scholarly journals A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells

2013 ◽  
Vol 23 (4) ◽  
pp. 581-591 ◽  
Author(s):  
K. Imberg-Kazdan ◽  
S. Ha ◽  
A. Greenfield ◽  
C. S. Poultney ◽  
R. Bonneau ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Rna Interference ◽  
Cancer Cells ◽  
Receptor Function ◽  
Prostate Cancer Cells ◽  
Genome Wide ◽  
A Genome ◽  
Androgen Receptor Function

Casein kinase 2 inhibition attenuates androgen receptor function and cell proliferation in prostate cancer cells

The Prostate ◽  
2012 ◽  
Vol 72 (13) ◽  
pp. 1423-1430 ◽  
Author(s):  
Kai Yao ◽  
Hyewon Youn ◽  
Xiaoyan Gao ◽  
Bijun Huang ◽  
Fangjian Zhou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Casein Kinase ◽  
Casein Kinase 2 ◽  
Receptor Function ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Function

scholarly journals Hsp70 Binds to the Androgen Receptor N-terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells

2018 ◽  
Vol 18 (1) ◽  
pp. 39-50 ◽  
Author(s):  
Jun Dong ◽  
Zeyu Wu ◽  
Dan Wang ◽  
Laura E. Pascal ◽  
Joel B. Nelson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Function ◽  
Prostate Cancer Cells ◽  
Terminal Domain

scholarly journals Genome-wide analysis of androgen receptor binding sites in prostate cancer cells

2015 ◽  
Vol 9 (6) ◽  
pp. 2319-2324 ◽  
Author(s):  
YUE CHENG ◽  
PAN YU ◽  
XIUZHI DUAN ◽  
CHUNHUA LIU ◽  
SIQI XU ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Binding ◽  
Binding Sites ◽  
Prostate Cancer Cells ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Genome-Wide Impact of Androgen Receptor Trapped clone-27 Loss on Androgen-Regulated Transcription in Prostate Cancer Cells

2009 ◽  
Vol 69 (7) ◽  
pp. 3140-3147 ◽  
Author(s):  
Jerome C. Nwachukwu ◽  
Paolo Mita ◽  
Rachel Ruoff ◽  
Susan Ha ◽  
Qianben Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Genome Wide

scholarly journals PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Payal Jain ◽  
Cecilia Ballare ◽  
Enrique Blanco ◽  
Pedro Vizan ◽  
Luciano Di Croce
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Target Genes ◽  
Embryonic Stem ◽  
Prostate Cancer Cells ◽  
Genome Wide ◽  
A Genome ◽  
Matrix Organization

The Polycomb-like protein PHF19/PCL3 associates with PRC2 and mediates its recruitment to chromatin in embryonic stem cells. PHF19 is also overexpressed in many cancers. However, neither PHF19 targets nor misregulated pathways involving PHF19 are known. Here, we investigate the role of PHF19 in prostate cancer cells. We find that PHF19 interacts with PRC2 and binds to PRC2 targets on chromatin. PHF19 target genes are involved in proliferation, differentiation, angiogenesis, and extracellular matrix organization. Depletion of PHF19 triggers an increase in MTF2/PCL2 chromatin recruitment, with a genome-wide gain in PRC2 occupancy and H3K27me3 deposition. Transcriptome analysis shows that PHF19 loss promotes deregulation of key genes involved in growth, metastasis, invasion, and of factors that stimulate blood vessels formation. Consistent with this, PHF19 silencing reduces cell proliferation, while promotes invasive growth and angiogenesis. Our findings reveal a role for PHF19 in controlling the balance between cell proliferation and invasiveness in prostate cancer.

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