Optical methods and image processing as a quantitative tool in photodynamic therapy: a proof of concept

2019 ◽  
Author(s):  
Josue D. Rivera-Fernandez ◽  
Karen Roa-Tort ◽  
Jose M. de la Rosa-Vazquez ◽  
Alma Valor-Reed ◽  
Suren Stolik-Isakina ◽  
...  
Keyword(s):  
Image Processing ◽  
Photodynamic Therapy ◽  
Optical Methods ◽  
Proof Of Concept ◽  
Quantitative Tool

scholarly journals Effective Combination of Photodynamic Therapy and Imiquimod 5% Cream in the Treatment of Actinic Keratoses: Three Cases

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Laura Held ◽  
Thomas Kurt Eigentler ◽  
Ulrike Leiter ◽  
Claus Garbe ◽  
Mark-Jürgen Berneburg
Keyword(s):  
Photodynamic Therapy ◽  
Patient Adherence ◽  
Proof Of Concept ◽  
Treatment Area ◽  
Skin Reactions ◽  
Local Skin ◽  
Once Daily ◽  
Actinic Keratoses ◽  
Effective Combination

Background. The therapy for actinic keratoses includes photodynamic therapy (PDT) and imiquimod 5% cream. The sequential use of both could result in better clinical outcomes.Objectives. To enhance efficacy of therapies while improving tolerability, convenience, and patient adherence with a scheme combining two concomitant or sequential AK treatments.Methods. All patients underwent one session of conventional PDT. Two weeks after, the PDT imiquimod 5% cream was applied to the treatment area once daily for three days per week. One course continued for four weeks followed by a clinical evaluation and decision about further treatment. Patients who had not cleared all of their AK lesions in the treatment area in course 1 participated in a second 4-week course of treatment.Limitations. Small size of population.Results. Three participants were enrolled. Two patients showed complete clinical clearance of AKs. The effect was also noted after long-term followup, at months seven and eleven. No subject discontinued for an adverse event. There were severe local skin reactions in two participants which were severe erythema, scaling, and crusting. One patient showed no response to the therapy.Conclusions. Photodynamic therapy followed by imiquimod was well tolerated and improved reduction of actinic keratoses. This initial proof-of-concept should be studied in larger clinical trials.

Image Processing for Optical Methods to Analyze Shape, Deformation, Stress and Strain

2006 ◽  
Vol 326-328 ◽  
pp. 13-18
Author(s):  
Yoshiharu Morimoto
Keyword(s):  
Image Processing ◽  
Real Time ◽  
High Speed ◽  
Video Camera ◽  
Image Sensor ◽  
Phase Shifting ◽  
Optical Methods ◽  
Shape Deformation ◽  
Stress And Strain ◽  
Deformation Stress

The authors have been developing some novel methods to measure shape, deformation, stress and strain of structures using optical methods and image processing as follows: (1) Phase analysis methods using Fourier, wavelet or Gabor transforms, etc., (2) Real-time 2-D strain measurement using moiré interferometry, (3) Scanning moiré method using thinning-out of scanning lines and a DMD camera (4) Strain rate distribution measurement by a high-speed video camera, (5) Real-time integrated phase-shifting method, (6) Shape measurement methods using multi-reference planes, a linear image sensor, or a frequency modulated grating, and (7) Windowed phase-shifting digital holographic interferometry (WPSDHI). Theories of these methods and some applications are introduced. The most accurate result is 88 picometer standard deviation of errors using the WPSDHI.

scholarly journals Tumor irradiation combined with minimally invasive surgery (vascular-targeted photodynamic therapy) enhances anti-tumour effects in preclinical prostate cancer

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Hannah Sjoberg
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Vascular Function ◽  
Locally Advanced ◽  
Tumour Microenvironment ◽  
Proof Of Concept ◽  
Fractionated Radiotherapy ◽  
Tumour Control ◽  
Targeted Photodynamic Therapy

