scholarly journals Factors associated with mothers' knowledge of children with congenital heart disease in Bangkok, Thailand

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Malatree Khouenkoup ◽  
Arunrat Srichantaranit ◽  
Wanida Sanasuttipun
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Rank Order ◽  
Severity Of Illness ◽  
Correlation Study ◽  
Knowledge Domain ◽  
Content Type ◽  
Exact Test ◽  
High Level

PurposeThis study aimed to determine mothers' knowledge of children with congenital heart disease (CHD) and to examine the relationship between types of CHD, the duration of treatments, the perception of the severity of illness and the mothers' knowledge.Design/methodology/approachA correlation study was conducted among 84 mothers of children (from infancy to six years old) with CHD who had attended pediatric cardiology clinics and pediatric units in three tertiary hospitals in Bangkok, Thailand. The two questionnaires aimed to evaluate the mothers' knowledge and perceptions of the severity of illness. Descriptive statistics, Spearman's rank-order correlation and Fisher's exact test were used to analyze the data.FindingsKnowledge levels of mothers of children with CHD were at a high level with a mean score of 34.79 (SD = 8.23), but the knowledge domain of preventing complications was at a low level with a mean score of 14.95 (SD = 5.28). The types of CHD and the perceptions of illness were not correlated with the mothers' knowledge, but the duration of treatments was significantly correlated (r = 0.271, p < 0.05).Originality/valueHealthcare professionals, especially nurses, should emphasize proper health education on complication prevention and the duration of treatments for children. Moreover, mothers should be supported to nurture children with CHD to reduce possible complications and prepare for cardiac surgery where needed.

scholarly journals In silico analysis of GATA4 variants demonstrates main contribution to congenital heart disease

2021 ◽  
Author(s):  
Shiva Abbasi ◽  
Neda Mohsen-Pour ◽  
Niloofar Naderi ◽  
Shahin Rahimi ◽  
Majid Maleki ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
In Silico ◽  
Structure Prediction ◽  
Congenital Heart ◽  
In Silico Analysis ◽  
Different Types ◽  
Frequent Variant ◽  
High Level ◽  
Silico Analysis

Introduction: Congenital heart disease (CHD) is the most common congenital abnormality and the main cause of infant mortality worldwide. Some of the mutations that occur in the GATA4 gene region may result in different types of CHD. Here, we report our in silico analysis of gene variants to determine the effects of the GATA4 gene on the development of CHD. Methods: Online 1000 Genomes Project, ExAC, gnomAD, GO-ESP, TOPMed, Iranome, GME, ClinVar, and HGMD databases were drawn upon to collect information on all the reported GATA4 variations.The functional importance of the genetic variants was assessed by using SIFT, MutationTaster, CADD,PolyPhen-2, PROVEAN, and GERP prediction tools. Thereafter, network analysis of the GATA4protein via STRING, normal/mutant protein structure prediction via HOPE and I-TASSER, and phylogenetic assessment of the GATA4 sequence alignment via ClustalW were performed. Results: The most frequent variant was c.874T>C (45.58%), which was reported in Germany.Ventricular septal defect was the most frequent type of CHD. Out of all the reported variants of GATA4,38 variants were pathogenic. A high level of pathogenicity was shown for p.Gly221Arg (CADD score=31), which was further analyzed. Conclusion: The GATA4 gene plays a significant role in CHD; we, therefore, suggest that it be accorded priority in CHD genetic screening.

Outcomes and Prognostic Factors for Adult Patients With Congenital Heart Disease Undergoing Primary or Reoperative Systemic Atrioventricular Valve Surgery

2017 ◽  
Vol 8 (3) ◽  
pp. 346-353
Author(s):  
Elizabeth H. Stephens ◽  
Jiho Han ◽  
Jonathan Ginns ◽  
Marlon Rosenbaum ◽  
Paul Chai ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Prognostic Factors ◽  
Adverse Events ◽  
Congenital Heart ◽  
Atrioventricular Septal Defect ◽  
The Other ◽  
Mitral Valve Stenosis ◽  
Atrioventricular Valve ◽  
Exact Test

Background: Adults with congenital heart disease (ACHD) undergoing systemic atrioventricular valve (SAVV) surgery are a complex, understudied population. We assessed midterm outcomes and prognostic factors in ACHD undergoing SAVV surgery. Methods: We performed retrospective evaluation of ACHD undergoing SAVV surgery from January 2005 to February 2016: 14 (33%) patients with congenital mitral valve stenosis/regurgitation, 15 (35%) with atrioventricular septal defect (AVSD), and 14 (33%) with congenitally corrected transposition of the great arteries (ccTGA) with systemic tricuspid valve regurgitation. Adverse events were defined as mortality, reoperation on SAVV, and late more-than-moderate (> moderate) SAVV regurgitation. Statistical analysis was performed using Fisher’s exact test and one-way analysis of variance as well as univariate and multivariate risk factor analysis. Results: Fifteen (35%) patients had preoperative systemic ventricular dysfunction, including 13 patients with ccTGA (93%, P < .001). Twenty-three (54%) patients underwent valve repair, 20 (47%) patients underwent replacement, and 20 (47%) patients underwent an associated procedure. Replacement was higher in patients with ccTGA (86%) than the other groups ( P < 0.01). Thirty-seven patients (91% of survivors) were free of significant SAVV regurgitation at last follow-up, with patients with AVSD having greater regurgitation grades compared to the other groups ( P < 0.01). In-hospital mortality, late mortality, late > moderate SAVV regurgitation, and SAVV reoperation rates were 5% (n = 2), 2% (n = 1), 9% (n = 3), and 7% (n = 3), respectively. On multivariate analysis, predischarge SAVV regurgitation grade was the only significant predictor of adverse events (odds ratio = 8.2, 95% confidence interval: 1.1-63.8, P = .045). Conclusion: Overall outcomes in this challenging population are good. The single factor associated with adverse events was predischarge SAVV regurgitation grade.

