Change in network dynamics over time by administering Notch response inhibitor DAPT to hippocampal culture

Author(s):  
Fumika Moriya ◽  
Kenta Shimba ◽  
Kiyoshi Kotani ◽  
Yasuhiko Jimbo
Author(s):  
Brian T. Pentland ◽  
Kenneth T. Goh

Current theory in routine dynamics focuses on patterning (Feldman 2016) as a mechanism for stability and change in routines. We define patterning as the process of adding, removing, or reinforcing paths in the narrative network that describes an organizational routine. Patterning is a hybrid mechanism that can be driven by any of the four change motors (teleology, dialectic, lifecycle, or evolution). Through patterning, routines change and adapt over time. In this chapter, the idea of organizational routines is illustrated with examples from videogame development. The authors suggest that narrative networks provide a way to see routine dynamics as network dynamics and to analyze routines and organizational change from a fresh point of view.


Author(s):  
Peter Dodds ◽  
Duncan J. Watts

This article explores dynamic networks and diffusion, with particular emphasis on evolving traces of enacted social relations. It begins with a review of models for the evolution of networks over time — making a distinction between ‘node-based’ and ‘edge-based’ models — and more specifically how and why networks change. It then considers how network timing affects the flow of things across networks, focusing on how edge timing reshapes the set of paths potentially useful for diffusion. It also discusses the structure requirements for network diffusion and shows how these requirements are affected when we assume edges come and go over time. Finally, it describes the effect of tie order on diffusion potential as well as the correlation between network evolution and diffusion.


2021 ◽  
Author(s):  
Eren Asena

This paper studies the factors that sustain mental disorders by taking a network approach. The network theory suggests that mental disorders are networks of symptoms that causally interact (Borsboom, 2017). Symptom networks share certain dynamics with other complex systems: abrupt transitions between stable states, critical slowing down and hysteresis (Cramer et al., 2016). These findings suggest that symptom networks that have transitioned to a pathological state tend to remain that state. We argue that this tendency leads to the Lindy effect in symptom networks. The Lindy effect means that the conditional probability of surviving beyond a time point, given survival until that time point, increases over time (Taleb, 2014). In other words, time benefits future survival. A symptom network is considered to have survived until a time point if it has remained in a pathological state until that point. We first show how the Lindy effect is formalised by examining the stopping time distribution of Brownian motion with an absorbing barrier (Cook, 2012; Taleb, 2018). Specifically, we describe the hazard function of the stopping time distribution and make a distinction between "strong Lindy" and "weak Lindy". Strong Lindy is a monotonically decreasing hazard function whereas weak Lindy means an inverted-U shaped hazard function. Then, major depressive disorder (MDD) networks were simulated, manipulating the level of symptom connectivity. As before, the presence of the Lindy effect in these networks were tested using hazard functions, and in addition, survival probabilities conditioned on time. Afterwards, we fit a distribution to the network lifetimes. The lifetime distribution of strongly connected networks were heavy tailed and showed the Lindy effect; the longer a network had been depressed, the more likely it was to remain depressed. The lifetime distribution of weakly connected networks were light tailed and did not show the Lindy effect. After discussing caveats and alternative explanations of the findings, we conclude that network dynamics and the resulting Lindy effect can explain several findings in psychology such as the chronicity of depression (Swaminath, 2009) and the frequency distribution of remission times (Simon, 2000; Patten et al., 2010).


2017 ◽  
Vol 5 (2) ◽  
pp. 187-212 ◽  
Author(s):  
JAMES HOLLWAY ◽  
ALESSANDRO LOMI ◽  
FRANCESCA PALLOTTI ◽  
CHRISTOPH STADTFELD

AbstractIn this paper, we seek to advance an updated concept of social space that integrates the multilayer and dynamic statistical network methods currently at the disposal of social network researchers. We demonstrate the analytic value of the new concept of social space that we propose with the help of an illustrative analysis of an organizational field involving organizations' external and internal decisions that congeal into a multilevel system of action that shapes the space of possibilities for other participants in the field. Through these internal and external decisions, organizations seek certain positions in their social space while simultaneously modifying that social space over time. We conclude by arguing that network researchers' choices of goodness-of-fit statistics should reflect a consideration about the dimensions of social space of most interest to the nodes involved.


