The Elderly ◽

Cross Sectional Study ◽

Control Group ◽

Case Group ◽

Sectional Study ◽

Cross Sectional ◽

Iranian Patients

Background. Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disorder which occurs mostly in the elderly. Several studies have reported an association between BP and neurological disorders (ND). Objective. The purpose of this study was to evaluate the association between BP and neurological disorders in Iranian patients. Methods. In this cross-sectional study, 87 patients with BP were enrolled. They were compared to 184 controls. Statistical analysis was done by SPSS statistical software version 19. Results. Out of 87 patients with BP, 17 (19.5%) had at least one neurological disease. Cerebrovascular accident (CVA) was the most common neurological disease that was seen in 7 patients (8.0%) in the case group and 4 (2.1%) in the control group. The incidence of CVA was significantly different between BP patients and the control group (P=0.022). Dementia was observed in 6 patients in the case group (16.8%) and 2 (1.0%) in the control group. The incidence of dementia was significantly different between BP patients and the control group (P=0.008). In this study, the incidences of Parkinson’s disease (P=0.830), epilepsy (P=0.067), and multiple sclerosis (P=0.326) were not statistically significant between the two groups. Conclusion. The incidence of CVA and dementia in patients with BP compared to the control group was significantly higher.

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Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

Journal of Clinical Medicine ◽

10.3390/jcm10184052 ◽

2021 ◽

Vol 10 (18) ◽

pp. 4052

Author(s):

Maria-Del-Carmen Moleon ◽

Estrella Martinez-Gomez ◽

Marisa Flook ◽

Andreina Peralta-Leal ◽

Juan Antonio Gallego ◽

...

Keyword(s):

Autoimmune Diseases ◽

Early Onset ◽

Age Of Onset ◽

Late Onset ◽

Cross Sectional Study ◽

Cytokine Profile ◽

Sectional Study ◽

Meniere Disease ◽

Cross Sectional ◽

Menière Disease

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.

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A novel Longshi Scale measured activity of daily living disability in elderly patients affected by neurological diseases: a multi-center cross-sectional study in China

BMC Geriatrics ◽

10.1186/s12877-021-02296-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jingpu Zhao ◽

Xiangxiang Liu ◽

Li Wan ◽

Yan Gao ◽

Meiling Huang ◽

...

Keyword(s):

Older Adults ◽

Activities Of Daily Living ◽

Barthel Index ◽

Neurological Disease ◽

Daily Living ◽

Cross Sectional Study ◽

Sectional Study ◽

Community Group ◽

Cross Sectional ◽

Significant Difference

Abstract Background Ability in the activities of daily life is often impaired in the older adults with a neurological disease. The Barthel Index is an instrument used worldwide to assess such ability. The Longshi Scale is a picture-based alternative, but its effectiveness has not been evaluated with older adult subjects. This study was to determine whether the Longshi Scale can effectively quantify the ability of older adults in the activities of daily living by comparing its ratings with those using the Barthel Index. Methods A multi-center cross-sectional study was conducted among patients over 65 years. A total of 2438 patients were divided into three groups, including bedridden, domestic, or community group based on their ability to go out of bed, move outdoors, and return indoors. Their ability in the activities of daily living among three groups was evaluated using both the Longshi Scale and the Barthel Index, and the results were compared. Results There was a significant difference in the average Barthel Index scores of three groups classified using the Longshi Scale. The average Longshi Scale scores also showed significant differences between the four groups classified using the Barthel Index. Spearman correlation coefficients showed strong correlation(>0.83) between the Longshi Scale and Barthel Index scores. Conclusions The Longshi Scale can efficiently distinguish the ability in the activities of daily living of people with a neurological disease. Its rating correlate well with those using the Barthel Index.

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