scholarly journals Oxygen saturation among newborns in the first 10 hours of life to detect Critical Congenital Heart Disease - Ductus Dependent

2020 ◽  
Vol 4 (2) ◽  
pp. 237
Author(s):  
Fatchul Wahab ◽  
Mahrus Abdul Rahman ◽  
Teddy Ontoseno ◽  
Risa Etika ◽  
Alit Utamayasa ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Oxygen Saturation ◽  
Pulse Oximetry ◽  
Gold Standard ◽  
Congenital Heart ◽  
Critical Congenital Heart Disease ◽  
Exact Test ◽  
Consecutive Sampling ◽  
The Right

ABSTRACT Delay diagnosis of Critical Congenital Heart Disease (CHD) can be associated with sudden clinical deterioration and dangerous cardiovascular conditions. The oxygen saturation screening among newborns in the first 10 hours of life is essential for early detection of critical CHD. This study aims to prove that measuring oxygen saturation among newborns in the first 10 hours of life can detect critical CHD. This study is a diagnostic experimental with consecutive sampling subjects in the infant care unit of Dr. Soetomo Hospital, including all newborns with birth weight ≥ 1500 grams and oxygen saturation at ≥ 1 hour of age below 90%. The measurement of oxygen saturation uses fingertip pulse oximetry in the right hand and foot at the age of 10 hours. A "positive oxygen saturation" is defined as oxygen saturation ≤ 85% or different oxygen saturation ≥ 3%, while a "negative oxygen saturation" is when the oxygen saturation is 85% to 90% or different oxygen saturation is 3%. Echocardiography is performed for the gold standard. From November 2019 to January 2020, 11 newborns underwent an oxygen saturation examination. Five subjects (45.46%) in the category of positive oxygen saturation, echocardiographic showed all Critical CHD (100%). Six subjects (54.54%) with negative oxygen saturation category, echocardiographic results showed two critical CHD (33.34%) and four non-critical CHD (66.66%). Fisher's exact test p < 0.005 (α). The diagnostic oxygen saturation test among newborns at 10 hours of life shows ≤85%, all subject’s echocardiography (100%) shows detection of critical CHD, while saturation 85% to 90% has of 33.3% for detection of critical CHD. The sensitivity and specificity of oxygen saturation for early diagnosis of critical CHD are 100% and 67%, respectively. Keywords: critical congenital heart disease, oxygen saturation, fingertip pulse oximetry, diagnostic tests*Corresponding Author: [email protected]

METABOLIC ACIDOSIS IN CHILDREN WITH SEVERE CYANOTIC CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1963 ◽  
Vol 31 (2) ◽  
pp. 251-254
Author(s):  
Norman L. Gootman ◽  
Emile M. Scarpelli ◽  
Abraham M. Rudolph
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Metabolic Acidosis ◽  
Congenital Heart ◽  
Respiratory Activity ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial Pco2 ◽  
Respiratory Compensation ◽  
Pulmonary Flow ◽  
High Level

Four children with severe cyanotic congenital heart disease and markedly reduced effective pulmonary blood flow were studied by cardiac catheterization. All children were severely hypoxic and acidotic, while the sytemic arterial pCO2 was relatively normal. These factors tended to maintain respiratory activity at a high level. However, due to the decreased pulmonary flow, respiratory compensation for the acidosis was ineffective. The chronic, uncompensated metabolic acidosis and hypoxemia suggested that (1) anaerobic tissue metabolism is significant, and (2) renal function may be compromised, in children with severe cyanotic congenital heart disease.

