scholarly journals Individual Survival Curves with Conditional Normalizing Flows

2021 ◽  
Author(s):  
Guillaume Ausset ◽  
Tom Ciffreo ◽  
Francois Portier ◽  
Stephan Clemencon ◽  
Timothee Papin
Keyword(s):  
Survival Curves ◽  
Individual Survival

Estimating the Survival of Clostridium botulinum Spores during Heat Treatments

2000 ◽  
Vol 63 (2) ◽  
pp. 190-195 ◽  
Author(s):  
M. PELEG ◽  
M. B. COLE
Keyword(s):  
Clostridium Botulinum ◽  
Heat Inactivation ◽  
Survival Ratio ◽  
Survival Curves ◽  
First Order Kinetics ◽  
Individual Survival ◽  
D Values ◽  
The Individual ◽  
Increasing Temperature ◽  
Limiting Case

A recently published study of the inactivation of Clostridium botulinum spores at various temperatures in the range of 101 to 121°C and neutral pH revealed that their semilogarithmic survival curves all had considerable upward concavity. This finding indicated that heat inactivation of the spores under these conditions did not follow a first-order kinetics and that meaningful D values could not be calculated. The individual survival curves could be described by the cumulative form of the Weibull distribution, i.e., by log S =−b(T)tn(T), where S is the survival ratio and b(T) and n(T) are temperature-dependent coefficients. The fact that at all temperatures in the above range n(T) was smaller than 1 suggested that as time increases sensitive members of the population parish and survivors with increasing resistance remain. If damage accumulation is not a main factor, and the inactivation is path independent, then survival curves under monotonously increasing temperature can be constructed using a relatively simple model, which can be used to calculate the spores' survival in a limiting case. This is demonstrated with computer-simulated heating curves and the experimental constants of the C. botulinum spores, setting the number of decades reduction to 8, 10, and 12 (the current criterion for commercial sterility).

scholarly journals Extrapolation of Individual Survival Curves: What Can We Learn From Registry Data?

2018 ◽  
Vol 21 ◽  
pp. S8
Author(s):  
J Gray ◽  
T Sullivan ◽  
M Sorich ◽  
A Salter ◽  
J Karnon
Keyword(s):  
Registry Data ◽  
Survival Curves ◽  
Individual Survival

scholarly journals Individual survival curves comparing subjective and observed mortality risks

2017 ◽  
Vol 26 (12) ◽  
Author(s):  
Luc Bissonnette ◽  
Michael D. Hurd ◽  
Pierre‐Carl Michaud
Keyword(s):  
Survival Curves ◽  
Mortality Risks ◽  
Individual Survival

scholarly journals Thermal Inactivation of Susceptible and Multiantimicrobial-Resistant Salmonella Strains Grown in the Absence or Presence of Glucose

2003 ◽  
Vol 69 (7) ◽  
pp. 4123-4128 ◽  
Author(s):  
R. T. Bacon ◽  
J. R. Ransom ◽  
J. N. Sofos ◽  
P. A. Kendall ◽  
K. E. Belk ◽  
...  
Keyword(s):  
Heat Stress ◽  
Protective Effect ◽  
Thermal Tolerance ◽  
Thermal Inactivation ◽  
Survival Curves ◽  
Acid Adaptation ◽  
Circulating Water ◽  
Glucose Levels ◽  
Study Results ◽  
Peptone Water

ABSTRACT The heat resistance of susceptible and multiantimicrobial-resistant Salmonella strains grown to stationary phase in glucose-free tryptic soy broth supplemented with 0.6% yeast extract (TSBYE−G; nonadapted), in regular (0.25% glucose) TSBYE, or in TSBYE−G with 1.00% added glucose (TSBYE+G; acid adapted) was determined at 55, 57, 59, and 61°C. Cultures were heated in sterile 0.1% buffered peptone water (50 μl) in heat-sealed capillary tubes immersed in a thermostatically controlled circulating-water bath. Decimal reduction times (D values) were calculated from survival curves having r 2 values of >0.90 as a means of comparing thermal tolerance among variables. D 59°C values increased (P < 0.05) from 0.50 to 0.58 to 0.66 min for TSBYE−G, TSBYE, and TSBYE+G cultures, respectively. D 61°C values of antimicrobial-susceptible Salmonella strains increased (P < 0.05) from 0.14 to 0.19 as the glucose concentration increased from 0.00 to 1.00%, respectively, while D 61°C values of multiantimicrobial-resistant Salmonella strains did not differ (P > 0.05) between TSBYE−G and TSBYE+G cultures. When averaged across glucose levels and temperatures, there were no differences (P > 0.05) between the D values of susceptible and multiantimicrobial-resistant inocula. Collectively, D values ranged from 4.23 to 5.39, 1.47 to 1.81, 0.50 to 0.66, and 0.16 to 0.20 min for Salmonella strains inactivated at 55, 57, 59, and 61°C, respectively. zD values were 1.20, 1.48, and 1.49°C for Salmonella strains grown in TSBYE+G, TSBYE, and TSBYE−G, respectively, while the corresponding activation energies of inactivation were 497, 493, and 494 kJ/mol. Study results suggested a cross-protective effect of acid adaptation on thermal inactivation but no association between antimicrobial susceptibility and the ability of salmonellae to survive heat stress.

