Determining Significant Risk Factors for Cardiovascular Complications of Patient with Type 2 Diabetes Mellitus and Hypertension Using Multi-Expert Multi-Criteria Decision Making

Author(s):  
Napa Rachata
2018 ◽  
Vol 3 (2) ◽  
pp. 41-44
Author(s):  
DN N Begun ◽  
EL L Borshchuk ◽  
KV V Leushina

Aim - to identify the most significant risk factors that affect the occurrence of cardiovascular complications in patients with type 2 diabetes and to create the supplement for the risk assessment of cardiovascular complications in patients with type 2 diabetes. Methods of research. The object of the study is adult patients with type 2 diabetes mellitus (n = 60). For the development and analysis of the material, a statistical method is used, a modeling method of constructing the classification trees. Discussion and results. Statistically significant risk factors for cardiovascular complications in type 2 diabetes are a high body mass index, the presence of insulin therapy, the duration of the disease, a high maximum level of systolic blood pressure, high concentrations of LDL, markers of cell damage, and some hemodynamic parameters of myocardial function. A multidimensional model of the risk of complications was developed, which served as an algorithm for the created computer program, their early prognosis and timely carrying out of preventive measures.


2017 ◽  
Vol 11 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Muhammad Abdur Rahim ◽  
Palash Mitra ◽  
Hasna Fahmima Haque ◽  
Tasrina Shamnaz Samdani ◽  
Shahana Zaman ◽  
...  

Background and objectives: Diabetes mellitus is one of the most common causes of chronic kidney disease (CKD). The prevalence of CKD in type 2 diabetes mellitus (T2DM) in Bangladesh is not well described. The present study aimed to find out the prevalence of CKD stages 3-5 and its risk factors among selected Bangladeshi T2DM patients.Methods: This cross-sectional study was conducted in BIRDEM (Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General Hospital, Dhaka, Bangladesh from July to December 2015. Diagnosed adult T2DM patients were consecutively and purposively included in this study. Pregnant women, patients with diagnosed kidney disease due to non-diabetic etiology, acute kidney injury (AKI), AKI on CKD and patients on renal replacement therapy were excluded. Age, gender, body mass index (BMI) and laboratory parameters were recorded systematically in a predesigned data sheet. Diagnosis of CKD and its stages were determined according to Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guidelines 2012 and estimated glomerular filtration rate (eGFR). Estimated GFR was calculated by using Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault (CG) and Chronic Kidney Disease Epidemiology (CKDEPI) creatinine based formula.Results: A total of 400 patients with T2DM of various durations were enrolled in the study. Out of 400 patients, 254 (63.5%), 259 (64.75%) and 218 (54.5%) cases had CKD stages 3-5 according to MDRD, C-G and CKD-EPI equations respectively. CKD was significantly more common in females (p<0.001) and in cases with long duration of diabetes (?5 years; p=0.007). CKD stages 3-5 were significantly associated with hypertension (?2=5.2125, p =0.02) and good control of diabetes (HbA1c <7%) as evidenced by higher proportion of CKD in them (73.3%) compared to those with poor glycemic control (52.1%).Conclusions: More than half of T2DM patients had CKD stages 3-5. Female gender, duration of diabetes and hypertension were significant risk factors and should be emphasized for the prevention of CKD in T2DM. Glycemic control may not reduce CKD in diabetes.IMC J Med Sci 2017; 11(1): 19-24


2017 ◽  
Vol 20 (4) ◽  
pp. 4-10
Author(s):  
Tatiana Olegovna Yalochkina ◽  
Janna Evgen'evna Belaya ◽  
Lyudmila Yakovlevna Rozhinskaya ◽  
Michail Borisovich Antsiferov ◽  
Larisa Konstantinovna Dzeranova ◽  
...  

