scholarly journals Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals

2019 ◽  
Author(s):  
Toshihiko Aso ◽  
Shinnichi Urayama ◽  
Fukuyama Hidenao ◽  
Toshiya Murai

AbstractPerfusion-related information is reportedly embedded in the low-frequency component of a blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal. The blood-propagation pattern through the cerebral vascular tree is detected as an interregional lag variation of spontaneous low-frequency oscillations (sLFOs). Mapping of this lag, or phase, has been implicitly treated as a projection of the vascular tree structure onto real space. While accumulating evidence supports the biological significance of this signal component, the physiological basis of the “perfusion lag structure,” a requirement for an integrative resting-state fMRI-signal model, is lacking. In this study, we conducted analyses furthering the hypothesis that the sLFO is not only largely of systemic origin, but also essentially intrinsic to blood, and hence behaves as a virtual tracer. By summing the small fluctuations of instantaneous phase differences between adjacent vascular regions, a velocity response to respiratory challenges was detected. Regarding the relationship to neurovascular coupling, the removal of the whole lag structure, which can be considered as an optimized global-signal regression, resulted in a reduction of inter-individual variance while preserving the fMRI response. Examination of the T2* and S0, or non-BOLD, components of the fMRI signal revealed that the lag structure is deoxyhemoglobin dependent, while paradoxically presenting a signal-magnitude reduction in the venous side of the cerebral vasculature. These findings provide insight into the origin of BOLD sLFOs, suggesting that they are highly intrinsic to the circulating blood.

Solar Physics ◽  
2021 ◽  
Vol 296 (6) ◽  
Author(s):  
Thomas Williams ◽  
Robert W. Walsh ◽  
Stephane Regnier ◽  
Craig D. Johnston

AbstractCoronal loops form the basic building blocks of the magnetically closed solar corona yet much is still to be determined concerning their possible fine-scale structuring and the rate of heat deposition within them. Using an improved multi-stranded loop model to better approximate the numerically challenging transition region, this article examines synthetic NASA Solar Dynamics Observatory’s (SDO) Atmospheric Imaging Assembly (AIA) emission simulated in response to a series of prescribed spatially and temporally random, impulsive and localised heating events across numerous sub-loop elements with a strong weighting towards the base of the structure: the nanoflare heating scenario. The total number of strands and nanoflare repetition times is varied systematically in such a way that the total energy content remains approximately constant across all the cases analysed. Repeated time-lag detection during an emission time series provides a good approximation for the nanoflare repetition time for low-frequency heating. Furthermore, using a combination of AIA 171/193 and 193/211 channel ratios in combination with spectroscopic determination of the standard deviation of the loop-apex temperature over several hours alongside simulations from the outlined multi-stranded loop model, it is demonstrated that both the imposed heating rate and number of strands can be realised.


Frequenz ◽  
2017 ◽  
Vol 71 (11-12) ◽  
Author(s):  
Xue Jiao ◽  
Bo Yang

AbstractTo study the lightning electromagnetic pulse (LEMP) coupling and protection problems of shielding enclosure with penetrating wire, we adopt the model with proper size which is close to the practical engineering and the two-step finite-difference time-domain (FDTD) method is used for calculation in this paper. It is shown that the coupling voltage on the circuit lead inside the enclosure increases about 34 dB, when add 1.0 m long penetrating wire at the aperture, comparing with the case without penetrating wire. Meanwhile, the waveform, has the same wave outline as the lightning current source, shows that the penetrating wire brings a large number of low frequency component into the enclosure. The coupling effect in the enclosure will reduce greatly when penetrating wire has electrical connection with the enclosure at the aperture and the coupling voltage increase only about 12 dB than the case without penetrating wire. Moreover, the results show that though the waveguide pipe can reduce the coupling effect brought by the penetrating wire, the exposing part of penetrating wire can increase the coupling when the penetrating wire outside the enclosure is longer than the waveguide pipe and the longer the exposing part is, the stronger the coupling is.