Outcomes of management of major aortopulmonary collaterals for pulmonary atresia and ventricular septal defect

2020 ◽  
pp. 1-9
Author(s):  
Dong Zhao ◽  
Keming Yang ◽  
Wei Feng ◽  
Shoujun Li ◽  
Jun Yan ◽  
...  
Keyword(s):  
Ventricular Septal Defect ◽  
Pulmonary Artery ◽  
Septal Defect ◽  
Pulmonary Atresia ◽  
Survival Curves ◽  
Major Aortopulmonary Collateral Arteries ◽  
Palliative Procedure ◽  
Collateral Arteries ◽  
Kaplan Meier ◽  
Aortopulmonary Collateral

Abstract Objective: This study aimed to investigate the association between long-term survival and different management of major aortopulmonary collateral arteries in patients with pulmonary atresia, ventricular septal defect, and major aortopulmonary collateral arteries. Methods: From November, 2009 to October, 2018, a total of 98 consecutive patients with pulmonary atresia, ventricular septal defect, major aortopulmonary collateral arteries, and hypoplastic pulmonary arteries treated with modified Blalock–Taussig shunt or right ventricle–pulmonary artery connection were included. Fifty-five patients who received occlusion or ligation of major aortopulmonary collateral arteries during or after palliative procedure were occlusion group, and the other 43 patients were no occlusion group. The early and late outcomes were compared. Results: The mean duration of follow-up was 30.9 months in no occlusion group and 49.8 months in the occlusion group (p < 0.001). Multivariate analysis showed that only no occlusion of major aortopulmonary collateral arteries was predictive of total mortality (Hazard Ratio: 4.42, 95% CI: 1.27 to 15.42, p = 0.02). The Kaplan–Meier survival curves confirmed that patients without occlusion of major aortopulmonary collateral arteries demonstrated worse survival as compared with the occlusion group (p = 0.013). The Kaplan–Meier survival curves of patients who underwent different palliative procedures showed no differences. Conclusions: For patients with pulmonary atresia, ventricular septal defect and major aortopulmonary collateral arteries when a primary repair is not feasible, those without occlusion of major aortopulmonary collateral arteries have a higher risk of death following an initial palliative procedure compared with patients who underwent occlusion of major aortopulmonary collateral arteries. The occlusion of major aortopulmonary collateral arteries is not associated with a higher rate of complete repair or better improvement of pulmonary artery growth.

scholarly journals ‘We are taught to act’: hustling on the move in Kampala and Nairobi

Africa ◽  
2021 ◽  
Vol 91 (1) ◽  
pp. 95-112
Author(s):  
William Monteith ◽  
George Mirembe
Keyword(s):  
East Africa ◽  
Film Industry ◽  
Language Skills ◽  
Young Men ◽  
Economic Opportunities ◽  
African Cities ◽  
Individual Survival ◽  
Urban Contexts

AbstractThis article explores the question of what happens when highly socialized and contingent forms of provisioning go wrong, and young men are forced to start again in unfamiliar urban contexts. The decline of George Mirembe's moneylending business in Kampala pre-empted his departure from the country and his arrival in Nairobi in search of new socio-economic opportunities. Lacking the documents and language skills necessary to enter formal sectors of the economy, George claimed asylum as a sexual refugee while working as a smuggler and a voice actor in the shadow film industry. His activities illustrate the advantages and limitations of the hustle as a framework for understanding the activities of transnational ‘others’ in African cities. I argue that translational practices of acting and storytelling have become a generalized tactic of survival among migrants in urban East Africa. Such practices are illustrative of a form of ‘uprooted hustle’ – or hustling on the move – that is oriented towards individual survival and exit rather than place-based transformation.

scholarly journals A Tale of Two Disasters

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 694-694
Author(s):  
Tammy Mermelstein
Keyword(s):  
Older Adults ◽  
Social Media ◽  
Interest Group ◽  
Media Analysis ◽  
Ice Storm ◽  
Social Media Analysis ◽  
Individual Survival ◽  
Social Media Platforms

Abstract Preparing for or experiencing a disaster is never easy, but how leaders communicate with older adults can ease a situation or make it exponentially worse. This case study describes two disasters in the same city: Hurricane Harvey and the 2018 Houston Texas Ice Storm and the variation in messaging provided to and regarding older adults. For example, during Hurricane Harvey, the primary pre-disaster message was self-preparedness. During the storm, messages were also about individual survival. Statements such as “do not [climb into your attic] unless you have an ax or means to break through,” generated additional fear for older adults and loved ones. Yet, when an ice storm paralyzed Houston a few months later, public messaging had a strong “check on your elderly neighbors” component. This talk will explore how messaging for these events impacted older adults through traditional and social media analysis, and describe how social media platforms assisted people with rescue and recovery. Part of a symposium sponsored by Disasters and Older Adults Interest Group.

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