Aim. To estimate the prevalence of and risk factors for low-traumatic fractures in patients with type 2 diabetes mellitus (T2DM).Materials and methods. We questioned 214 patients with T2DM from a single outpatient clinic located in Moscow to evaluate the prevalence of and risk factors for low-traumatic fractures, the duration of and complications from TD2M and HbA1c levels.Results. Of 214 patients, 65 reported low-traumatic bone fractures. Patients with a history of low-traumatic fractures reported falls in the previous year (28%), whereas only 13% of patients without fractures reported falls. The difference was statistically significant, with an odds ratio of 2.34 (1,144,76), P=0,022. Men reported fractures more frequently than women (43.3% vs. 24.7%, respectively, P = 0.01). Patients with bone fractures had a lower body mass index (P = 0.022); however, a multivariate analysis revealed that a history of falls and male sex were the most significant risk factors for fracture.Conclusion. Around 30% of patients with T2DM from a Moscow outpatient clinic reported bone fractures. The most significant risk factors for fracture were a history of falls in the previous year and male sex. The article is the RePrint from the original article inDiabetes Mellitus (2016); 19(5) pp. 359-365. doi: 10.14341/DM7796


2018 ◽  
Vol 4 (1) ◽  
pp. 16-21
Author(s):  
Nilam Munakarmi ◽  
Amrit Pokharel ◽  
Om Krishna Malla ◽  
Chhabindra Lal Pradhananga

INTRODUCTION: Diabetic maculopathy is a complication of type 2 diabetes mellitus. This study was done to assess the prevalence and risk factors of Diabetic maculopathy in type 2 diabetes mellitus in Nepalese patients presenting to our hospital. MATERIAL AND METHODS: A hospital-based, descriptive, cross-sectional study was conducted at the department of ophthalmology, Kathmandu Medical College Teaching Hospital (KMCTH), Sinamangal, Kathmandu, Nepal from August, 2012 to October, 2014. 200 patients with type 2 diabetes mellitus underwent a detailed interview and a comprehensive dilated ocular evaluation by an ophthalmologist. Diabetic maculopathy was defined according to the international classification and grading system.  RESULTS: 200 patients suffering from type 2 diabetes mellitus included 90 men (45%) and 110 women (55%) of age ranging from 23 80 years (mean age = 56.23, median age = 57.5 and SD = 10.83). Diabetic maculopathy was detected in 22 patients (11%). The disease duration of 6 to 15 years had the highest prevalence of Diabetic maculopathy. Significant risk factors for diabetic maculopathy were higher levels of HbA1c (p = 0.005), higher values of blood pressure (p = 0.001), higher cholesterol levels (p = 0.000), higher LDL-cholesterol levels (p = 0.000), higher triglyceride levels (p = 0.000), higher creatinine values (p = 0.000), higher urea values (p = 0.000), higher FBS levels (p = 0.020), higher PPBS levels (p = 0.001) and lower hemoglobin values (p = 0.000). CONCLUSION: Significant risk factors for diabetic maculopathy were higher levels of HbA1c, higher values of blood pressure, higher cholesterol levels, higher LDL-cholesterol levels, higher triglyceride levels, higher creatinine values, higher urea values, higher FBS levels, higher PPBS levels and lower hemoglobin values. However, smoking, drinking alcohol, dietary habits, HDL and BMI contributed as insignificant risk factors.Journal of Universal College of Medical Sciences (2016) Vol.04 No.01 Issue 13, Page: 16-21


2020 ◽  
pp. 75-77
Author(s):  
Satish Desai ◽  
Priyanka A. Mahendrakar

AIM: To estimate the frequency of Diabetic Retinopathy and the possible risk factors associated with Diabetic Retinopathy. MATERIALS AND METHODS: All patients of diagnosed type 2 Diabetes Mellitus attending Ophthalmology Outpatient Department in Government Medical College and Hospital, Miraj during the study period were included. History was taken and a complete ophthalmic examination was done. Diabetic Retinopathy was graded according to ETDRS classification. Data was analyzed using SPSS 22 version software. RESULT: A total of 275 patients with diagnosed Diabetes Mellitus were examined. Frequency of diabetic retinopathy in the study was 30.91%. Significant association was found with male gender (p=0.008), duration of Diabetes Mellitus more than 10 years (p<0.001), positive family history (p<0.001), use of insulin (p<0.001), raised systolic and diastolic blood pressure (p<0.001), fasting and post prandial blood sugar levels (p<0.001). Age, smoking status and body mass index were not found to be significant risk factors for the development of diabetic retinopathy.


