Magnetic Resonance Imaging compatible Elastic Loading Mechanism (MELM): A minimal footprint device for MR imaging under load

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.

Download Full-text

Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458513512709 ◽

2013 ◽

Vol 20 (1) ◽

pp. 3-11 ◽

Cited By ~ 5

Author(s):

Nabeela Nathoo ◽

V Wee Yong ◽

Jeff F Dunn

Keyword(s):

Magnetic Resonance Imaging ◽

Multiple Sclerosis ◽

Clinical Trials ◽

Magnetic Resonance ◽

Animal Models ◽

Mr Imaging ◽

Preclinical Studies ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Mri ◽

Potential Therapeutics

Major advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or neuroprotection. With an increase in diversity of MS therapies comes the need to assess the effectiveness of such therapies. Magnetic resonance imaging (MRI) is one of the main tools used to evaluate the effectiveness of MS therapeutics in clinical trials. As all new therapeutics for MS are tested in animal models first, it is logical that MRI be incorporated into preclinical studies assessing therapeutics. Here, we review key papers showing how MR imaging has been combined with a range of animal models to evaluate potential therapeutics for MS. We also advise on how to maximize the potential for incorporating MRI into preclinical studies evaluating possible therapeutics for MS, which should improve the likelihood of discovering new medications for the condition.

Download Full-text

Normal Magnetic Resonance Imaging Anatomy of the Capsular Ligamentous Supporting Structures of the Knee

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2015.11.004 ◽

2016 ◽

Vol 67 (4) ◽

pp. 356-367 ◽

Cited By ~ 3

Author(s):

Lana H. Gimber ◽

Jolene C. Hardy ◽

David M. Melville ◽

Luke R. Scalcione ◽

Andrew Rowan ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Proximal Tibiofibular Joint ◽

Imaging Findings ◽

Resonance Imaging ◽

Tibiofibular Joint ◽

Anatomic Variants ◽

Neurovascular Structures ◽

Supporting Structures

Recognition of the normal magnetic resonance (MR) imaging appearances of the capsular ligaments of the knee is of great importance. These ligaments contribute to stability of the knee joint and are frequently injured. In this article, we describe the normal MR imaging anatomy of the capsular ligaments of the knee including the lateral and medial collateral ligamentous complexes, the extensor mechanism, and the supporting ligamentous structures of the proximal tibiofibular joint. Normal MR imaging findings and important anatomic variants of the neurovascular structures of the knee are also described.

Download Full-text

Magnetic Resonance Imaging, Molecular MR Imaging

Encyclopedia of Diagnostic Imaging ◽

10.1007/978-3-540-35280-8_1478 ◽

2008 ◽

pp. 1087-1091 ◽

Cited By ~ 1

Author(s):

Ralph Weissleder ◽

Alexander R. Guimaraes

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Resonance Imaging

Download Full-text

Setup of an Ablation Magnetic Resonance Imaging Hybrid System: Using MR Imaging Sequences to Destroy Tissue

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) ◽

10.1109/embc.2019.8857894 ◽

2019 ◽

Author(s):

Thomas Gerlach ◽

Enrico Pannicke ◽

Marcus Prier ◽

Frank Seifert ◽

Oliver Speck ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Hybrid System ◽

Resonance Imaging

Download Full-text

Correlation of the relationships of brain—tumor interfaces, magnetic resonance imaging, and angiographic findings to predict cleavage of meningiomas

Journal of Neurosurgery ◽

10.3171/jns.1999.91.3.0384 ◽

1999 ◽

Vol 91 (3) ◽

pp. 384-390 ◽

Cited By ~ 67

Author(s):

Faruk İldan ◽

Metin Tuna ◽

Alp İskender Göcer ◽

Bülent Boyar ◽

Hüseyin Bağdatoğlu ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Brain Tumor ◽