2018 ◽  
Vol 41 ◽  
Author(s):  
David Hirshleifer ◽  
Siew Hong Teoh

AbstractEvolved dispositions influence, but do not determine, how people think about economic problems. The evolutionary cognitive approach offers important insights but underweights the social transmission of ideas as a level of explanation. The need for asocialexplanation for the evolution of economic attitudes is evidenced, for example, by immense variations in folk-economic beliefs over time and across individuals.


1988 ◽  
Vol 19 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Virginia I. Wolfe ◽  
Suzanne D. Blocker ◽  
Norma J. Prater

Articulatory generalization of velar cognates /k/, /g/ in two phonologically disordered children was studied over time as a function of sequential word-morpheme position training. Although patterns of contextual acquisition differed, correct responses to the word-medial, inflected context (e.g., "picking," "hugging") occurred earlier and exceeded those to the word-medial, noninflected context (e.g., "bacon," "wagon"). This finding indicates that the common view of the word-medial position as a unitary concept is an oversimplification. Possible explanations for superior generalization to the word-medial, inflected position are discussed in terms of coarticulation, perceptual salience, and the representational integrity of the word.


2020 ◽  
Vol 29 (1S) ◽  
pp. 412-424
Author(s):  
Elissa L. Conlon ◽  
Emily J. Braun ◽  
Edna M. Babbitt ◽  
Leora R. Cherney

Purpose This study reports on the treatment fidelity procedures implemented during a 5-year randomized controlled trial comparing intensive and distributed comprehensive aphasia therapy. Specifically, the results of 1 treatment, verb network strengthening treatment (VNeST), are examined. Method Eight participants were recruited for each of 7 consecutive cohorts for a total of 56 participants. Participants completed 60 hr of aphasia therapy, including 15 hr of VNeST. Two experienced speech-language pathologists delivered the treatment. To promote treatment fidelity, the study team developed a detailed manual of procedures and fidelity checklists, completed role plays to standardize treatment administration, and video-recorded all treatment sessions for review. To assess protocol adherence during treatment delivery, trained research assistants not involved in the treatment reviewed video recordings of a subset of randomly selected VNeST treatment sessions and completed the fidelity checklists. This process was completed for 32 participants representing 2 early cohorts and 2 later cohorts, which allowed for measurement of protocol adherence over time. Percent accuracy of protocol adherence was calculated across clinicians, cohorts, and study condition (intensive vs. distributed therapy). Results The fidelity procedures were sufficient to promote and verify a high level of adherence to the treatment protocol across clinicians, cohorts, and study condition. Conclusion Treatment fidelity strategies and monitoring are feasible when incorporated into the study design. Treatment fidelity monitoring should be completed at regular intervals during the course of a study to ensure that high levels of protocol adherence are maintained over time and across conditions.


2008 ◽  
Vol 18 (2) ◽  
pp. 87-98 ◽  
Author(s):  
Vinciya Pandian ◽  
Thai Tran Nguyen ◽  
Marek Mirski ◽  
Nasir Islam Bhatti

Abstract The techniques of performing a tracheostomy has transformed over time. Percutaneous tracheostomy is gaining popularity over open tracheostomy given its advantages and as a result the number of bedside tracheostomies has increased necessitating the need for a Percutaneous Tracheostomy Program. The Percutaneous Tracheostomy Program at the Johns Hopkins Hospital is a comprehensive service that provides care to patients before, during, and after a tracheostomy with a multidisciplinary approach aimed at decreasing complications. Education is provided to patients, families, and health-care professionals who are involved in the management of a tracheostomy. Ongoing prospective data collection serves as a tool for Quality Assurance.


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