2020 ◽  
Vol 2 (1) ◽  
pp. 62-65
Author(s):  
M.R. Rahmetova ◽  

Purpose: to study the influence of risk factors on the development of cardiovascular complications in patients with diabetes mellitus and to evaluate the effectiveness of treatment depending on the effect of certain factors. Materials and methods. Westudied 23 patients with type 2 diabetes mellitus with chronic cardiovascular complications, who were prescribed long-term therapy for diabetes and cardiovascular complications. Patients were offered questionnaires with questions about the prescribed treatment, the actual treatment received and the reasons for the violation of the recommendations.


Author(s):  
Jakub Mesinovic ◽  
David Scott ◽  
Markus J Seibel ◽  
Robert G Cumming ◽  
Vasi Naganathan ◽  
...  

Abstract Background Type 2 diabetes mellitus (T2DM) increases falls and fracture risk. Our objective was to compare incidence and risk factors for falls and fractures in community-dwelling older men with and without T2DM. Methods A total of 1,705 men (471 with T2DM; 1234 without T2DM) aged ≥70 years were assessed at baseline. Men were contacted every 4 months for 6.0 ± 2.2 years to ascertain incident falls and fractures, with the latter being confirmed by radiographic reports. Hip fractures were ascertained via data linkage (follow up: 8.8 ± 3.6 years). Risk factors for falls and fractures included physical activity and function, body composition, medications and vision measures. Results Men with T2DM had similar fall (IRR: 0.92 [95%CI: 0.70, 1.12], n=1246) and fracture rates (HR: 0.86 [95%CI: 0.56, 1.32], n=1326) compared to men without T2DM after adjustment for significant risk factors. In men with T2DM, depression (IRR: 1.87 [95%CI: 1.05, 3.34], n=333), sulphonylurea usage (IRR: 2.07 [95%CI: 1.30, 3.27]) and a greater number of prescription medications (IRR: 1.13 [95%CI: 1.03, 1.24]) were independently associated with increased fall rates, and higher total hip BMD was independently associated with lower fracture rates (HR: 0.63 [95%CI: 0.47, 0.86], n=351). Interaction terms demonstrated that better contrast sensitivity was independently associated with lower fracture rates (HR: 0.14 [95%CI: 0.02, 0.87]) in men with T2DM compared to men without T2DM. Conclusion Fall and fracture rates were similar in men with and without T2DM after adjusting for significant risk factors. Vision assessments including contrast sensitivity measures may improve fracture prediction in older men with T2DM.


2016 ◽  
Vol 19 (5) ◽  
pp. 359-365 ◽  
Author(s):  
Tatiana Olegovna Yalochkina ◽  
Janna Evgen'evna Belaya ◽  
Lyudmila Yakovlevna Rozhinskaya ◽  
Michail Borisovich Antsiferov ◽  
Larisa Konstantinovna Dzeranova ◽  
...  

Aim. To estimate the prevalence of and risk factors for low-traumatic fractures in patients with type 2 diabetes mellitus (T2DM).Materials and methods. We questioned 214 patients with T2DM from a single outpatient clinic located in Moscow to evaluate the prevalence of and risk factors for low-traumatic fractures, the duration of and complications from TD2M and HbA1c levels.Results. Of 214 patients, 65 reported low-traumatic bone fractures. Patients with a history of low-traumatic fractures reported falls in the previous year (28%), whereas only 13% of patients without fractures reported falls. The difference was statistically significant, with an odds ratio of 2.34 (1,14–4,76), P=0,022. Men reported fractures more frequently than women (43.3% vs. 24.7%, respectively, P = 0.01). Patients with bone fractures had a lower body mass index (P = 0.022); however, a multivariate analysis revealed that a history of falls and male sex were the most significant risk factors for fracture.Conclusion. Around 30% of patients with T2DM from a Moscow outpatient clinic reported bone fractures. The most significant risk factors for fracture were a history of falls in the previous year and male sex.


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