Magnetic Resonance ◽

Mr Imaging ◽

Vascular Supply ◽

Peritumoral Edema ◽

Resonance Imaging ◽

Content Type ◽

Angiographic Findings ◽

Fine Print

Object. The authors examined the relationships of brain—tumor interfaces, specific magnetic resonance (MR) imaging features, and angiographic findings in meningiomas to predict tumor cleavage and difficulty of resection.Methods. Magnetic resonance imaging studies, angiographic data, operative reports, clinical data, and histopathological findings were examined retrospectively in this series, which included 126 patients with intracranial meningiomas who underwent operations in which microsurgical techniques were used. The authors have identified three kinds of brain—tumor interfaces characterized by various difficulties in microsurgical dissection: smooth type, intermediate type, and invasive type. The signal intensity on T1-weighted MR images was very similar regardless of the type of brain—tumor interface (p > 0.1). However, on T2-weighted images the different interfaces seemed to correlate very precisely with the signal intensity and the amount of peritumoral edema (p < 0.01), allowing the prediction of microsurgical effort required during surgery. On angiographic studies, the pial—cortical arterial supply was seen to participate almost equally with the meningeal—dural arterial supply in vascularizing the tumor in 57.9% of patients. Meningiomas demonstrating hypervascularization on angiography, particularly those fed by the pial—cortical arteries, exhibited significantly more severe edema compared with those supplied only from meningeal arteries (p < 0.01). Indeed, a positive correlation was found between the vascular supply from pial—cortical arteries and the type of cleavage (p < 0.05).Conclusions. In this analysis the authors proved that there is a strong correlation between the amount of peritumoral edema, hyperintensity of the tumor on T2-weighted images, cortical penetration, vascular supply from pial—cortical arteries, and cleavage of the meningioma. Therefore, the consequent difficulty of microsurgical dissection can be predicted preoperatively by analyzing MR imaging and angiographic studies.

Download Full-text

Ce6/Mn2+-chelated polydopamine@black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer

Nanoscale ◽

10.1039/c9nr09236f ◽

2020 ◽

Vol 12 (3) ◽

pp. 1801-1810 ◽

Cited By ~ 5

Author(s):

Yang Gao ◽

Luyun Zhang ◽

Yanhong Liu ◽

Sijia Sun ◽

Zhibin Yin ◽

...

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Shell Structure ◽

Core Shell ◽

Resonance Imaging ◽

Black Tio2 ◽

Core Shell Structure ◽

4T1 Breast Cancer

Ce6/Mn2+-chelated, polydopamine (PDA)-coated black TiO2 (b-P25@PDA-Ce6 (Mn)) nanoprobes with core–shell structure were constructed for enhanced synergistic phototherapy and magnetic resonance (MR) imaging.

Download Full-text

Magnetic Resonance Imaging of Hard Tissues and Hard Tissue Engineered Bio-substitutes

Molecular Imaging and Biology ◽

10.1007/s11307-019-01345-2 ◽

2019 ◽

Vol 21 (6) ◽

pp. 1003-1019 ◽

Cited By ~ 7

Author(s):

Simone Mastrogiacomo ◽

Weiqiang Dou ◽

John A. Jansen ◽

X. Frank Walboomers

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Resonance Imaging ◽

Hard Tissue ◽

Comprehensive Overview ◽

Ultrashort Echo Time ◽

Dental Tissues ◽

Hard Tissues ◽

Echo Time

Abstract Magnetic resonance imaging (MRI) is a non-invasive diagnostic imaging tool based on the detection of protons into the tissues. This imaging technique is remarkable because of high spatial resolution, strong soft tissue contrast and specificity, and good depth penetration. However, MR imaging of hard tissues, such as bone and teeth, remains challenging due to low proton content in such tissues as well as to very short transverse relaxation times (T2). To overcome these issues, new MRI techniques, such as sweep imaging with Fourier transformation (SWIFT), ultrashort echo time (UTE) imaging, and zero echo time (ZTE) imaging, have been developed for hard tissues imaging with promising results reported. Within this article, MRI techniques developed for the detection of hard tissues, such as bone and dental tissues, have been reviewed. The main goal was thus to give a comprehensive overview on the corresponding (pre-) clinical applications and on the potential future directions with such techniques applied. In addition, a section dedicated to MR imaging of novel biomaterials developed for hard tissue applications was given as well.