Author(s):  
Sara Kobbi ◽  
Salima Guerricha ◽  
Smaïl Chihi ◽  
Abdallah Bekkouche ◽  
Mohammed Tayeb Meftah

2004 ◽  
Vol 11 (2) ◽  
pp. 215-218 ◽  
Author(s):  
S. G. Tagare ◽  
S. V. Singh ◽  
R. V. Reddy ◽  
G. S. Lakhina

Abstract. Small amplitude electron - acoustic solitons are studied in a magnetized plasma consisting of two types of electrons, namely cold electron beam and background plasma electrons and two temperature ion plasma. The analysis predicts rarefactive solitons. The model may provide a possible explanation for the perpendicular polarization of the low-frequency component of the broadband electrostatic noise observed in the Earth's magnetotail.


10.14311/450 ◽  
2003 ◽  
Vol 43 (4) ◽  
Author(s):  
P. Hasal ◽  
I. Fořt ◽  
J. Kratěna

Experimental data obtained by measuring the tangential component of the force affecting radial baffles in a flat-bottomed cylindrical mixing vessel stirred with a Rushton turbine impeller is analysed. Spectral analysis of the experimental data demonstrated the presence of its macro-instability (MI) related low-frequency component embedded in the total force. Two distinct dimensionless frequencies (both directly proportional to the impeller speed of rotation N) of the occurence of the MI component were detected: a lower frequency of approximately 0.025N and a higher frequency of about 0.085N. The relative magnitude QMI of the MI-related component of the total tangential force was evaluated by a combination of proper orthogonal decomposition (POD) and spectral analysis. The values of magnitude QMI varied in the interval [rom approximately 0.05 to 0.30. The magnitude QMI takes maximum values at low Reynolds number values (in laminar and transitional regions). In the turbulent region (ReM >20000) the QMI value is low and practically constant. The dependence oj the QMI values on vertical position in the vessel is only marginal. The results suggest that the magnitude of the MI component of the force is significantly influenced by the liquid viscosity and density.


2017 ◽  
Vol 46 (2) ◽  
pp. 792-801 ◽  
Author(s):  
W-J Guo ◽  
S-K Yao ◽  
Y-L Zhang ◽  
S-Y Du ◽  
H-F Wang ◽  
...  

Objective This study was performed to investigate impaired vagal activity to meal in patients with functional dyspepsia (FD) with delayed gastric emptying (GE). Methods Eighty-five patients were studied. GE parameters, including those in the overall and proximal stomach, were measured by GE functional tests at the Department of Nuclear Medicine. Autonomic nervous function was tested by spectral analysis of heart rate variability (HRV). The vagal activity and sympathetic activity were analyzed by recording the power in the high-frequency component (HF), low-frequency component (LF), and LF/HF ratio. Results Overall and proximal GE were delayed in 47.2% and 50.9% of the patients, respectively. Spectral analysis of HRV showed that the HF in patients with delayed proximal GE was significantly lower and that the LF/HF ratio was significantly higher than those in patients with normal proximal GE after a meal. Conclusion Delayed proximal GE might be caused by disrupted sympathovagal balance as a result of decreased vagal activity after a meal. Improvement in vagal activity may constitute an effective treatment method for patients with FD.


1992 ◽  
Vol 114 (1) ◽  
pp. 26-31 ◽  
Author(s):  
M. Suk ◽  
T. Ishii ◽  
D. Bogy

We investigate the influence of crown on slider dynamics during the takeoff stages of disk drives using the multi-channel laser interferometer. We show that a two-dimensional analysis of slider dynamics during takeoff/landing cannot explain all the observed phenomena. We also examine the crown effect on slider motion while it is flying on a thin film disk with a crater-like surface defect. Finally, we measure the spacing variation of the slider as a function of disk speed. It is observed that the initial motion of negative crown sliders during takeoff can be quite similar to positive crown sliders, although the process is quite different. Furthermore, the results suggest that the negative crown sliders may lead to more disk wear due to longer sliding distances. We observed that during steady flying conditions the craterlike surface defect on the disk produced significantly larger motions for negative crown sliders than positive crown sliders. Lastly, we found that both the waveform and magnitude of the low frequency component of the spacing fluctuation is independent of the slider flying height.


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