Modeling of Glutamate Pathway in Alzheimer's Disease using Biochemical Systems Theory

2018 ◽  
Author(s):  
Hemalatha Sasidharakurup ◽  
Malavika Pradeep ◽  
Maanasa Bhaskaran ◽  
Anu Priya ◽  
Evelin Pradeep ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Systems Theory ◽  
Biochemical Systems Theory ◽  
Biochemical Systems

P1-102: Building a Testable Mathematical Model for Alzheimer’s Disease Using Gene Expression Changes and Biochemical Systems Theory (BST)

2016 ◽  
Vol 12 ◽  
pp. P440-P441
Author(s):  
Randolph A. Coleman ◽  
Ceyda Durmaz ◽  
Alec A. Weech ◽  
Frank J. Castora
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Mathematical Model ◽  
Alzheimer's Disease ◽  
Systems Theory ◽  
Biochemical Systems Theory ◽  
Biochemical Systems

Modeling Crosstalk of Tau and ROS Implicated in Parkinson’s Disease Using Biochemical Systems Theory

2021 ◽  
pp. 55-61
Author(s):  
Hemalatha Sasidharakurup ◽  
Parvathy Devi Babulekshmanan ◽  
Sreehari Sathianarayanan ◽  
Shyam Diwakar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Systems Theory ◽  
Biochemical Systems Theory ◽  
Biochemical Systems

Toward a Molecular Etiology of Alzheimer's Disease

1990 ◽  
Vol 2 (2) ◽  
pp. 135-147 ◽  
Author(s):  
Carl Banner
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biochemical Characterization ◽  
Phospholipid Metabolism ◽  
Biochemical Systems ◽  
The Central Nervous System ◽  
Molecular Etiology ◽  
Neutral Proteases ◽  
Significant Bearing

Recent progress in the biochemical characterization of Alzheimer's disease (AD) neuropathology has led to the proposal of three hypotheses for the molecular etiology of AD. One focuses on calcium-activated neutral proteases or calpains (Nixon, 1989). Another focuses on protein phosphorylation (Saitoh & Iimoto, 1989). A third is centered on altered phospholipid metabolism (Pettegrew, 1989). Interestingly, all three hypotheses are mutually compatible, involving closely interlocking biochemical systems. Disturbances in any one of these systems might result in the same type of neuropathology, consistent with suggestions that AD could have multiple etiologies. Future investigations of the function and interrelation of these systems in the central nervous system in general and at the synaptic junction in particular are likely to have significant bearing on our understanding of AD.

scholarly journals Strategies for representing metabolic pathways within biochemical systems theory: Reversible pathways

1989 ◽  
Vol 94 (2) ◽  
pp. 239-269 ◽  
Author(s):  
Albert Sorribas ◽  
Michael A. Savageau
Keyword(s):  
Systems Theory ◽  
Metabolic Pathways ◽  
Biochemical Systems Theory ◽  
Biochemical Systems
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