Psychological aspects of congenital heart disease

1995 ◽  
Vol 5 (4) ◽  
pp. 302-309 ◽  
Author(s):  
Freda V. Gardner ◽  
G. D. Angelini
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Neonatal Period ◽  
School Age Children ◽  
Psychological Care ◽  
The 1960S ◽  
High Level ◽  
Psychosocial Morbidity ◽  
The Impact

AbstractOutcome following the treatment of congenital heart disease continues to improve and interest has focused on reducing morbidity as well as mortality. One important aspect of this is the psychological effect of congenital heart disease and its treatment on both children and their parents. This review addresses the extent and nature of the psychological morbidity associated with this disease, in particular the impact of the diagnosis on the management of patient and family. The etiology of the high level of psychosocial morbidity remains poorly understood. Data from the 1960s concerned with pre-school and school-age children is now of little value given the dramatic changes in the treatment of congenital heart disease, which is now predominantly in the neonatal period. While theory from developmental and pediatric psychology may be usefully applied to this area, further research is required to define effective psychological care for patients and their families.

scholarly journals Rare case report of infective endocarditis due to Kocuria kristinae in a patient with ventricular septal defect

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Arif Maqsood Ali ◽  
Gule Raana Waseem ◽  
Shazia Arif
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Infective Endocarditis ◽  
Type Species ◽  
Rare Case ◽  
Congenital Heart ◽  
Septal Defect ◽  
Blood Cultures ◽  
Content Type ◽  
Link Type

Background. Infective endocarditis (IE) is an uncommon but life-threatening infection. It is commonly associated with diseased or damaged valves. Patients with congenital heart disease are more prone to getting IE than the general population. The typical organisms that cause IE include Staphylococcus , Coagulase-negative Staphylococcus, Streptococcus viridians and Enterococci. However, the importance of rare micro-organisms like Kocuria kristinae should not be underestimated especially when isolated from multiple blood cultures in patients suspected of IE. Case presentation. We report a rare case of right-sided infective endocarditis due to K. kristinae in a young non-diabetic, non-addict female of low socioeconomic class who presented with undiagnosed fever for 1 year. She was investigated and treated for fever by several general practitioners without relief. Later on, she was diagnosed by a local cardiologist to have perimembranous ventricular septal defect with a small pulmonary valve vegetation. She was referred to a tertiary care cardiac hospital in Rawalpindi, Pakistan for further management. Transthoracic and transesophageal echocardiography confirmed IE secondary to preexisting congenital heart disease complicated with a small pulmonary vegetation. Her blood cultures yielded growth of K. kristanae, a rare micro-organism to cause IE. The patient responded to the antibiotic therapy. Conclusion. Clinicians should have a high index of suspicion for K. kristanae IE as a possible cause of a prolonged fever especially in the presence of congenital heart disease. Antibiotic susceptibility is required for adequate therapy.

scholarly journals Hubungan kelahiran prematur dengan penyakit jantung bawaan di RSUP Prof. Dr. R.D. Kandou Manado periode tahun 2013-2014

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Vivi N. Binalole ◽  
Erling D. Kaunang ◽  
Novie H. Rampengan
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Preterm Birth ◽  
Significant Relationship ◽  
Congenital Heart ◽  
Fisher Exact Test ◽  
Exact Test ◽  
A Value ◽  
Study Population ◽  
And Function

Abstract: Preterm birth is all births before 37 completed weeks of gestation since the first day of a woman's last menstrual period. In the maturation of all organs of preterm birth has not been achieved so well that it may cause disruption, one of them is called the heart of congenital heart disease. Congenital heart disease is a problem with the heart's structure and function that is present at birth. The study aimed is to examine the relationship between preterm birth with congenital heart disease. This studied was conducted using observational analytic study design with a retrospective approach. The studied sample was children who were born Preterm in the Section of Child Health Prof. Dr R. D Kandou Manado diagnosed with congenital heart disease in 2013-2014. The study population numbered 353 children born prematurely, the sample fulfilled inclusion criteria are children born prematurely with CHD totaling 35 samples, and 30 samples were taken comparators. The assay used in this study is the Fisher Exact Test, produces a value p = 0.011 <α = 0.05, which indicates there is a significant relationship between preterm birth with congenital heart disease. Conclusion: There was a significant relationship between preterm birth with congenital heart disease.Keywords: Preterm birth, congenital heart diseaseAbstrak: Kelahiran prematur adalah semua kelahiran sebelum 37 minggu masa kehamilan sejak hari pertama haid terakhir seorang wanita. Pada kelahiran prematur kematangan semua organ belum tercapai dengan baik sehingga dapat menyebabkan gangguan, salah satu diantaranya yaitu jantung yang disebut PJB. Penyakit jantung bawaan (PJB) sendiri adalah permasalahan pada struktur jantung yang tampak setelah kelahiran. Tujuan penelititan ini adalah mengetahui hubungan antara kelahiran prematur dengan penyakit jantung bawaan. Penelitian ini dilakukan dengan menggunakan desain penelitian analitik observasional dengan pendekatan retrospektif. Sampel penelitian yaitu anak yang lahir prematur di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado yang terdiagnosis PJB pada tahun 2013-2014. Populasi penelitian berjumlah 353 anak yang lahir prematur, sampel penelitian yang memenuhi kriteria inklusi yaitu anak yang lahir prematur dengan PJB berjumlah 35 sampel, dan diambil 30 sampel pembanding . Uji yang digunakan pada penelitian ini adalah Uji Fisher Exact, menghasilkan nilai p = 0,011 < α = 0,05, yang menunjukan ada hubungan yang bermakna antara kelahiran prematur dengan PJB. Simpulan: Ada hubungan yang bermakna antara kelahiran prematur dengan PJB.Kata kunci: Kelahiran prematur, PJB

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