scholarly journals Evaluation of silicon strip detectors in transmission mode for online beam monitoring in microbeam radiation therapy at the Australian Synchrotron

2022 ◽  
Vol 29 (1) ◽  
Author(s):  
Jeremy Davis ◽  
Andrew Dipuglia ◽  
Matthew Cameron ◽  
Jason Paino ◽  
Ashley Cullen ◽  
...  

Successful transition of synchrotron-based microbeam radiation therapy (MRT) from pre-clinical animal studies to human trials is dependent upon ensuring that there are sufficient and adequate measures in place for quality assurance purposes. Transmission detectors provide researchers and clinicians with a real-time quality assurance and beam-monitoring instrument to ensure safe and accurate dose delivery. In this work, the effect of transmission detectors of different thicknesses (10 and 375 µm) upon the photon energy spectra and dose deposition of spatially fractionated synchrotron radiation is quantified experimentally and by means of a dedicated Geant4 simulation study. The simulation and experimental results confirm that the presence of the 375 µm thick transmission detector results in an approximately 1–6% decrease in broad-beam and microbeam peak dose. The capability to account for the reduction in dose and change to the peak-to-valley dose ratio justifies the use of transmission detectors as thick as 375 µm in MRT provided that treatment planning systems are able to account for their presence. The simulation and experimental results confirm that the presence of the 10 µm thick transmission detector shows a negligible impact (<0.5%) on the photon energy spectra, dose delivery and microbeam structure for both broad-beam and microbeam cases. Whilst the use of 375 µm thick detectors would certainly be appropriate, based upon the idea of best practice the authors recommend that 10 µm thick transmission detectors of this sort be utilized as a real-time quality assurance and beam-monitoring tool during MRT.

2019 ◽  
Vol 65 ◽  
pp. 227-237
Author(s):  
Alexandre Ocadiz ◽  
Jayde Livingstone ◽  
Mattia Donzelli ◽  
Stefan Bartzsch ◽  
Christian Nemoz ◽  
...  

2017 ◽  
Vol 24 (4) ◽  
pp. 866-876 ◽  
Author(s):  
Matthew Cameron ◽  
Iwan Cornelius ◽  
Dean Cutajar ◽  
Jeremy Davis ◽  
Anatoly Rosenfeld ◽  
...  

Microbeam radiation therapy (MRT) is a promising radiotherapy modality that uses arrays of spatially fractionated micrometre-sized beams of synchrotron radiation to irradiate tumours. Routine dosimetry quality assurance (QA) prior to treatment is necessary to identify any changes in beam condition from the treatment plan, and is undertaken using solid homogeneous phantoms. Solid phantoms are designed for, and routinely used in, megavoltage X-ray beam radiation therapy. These solid phantoms are not necessarily designed to be water-equivalent at low X-ray energies, and therefore may not be suitable for MRT QA. This work quantitatively determines the most appropriate solid phantom to use in dosimetric MRT QA. Simulated dose profiles of various phantom materials were compared with those calculated in water under the same conditions. The phantoms under consideration were RMI457 Solid Water (Gammex-RMI, Middleton, WI, USA), Plastic Water (CIRS, Norfolk, VA, USA), Plastic Water DT (CIRS, Norfolk, VA, USA), PAGAT (CIRS, Norfolk, VA, USA), RW3 Solid Phantom (PTW Freiburg, Freiburg, Germany), PMMA, Virtual Water (Med-Cal, Verona, WI, USA) and Perspex. RMI457 Solid Water and Virtual Water were found to be the best approximations for water in MRT dosimetry (within ±3% deviation in peak and 6% in valley). RW3 and Plastic Water DT approximate the relative dose distribution in water (within ±3% deviation in the peak and 5% in the valley). PAGAT, PMMA, Perspex and Plastic Water are not recommended to be used as phantoms for MRT QA, due to dosimetric discrepancies greater than 5%.


2014 ◽  
Vol 30 ◽  
pp. e135
Author(s):  
P. Fournier ◽  
I. Cornelius ◽  
M. Petasecca ◽  
E. Bräuer-Krisch ◽  
H. Requardt ◽  
...  

2008 ◽  
Vol 102 ◽  
pp. 012005 ◽  
Author(s):  
M De Felici ◽  
E A Siegbahn ◽  
J Spiga ◽  
A L Hanson ◽  
R Felici ◽  
...  

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