Hanna T Sjoberg, Yiannis Philippou, Anette L Magnussen, Iain DC Tullis, Esther Bridges, Andrea Chatrian, Joel Loefebvre, Ka Ho Tam, Emma A Murphy, Jens Rittscher, Dina Preise, Lilach Agemy, Tamar Yechezkel, Sean C Smart, Paul Kinchesh, Stuart Gilchrist, Danny P Allen, David A Scheiblin, Stephen J Lockett, David A Wink, Alastair D Lamb, Ian G Mills, Adrian Harris, Ruth J Muschel, Boris Vojnovic, Avigdor Scherz, Freddie C Hamdy, Richard J Bryant.   Introduction There is an important clinical need to improve the treatment of high risk localised and locally advanced prostate cancer (PCa), and to reduce the side effects of these treatments. We hypothesised that multi-modality therapy combining radiotherapy and vascular-targeted photodynamic therapy (VTP) could PCa tumour control compared against monotherapy with each of these treatments alone. This could provide proof-of-concept to take to the clinic. VTP is a minimally invasive focal surgical therapy for localised PCa, which rapidly destroys targeted tumours through vascular disruption. Tumour vasculature is characterised by vessel immaturity, increased permeability, aberrant branching and inefficient flow. Fractionated radiotherapy (FRT) alters the tumour microenvironment and promotes transient vascular normalisation. Materials and Methods We investigated whether sequential delivery of FRT followed by VTP 7 days later improves PCa tumour control compared to monotherapy with FRT or VTP alone. Results FRT induced vascular normalisation changes in PCa flank tumour allografts, improving vascular function as demonstrated using dynamic contrast enhanced magnetic resonance imaging. FRT followed by VTP significantly delayed tumour growth in flank PCa allograft pre-clinical models, compared with monotherapy with FRT or VTP alone, and improved overall survival. Conclusion Taken together, these results suggest that combining FRT and VTP could become a promising multimodal clinical strategy in PCa therapy. This provides proof-of-concept for this multi-modality therapy approach to take forward to early phase clinical trials.

Qualifying Glass Surfaces by Scratch Test with Integrated Image Processing

2009 ◽  
Vol 409 ◽  
pp. 267-274
Author(s):  
Maria Berkes Maros ◽  
Attila Fazekas ◽  
Péter Barkóczy ◽  
Szilvia Szeghalmy ◽  
Zsuzsanna Koncsik
Keyword(s):  
Image Processing ◽  
Image Analysis ◽  
Residual Stresses ◽  
Information Content ◽  
Scratch Test ◽  
Analysis Procedure ◽  
Test Method ◽  
Current Paper ◽  
Optical Methods ◽  
Glass Surfaces

Residual stresses of production origin superimposed with the operational stresses influences the reliability of glass products. The most widely used procedures for their detection and qualification are optical methods that can not be utilized for testing of non-transparent glasses. A recently developed glass qualifying procedure based on scratch test with integrated image processing is applicable for evaluating the residual stresses in surface of both the transparent and non-transparent glasses. The reliability of the suggested test method is greatly dependent on the information content provided by the involved image analysis procedure. The current paper introduces the principle, and methodology of the test method, furthermore presents the latest results gained by applying an improved algorithm of the image processing.

scholarly journals Tumor irradiation combined with vascular-targeted photodynamic therapy enhances anti-tumor effects in preclinical prostate cancer

2020 ◽  
Author(s):  
Hanna T Sjoberg ◽  
Yiannis Philippou ◽  
Anette L Magnussen ◽  
Iain DC Tullis ◽  
Esther Bridges ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Vascular Function ◽  
Locally Advanced ◽  
Tumor Control ◽  
Proof Of Concept ◽  
Vascular Normalization ◽  
Fractionated Radiotherapy ◽  
Tumour Control ◽  
Targeted Photodynamic Therapy

AbstractRationaleThere is an important clinical need to improve the treatment of high risk localized and locally advanced prostate cancer (PCa), and to reduce the side effects of these treatments. We hypothesized that multi-modality therapy combining radiotherapy and vascular-targeted photodynamic therapy (VTP) could PCa tumour control compared against monotherapy with each of these treatments alone. This could provide proof-of-concept to take to the clinic. VTP is a focal therapy for localized PCa, which rapidly destroys targeted tumors through vascular disruption. Tumor vasculature is characterized by vessel immaturity, increased permeability, aberrant branching and inefficient flow. Fractionated radiotherapy (FRT) alters the tumor microenvironment and promotes transient vascular normalization.ObjectiveWe investigated whether sequential delivery of FRT followed by VTP 7 days later improves PCa tumor control compared to monotherapy with FRT or VTP alone.FindingsFRT induced vascular normalization changes in PCa flank tumor allografts, improving vascular function as demonstrated using dynamic contrast enhanced magnetic resonance imaging. FRT followed by VTP significantly delayed tumor growth in flank PCa allograft pre-clinical models, compared with monotherapy with FRT or VTP alone, and improved overall survival.ConclusionTaken together, these results suggest that combining FRT and VTP could become a promising multimodal clinical strategy in PCa therapy. This provides proof-of-concept for this multi-modality therapy approach to take forward to early phase clinical trials.

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