Download Full-text

Diagnostic value of magnetic resonance imaging in perimesencephalic and nonperimesencephalic subarachnoid hemorrhage of unknown origin

Journal of Neurosurgery ◽

10.3171/2010.6.jns10310 ◽

2011 ◽

Vol 114 (4) ◽

pp. 1003-1007 ◽

Cited By ~ 40

Author(s):

Homajoun Maslehaty ◽

Athanassios K. Petridis ◽

Harald Barth ◽

Hubertus Maximilian Mehdorn

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

Unknown Origin ◽

Diagnostic Value ◽

Digital Subtraction ◽

Resonance Imaging ◽

Bleeding Pattern ◽

Group 2 ◽

Group 1

Object The aim of this study was to evaluate the diagnostic value of MR imaging in perimesencephalic (PM) and nonperimesencephalic (non-PM) subarachnoid hemorrhage (SAH) of unknown origin. Methods The authors conducted a retrospective review of all patients with SAH (1226 patients) in their department between January 1991 and December 2008. Included in the study were cases of spontaneous SAH diagnosed using CT scans obtained within 24 hours of the initial symptoms and initially negative digital subtraction (DS) angiograms. Patients with traumatic SAH and an unknown history were excluded from the study. Patients with initially negative DS angiograms were divided into 2 groups: Group 1, a typically PM bleeding pattern (PM SAH); and Group 2, a non-PM bleeding pattern (non-PM SAH) such as hemorrhage in the sylvian or interhemispheric fissure. Cranial MR imaging including the craniocervical region was performed within 72 hours after SAH was diagnosed in all patients in Groups 1 and 2. Results One thousand sixty-eight patients underwent DS angiography, and among them were 179 (16.7%) with negative angiograms—47 patients (26.3%) from Group 1 and 132 patients (73.7%) from Group 2. Magnetic resonance imaging demonstrated no bleeding sources in any case (100% negative). Thirty-four patients in Group 1 and 120 patients in Group 2 underwent a second DS angiography study. Digital subtraction angiography revealed an aneurysm as the bleeding source in 1 case in Group 1 and in 13 cases in Group 2. Conclusions Magnetic resonance imaging of the brain and craniocervical region did not produce additional benefit for the detection of a bleeding source and the therapy administered for PM SAH and non-PM SAH (100% negative). The costs of this examination exceeded the clinical value. Despite the results of this study, MR imaging should be discussed on a case-by-case basis because rare bleeding sources are periodically diagnosed in cases of non-PM SAH. A second-look DS angiogram is necessary because aneurysmal hemorrhage occasionally produces PM SAH as well as non-PM SAH. Further prospective studies are needed to verify the authors' results in the future.

Download Full-text

Susceptibility weighted magnetic resonance imaging of cerebral cavernous malformations: prospects, drawbacks, and first experience at ultra–high field strength (7-Tesla) magnetic resonance imaging

Neurosurgical FOCUS ◽

10.3171/2010.6.focus10130 ◽

2010 ◽

Vol 29 (3) ◽

pp. E5 ◽

Cited By ~ 29

Author(s):

Philipp Dammann ◽

Markus Barth ◽

Yuan Zhu ◽

Stefan Maderwald ◽

Marc Schlamann ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mr Imaging ◽

High Field ◽

Susceptibility Weighted Imaging ◽

Cerebral Cavernous Malformations ◽

Resonance Imaging ◽

High Field Strength ◽

Ultra High Field ◽

Cavernous Malformations

High-resolution susceptibility weighted MR imaging at high field strength provides excellent depiction of venous structures, blood products, and iron deposits, making it a promising complementary imaging modality for cerebral cavernous malformations (CCMs). Although already introduced in 1997 and being constantly improved, susceptibility weighted imaging is not yet routine in clinical neuroimaging protocols for CCMs. In this article, the authors review the recent literature dealing with clinical and scientific susceptibility weighted imaging of CCMs to summarize its prospects and drawbacks and provide their first experience with its use in ultra–high field (7-T) MR imaging.

Download Full-text